Dried semduramicin fermentation products, soybean mill run, mineral oil, sodium carbonate and
sodium aluminosilicate.
For use in the manufacture of broiler chicken feed.
CAUTION:
Certain components of animal feeds, including medicated premixes, possess properties that may be a potential health hazard or a source of personal discomfort to certain individuals who are exposed to them. Human exposure should, therefore, be minimized by observing the general industry standards for occupational health and safety.
Precautions such as the following should be considered: avoid contact with skin, eyes, or mucous membranes; dust masks or respirators, safety glasses, gloves, and protective clothing should be worn; dust-arresting equipment and adequate ventilation should be utilized; personal hygiene should be observed; wash before eating or leaving a work site; be alert for signs of allergic reactions-seek prompt medical attention if such reactions are suspected.
IMPORTANT:
Must be thoroughly mixed with feed before use.
STORE AT OR BELOW 25°C (77°F)
SEE BACK OF PACKAGE FOR FURTHER USE DIRECTIONS
Indications for Use
For the prevention of coccidiosis in broiler chickens caused by Eimeria tenella, E. acervulina, E. maxima, E. brunetti, E. necatrix, and E. mitis.
Mixing and Feeding Directions
Thoroughly mix 1 lb of Aviax II Type A Medicated Article per 2000 lb of feed ingredients to provide 25 ppm (22.7 g) of semduramicin per ton of Type C finished broiler feeds. Feed continuously as the sole ration to broiler chickens.
WARNING:
Do not feed to laying hens.
Aviax® is a registered trademark of Phibro Animal Health, Inc. Phibro Animal Health, Inc., Ridgefield Park, NJ 07660
Doxycycline is a tetracycline antibiotic. It fights bacteria in the body.
Doxycycline is used to treat many different bacterial infections, such as urinary tract infections, acne, gonorrhea, and chlamydia, periodontitis (gum disease), and others.
Doxycycline is also used to treat blemishes, bumps, and acne-like lesions caused by rosacea. Doxycycline will not treat facial redness caused by rosacea.
Doxycycline may also be used for other purposes not listed in this medication guide.
What is the most important information I should know about Avidoxy (doxycycline)?
Do not use this medication if you are pregnant. It could cause harm to the unborn baby, including permanent discoloration of the teeth later in life. Doxycycline can make birth control pills less effective. Use a second method of birth control while you are taking doxycycline to keep from getting pregnant. Doxycycline passes into breast milk and may affect bone and tooth development in a nursing baby. Do not take this medication without telling your doctor if you are breast-feeding a baby. Do not use this medication if you are allergic to doxycycline, or to similar medicines such as demeclocycline (Declomycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap). Before taking doxycycline, tell your doctor if you have liver or kidney disease. You may not be able to take doxycycline, or you may need a dose adjustment or special tests during treatment. Do not give doxycycline to a child younger than 8 years old. Doxycycline can cause permanent yellowing or graying of the teeth, and it can affect a child’s growth. Throw away any unused doxycycline when it expires or when it is no longer needed. Do not take any doxycycline after the expiration date printed on the bottle. Expired doxycycline can cause a dangerous syndrome resulting in damage to the kidneys.
What should I discuss with my healthcare provider before taking Avidoxy (doxycycline)?
Do not use this medication if you are allergic to doxycycline, or to similar medicines such as demeclocycline (Declomycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap). If you have liver or kidney disease, you may need a dose adjustment or special tests to safely take doxycycline.
If you are using doxycycline to treat gonorrhea, your doctor may test you to make sure you do not also have syphilis, another sexually transmitted disease.
Do not use doxycycline syrup (Vibramycin) without first talking to your doctor if you have asthma or are allergic to sulfites.
FDA pregnancy category D. This medication can cause harm to an unborn baby, including permanent discoloration of the teeth later in life. Do not use doxycycline without your doctor’s consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Doxycycline can make birth control pills less effective. Use a non-hormonal method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while you are taking doxycycline. Doxycycline passes into breast milk and may affect bone and tooth development in a nursing infant. Do not take this medication without first talking to your doctor if you are breast-feeding a baby. Children younger than 8 years old should not take doxycycline. Doxycycline can cause permanent tooth discoloration and can also affect a child’s growth.
How should I take Avidoxy (doxycycline)?
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
Take doxycycline with a full glass of water (8 ounces).
You may take this medication with or without food. Do not take the medication with milk or other dairy products, unless your doctor has told you to. Dairy products can make it harder for your body to absorb the medicine. Certain brands of doxycycline may not have restrictions about taking them with dairy products. If your doctor has instructed you to take doxycycline with milk, tell your pharmacist that you need a brand of doxycycline that can be taken with milk.
Do not crush, break, or open a delayed-release capsule (Orecea). Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time. Shake the oral suspension (liquid) well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Doxycycline will not treat a viral infection such as the common cold or flu. Do not give this medicine to another person, even if they have the same condition you have.
If you need to have any type of surgery, tell the surgeon ahead of time that you are taking doxycycline. You may need to stop using the medicine for a short time.
Throw away any unused doxycycline when it expires or when it is no longer needed. Do not take any doxycycline after the expiration date printed on the label. Using expired doxycycline can cause damage to your kidneys. Store this medication at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include nausea, vomiting, and diarrhea.
What should I avoid while taking Avidoxy (doxycycline)?
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.
Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Doxycycline can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun. Do not take iron supplements, multivitamins, calcium supplements, antacids, or laxatives within 2 hours before or after taking doxycycline.
Avidoxy (doxycycline) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using doxycycline and call your doctor at once if you have any of these serious side effects:
severe headache, dizziness, blurred vision;
fever, chills, body aches, flu symptoms;
severe blistering, peeling, and red skin rash;
urinating less than usual or not at all;
pale or yellowed skin, dark colored urine, fever, confusion or weakness;
severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;
loss of appetite, jaundice (yellowing of the skin or eyes); or
easy bruising or bleeding, unusual weakness.
Less serious side effects may include:
swollen tongue, trouble swallowing;
mild nausea, vomiting, diarrhea, or stomach upset;
white patches or sores inside your mouth or on your lips;
sores or swelling in your rectal or genital area; or
vaginal itching or discharge.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Avidoxy (doxycycline)?
Before taking doxycycline, tell your doctor if you are taking any of the following drugs:
cholesterol-lowering medications such as cholestyramine (Prevalite, Questran) or colestipol (Colestid);
isotretinoin (Accutane);
tretinoin (Renova, Retin-A, Vesanoid);
an antacid such as Tums, Rolaids, Milk of Magnesia, Maalox, and others;
a product that contains bismuth subsalicylate such as Pepto-Bismol;
minerals such as iron, zinc, calcium, magnesium, and over-the-counter vitamin and mineral supplements;
a blood thinner such as warfarin (Coumadin); or
a penicillin antibiotic such as amoxicillin (Amoxil, Trimox, others), penicillin (BeePen-VK, Pen-Vee K, Veetids, others), dicloxacillin (Dynapen), oxacillin (Bactocill), and others.
This list is not complete and there may be other drugs that can interact with doxycycline. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Where can I get more information?
Your pharmacist can provide more information about doxycycline.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Treating acne. It may also be used for other conditions as determined by your doctor.
Avidoxy DK is a kit containing a tetracycline antibiotic, a topical salicylate, and a sunscreen. The tablets work by slowing the growth of bacteria, which allows the body’s immune system to destroy the bacteria. The wash works to clean the skin of dirt and oil and helps to remove dead skin cells. The sunscreen helps to prevent sunburn.
Do NOT use Avidoxy DK if:
you are allergic to any ingredient in Avidoxy DK or to another tetracycline (eg, minocycline)
you are taking acitretin, isotretinoin, or a penicillin (eg, amoxicillin)
you have recently received or will be receiving a live oral typhoid vaccine
Contact your doctor or health care provider right away if any of these apply to you.
Before using Avidoxy DK:
Some medical conditions may interact with Avidoxy DK. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have diarrhea, a history of lupus, or the blood disease porphyria
if you have a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to aspirin or a nonsteroidal anti-inflammatory drug (NSAID) (eg, celecoxib, ibuprofen, naproxen)
if you have liver or kidney problems, skin irritation, diabetes, or poor blood circulation
Some MEDICINES MAY INTERACT with Avidoxy DK. Tell your health care provider if you are taking any other medicines, especially any of the following:
Barbiturates (eg, phenobarbital), carbamazepine, hydantoins (eg, phenytoin), iron, or urinary alkalinizers (eg, sodium bicarbonate) because they may decrease Avidoxy DK’s effectiveness
Acitretin, anticoagulants (eg, heparin, warfarin), aspirin, digoxin, isotretinoin, methotrexate, or methoxyflurane because the risk of their side effects may be increased by Avidoxy DK
Live oral typhoid vaccine, hormonal birth control (eg, birth control pills), or a penicillin (eg, amoxicillin) because their effectiveness may be decreased by Avidoxy DK
This may not be a complete list of all interactions that may occur. Ask your health care provider if Avidoxy DK may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Avidoxy DK:
Use Avidoxy DK as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Take Avidoxy DK by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
To clear up your acne completely, take Avidoxy DK for the full course of treatment. Keep taking it even if you feel better in a few days.
Drink plenty of fluids with Avidoxy DK to wash it down and avoid the risk of throat irritation.
Wash your face or the affected area with the wash and thoroughly dry.
Apply a thin layer of the sunscreen to your face or the affected area. Gently rub the sunscreen in until it is evenly distributed. Be sure to wash your hands after each use.
Do not take an antacid that has aluminum, calcium, or magnesium in it; bismuth-containing products; iron; urinary alkalinizers (eg, sodium bicarbonate); or multivitamins with minerals within 2 hours before or 2 hours after you take Avidoxy DK.
Do not use Avidoxy DK if it is out of date or has been stored incorrectly.
If you miss a dose of Avidoxy DK, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Avidoxy DK.
Important safety information:
Be sure to use Avidoxy DK for the full course of treatment. If you do not, the medicine may not clear up your acne completely. The bacteria could also become less sensitive to this or other medicines.
Long-term or repeated use of Avidoxy DK may cause a second infection. Tell your doctor if signs of a second infection occur.
Hormonal birth control (eg, birth control pills) may not work as well while you are using Avidoxy DK. To prevent pregnancy, use an extra form of birth control (eg, condoms).
Avidoxy DK may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Avidoxy DK. Use the sunscreen included in this kit or wear protective clothing if you must be outside for more than a short time.
Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or blood stools occur. Do not treat diarrhea without first checking with your doctor.
The wash is for external use only. Avoid getting the wash in your eyes, nose, or mouth, or on your genitals. If contact with your eyes occurs, flush with water for 15 minutes. Do not inhale the vapors of the wash.
Do NOT take more than the recommended dose of the tablets or use the wash for longer than prescribed without checking with your doctor. Overuse of the topical wash may worsen your condition.
Be sure to use the wash only on the affected area and not on normal healthy skin. Do not use the wash on open skin wounds, moles, birthmarks, genital warts, warts on the face, or warts growing hair.
Do not use any other medicines or drying products on your skin unless your doctor instructs you otherwise.
The wash may be harmful if swallowed. If you may have taken the wash by mouth, contact your local poison control center or emergency room immediately.
The wash contains a salicylate, which has been linked to Reye syndrome. Do not use the wash on children or teenagers during or after chickenpox, flu, or other viral infections without checking with your doctor or pharmacist.
Avidoxy DK may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Avidoxy DK.
Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed while you use Avidoxy DK. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
Avidoxy DK should not be used in CHILDREN younger than 8 years old; permanent yellow-gray-brown tooth discoloration may occur.
PREGNANCY and BREAST-FEEDING: Avidoxy DK has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Avidoxy DK while you are pregnant. Avidoxy DK is found in breast milk. Do not breast-feed while taking Avidoxy DK.
Possible side effects of Avidoxy DK:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Dry, peeling, red, or scaling skin; loss of appetite; mild diarrhea; nausea; sensitivity to sunlight; vomiting.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody stools; dark urine; decreased urination; fever, chills, or sore throat; moderate to severe sunburn; severe diarrhea; severe or persistent headache; severe skin irritation; stomach pain or cramps; throat irritation; trouble swallowing; unusual bruising or bleeding; unusual joint pain; vaginal irritation or discharge; vision changes; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately
Proper storage of Avidoxy DK:
Store Avidoxy DK at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Avidoxy DK out of the reach of children and away from pets.
General information:
If you have any questions about Avidoxy DK, please talk with your doctor, pharmacist, or other health care provider.
Avidoxy DK is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.
This information is a summary only. It does not contain all information about Avidoxy DK. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Generic Name: morphine (MOR feen)
Brand Names: Avinza, Kadian, Morphine IR, MS Contin, MSIR, Oramorph SR, Roxanol
What is morphine?
Morphine is in a group of drugs called narcotic pain relievers.
Morphine is used to treat moderate to severe pain. Short-acting morphine is taken as needed for pain. Extended-release morphine is for use when around-the-clock pain relief is needed.
Morphine is not for treating pain just after surgery unless you were already taking morphine before the surgery.
Morphine may also be used for purposes other than those listed in this medication guide.
What is the most important information I should know about morphine?
You may not be able to take this medicine unless you are already being treated with a similar opioid pain medicine and your body is tolerant to it. Talk with your doctor if you are not sure you are opioid-tolerant.
Morphine may be habit-forming and should be used only by the person it was prescribed for. Morphine should never be given to another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Do not drink alcohol while you are using morphine. Dangerous side effects or death can occur when alcohol is combined with morphine. Check your food and medicine labels to be sure these products do not contain alcohol.
Never take more than your prescribed dose of morphine. Tell your doctor if the medicine seems to stop working as well in relieving your pain.
Do not stop taking morphine suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.
What should I discuss with my healthcare provider before using morphine?
Do not use this medication if you have ever had an allergic reaction to a narcotic medicine (examples include codeine, methadone, Oxycontin, Darvocet, Percocet, Vicodin, Lortab, and many others). You should also not take morphine if you are having an asthma attack or if you have a bowel obstruction called paralytic ileus. Morphine may be habit-forming and should be used only by the person it was prescribed for. Morphine should never be given to another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.
Before using morphine, tell your doctor if you are allergic to any drugs, or if you have:
asthma, COPD, sleep apnea, or other breathing disorders;
liver or kidney disease;
underactive thyroid;
curvature of the spine;
a history of head injury or brain tumor;
epilepsy or other seizure disorder;
low blood pressure;
gallbladder disease;
Addison’s disease or other adrenal gland disorders;
enlarged prostate, urination problems;
mental illness; or
a history of drug or alcohol addiction.
You may not be able to take morphine unless you are already being treated with a similar opioid pain medicine and your body is tolerant to it. Talk with your doctor if you are not sure you are opioid-tolerant. FDA pregnancy category C. This medication may be harmful to an unborn baby, and could cause addiction or withdrawal symptoms in a newborn. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Morphine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Older adults may be more sensitive to the effects of this medicine.
How should I use morphine?
Use this medication exactly as it was prescribed for you. Never take morphine in larger amounts, or use it for longer than recommended by your doctor. Follow the directions on your prescription label. Too much morphine could be very harmful. Tell your doctor if the medicine seems to stop working as well in relieving your pain.
Do not crush, chew, or break an extended-release tablet. Swallow the pill whole. It will release medicine slowly in the body. Breaking the pill would cause too much of the drug to be released at one time.
To make swallowing easier, you may open the extended-release capsule and sprinkle the medicine into a spoonful of applesauce. Swallow this mixture right away without chewing. Do not save the mixture for later use. Discard the empty capsule.
Measure the liquid form of morphine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.
Do not stop using morphine suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication. Store this medication at room temperature, away from heat, moisture, and light.
Keep track of how many pills have been used from each new bottle of this medicine. Morphine is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.
After you have stopped using this medication, flush any unused pills down the toilet. Throw away any unused liquid morphine that is older than 90 days.
What happens if I miss a dose?
Since morphine is sometimes used as needed, you may not be on a dosing schedule. If you are using the medication regularly, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not use extra medicine to make up the missed dose.
Extended-release morphine is not for use on an as-needed basis for pain.
What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine. An overdose of morphine can be fatal.
Overdose symptoms may include extreme drowsiness, pinpoint pupils, confusion, cold and clammy skin, weak pulse, shallow breathing, fainting, or breathing that stops.
What should I avoid while using morphine?
Do not drink alcohol while you are taking this medication. Dangerous side effects or death can occur when alcohol is combined with morphine. Check your food and medicine labels to be sure these products do not contain alcohol. Morphine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
Morphine side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
shallow breathing, slow heartbeat;
seizure (convulsions);
cold, clammy skin;
confusion;
severe weakness or dizziness; or
feeling light-headed, fainting.
Less serious side effects are more likely to occur, such as:
constipation;
warmth, tingling, or redness under your skin;
nausea, vomiting, stomach pain, diarrhea, loss of appetite;
dizziness, headache, anxiety;
memory problems; or
sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect morphine?
Avoid taking morphine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Side effects can be more severe if you use morphine before the MAO inhibitor has cleared from your body. Do not take morphine with other narcotic pain medications, sedatives, tranquilizers, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Dangerous side effects may result.
Before taking morphine, tell your doctor if you are using pentazocine (Talwin), nalbuphine (Nubain), butorphanol (Stadol), or buprenorphine (Buprenex, Subutex). If you are using any of these drugs, you may not be able to use morphine, or you may need dosage adjustments or special tests during treatment.
This list is not complete and there may be other drugs that can interact with morphine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Where can I get more information?
Your pharmacist can provide more information about morphine.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Avinza Extended-Release Capsules are an extended-release form of morphine that is normally taken only once a day. It should only be used for moderate to severe pain that requires continuous, around-the-clock treatment over a long period of time. Swallow Avinza Extended-Release Capsules whole. If you have trouble swallowing Avinza Extended-Release Capsules whole, you may sprinkle the contents of the capsule on a small amount of applesauce and then swallow the mixture. Do not chew, crush, or dissolve the contents of the capsule before swallowing. Do not drink alcoholic beverages or take any prescription or nonprescription medicines that contain alcohol at any time while taking Avinza Extended-Release Capsules. Doing any of these things may cause too much medicine to be absorbed too quickly and may cause severe or possibly fatal side effects.
Avinza Extended-Release Capsules are used for:
Managing moderate to severe pain for more than a few days. It may also be used for other conditions as determined by your doctor.
Avinza Extended-Release Capsules are a narcotic pain reliever. It works by dulling the pain perception center in the brain. It may also affect other body systems (eg, breathing and circulatory systems) at higher doses.
Do NOT use Avinza Extended-Release Capsules if:
you are allergic to any ingredient in Avinza Extended-Release Capsules
you have known or suspected paralysis of the intestines or antibiotic associated colitis
you are taking cimetidine, sodium oxybate (GHB), or a tricyclic antidepressant (eg, amitriptyline), or you drink alcohol
you are taking or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the past 14 days
you have slowed breathing or severe asthma, or you are having an asthma attack
Contact your doctor or health care provider right away if any of these apply to you.
Before using Avinza Extended-Release Capsules:
Some medical conditions may interact with Avinza Extended-Release Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have asthma, chronic obstructive pulmonary disease (COPD), or other lung or breathing problems, or you have a history of drug abuse or dependence
if you have increased pressure in the head, a recent head injury, or lesions in the head
if you have difficulty urinating; heart, liver, or thyroid disease; hypercapnia (abnormally increased carbon dioxide tension in your arteries); curvature of the spine; seizures; or a history of suicidal thoughts or behaviors
if you have low blood volume, a stomach blockage or inflammatory bowel disease, have had stomach tract surgery, or are in shock
Some MEDICINES MAY INTERACT with Avinza Extended-Release Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:
Fluoxetine, naltrexone, narcotic agonists/antagonists (eg, pentazocine), rifampin, or risperidone because they may decrease Avinza Extended-Release Capsules’s effectiveness
Barbiturate anesthetics (eg, thiopental), cimetidine, ethanol, ketorolac, MAOIs (eg, phenelzine) sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline ) because side effects (eg, disorientation, respiratory depression, seizures) may occur
Barbiturate anesthetics (eg, thiopental) or sodium oxybate (GHB) because the risk of their side effects may be increased by Avinza Extended-Release Capsules
Mexiletine or trovafloxacin because their effectiveness may be decreased by Avinza Extended-Release Capsules
This may not be a complete list of all interactions that may occur. Ask your health care provider if Avinza Extended-Release Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Avinza Extended-Release Capsules:
Use Avinza Extended-Release Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Take Avinza Extended-Release Capsules by mouth with or without food.
Swallow Avinza Extended-Release Capsules whole. Do not dissolve, crush, or chew before swallowing.
If you cannot swallow the capsule whole, you may open it and sprinkle the contents over a spoonful of applesauce. Mix the medicine with the applesauce and swallow the mixture right away, followed by a glass of water. Do not crush or chew the medicine before swallowing. Do not store the mixture for future use.
Take Avinza Extended-Release Capsules on a regular schedule to get the most benefit from it.
Taking Avinza Extended-Release Capsules at the same time each day will help you remember to take it.
If you also take trovafloxacin, do not take it within 4 hours before or after taking Avinza Extended-Release Capsules. Check with your doctor if you have questions.
If you miss a dose of Avinza Extended-Release Capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Avinza Extended-Release Capsules.
Important safety information:
Avinza Extended-Release Capsules may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Avinza Extended-Release Capsules with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Avinza Extended-Release Capsules; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
Do not drink alcohol or take any prescription or nonprescription medicines that have alcohol in them while you are taking Avinza Extended-Release Capsules. Ask your pharmacist if you have questions about if any of your medicines have alcohol in them.
Excessive drowsiness usually disappears in 3 to 5 days. Consult your doctor if it continues or is accompanied by unsteadiness or confusion.
Avinza Extended-Release Capsules may cause constipation. Constipation may be avoided by using a stool softener or fiber laxative.
The risk of Avinza Extended-Release Capsules becoming habit-forming may be greater if you take it in high doses or for a long time. Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
Tell your doctor or dentist that you take Avinza Extended-Release Capsules before you receive any medical or dental care, emergency care, or surgery.
Do not take Avinza Extended-Release Capsules if you have had a severe allergic reaction to morphine or hydromorphone (eg, MS Contin, Roxanol, Dilaudid). If you have a question about whether you are allergic to Avinza Extended-Release Capsules or if a certain medicine contains morphine or hydromorphone, contact your doctor or pharmacist.
Lab tests, including liver function, kidney function, lung function, and complete blood cell counts, may be performed while you use Avinza Extended-Release Capsules. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
Use Avinza Extended-Release Capsules with caution in the ELDERLY; they may be more sensitive to its effects.
Avinza Extended-Release Capsules should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Avinza Extended-Release Capsules while you are pregnant. Avinza Extended-Release Capsules are found in breast milk. Do not breast-feed while taking Avinza Extended-Release Capsules.
When used for long periods of time or at high doses, Avinza Extended-Release Capsules may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Avinza Extended-Release Capsules stops working well. Do not take more than prescribed
Some people who use Avinza Extended-Release Capsules for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction. If you stop taking Avinza Extended-Release Capsules suddenly, you may have WITHDRAWAL symptoms. These may include anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping.
Possible side effects of Avinza Extended-Release Capsules:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); excessive drowsiness; face or throat swelling; fast, irregular, or slow heartbeat; hallucinations; itching; pounding in the chest; seizures; shock; shortness of breath; sudden chest pain; sweating.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include cold and clammy skin; convulsions; deep sleep; dizziness; drowsiness; lightheadedness; loss of consciousness; low body temperature; slowed breathing; slowed heartbeat.
Proper storage of Avinza Extended-Release Capsules:
Store Avinza Extended-Release Capsules at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Protect from heat, moisture, and light. Do not store in the bathroom. Keep Avinza Extended-Release Capsules out of the reach of children and away from pets.
General information:
If you have any questions about Avinza Extended-Release Capsules, please talk with your doctor, pharmacist, or other health care provider.
Avinza Extended-Release Capsules are to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.
This information is a summary only. It does not contain all information about Avinza Extended-Release Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Avar is a gel used to treat the inflammation and skin eruptions associated with acne and rosacea. Avar Green is a tinted version of the gel that helps tone down redness. Avar can also be used to treat the dry, scaly skin known as seborrheic dermatitis.
Avar is intended for use on a daily basis. It may take several weeks to see an improvement in the skin.
Most important fact about Avar
Avar contains an ingredient similar to sulfa drugs such as Bactrim and Septra. On rare occasions these medications have caused severe allergic reactions. If you are allergic to any sulfa drug, you may also be allergic to Avar. In addition, if you have taken one of these medications in the past, you may have developed a “hidden” allergy to sulfa drugs that might show up when you use Avar. Notify your doctor immediately at the first sign of a severe reaction such as skin rash, sore throat, fever, joint pain, cough, shortness of breath, abnormal skin paleness, reddish or purplish skin spots, or yellowing of the skin or whites of the eyes.
How should you take Avar?
Apply a thin film to the skin, being careful to avoid the eyes. Wash your hands after each application.
If you have rosacea, be sure to avoid things that make your face turn red or flush. Typical offenders include hot or spicy foods, hot drinks such as tea or coffee, and alcohol. You should also avoid using cleanser and other facial products that contain alcohol or astringents.
–If you miss a dose…
Take it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to your regular schedule.
–Storage instructions…
Store at room temperature. Do not allow the gel to freeze.
Avar side effects
Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue using Avar.
Side effects may include:
Reddening of the skin, scaling skin, skin irritation
Why should Avar not be prescribed?
Do not use Avar if you are allergic to sulfa drugs (see “Most important fact about Avar”) or if you have kidney disease.
Special warnings about Avar
Inform your doctor if your skin becomes excessively red or irritated while using Avar.
Possible food and drug interactions when taking Avar
No interactions have been reported.
Special information if you are pregnant or breastfeeding
The effects of Avar during pregnancy and breastfeeding have not been adequately studied. If you are pregnant or plan to become pregnant, notify your doctor immediately. Small amounts of the drug could appear in breast milk. If you are nursing, use Avar with caution.
Recommended dosage for Avar
Apply a thin film of Avar gel to the affected areas 1 to 3 times daily, or as directed by your doctor.
Overdosage
An overdose is unlikely. However, if your skin becomes severely irritated, you should stop applying Avar and call your doctor.
Generic Name:Sulfacetamide/Sulfur (sul-fa-SEE-ta-mide/SULL-fer) Brand Name: Examples include Avar and Plexion SCT
Avar Cream is used for:
Treating acne, rosacea, and seborrhea. It may also be used for other conditions as determined by your doctor.
Avar Cream is a sulfonamide antibiotic and keratolytic. It works by killing bacteria and shedding the top layer of skin to help treat acne.
Do NOT use Avar Cream if:
you are allergic to any ingredient in Avar Cream
you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to any other sulfonamide medicine, such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glyburide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide
you have kidney disease
Contact your doctor or health care provider right away if any of these apply to you.
Before using Avar Cream:
Some medical conditions may interact with Avar Cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have eczema or a history of lupus
Some MEDICINES MAY INTERACT with Avar Cream. Tell your health care provider if you are taking any other medicines, especially any of the following:
Silver-containing products (eg, silver sulfadiazine) because they may decrease Avar Cream’s effectiveness
Methenamine because it may increase the risk of Avar Cream’s side effects
This may not be a complete list of all interactions that may occur. Ask your health care provider if Avar Cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Avar Cream:
Use Avar Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Avar Cream is for use on the skin only. Avar Cream may stain clothing and the skin if too much is used.
Wash hands before and after using Avar Cream.
Gently wash and dry the affected area. Apply a small amount of Avar Cream to the affected area. Rub in gently.
To clear up your infection completely, continue using Avar Cream for the full course of treatment even if you feel better in a few days.
Avar Cream works best if it is used at the same time each day.
Continue to use Avar Cream even if you feel well. Do not miss any doses.
If you miss a dose of Avar Cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Avar Cream.
Important safety information:
It may take several days for Avar Cream to work fully.
Avoid getting Avar Cream in your eyes, nose, or mouth. If you get Avar Cream in your eyes, rinse immediately with cool tap water.
Talk with your doctor before you use any other medicines or cleansers on your skin.
Do not apply Avar Cream to open wounds or to damaged or burned skin without first checking with your doctor.
If you use topical products too often, your condition may become worse.
Avar Cream only works against bacteria; it does not treat viral infections.
Be sure to use Avar Cream for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
Long-term or repeated use of Avar Cream may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
Avar Cream should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.
PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Avar Cream while you are pregnant. It is not known if Avar Cream is found in breast milk after topical use. If you are or will be breast-feeding while you use Avar Cream, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Avar Cream:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Mild irritation, stinging, or burning of the skin.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); cracked or extremely dry skin; fever; joint pain; red, swollen, scaling, or blistered skin; severe diarrhea; sores in the mouth; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Avar Cream may be harmful if swallowed. Symptoms of ingestion may include change in the amount of urine; nausea; vomiting.
Proper storage of Avar Cream:
Store Avar Cream at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Do not freeze. Keep Avar Cream out of the reach of children and away from pets.
General information:
If you have any questions about Avar Cream, please talk with your doctor, pharmacist, or other health care provider.
Avar Cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.
This information is a summary only. It does not contain all information about Avar Cream. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Bevacizumab is a cancer medicine that interferes with the growth of cancer cells and slows their growth and spread in the body.
Bevacizumab is used to treat a certain type of brain tumor as well as cancers of the kidney, colon, rectum, lung, or breast. It is usually given as part of a combination of cancer medicines.
Bevacizumab may also be used for other purposes not listed in this medication guide.
What is the most important information I should know about bevacizumab?
Avoid having surgery while you are being treated with bevacizumab. You may have problems with wound healing, which could result in bleeding or infection.
If you need to have any type of surgery, you will need to stop receiving bevacizumab for at least 4 weeks while your surgical incision heals.
Before being treated with bevacizumab, tell your doctor if you have liver disease, kidney disease, heart disease, high blood pressure, a history of stroke or blood clots, or an open wound.
Some people receiving a bevacizumab injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel dizzy, nauseated, light-headed, sweaty, itchy, or have a fast heartbeat, chills, wheezing, or chest pain during the injection.
Call your doctor at once if you have serious side effects such as blood in your stools or vomit, sudden numbness or weakness (especially on one side of the body), sudden headache or confusion, problems with vision or speech, chest pain spreading to the arm or shoulder, shortness of breath, swelling, rapid weight gain, or flu symptoms.
Bevacizumab can cause a rare but serious neurologic disorder affecting the brain. Symptoms include headache, confusion, vision problems, feeling light-headed, fainting, and seizure (blackout or convulsions). These rare symptoms may occur within hours of your first dose of bevacizumab, or they may not appear for up to a year after your treatment started. Call your doctor at once if you have any of these side effects.
To be sure this medication is not causing harmful effects, your blood pressure will need to be tested on a regular basis. Your urine may also need to be tested. Do not miss any scheduled visits to your doctor.
This medication can affect a woman’s fertility (ability to have children). Talk to your doctor about your specific risks.
What should I discuss with my healthcare provider before using bevacizumab?
Treatment with bevacizumab may cause you to have problems with wound healing, which could result in bleeding or infection. Before receiving this medication, tell your doctor if you have had any type of surgery within the past 4 weeks. You may need to wait until your incision is completely healed before you are treated with bevacizumab.
If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before receiving bevacizumab, tell your doctor if you have:
liver disease;
kidney disease;
heart disease or high blood pressure;
a history of stroke or blood clots;
if you have an open wound; or
if you are receiving chemotherapy or medications to prevent anemia (lack of red blood cells).
FDA pregnancy category C. It is not known whether bevacizumab is harmful to an unborn baby. Before receiving this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether bevacizumab passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have side effects from this medication.
Bevacizumab can affect a woman’s fertility (ability to have children). Talk to your doctor about your specific risks.
How is bevacizumab used?
This medication is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting. The medicine must be given slowly through an IV infusion, and can take up to 90 minutes to complete.
Bevacizumab is usually given once every 2 weeks.
To be sure this medication is not causing harmful effects, your blood pressure will need to be tested on a regular basis. Your urine may also need to be tested. Do not miss any scheduled visits to your doctor.
Bevacizumab must be stored in a refrigerator and kept from freezing. Bevacizumab bottles should never be shaken.
What happens if I miss a dose?
Contact your doctor if you miss an appointment to receive your bevacizumab infusion.
What happens if I overdose?
Seek emergency medical attention if you think you have received too much of this medicine. An overdose of bevacizumab may cause a severe headache.
What should I avoid while using bevacizumab?
Avoid having surgery while you are being treated with bevacizumab. You could have problems with wound healing, which may result in bleeding or infection.
If you need to have any type of surgery, you will need to stop receiving bevacizumab for at least 4 weeks while your surgical incision heals.
Bevacizumab side effects
Bevacizumab can cause a rare but serious neurologic disorder affecting the brain. Symptoms include headache, confusion, vision problems, feeling light-headed, fainting, and seizure (blackout or convulsions). These rare symptoms may occur within hours of your first dose of bevacizumab, or they may not appear for up to a year after your treatment started. Call your doctor at once if you have any of these side effects.
Some people receiving a bevacizumab injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel dizzy, nauseated, light-headed, sweaty, itchy, or have a fast heartbeat, chills, wheezing, or chest pain during the injection.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
stomach pain with vomiting or constipation;
black, bloody, or tarry stools;
vomit that looks like blood or coffee grounds;
sudden numbness or weakness, especially on one side of the body;
sudden headache, confusion, problems with vision, speech, or balance;
chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
unusual bleeding such as nosebleeds, bleeding gums, or any bleeding that will not stop; or
white patches or sores inside your mouth or on your lips.
Less serious side effects may include::
diarrhea, stomach pain, loss of appetite;
dry mouth, increased thirst;
dizziness; or
hair loss.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect bevacizumab?
There may be other drugs that can interact with bevacizumab. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Where can I get more information?
Your healthcare provider can provide more information about bevacizumab.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Avastin Solution may cause severe stomach or bowel problems (eg, abscess, fistula, perforation). These effects are not common, but are serious and sometimes may be fatal. Contact your doctor immediately if you develop unusual stomach pain along with constipation, fever, nausea, or vomiting.
Avastin Solution may cause serious and sometimes fatal wound healing problems. Tell your doctor immediately if you notice any wounds that do not heal. Tell your doctor if you have had surgery within the past 28 days. If possible, Avastin Solution should be stopped at least 28 days before surgery and until the surgical wound heals.
Avastin Solution may cause severe and sometimes fatal bleeding. This may occur in the lungs, stomach or intestines, or brain. Nosebleed or vaginal bleeding may also occur. Patients who have current severe bleeding or a recent history of coughing up blood should not use Avastin Solution. Contact your doctor right away if you experience unusual bleeding or bruising.
Avastin Solution is used for:
Treating certain types of advanced lung cancer. It is also used to treat certain types of brain, breast, kidney, colon, or rectal cancer. It is used with other cancer medicines.
Avastin Solution is a monoclonal antibody. It works by decreasing the formation and growth of new blood vessels in the tumor by blocking the action of a protein called vascular endothelial growth factor (VEGF). This helps to slow the growth and spread of cancer.
Do NOT use Avastin Solution if:
you are allergic to any ingredient in Avastin Solution
you have a tear or hole in your stomach or intestines
you have a wound that is not healing well or has split apart
you have recently coughed up blood or you have had surgery within the last 28 days
you are taking sunitinib
Contact your doctor or health care provider right away if any of these apply to you.
Before using Avastin Solution:
Some medical conditions may interact with Avastin Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances, including mouse or murine proteins
if you have a history of high blood pressure or heart problems (eg, congestive heart failure, heart disease), blood vessel problems, blood clotting problems, or coughing up blood
if you have kidney problems, high amounts of protein in your urine, a low blood sodium level, or a wound that has not fully healed, or if you are scheduled for surgery
if you have nerve problems or a history of stomach or bowel problems
Some MEDICINES MAY INTERACT with Avastin Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:
Sunitinib because a certain type of severe anemia (eg, hemolytic anemia) may occur
This may not be a complete list of all interactions that may occur. Ask your health care provider if Avastin Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Avastin Solution:
Use Avastin Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Avastin Solution is usually given as an injection at your doctor’s office, hospital, or clinic. If you will be using Avastin Solution at home, a health care provider will teach you how to use it. Be sure you understand how to use Avastin Solution. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
Do not use Avastin Solution if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
Do not shake Avastin Solution.
If you miss a dose of Avastin Solution, contact your doctor immediately to establish a new dosing schedule.
Ask your health care provider any questions you may have about how to use Avastin Solution.
Important safety information:
Avastin Solution may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Avastin Solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
If nausea, vomiting, or loss of appetite occurs, ask your doctor or pharmacist for ways to lessen these effects.
Avastin Solution may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
Avastin Solution may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
Talk with your doctor before you receive any vaccine while you are using Avastin Solution.
Tell your doctor or dentist that you take Avastin Solution before you receive any medical or dental care, emergency care, or surgery.
Lab tests, including blood pressure and urine protein levels, may be performed while you use Avastin Solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
Use Avastin Solution with caution in the ELDERLY; they may be more sensitive to its effects, especially the risk of blood clotting problems (eg, heart attack, stroke).
Avastin Solution should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
PREGNANCY and BREAST-FEEDING: Avastin Solution may cause harm to the fetus. Do not become pregnant while you are using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Avastin Solution while you are pregnant. If you are able to become pregnant, talk with your doctor or pharmacist about the use of effective birth control while taking Avastin Solution and for at least 6 months following the last dose of Avastin Solution. It is not known if Avastin Solution is found in breast milk. Do not breast-feed while taking Avastin Solution. Do not become pregnant or breast-feed immediately after you stop Avastin Solution. Avastin Solution can stay in your body for a long time after you stop using it. Talk with your doctor about when it may be safe to become pregnant or breast-feed.
Possible side effects of Avastin Solution:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Changes in taste; constipation; diarrhea; dizziness; dry mouth; dry skin; hair loss; headache; increased thirst; indigestion; loss of appetite; minor nosebleeds; mouth pain or sores; muscle pain; nausea; pain, swelling, or redness at the injection site; sluggishness; stuffy or runny nose; tiredness; voice changes; vomiting; weakness; weight loss.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; blood in the urine; calf pain or tenderness; chest pain; confusion; cough; coughing or choking while eating; coughing up or vomiting blood; dark urine; difficult or painful urination; fainting; fever, chills, or persistent sore throat; frequent or urgent urination; loss of coordination; numbness of the arms or legs; one-sided weakness; peeling of skin; seizure; severe or persistent headache; severe or persistent nosebleed; severe or persistent stomach pain, constipation, nausea, or vomiting; severe or persistent weakness; shortness of breath; skin discoloration, irritation, or lesions; speech changes; sudden, severe dizziness; swelling, discoloration, or pain in the legs; swelling of the hands, ankles, or feet; trouble swallowing; unusual bruising or bleeding; unusual or severe sweating; unusual weight gain; vaginal pain, bleeding, or discharge; vision loss, blurred vision, or other vision changes; wheezing; wounds that do not heal.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include severe headache.
Proper storage of Avastin Solution:
Avastin Solution is usually handled and stored by a health care provider. If you are using Avastin Solution at home, store Avastin Solution as directed by your pharmacist or health care provider.
General information:
If you have any questions about Avastin Solution, please talk with your doctor, pharmacist, or other health care provider.
Avastin Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.
This information is a summary only. It does not contain all information about Avastin Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Generic Name: lasalocid sodium
Dosage Form: FOR ANIMAL USE ONLY
Avatec®
Lasalocid Sodium
Type A Medicated Article
(medicated premix)
Coccidiocidal
Active drug ingredient
Each pound contains 90.7 g (20%) of lasalocid sodium activity in a carrier suitable for incorporation in feed.
For use in the manufacture of medicated feeds only
For the prevention of coccidiosis in
Target Species:
Caused by:
Broiler or Fryer Chickens:
Eimeria tenella, E. necatrix, E. acervulina, E. brunetti, E. mivati, and E. maxima
Growing Turkeys:
E. meleagrimitis, E. gallopavonis, E. adenoeides
Rabbits:
Eimeria stiedae
Chukar Partridges:
Eimeria legionensis
Directions for use
Broiler, Fryer Chickens and Growing Turkeys
Use Avatec® continuously in the feed to provide from 68 g per ton (0.0075%) to 113 g per ton (0.0125%) lasalocid sodium concentration. The dosage range allows adjustment of drug level to severity of exposure. The higher levels are indicated for severe exposure. Consult a poultry disease diagnostician for advice regarding the optimal level of drug.
Rabbits
Use Avatec® continuously in the feed for rabbits up to 6 1/2 weeks of age to provide 113 g per ton (0.0125%) lasalocid sodium concentration.
Chukar Partridges
Use Avatec® continuously in the feed for young birds up to 8 weeks of age to provide 113 g per ton (0.0125%) lasalocid sodium concentration.
Mixing directions
Thoroughly mix the following amounts of Avatec® to make one ton of feed to provide from 68 g per ton (0.0075%) to 113 g per ton (0.0125%) lasalocid sodium concentration. When adding less than one pound of premix per ton of feed, it is recommended that the premix first be mixed with a small amount of feed (10-25 lbs.) prior to incorporation into the final feed.
When mixing and handling lasalocid premix, use protective clothing, impervious gloves and a dust mask. Avoid contact with eyes. Operators should wash thoroughly with soap and water after handling.
Note: In addition to label statements of identity, ingredients and directions for use, labeling of feeds containing Avatec® must contain the following statements:
FOR BROILER OR FRYER CHICKENS ONLY and/or
FOR GROWING TURKEYS ONLY and/or
FOR CHUKAR PARTRIDGES (UP TO EIGHT WEEKS OF AGE) ONLY and/or
FOR RABBITS (UP TO SIX AND ONE HALF WEEKS OF AGE) ONLY
Additionally, all feed labeling must state:
FEED CONTINUOUSLY AS THE SOLE RATION
NADA 96-298, Approved by FDA
Marketed by
Alpharma Inc.
Bridgewater, New Jersey 08807
Net wt 50 LB (22.68 kg)
Made in USA
Trademarks registered
by Alpharma Inc.
710309 0904
PRINCIPAL DISPLAY PANEL – 50 LB Label
Avatec®
ALPHARMA
Lasalocid Sodium
Type A Medicated Article
(medicated premix)
Coccidiocidal