Hello, I’d like to tell you how I got cured from a non-viral respiratory infection with the help of AVELOX tablets. I am a 19-year-old girl, and I am, like my mom says, “weak on my throat”. I always suffer from colds, flu, or other viral lungs infections, once I even had pneumonia. And not so long ago I caught some bacterial infection, like I’ve just said. I often take antibiotics, but last time I was prescribed antibiotics of penicillin class, and now my doctor said that I would have to buy a medicine of quinolone class. Such antibiotics would not work for colds, flu, or other viral infections, but would work OK in my case.
I bought from you MOXIFLOXACIN, or (trade name) AVELOX. It was said that it is a powerful quinolone antibiotic, which is designed especially for killing bacteria and preventing their growth. It is prescribed in case of treating different kinds of infections, but mostly dermatological and respiratory infections.
I liked the action of this medicine very much. It has no limitations for me (I am neither pregnant nor breast-feeding, and I have no cerebral and heart diseases, and I am not allergic), and it is really very effective.
This medicine helped me very much. I rook ir, as prescribed, at regular intervals with plenty of water, and in 4 days I was healthy again!
My doctor tokd me that moxifloxacin could be taken with or without food. First I tried it without food, but I had side effects in the form of headaches. When I started to take pills with the meal, headaches have quickly gone away. I also sometines felt drowsy or dizzy, especially when standing up or sitting up quickly, but this was not very bothersome. All in all, this medicine is splendid!

I am 47 and my husband is 59, we’ve been living long together, and I always care for his health and take responsibility to purchase all medicaments. Not so long ago, he has had pneumonia, and we were very much afraid that there could be some bothersome consequences. So we consulted my husband’s doctor. He prescribed staying in bed and intensive treatment, enhanced with antibiotics. He decided that it will be best of all to take drugs of penicillin class, among which he recommended Amoxycillin.
On your website, I found out that Amoxycillin is produced under the trade name Amoxil, which is a very effective and powerful medicine. Amoxil is known for its ability to fight a wide range of bacteria in different parts of the body, and so effectively treats such types of infections as: urinary tract infections, gonorrhea, lung and nasopharynx infections (pneumonia, bronchitis, tonsillitis), ear infections, dermatological infections. I also read testimonials over Internet and found these pills very good.
Ny husband has problems with kidneys, so I was afraid that antibiotics would be a heavy load for his kidneys. We told it all to the doctor, and he prescribed a certain scheme of taking the pills. He warned never to take double doses or miss a doze, and recommended to take Amoxil at regular intervals.
My husband took Amoxil orally with meal and glass of water. He was taking the pills for two weeks, as prescribed. The results  were astonishing, pneumonia has gone away without trace.
Our doctor warned us about side effects which might be noticed while taking Amoxil, but my husband did not have any. Amoxil is wonderful!

Last month I had a very unpleasant stomatological infection. I was suffering a lot, and my doctor prescribed me DOXYCYCLINE tablets. He said that doxycycline was a kind of tetracycline antibiotic which was able to kill or stop growth of wide range of bacteria. It is prescribed for treating many types of infections: for example, dermatic, dental, respiratory, and urinary tract infections. It also treats acne, Lyme disease, malaria, and certain sexually transmitted infections. It also can have other uses.
In this shop, there are very nice and competent pharmacists which helped me with the medicine. They asked me if I had any stomach problems, and I remembered that I had colitis, so they advised me to diminish the prescribed dose. They also advised not to take these ppills just before going to bed, becaise it is likely not to dissolve properly when you lay down, and thus may cause pain in the throat. This medicine also has certain side effects, they said. It makes skin you more sensitive to the sun, and sometimes causes redness, itching and peeling of skin, and some more negative effects. Well, I took it as the doctor prescribed me, and did not notice any side effects, except for little loss of appetite.
I must say, ADOXA was very effective in my case. I took it for a week, every day, with plenty of water, and I noticed quick relief. Very easily and fastly I got cured! And also, I’d like to say that here they have very nice prices! How can these pills have such a low price? But as I have already told, the pills are OK. Thank you again!

If you’re pain from major depression, antidepressant medication may support some of your symptoms. Antidepressants aren’t a whitish-grey bullet for depression, and they come with their own side effects and dangers. Added to, recent studies have raised questions on touching  their effectiveness. Learning the facts close toemployees  you make an informed and personal decision about whether medication is valid for you. This information is not intended to be a substitute for medical counsel. If you are taking an antidepressant, do not change your dosage without consulting your physician! antidepressants and weighing the benefits against the risks can

Is pit caused by a chemical imbalance in the brain?

You’ve seen it in tube ads, read it in newspaper articles, maybe even heard it from your doctor: melancholy is caused by a chemical imbalance in the brain that medication can remedy. According to the chemical imbalance theory, low levels of the mastermind chemical serotonin lead to depression and depression medication works by bringing serotonin levels without hope to normal. However, the truth is that researchers remember very little about how antidepressants work. There is no evaluate that can measure the amount of serotonin in the living understanding—no way to even know what a low or normal level of serotonin is, let solitary show that depression medication fixes these levels.

While antidepressant drugs such as Prozac growing serotonin levels in the brain, this doesn’t undignified that depression is caused by a serotonin shortage. After all, aspirin may remedy a headache, but it doesn’t mean that headaches are caused by an aspirin deficiency. Furthermore, innumerable studies contradict the chemical imbalance theory of economic decline. Experiments have shown that lowering people’s serotonin levels doesn’t in any case lower mood, nor does it worsen symptoms in people who are already depressed. And while antidepressants bring up serotonin levels within hours, it takes weeks in the future medication kicks in to relieve depression. If depression were due to low serotonin, there wouldn’t be an antidepressant medication lag.

How functional are antidepressants?

Researchers agree that when unhappiness is severe, medication can be helpful—even life frugality. However, research shows that antidepressants go about short for many people. A major government analysis released in 2006 showed that fewer than 50 percent of people behoove symptom-free on antidepressants, even after infuriating two different medications. Furthermore, many who do respond to medication let out back into major depression within a elfin while, despite sticking with drug treatment. Other studies grandstand a expose that the benefits of depression medication have been exaggerated, with some researchers concluding that, when it comes to merciful to moderate depression, antidepressants are only slightly more paraphernalia than placebos.

If you fool severe depression that’s interfering with your talent to function, medication may be right for you. However, many people use antidepressants when remedial programme, exercise, or self-help strategies would lift weights just as well or better—minus the side effects. Treatment can also help you get to the bottom of your underlying issues and manifest the tools to beat depression for good.

Antidepressants and suicide hazard

There is a danger that, in some people, antidepressant treatment force cause an increase, rather than a decrease, in despondency. In fact, the U.S. Food and Drug Administration requires that all hollow medications include a warning label about the increased imperil of suicide in children and young adults. The suicide endanger is particularly great during the first month to two months of treatment. Anyone engaging antidepressants should be closely watched for suicidal thoughts and behaviors. Monitoring is noticeably important if this is the person’s first time on dip medication or if the dose has recently been changed. Signs that medication is making things worse comprehend anxiety, insomnia, hostility, and extreme agitation—very if the symptoms appear suddenly or rapidly deteriorate. If you situation the warning signs in yourself or a loved one, contact your doctor or counsellor immediately.

Generic Name: aztreonam (AZ tree oh nam)
Brand names: Azactam, Cayston

What is aztreonam?

Aztreonam is an antibiotic that fights severe or life-threatening infection caused by bacteria.

Aztreonam is used to treat severe infections of the urinary tract, lower respiratory tract, skin, stomach, female reproductive organs, and other body systems.

Aztreonam may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about aztreonam?

You should not use this medication if you are allergic to aztreonam or to a penicillin antibiotic such as amoxicillin (Amoxil, Augmentin), ampicillin (Omnipen, Principen), penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids), and others.

Before using aztreonam, tell your doctor if you are allergic to cephalosporins such as Ceftin, Cefzil, Keflex, Omnicef, and others, or if you have liver or kidney disease, or a history of any type of allergy.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Aztreonam will not treat a viral infection such as the common cold or flu.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking aztreonam and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

What should I discuss with my health care provider before using aztreonam?

You should not use this medication if you are allergic to aztreonam or to a penicillin antibiotic, such as:

• amoxicillin (Amoxil, Augmentin, Amoxicot, Biomox, Dispermox, Trimox);

• ampicillin (Omnipen, Principen);

• carbenicillin (Geocillin);

• dicloxacillin (Dycill, Dynapen);

• oxacillin (Bactocill); or

• penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids, and others).

Also tell your doctor if you are allergic to any other drugs, especially:

• cephalosporins such as cefdinir (Omnicef), cefprozil (Cefzil), cefuroxime (Ceftin), cephalexin (Keflex), and others; or

• similar antibiotics such as ertapenem (Invanz), imipenem (Primaxin), or meropenem (Marum).

If you have any of these other conditions, you may need an aztreonam dose adjustment or special tests:

• liver disease;

• kidney disease; or

• a history of any type of allergy.

FDA pregnancy category B. Aztreonam is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Aztreonam can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use aztreonam?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Aztreonam is injected into a muscle or a vein. Aztreonam is usually given in a clinic or hospital setting. The medicine may need to be given for several hours or several weeks, depending on how severe your infection is.

You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

Aztreonam is usually given as long as needed until your infection has cleared or you have been symptom-free for at least 48 hours.

Use aztreonam for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Aztreonam will not treat a viral infection such as the common cold or flu. Do not give this medication to another person, even if they have the same symptoms you have. Aztreonam is supplied as a frozen solution in a plastic container. If you use this medicine at home, store the frozen medicine in a freezer. If possible, keep the freezer set at 4 degrees below 0 Fahrenheit or colder.

Thaw the medicine either in a refrigerator or at room temperature. Do not heat the medicine to thaw it more quickly. Aztreonam that is thawed in the refrigerator should be used within 2 weeks.

If you have thawed the medicine at room temperature, you must use it within 48 hours. Once aztreonam has been thawed, it should be clear and appear colorless or slightly yellow. Do not use the medicine if it has changed color or has particles in it, or if the medicine container leaks. Call your doctor or pharmacist for a new prescription.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using aztreonam?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking aztreonam and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Aztreonam side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• diarrhea that is watery or bloody;

• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;

• confusion, seizure (convulsions);

• feeling light-headed, fainting;

• pale skin, easy bruising or bleeding, unusual weakness;

• fever, chills, body aches, flu symptoms; or

• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

• mild stomach discomfort;

• warmth, redness, or tingly feeling under your skin;

• dizziness;

• numbness, tingling, or burning pain;

• mild skin rash or itching;

• vaginal itching or discharge; or

• pain, swelling, or irritation around the IV needle.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Aztreonam Dosing Information

Usual Adult Dose for Bacteremia:

2 g IV every 6 to 8 hours

Therapy should be continued for approximately 10 to 14 days, depending on the nature and severity of the infection.

Usual Adult Dose for Bacterial Infection:

Moderately severe infections: 1 to 2 g IV or IM every 8 to 12 hours
Severe infections: 2 g IV every 6 to 8 hours (maximum, 8 g/day)

Usual Adult Dose for Cystic Fibrosis:

Inhalation:
Initial dose: 75 mg via nebulizer over approximately 2 to 3 minutes 3 times a day for 28 days; doses should be at least 4 hours apart

Maintenance dose: Administer in alternating cycles of 28 days on and 28 days off.

For patients on multiple inhaled therapies, the following order of administration is recommended: bronchodilator, mucolytics, and lastly, aztreonam for inhalation.

Usual Adult Dose for Febrile Neutropenia:

2 g IV every 6 to 8 hours

Therapy should be continued until the absolute neutrophil count is greater than 500/mm3 and no infection is found or until an adequate clinical response is achieved if a susceptible infection is found and the patient has been afebrile for at least 24 hours. Therapy for neutropenic patients is often required for up to 3 weeks.

Usual Adult Dose for Intraabdominal Infection:

1 to 2 g IV every 8 or 12 hours

For severe or life-threatening infections, a dose of 2 g IV every 6 to 8 hours is recommended. Therapy should be continued for approximately 10 to 14 days, depending on the nature and severity of the infection.

Usual Adult Dose for Peritonitis:

1 to 2 g IV every 8 or 12 hours

For severe or life-threatening infections, a dose of 2 g IV every 6 to 8 hours is recommended. Therapy should be continued for approximately 10 to 14 days, depending on the nature and severity of the infection.

Usual Adult Dose for Osteomyelitis:

1 to 2 g IV every 8 or 12 hours

For severe or life-threatening infections, a dose of 2 g IV every 6 to 8 hours is recommended. Therapy should be continued for approximately 4 to 6 weeks, depending on the nature and severity of the infection. Chronic osteomyelitis may require an additional 2 months of oral antibiotics.

Usual Adult Dose for Pelvic Inflammatory Disease:

1 to 2 g IV every 8 or 12 hours

For severe or life-threatening infections, a dose of 2 g IV every 6 to 8 hours is recommended. Therapy should be continued until this patient is afebrile and pain-free for 24 to 36 hours.

Usual Adult Dose for Pneumonia:

1 to 2 g IV every 8 or 12 hours

For severe or life-threatening infections, a dose of 2 g IV every 6 to 8 hours is recommended. Therapy should be continued for approximately 21 days, depending on the nature and severity of the infection.

Usual Adult Dose for Pyelonephritis:

1 to 2 g IV every 8 or 12 hours

For severe or life-threatening infections, a dose of 2 g IV every 6 to 8 hours is recommended. Therapy should be continued for approximately 14 days, depending on the nature and severity of the infection.

Usual Adult Dose for Skin or Soft Tissue Infection:

1 to 2 g IV every 8 or 12 hours

For severe or life-threatening infections, a dose of 2 g IV every 6 to 8 hours is recommended. Therapy should be continued for approximately 7 days or until 3 days after acute inflammation disappears. For more severe infections, such as diabetic soft tissue infections, 14 to 21 days of therapy may be required.

Usual Adult Dose for Urinary Tract Infection:

500 mg to 1 g IV or IM every 8 to 12 hours

Usual Pediatric Dose for Intraabdominal Infection:

7 days or less, 2000 g or less: 30 mg/kg IV every 12 hours
7 days or less, 2001 g or more: 30 mg/kg IV every 8 hours

8 to 30 days, 1199 g or less: 30 mg/kg IV every 12 hours
8 to 30 days, 1200 to 2000 g: 30 mg/kg IV every 8 hours
8 to 30 days, 2001 g or more: 30 mg/kg IV every 6 hours

1 month to 18 years: 30 mg/kg IV every 6 to 8 hours, up to a maximum of 2 g/dose or 8 g/day

Usual Pediatric Dose for Pneumonia:

7 days or less, 2000 g or less: 30 mg/kg IV every 12 hours
7 days or less, 2001 g or more: 30 mg/kg IV every 8 hours

8 to 30 days, 1199 g or less: 30 mg/kg IV every 12 hours
8 to 30 days, 1200 to 2000 g: 30 mg/kg IV every 8 hours
8 to 30 days, 2001 g or more: 30 mg/kg IV every 6 hours

1 month to 18 years: 30 mg/kg IV every 6 to 8 hours, up to a maximum of 2 g/dose or 8 g/day

Usual Pediatric Dose for Bacterial Infection:

7 days or less, 2000 g or less: 30 mg/kg IV every 12 hours
7 days or less, 2001 g or more: 30 mg/kg IV every 8 hours

8 to 30 days, 1199 g or less: 30 mg/kg IV every 12 hours
8 to 30 days, 1200 to 2000 g: 30 mg/kg IV every 8 hours
8 to 30 days, 2001 g or more: 30 mg/kg IV every 6 hours

1 month to 18 years: 30 mg/kg IV every 6 to 8 hours, up to a maximum of 2 g/dose or 8 g/day

Usual Pediatric Dose for Urinary Tract Infection:

7 days or less, 2000 g or less: 30 mg/kg IV every 12 hours
7 days or less, 2001 g or more: 30 mg/kg IV every 8 hours

8 to 30 days, 1199 g or less: 30 mg/kg IV every 12 hours
8 to 30 days, 1200 to 2000 g: 30 mg/kg IV every 8 hours
8 to 30 days, 2001 g or more: 30 mg/kg IV every 6 hours

1 month to 18 years: 30 mg/kg IV every 6 to 8 hours, up to a maximum of 2 g/dose or 8 g/day

Usual Pediatric Dose for Skin and Structure Infection:

7 days or less, 2000 g or less: 30 mg/kg IV every 12 hours
7 days or less, 2001 g or more: 30 mg/kg IV every 8 hours

8 to 30 days, 1199 g or less: 30 mg/kg IV every 12 hours
8 to 30 days, 1200 to 2000 g: 30 mg/kg IV every 8 hours
8 to 30 days, 2001 g or more: 30 mg/kg IV every 6 hours

1 month to 18 years: 30 mg/kg IV every 6 to 8 hours, up to a maximum of 2 g/dose or 8 g/day

Usual Pediatric Dose for Cystic Fibrosis:

Inhalation:
7 years or older:
Initial dose: 75 mg via nebulizer over approximately 2 to 3 minutes 3 times a day for 28 days; doses should be at least 4 hours apart

Maintenance dose: Administer in alternating cycles of 28 days on and 28 days off.

For patients on multiple inhaled therapies, the following order of administration is recommended: bronchodilator, mucolytics, and lastly, aztreonam for inhalation.

What other drugs will affect aztreonam?

The following drugs can interact with aztreonam. Tell your doctor if you are using any of these:

• amikacin (Amikin);

• gentamicin (Garamycin);

• kanamycin (Kantrex);

• neomycin (Mycifradin, Neo-Fradin, Neo-Tab);

• streptomycin; or

• tobramycin (Nebcin, Tobi).

This list is not complete and other drugs may interact with aztreonam. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

• Your doctor or pharmacist can provide more information about aztreonam.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 1.05. Revision Date: 03/09/2010 4:45:21 PM.

az-TREE-oh-nam

Commonly used brand name(s):

In the U.S.

• Azactam

Available Dosage Forms:

• Powder for Solution
• Solution

Therapeutic Class: Antibiotic

Chemical Class: Monobactam

Uses For aztreonam

Aztreonam is an antibiotic that is used to treat infections caused by bacteria. It works by killing bacteria or preventing their growth.

Aztreonam is used to treat bacterial infections in many different parts of the body. It is sometimes given with other antibiotics. aztreonam will not work for colds, flu, or other viral infections.

aztreonam is available only with your doctor’s prescription.

Before Using aztreonam

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For aztreonam, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to aztreonam or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies have been done in children and have shown that aztreonam is effective in treating certain bacterial infections and that side effects in children are similar to those experienced by adults. Elevations of liver enzymes and reductions in white blood cell counts were seen in children who were given high doses of aztreonam or who had more serious infections.

Geriatric

Aztreonam has been tested in a limited number of patients 65 years of age or older and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of aztreonam. Make sure you tell your doctor if you have any other medical problems, especially:

• Liver disease—Patients receiving high doses of aztreonam for a long time, who also have severe liver disease, may have an increased chance of side effects

• Kidney disease—Patients with kidney disease may have an increased chance of side effects

Proper Use of aztreonam

To help clear up your infection completely, aztreonam must be given for the full time of treatment, even if you begin to feel better after a few days. Also, aztreonam works best when there is a constant amount in the blood or urine. To help keep the amount constant, aztreonam must be given on a regular schedule.

Dosing

The dose of aztreonam will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of aztreonam. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For injection dosage form:
  • Adults and children 16 years of age and older: 1 to 2 grams injected slowly into a vein over a twenty- to sixty-minute period. This is repeated every six to twelve hours.
  • Children up to 16 years of age: Dosage is based on body weight and must be determined by your doctor.

aztreonam Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common or rare

• Black, tarry stools
• blood in urine or stools
• burning or itching of vagina
• chest pain
• chills
• confusion
• convulsions (seizures)
• cough
• dark urine
• diarrhea
• difficulty in breathing
• discharge from vagina
• discomfort, inflammation, or swelling at the injection site
• dizziness
• eye pain
• fever
• flu-like symptoms
• general feeling of illness
• headache
• hives
• light gray-colored stools
• loss of appetite
• numbness of tongue
• pinpoint red spots on skin
• seeing double
• skin rash, redness, or itching
• sore throat
• unusual bleeding or bruising
• unusual tiredness or weakness
• yellow skin or eyes

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

• Abdominal or stomach cramps
• altered sense of taste
• bad breath
• breast tenderness
• burning or prickling feeling of skin
• flushing
• increased sweating
• mouth ulcers
• muscular aches
• nasal congestion
• nausea or vomiting
• ringing, buzzing, or noise in ear
• small, nonraised, round, purplish or red spots on skin
• sneezing
• trouble in sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided “AS IS” and “as available” for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

az-TREE-oh-nam

Commonly used brand name(s):

In the U.S.

• Cayston

Available Dosage Forms:

• Powder for Solution

Therapeutic Class: Antibiotic

Chemical Class: Monobactam

Uses For aztreonam

Aztreonam inhalation is an antibiotic that is used to treat lung infections in patients with cystic fibrosis. The medicine is breathed into the lungs through the mouth to treat infections caused by the Pseudomonas aeruginosa bacteria.

Aztreonam works by killing bacteria or preventing their growth. However, aztreonam will not work for colds, flu, or other virus infections.

aztreonam is available only with your doctor’s prescription.

Before Using aztreonam

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For aztreonam, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to aztreonam or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of aztreonam inhalation in children younger than 7 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies on the relationship of age to the effects of aztreonam inhalation have not been performed in the geriatric population.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of aztreonam

Use aztreonam only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered.

Keep using aztreonam for the full treatment time, even if you or your child feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.

aztreonam should be used with the Altera® Nebulizer System. The inhaled liquid and nebulizer will come with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Your doctor may give you or your child additional medicines to use before the aztreonam inhalation liquid, such as bronchodilators or mucolytics. Bronchodilators help open the lungs so you can breathe easier. Mucolytics help clear the mucus from your lungs. Carefully follow your doctor’s instructions about how to use your medicines. Aztreonam inhalation will work better if you use all of your medicines in the right order.

To use the inhalation solution:

• Mix the powder in the vial (glass container) with the saline or diluent liquid.
• Slowly swirl the vial until the powder has completely dissolved. If the liquid in the vial is cloudy or has specks in it, throw it away and mix a new dose.
• Place the mixed liquid in the medicine reservoir or nebulizer cup right away.
• Do not mix other medicines with the liquid in the nebulizer.
• Use the mouthpiece of the nebulizer to breathe in the medicine.
• Use the nebulizer for 2 to 3 minutes, or until the liquid in the nebulizer cup is gone.
• Clean the nebulizer after each use and throw out the empty vial, rubber stopper, and saline container.

Dosing

The dose of aztreonam will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of aztreonam. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For inhalation dosage form (solution in a nebulizer):
  • For lung infections:
    • Adults, teenagers, and children 7 years of age and older—One vial or container with 75 milligrams (mg) three times per day in the nebulizer. You should space the doses at least 4 hours apart.
    • Children younger than 7 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of aztreonam, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is best to store the unopened vials and saline ampules in the original carton in the refrigerator. You may also store the unopened vials at room temperature, away from heat and direct light, for up to 28 days. Do not store the liquid mixture after the powder is dissolved.

Precautions While Using aztreonam

It is very important that your doctor check the progress of you or your child at regular visits. This will allow your doctor to make sure aztreonam is working properly and to check for unwanted effects.

aztreonam may cause bronchospasm, which may be life-threatening. Check with your doctor right away if you or your child are having a cough, difficulty with breathing, shortness of breath, or wheezing after using the medicine.

Stop using aztreonam and check with your doctor right away if you or your child develop a skin rash, hives, swelling of the face, tightness in the throat, or any allergic reaction to aztreonam.

If your or your child’s symptoms do not improve or if they get worse, call your doctor.

aztreonam Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Chest discomfort
• cough
• difficulty with breathing or troubled breathing
• fever

Less common

• Noisy breathing
• shortness of breath
• tightness in the chest

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Abdominal or stomach pain
• sore throat
• stuffy nose
• vomiting

Less common

• Rash

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided “AS IS” and “as available” for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

Generic Name: sulfasalazine (SUL fa SAL a zeen)
Brand Names: Azulfidine, Azulfidine EN-tabs, Sulfazine

What is sulfasalazine oral?

Sulfasalazine affects a substance in the body that causes inflammation, tissue damage, and diarrhea.

Sulfasalazine is used to treat moderate to severe ulcerative colitis. It is also used to treat rheumatoid arthritis in children and adults who have received other arthritis medications without successful treatment of symptoms.

Sulfasalazine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about sulfasalazine oral?

You should not use this medication if you have porphyria, a blockage in your bladder or intestines, or if you are allergic to sulfasalazine, sulfa drugs, aspirin, or salicylates (such as Disalcid, Doan’s Pills, Dolobid, Salflex, Tricosal, and others).

Before using sulfasalazine, tell your doctor if you have asthma, kidney or liver disease, or glucose-6-phosphate dehydrogenase (G6PD) deficiency.

Also tell your doctor about all other medications you use, especially digoxin (digitalis, Lanoxin), folic acid (Folicin, FA-8), or vitamin or mineral supplements that contain folic acid.

Do not crush, break, or chew a sulfasalazine tablet. Swallow the pill whole. The enteric-coated tablet has a special coating to protect your stomach. Breaking the pill could damage this coating. For best results, keep using the medication as directed. Sulfasalazine will not cure ulcerative colitis, but it can reduce the number of attacks you have. If you are treating arthritis, do not stop using any of your other arthritis medications until your doctor tells you to.

What should I discuss with my healthcare provider before taking sulfasalazine oral?

You should not use this medication if you are allergic to sulfasalazine, or if you have:

• a blockage in your bladder or intestines;

• porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system);

• if you are allergic to sulfa drugs (such as Bactrim, Septra, Cotrim, and others); or

• if you are allergic to aspirin or other salicylates (such as Disalcid, Doan’s Pills, Dolobid, Salflex, Tricosal, and others).

Before using sulfasalazine, tell your doctor if you are allergic to any drugs, or if you have:

• asthma;

• glucose-6-phosphate dehydrogenase (G6PD) deficiency;

• kidney disease; or

• liver disease.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take sulfasalazine.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Sulfasalazine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take sulfasalazine oral?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take this medication after a meal. Do not crush, break, or chew a sulfasalazine tablet. Swallow the pill whole. The enteric-coated tablet has a special coating to protect your stomach. Breaking the pill could damage this coating. For best results, keep using the medication as directed. Sulfasalazine will not cure ulcerative colitis, but it can reduce the number of attacks you have. If you are treating arthritis, do not stop using any of your other arthritis medications until your doctor tells you to. Your symptoms may not improve right away when you start taking sulfasalazine, and you may still need your other medications for awhile.

To be sure this medication is not causing harmful effects, your liver and kidney function may need to be checked with blood and urine tests on a regular basis. Do not miss any scheduled appointments.

Store sulfasalazine at room temperature away from moisture and heat.

See also: Azulfidine dosage in more detail

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include nausea, vomiting, stomach pain, drowsiness, or seizure (convulsions).

What should I avoid while taking sulfasalazine oral?

Follow your doctor’s instructions about any restrictions on food, beverages, or activity while you are using sulfasalazine.

Sulfasalazine oral side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using sulfasalazine and call your doctor at once if you have any of these serious side effects:

• fever, sore throat, or other flu symptoms;

• pale skin, easy bruising;

• dark urine, jaundice (yellowing of the skin or eyes);

• pain or burning when you urinate;

• urinating less than usual or not at all;

• the appearance of a whole tablet in your stool; or

• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash.

Less serious side effects may include:

• mild nausea, vomiting, diarrhea, upset stomach;

• loss of appetite;

• headache, ringing in your ears;

• dizziness, spinning sensation;

• white patches or sores inside your mouth or on your lips;

• sleep problems (insomnia); or

• mild itching or skin rash.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect sulfasalazine oral?

Before taking sulfasalazine, tell your doctor if you are using any of the following drugs:

• digoxin (digitalis, Lanoxin);

• folic acid (Folicin, FA-8); or

• vitamin or mineral supplements that contain folic acid.

This list is not complete and there may be other drugs that can interact with sulfasalazine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about sulfasalazine.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 4.06. Revision Date: 4/12/2009 4:37:16 PM.

Generic Name: sulfasalazine (SUL fa SAL a zeen)
Brand Names: Azulfidine, Azulfidine EN-tabs, Sulfazine

What is sulfasalazine oral?

Sulfasalazine affects a substance in the body that causes inflammation, tissue damage, and diarrhea.

Sulfasalazine is used to treat moderate to severe ulcerative colitis. It is also used to treat rheumatoid arthritis in children and adults who have received other arthritis medications without successful treatment of symptoms.

Sulfasalazine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about sulfasalazine oral?

You should not use this medication if you have porphyria, a blockage in your bladder or intestines, or if you are allergic to sulfasalazine, sulfa drugs, aspirin, or salicylates (such as Disalcid, Doan’s Pills, Dolobid, Salflex, Tricosal, and others).

Before using sulfasalazine, tell your doctor if you have asthma, kidney or liver disease, or glucose-6-phosphate dehydrogenase (G6PD) deficiency.

Also tell your doctor about all other medications you use, especially digoxin (digitalis, Lanoxin), folic acid (Folicin, FA-8), or vitamin or mineral supplements that contain folic acid.

Do not crush, break, or chew a sulfasalazine tablet. Swallow the pill whole. The enteric-coated tablet has a special coating to protect your stomach. Breaking the pill could damage this coating. For best results, keep using the medication as directed. Sulfasalazine will not cure ulcerative colitis, but it can reduce the number of attacks you have. If you are treating arthritis, do not stop using any of your other arthritis medications until your doctor tells you to.

What should I discuss with my healthcare provider before taking sulfasalazine oral?

You should not use this medication if you are allergic to sulfasalazine, or if you have:

• a blockage in your bladder or intestines;

• porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system);

• if you are allergic to sulfa drugs (such as Bactrim, Septra, Cotrim, and others); or

• if you are allergic to aspirin or other salicylates (such as Disalcid, Doan’s Pills, Dolobid, Salflex, Tricosal, and others).

Before using sulfasalazine, tell your doctor if you are allergic to any drugs, or if you have:

• asthma;

• glucose-6-phosphate dehydrogenase (G6PD) deficiency;

• kidney disease; or

• liver disease.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take sulfasalazine.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Sulfasalazine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take sulfasalazine oral?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take this medication after a meal. Do not crush, break, or chew a sulfasalazine tablet. Swallow the pill whole. The enteric-coated tablet has a special coating to protect your stomach. Breaking the pill could damage this coating. For best results, keep using the medication as directed. Sulfasalazine will not cure ulcerative colitis, but it can reduce the number of attacks you have. If you are treating arthritis, do not stop using any of your other arthritis medications until your doctor tells you to. Your symptoms may not improve right away when you start taking sulfasalazine, and you may still need your other medications for awhile.

To be sure this medication is not causing harmful effects, your liver and kidney function may need to be checked with blood and urine tests on a regular basis. Do not miss any scheduled appointments.

Store sulfasalazine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include nausea, vomiting, stomach pain, drowsiness, or seizure (convulsions).

What should I avoid while taking sulfasalazine oral?

Follow your doctor’s instructions about any restrictions on food, beverages, or activity while you are using sulfasalazine.

Sulfasalazine oral side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using sulfasalazine and call your doctor at once if you have any of these serious side effects:

• fever, sore throat, or other flu symptoms;

• pale skin, easy bruising;

• dark urine, jaundice (yellowing of the skin or eyes);

• pain or burning when you urinate;

• urinating less than usual or not at all;

• the appearance of a whole tablet in your stool; or

• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash.

Less serious side effects may include:

• mild nausea, vomiting, diarrhea, upset stomach;

• loss of appetite;

• headache, ringing in your ears;

• dizziness, spinning sensation;

• white patches or sores inside your mouth or on your lips;

• sleep problems (insomnia); or

• mild itching or skin rash.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect sulfasalazine oral?

Before taking sulfasalazine, tell your doctor if you are using any of the following drugs:

• digoxin (digitalis, Lanoxin);

• folic acid (Folicin, FA-8); or

• vitamin or mineral supplements that contain folic acid.

This list is not complete and there may be other drugs that can interact with sulfasalazine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about sulfasalazine.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 4.06. Revision Date: 4/12/2009 4:37:16 PM.

Generic Name: Sulfasalazine (SUL-fa-SAL-a-zeen)
Brand Name: Azulfidine EN-tabs

Azulfidine EN-tabs Delayed-Release Tablets are used for:

Treating ulcerative colitis, rheumatoid arthritis, or polyarticular-course juvenile rheumatoid arthritis in certain patients. It may be used along with other medicines. It is also used to increase the time between attacks of ulcerative colitis. It may also be used for other conditions as determined by your doctor.

Azulfidine EN-tabs Delayed-Release Tablets are a salicylate. It decreases inflammation. Exactly how it works to treat ulcerative colitis is not known.

Do NOT use Azulfidine EN-tabs Delayed-Release Tablets if:

• you are allergic to any ingredient in Azulfidine EN-tabs Delayed-Release Tablets or to a salicylate (eg, aspirin) or a sulfonamide (eg, sulfisoxazole)
• you have the blood disorder porphyria or a stomach, bowel, or urinary tract blockage
• you have folate deficiency anemia
• the patient has systemic-course juvenile rheumatoid arthritis

Contact your doctor or health care provider right away if any of these apply to you.

Before using Azulfidine EN-tabs Delayed-Release Tablets:

Some medical conditions may interact with Azulfidine EN-tabs Delayed-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have liver or kidney problems, asthma, severe allergies, blood problems (eg, anemia, low white blood cell levels), or rheumatoid arthritis
• if you have glucose-6-phosphate dehydrogenase deficiency
• if you have an infection (eg, strep throat)

Some MEDICINES MAY INTERACT with Azulfidine EN-tabs Delayed-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin) or methotrexate because the risk of their side effects may be increased by Azulfidine EN-tabs Delayed-Release Tablets
• Beta-blockers (eg, propranolol), digoxin, or folic acid because their effectiveness may be decreased by Azulfidine EN-tabs Delayed-Release Tablets
• Methenamine because the risk of crystals in the urine is increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Azulfidine EN-tabs Delayed-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Azulfidine EN-tabs Delayed-Release Tablets:

Use Azulfidine EN-tabs Delayed-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Azulfidine EN-tabs Delayed-Release Tablets by mouth after meals.
• Take Azulfidine EN-tabs Delayed-Release Tablets with a full glass of water (8 oz/240 mL).
• Swallow Azulfidine EN-tabs Delayed-Release Tablets whole. Do not break, crush, or chew before swallowing.
• Drinking extra fluids while you are taking Azulfidine EN-tabs Delayed-Release Tablets are recommended. Check with your doctor for instructions.
• Take Azulfidine EN-tabs Delayed-Release Tablets on a regular schedule to get the most benefit from it.
• Continue to take Azulfidine EN-tabs Delayed-Release Tablets even if you feel well. Do not miss any doses.
• If you miss a dose of Azulfidine EN-tabs Delayed-Release Tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Azulfidine EN-tabs Delayed-Release Tablets.

Important safety information:

• Azulfidine EN-tabs Delayed-Release Tablets may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Azulfidine EN-tabs Delayed-Release Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Azulfidine EN-tabs Delayed-Release Tablets may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Azulfidine EN-tabs Delayed-Release Tablets. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
• Azulfidine EN-tabs Delayed-Release Tablets may discolor the urine or skin an orange-yellow color. This is normal and not a cause for concern.
• Contact your doctor if you develop sore throat, fever, unusually pale skin, dark urine, pale stools, persistent stomach pain or loss of appetite, yellowing of the skin or eyes, or unusual bruising or bleeding. Contact your doctor if you have yellowing of the skin along with dark urine, pale stools, or persistent stomach pain or loss of appetite. These could be signs of a serious side effect.
• If you see the tablet in your stool, contact your doctor right away.
• Some men taking Azulfidine EN-tabs Delayed-Release Tablets have developed a decreased number of sperm and infertility. These effects usually went away after Azulfidine EN-tabs Delayed-Release Tablets was stopped. Discuss any questions or concerns with your doctor.
• Lab tests, including liver function, kidney function, complete blood cell counts, or urine tests, may be performed while you use Azulfidine EN-tabs Delayed-Release Tablets. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Azulfidine EN-tabs Delayed-Release Tablets with caution in the ELDERLY; they may be more sensitive to its effects.
• Azulfidine EN-tabs Delayed-Release Tablets should not be used in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.
• Use Azulfidine EN-tabs Delayed-Release Tablets with extreme caution in CHILDREN younger than 10 years old who have diarrhea or an infection of the stomach or bowel.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Azulfidine EN-tabs Delayed-Release Tablets while you are pregnant. Azulfidine EN-tabs Delayed-Release Tablets are found in breast milk. If you are or will be breast-feeding while you use Azulfidine EN-tabs Delayed-Release Tablets, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Azulfidine EN-tabs Delayed-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; headache; loss of appetite; mild stomach upset or pain; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody diarrhea; bluish discoloration of the skin or nails; chest pain; dark urine; decreased urination; fever, chills, or sore throat; hearing loss; mental or mood changes; muscle pain; numbness or tingling in the fingers or toes; pale stools; persistent loss of appetite; pinpoint bruises; red, swollen, peeling, or blistered skin; seizures; severe or persistent dizziness, drowsiness, headache, or trouble sleeping; severe or persistent stomach pain; shortness of breath; trouble walking; unusual bruising or bleeding; unusual tiredness or weakness; unusually pale skin; yellowing of the eyes; yellowing of the skin along with dark urine, pale stools, or persistent loss of appetite.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include seizures; severe stomach pain, nausea, or vomiting; unusual or severe drowsiness.

Proper storage of Azulfidine EN-tabs Delayed-Release Tablets:

Store Azulfidine EN-tabs Delayed-Release Tablets at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Keep Azulfidine EN-tabs Delayed-Release Tablets out of the reach of children and away from pets.

General information:

• If you have any questions about Azulfidine EN-tabs Delayed-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.
• Azulfidine EN-tabs Delayed-Release Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Azulfidine EN-tabs Delayed-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.