Generic Name: Chloroquine (KLOR-oh-kwin)
Brand Name: Aralen

Aralen is used for:

Treating and suppressing acute attacks of certain strains of malaria and a certain type of parasitic infection (extraintestinal amebiasis). It may also be used for other conditions as determined by your doctor.

Aralen is an aminoquinoline. It is thought to kill sensitive malaria parasites by stopping normal metabolism inside the parasite.

Do NOT use Aralen if:

• you are allergic to any ingredient in Aralen
• you have vision problems or retinal changes
• you are taking arsenic, astemizole, terfenadine, cimetidine, cisapride, quinacrine, or dofetilide

Contact your doctor or health care provider right away if any of these apply to you.

Before using Aralen:

Some medical conditions may interact with Aralen. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines or other substances
• if you have porphyria or any other blood disease, glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, or a history of seizures
• if you have psoriasis, stomach or intestinal problems, liver disease, or central nervous system problems

Some MEDICINES MAY INTERACT with Aralen. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Cimetidine or quinacrine because the side effects of Aralen may be increased
• Ampicillin, rabies vaccine, or thyroid hormones (eg, levothyroxine) because the effectiveness of these medicines may be decreased
• Arsenic, astemizole, cisapride, dofetilide, or terfenadine because the risk of severe side effects, including irregular heartbeat, may be increased
• Cyclosporine because its side effects may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Aralen may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Aralen:

Use Aralen as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Aralen is usually administered as an injection at your doctor’s office, hospital, or clinic. If you are using Aralen at home, carefully follow the injection procedures taught to you by your health care provider.
• If Aralen contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
• Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
• If you miss a dose of Aralen, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Aralen.

Important safety information:

• Aralen may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Aralen. Using Aralen alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
• If your symptoms do not improve or if they become worse, check with your doctor.
• Aralen may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Aralen. Use a sunscreen or protective clothing if you must be outside for a prolonged period.
• Contact your health care provider if you notice any muscle weakness or problems with vision or hearing. Your knee and ankle reflexes will be tested periodically.
• LAB TESTS, such as complete blood cell counts and eye tests, may be needed to monitor your progress. Be sure to keep appointments.
• Use Aralen with caution in the ELDERLY because they may be more sensitive to its effects.
• Caution is advised when using Aralen in CHILDREN because they may be more sensitive to its effects.
• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Aralen, discuss with your doctor the benefits and risks of using Aralen during pregnancy. Aralen is excreted in breast milk. Do not breast-feed while taking Aralen.

Possible side effects of Aralen:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Appetite loss; clumsiness; diarrhea; dizziness; feeling of whirling motion; mild headache; nausea; stomach cramps; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bizarre behavior; change in color or skin or inside of mouth; diarrhea; difficulty seeing and reading (words, letters, or parts of objects missing when reading); fever or sore throat; hair loss; hearing loss; mood changes; ringing in the ears; seizures; sensitivity to sunlight; unusual bleeding or bruising; unusual weakness; vision problems; weight loss.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include blurred vision; drowsiness; excessive excitability; fainting; headache; irregular heartbeat; loss of consciousness; mood changes; seizures; severe drowsiness or dizziness; slow, shallow breathing.

Proper storage of Aralen:

Store Aralen in a tightly closed container at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Aralen out of the reach of children and away from pets.

General information:

• If you have any questions about Aralen, please talk with your doctor, pharmacist, or other health care provider.
• Aralen is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Aralen. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Mesalamine (me-SAL-a-meen)
Brand Name: Apriso

Apriso Extended-Release Capsules are used for:

Maintaining remission of ulcerative colitis (inflammation of the colon). It may also be used for other conditions as determined by your doctor.

Apriso Extended-Release Capsules are a 5-aminosalicylic acid (5-ASA). It works by preventing the production of substances that cause inflammation of the colon.

Do NOT use Apriso Extended-Release Capsules if:

• you are allergic to any ingredient in Apriso Extended-Release Capsules, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, naproxen), or salicylates (eg, aspirin)
• you are younger than 18 years of age and you have the flu or chickenpox or you have received a live vaccine (eg, varicella, influenza) within the past 6 weeks
• you are taking probenecid or sulfinpyrazone

Contact your doctor or health care provider right away if any of these apply to you.

Before using Apriso Extended-Release Capsules:

Some medical conditions may interact with Apriso Extended-Release Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines (eg, sulfasalazine, aspirin), foods, or other substances
• if you have had a stroke, bleeding in the brain, or an aneurysm
• if you have a history of liver or kidney problems, certain stomach problems (pyloric stenosis), pancreas problems (eg, pancreatitis), Kawasaki syndrome, or a rheumatic (inflammatory) disease (eg, rheumatoid arthritis)
• if you have a history of heart problems (eg, inflammation of the sac around your heart)
• if you have the flu or chickenpox or if you have recently received a live vaccine (eg, varicella, influenza)

Some MEDICINES MAY INTERACT with Apriso Extended-Release Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Gingko biloba extract because side effects, such as increased bleeding, may occur
• Corticosteroids (eg, prednisone) because they may decrease Apriso Extended-Release Capsules’s effectiveness
• Carbonic anhydrase inhibitors (eg, acetazolamide), insulin, meglitinide antidiabetics (eg, repaglinide), sulfonylureas (eg, glipizide), or valproic acid because the risk of their side effects may be increased by Apriso Extended-Release Capsules
• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), anticoagulants (eg, warfarin), beta-blockers (eg, propranolol), probenecid, spironolactone, or sulfinpyrazone because their effectiveness may be decreased by Apriso Extended-Release Capsules

This may not be a complete list of all interactions that may occur. Ask your health care provider if Apriso Extended-Release Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Apriso Extended-Release Capsules:

Use Apriso Extended-Release Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Apriso Extended-Release Capsules by mouth with or without food. If stomach upset occurs, take with food or milk to reduce stomach irritation.
• Swallow Apriso Extended-Release Capsules whole. Do not break, crush, or chew before swallowing.
• Do not take an antacid within 1 hour before or 2 hours after you take Apriso Extended-Release Capsules.
• If you miss a dose of Apriso Extended-Release Capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Apriso Extended-Release Capsules.

Important safety information:

• Apriso Extended-Release Capsules may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Apriso Extended-Release Capsules with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• This product contains phenylalanine. If you must have a diet that is low in phenylalanine, contact your doctor.
• Apriso Extended-Release Capsules may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Apriso Extended-Release Capsules. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
• Some patients may experience an intolerance reaction to Apriso Extended-Release Capsules. Signs of intolerance are very similar to symptoms of inflammatory bowel disease. They may include severe or persistent stomach pain or cramping, bloody diarrhea, fever, headache or rash. If you experience any of these symptoms, contact your doctor right away.
• Salicylates have been linked to a serious illness called Reye syndrome. Do not give Apriso Extended-Release Capsules to a child or teenager who has the flu, chickenpox, or a viral infection. Contact your doctor with any questions or concerns.
• Lab tests, including kidney function, liver function, or complete blood cell counts, may be performed while you use Apriso Extended-Release Capsules. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Apriso Extended-Release Capsules with caution in the ELDERLY; they may be more sensitive to its effects.
• Apriso Extended-Release Capsules should be used with extreme caution in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Apriso Extended-Release Capsules while you are pregnant. Apriso Extended-Release Capsules are found in breast milk. If you are or will be breast-feeding while you use Apriso Extended-Release Capsules, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Apriso Extended-Release Capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; headache; mild abdominal discomfort or pain; nausea; runny or stuffy nose.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine; bloody diarrhea; bloody or coffee ground-like vomit; change in amount of urine; chest pain; dark urine; fever, chills, or persistent sore throat; severe or persistent headache; severe or sudden stomach pain or cramping; sudden shortness of breath; unusual bruising or bleeding; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include confusion; diarrhea; dizziness; drowsiness; fast or difficult breathing; fever; headache; hearing loss; ringing in the ears; seizures; sweating; vomiting of blood; weakness.

Proper storage of Apriso Extended-Release Capsules:

Store Apriso Extended-Release Capsules at room temperature, between 68 to 77 degrees F (20 to 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Apriso Extended-Release Capsules out of the reach of children and away from pets.

General information:

• If you have any questions about Apriso Extended-Release Capsules, please talk with your doctor, pharmacist, or other health care provider.
• Apriso Extended-Release Capsules are to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Apriso Extended-Release Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: pseudoephedrine and triprolidine (try PROE li deen and soo doe e FED rin)
Brand Names: A-Phedrin, Allerfrim, Allerphed, Altafed, Aphedrid, Aprodine, Biofed-PE, Genac, Histafed, Pediatex TD, Tripohist D, Vi-Sudo, Zymine-D

What is Aprodine (pseudoephedrine and triprolidine)?

Triprolidine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of pseudoephedrine and triprolidine is used to treat sneezing, cough, runny or stuffy nose, itchy or watery eyes, hives, skin rash, itching, and other symptoms of allergies and the common cold.

Pseudoephedrine and triprolidine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Aprodine (pseudoephedrine and triprolidine)?

Do not give this medication to a child younger than 2 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not use any other over-the-counter cold, allergy, or sleep medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of a certain drug. Read the label of any other medicine you are using to see if it contains an antihistamine or decongestant. Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body. Pseudoephedrine and triprolidine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of this medication.

What should I discuss with my healthcare provider before taking Aprodine (pseudoephedrine and triprolidine)?

Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body.

Ask a doctor or pharmacist if it is safe for you to take pseudoephedrine and triprolidine if you have:

• kidney disease;

• diabetes;

• glaucoma;

• heart disease or high blood pressure;

• diabetes;

• a thyroid disorder;

• an enlarged prostate; or

• problems with urination.

This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Pseudoephedrine and triprolidine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Artificially-sweetened liquid forms of cold medicine may contain phenylalanine. This would be important to know if you have phenylketonuria (PKU). Check the ingredients and warnings on the medication label if you are concerned about phenylalanine.

How should I take Aprodine (pseudoephedrine and triprolidine)?

Use this medication exactly as directed on the label, or as it has been prescribed by your doctor. Do not use the medication in larger amounts, or use it for longer than recommended. Cold medicine is usually taken only for a short time until your symptoms clear up.

Do not give this medication to a child younger than 2 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Take this medicine with a full glass of water. Do not crush, chew, or break an extended-release tablet. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time.

Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

If you need to have any type of surgery, tell the surgeon ahead of time if you have taken a cold medicine within the past few days.

This medication can cause you to have unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.

Store the medication at room temperature away from moisture and heat.

What happens if I miss a dose?

Since cold or allergy medicine is usually taken only as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include feeling restless or nervous, nausea, vomiting, stomach pain, dizziness, drowsiness, dry mouth, warmth or tingly feeling, or seizure (convulsions).

What should I avoid while taking Aprodine (pseudoephedrine and triprolidine)?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of this medication.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor’s advice. Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

Do not use any other over-the-counter cold, allergy, or sleep medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of a certain drug. Read the label of any other medicine you are using to see if it contains an antihistamine or decongestant.

Aprodine (pseudoephedrine and triprolidine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:

• fast, pounding, or uneven heartbeat;

• confusion, hallucinations, unusual thoughts or behavior;

• severe dizziness, anxiety, restless feeling, or nervousness;

• increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);

• confusion, hallucinations, unusual thoughts or behavior;

• easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms; or

• urinating less than usual or not at all.

Less serious side effects may include:

• blurred vision;

• dry mouth;

• nausea, stomach pain, constipation;

• mild loss of appetite, stomach upset;

• warmth, tingling, or redness under your skin;

• sleep problems (insomnia);

• restless or excitability (especially in children);

• skin rash or itching;

• dizziness, drowsiness;

• problems with memory or concentration; or

• ringing in your ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Aprodine (pseudoephedrine and triprolidine)?

Tell your doctor if you regularly use other medicines that make you sleepy (such as narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by pseudoephedrine and triprolidine.

Tell your doctor about all other medications you use, especially:

• medicines to treat high blood pressure;

• a diuretic (water pill);

• medication to treat irritable bowel syndrome;

• bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol) or tolterodine (Detrol);

• aspirin or salicylates (such as Disalcid, Doan’s Pills, Dolobid, Salflex, Tricosal, and others);

• a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others; or

• antidepressants such as amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Janimine, Tofranil), and others.

This list is not complete and there may be other drugs that can interact with pseudoephedrine and triprolidine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about pseudoephedrine and triprolidine.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 5.09. Revision Date: 11/19/2009 1:28:27 PM.

Generic Name: Aprotinin (a-proe-TYE-nin)
Brand Name: Trasylol

Aprotinin is used for:

Reducing blood loss and the need for blood transfusions in patients undergoing certain types of heart surgery.

Aprotinin is a protease inhibitor. It works by reducing the inflammatory response associated with cardiopulmonary bypass surgery.

Do NOT use Aprotinin if:

• you are allergic to any ingredient in Aprotinin
• you have received Aprotinin within the past 12 months

Contact your doctor or health care provider right away if any of these apply to you.

Before using Aprotinin:

Some medical conditions may interact with Aprotinin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have kidney problems
• if you have previously had heart surgery

Some MEDICINES MAY INTERACT with Aprotinin. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Aminoglycosides (eg, gentamicin) or medicines that alter kidney function because the risk of kidney damage may be increased
• Angiotensin-converting enzyme (ACE) inhibitors (eg, captopril) or fibrinolytics (eg, streptokinase) because the effectiveness of these medicines may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Aprotinin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Aprotinin:

Use Aprotinin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Aprotinin. Talk to your pharmacist if you have questions about this information.
• Aprotinin is administered as an intravenous (IV; into a vein) injection only in a medical setting.
• If you miss a dose of Aprotinin, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Aprotinin.

Important safety information:

• Lab tests, including kidney function and blood clotting tests, may be performed while you use Aprotinin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Aprotinin should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Aprotinin while you are pregnant. It is not known if Aprotinin is found in breast milk. If you are or will be breast-feeding while you use Aprotinin, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Aprotinin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; difficulty urinating; infection (eg, fever, chills, sore throat); lightheadedness; sleeplessness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); asthma; chest pain; confusion; decreased urination; fast or irregular heartbeat; lung disorder; nausea; numbness of an arm or leg; one-sided weakness; severe stomach pain; sudden severe headache, dizziness, fainting, or vomiting; sudden weight gain; swelling of the hands, legs, or feet; vision or speech changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800 -222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Aprotinin:

Aprotinin is usually handled and stored by a health care provider. Keep Aprotinin out of the reach of children and away from pets.

General information:

• If you have any questions about Aprotinin, please talk with your doctor, pharmacist, or other health care provider.
• Aprotinin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Aprotinin. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: tipranavir (tip RA na veer)
Brand Names: Aptivus

What is tipranavir?

Tipranavir is an antiviral medication in a group of HIV medicines called protease (PRO-tee-ayz) inhibitors. Tipranavir prevents human immunodeficiency virus (HIV) cells from multiplying in your body.

Tipranavir is used to treat HIV, which causes acquired immunodeficiency syndrome (AIDS). Tipranavir is not a cure for HIV or AIDS.

Tipranavir may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about tipranavir?

Do not use this medication if you are allergic to tipranavir or ritonavir (Norvir), or if you have moderate to severe liver disease.

Life-threatening side effects can occur if you take tipranavir with any of the following medications: amiodarone (Cordarone, Pacerone), bepridil (Vascor), cisapride (Propulsid), flecainide (Tambocor), lovastatin (Mevacor), simvastatin (Zocor, Vytorin), propafenone (Rythmol), rifampin (Rifadin, Rifamate, Rimactane), quinidine (Quinaglute, Quinidex), pimozide (Orap), midazolam (Versed), triazolam (Halcion), St. John’s wort, or an ergot medicine such as Ergomar, Ergotrate, Cafergot, D.H.E. 45, Migranal, or Methergine.

There are many other medicines that can interact with tipranavir.Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors.

Tipranavir is used in combination with a similar drug called ritonavir (Norvir). Some people taking this combination of medicines have developed life-threatening medical problems including liver damage and bleeding in the brain. If you are taking these two medications, call your doctor at once if you have any of the following side effects:

• unusual bleeding (such as a nosebleed or blood in your urine or stools);

• sudden headache, confusion, problems with vision, speech, or balance;

• low fever, nausea, stomach pain, loss of appetite;

• dark urine, clay-colored stools; or

• jaundice (yellowing of the skin or eyes).

What should I discuss with my health care provider before taking tipranavir?

Do not use this medication if you are allergic to tipranavir or ritonavir (Norvir), if you have moderate to severe liver disease, or if you are using any of the following drugs:

• amiodarone (Cordarone, Pacerone);

• bepridil (Vascor);

• cisapride (Propulsid);

• flecainide (Tambocor);

• lovastatin (Mevacor, Altocor) or simvastatin (Zocor, Vytorin);

• midazolam (Versed) or triazolam (Halcion);

• pimozide (Orap);

• propafenone (Rythmol);

• quinidine (Cardioquin, Quinidex, Quinaglute);

• rifampin (Rifadin, Rifamate, Rimactane);

• St. John’s wort; or

• ergot medicines such as ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine).

These drugs can cause life-threatening side effects if you use them while you are taking tipranavir.

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before using tipranavir, tell your doctor if you have:

• liver disease (especially hepatitis B or C);

• diabetes;

• high cholesterol or triglycerides;

• a bleeding disorder such as hemophilia; or

• if you are allergic to sulfa drugs.

FDA pregnancy category C. It is not known whether tipranavir is harmful to an unborn baby. HIV can be passed to the baby if the mother is not properly treated during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Take all of your HIV medicines as directed to control your infection while you are pregnant. Tipranavir can make birth control pills less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking tipranavir. You should not breast-feed while you are using tipranavir. Women with HIV or AIDS should not breast-feed at all. Even if your baby is born without HIV, you may still pass the virus to the baby in your breast milk.

How should I take tipranavir?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

If you also take ritonavir, take it at the same time you take tipranavir unless your doctor has told you otherwise.

Tipranavir works best if you take it with food. Swallow the capsule whole. Do not break or chew it.

Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

To be sure this medication is helping your condition, your blood will need to be tested on a regular basis. Your liver function may also need to be tested. Do not miss any scheduled visits to your doctor.

If you need to have any type of surgery, tell the surgeon ahead of time that you are using tipranavir.

It is important to use tipranavir regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

HIV/AIDS is usually treated with a combination of different drugs. To best treat your condition, use all of your medications as directed by your doctor. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor. Every person with HIV or AIDS should remain under the care of a doctor.

Store an unopened bottle of tipranavir capsules in the refrigerator. Do not freeze. After opening the bottle for the first time, you may store the capsules at room temperature. Throw away any capsules you have not used within 60 days after you first opened the medicine bottle.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a tipranavir overdose are unknown.

What should I avoid while taking tipranavir?

If you also take didanosine, take it 2 hours before or after you take tipranavir.

Avoid having unprotected sex or sharing needles, razors, or toothbrushes. Taking this medication will not prevent you from passing HIV to other people. Talk with your doctor about safe methods of preventing HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

Tipranavir side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Some people taking tipranavir and ritonavir have developed life-threatening medical problems including liver damage and bleeding in the brain. If you are taking these two medications, call your doctor at once if you have any of the following side effects:

• unusual bleeding (such as a nosebleed or blood in your urine or stools);

• sudden headache, confusion, problems with vision, speech, or balance;

• low fever, nausea, stomach pain, loss of appetite;

• dark urine, clay-colored stools; or

• jaundice (yellowing of the skin or eyes).

Stop taking tipranavir and call your doctor at once if you have any of these serious side effects:

• severe skin rash, blistering, peeling, or sunburn;

• increased urination or extreme thirst;

• easy bruising or bleeding; or

• signs of a new infection, such as fever or chills, cough, skin lesions, or flu symptoms.

Less serious side effects may include:

• mild nausea, vomiting, diarrhea, stomach pain;

• headache, tired feeling; or

• changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect tipranavir?

Many drugs can interact with tipranavir. Below is just a partial list. Tell your doctor if you are using:

• a blood thinner such as warfarin (Coumadin);

• disulfiram (Antabuse);

• enfuvirtide (Fuseon);

• fluticasone (Advair, Flonase, Flovent);

• insulin or diabetes medication you take by mouth;

• itraconazole (Sporanox) or ketoconazole (Nizoral);

• methadone (Methadose, Diskets, Dolophine);

• omeprazole (Prilosec);

• rifabutin (Mycobutin);

• vitamin E (especially at high doses);

• an antidepressant such as desipramine (Norpramin), fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), trazodone (Desyrel), and others;

• a calcium channel blocker such as diltiazem (Tiazac, Cartia, Dilacor), felodipine (Plendil), nicardipine (Cardene), nisoldipine (Sular), verapamil (Calan, Covera, Isoptin, Verelan);

• cholesterol-lowering medicine such as atorvastatin (Lipitor), rosuvastatin (Crestor), and others;

• drugs that weaken the immune system, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf);

• medication used to prevent blood clots, such as clopidogrel (Plavix), dipyridamole (Persantine), and others;

• medicines to treat erectile dysfunction, such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra);

• other HIV /AIDS medicine such as atazanavir (Reyataz), fosamprenavir (Lexiva), lopinavir/ritonavir (Kaletra), or saquinavir (Invirase); or

• seizure medications such as carbamazepine (Carbatrol, Tegretol), clonazepam (Klonopin), divalproex (Depakote), ethosuximide (Zarontin), lamotrigine (Lamictal), phenobarbital (Solfoton), phenytoin (Dilantin), or valproic acid (Depakene).

This list is not complete and there are many other medicines that can interact with tipranavir. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about tipranavir.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 4.01. Revision Date: 08/03/2009 2:59:35 PM.

Generic Name: Tipranavir (tye-PRAN-a-vir)
Brand Name: Aptivus

Aptivus Solution is used for:

Treating HIV infection. Aptivus Solution should be used with ritonavir.

Aptivus Solution is a protease inhibitor. It works by blocking the growth of an enzyme (HIV protease) that the HIV virus needs to reproduce in the body.

Do NOT use Aptivus Solution if:

• you are allergic to any ingredient in Aptivus Solution
• you are taking certain antiarrhythmics (eg, amiodarone, bepridil, flecainide, propafenone, quinidine), astemizole, certain benzodiazepines (eg, midazolam, triazolam), certain HMG-CoA reductase inhibitors (eg, lovastatin, simvastatin), cisapride, ergot derivatives (eg, ergonovine, ergotamine), other HIV protease inhibitors (eg, saquinavir), pimozide, rifampin, a serotonin 5-HT₁ receptor antagonist (eg, eletriptan, sumatriptan), St. John’s wort, or terfenadine
• you have moderate to severe liver disease

Contact your doctor or health care provider right away if any of these apply to you.

Before using Aptivus Solution:

Some medical conditions may interact with Aptivus Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to any other sulfonamide medicine, such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glyburide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide
• if you have cholesterol or lipid problems, diabetes or a family history of diabetes, liver problems (eg, hepatitis B or C), abnormal liver function tests, severe kidney problems, or bleeding problems (eg, hemophilia)
• if you take vitamin E or you have a recent injury or other medical condition that may increase your risk for bleeding or serious bruising
• if you will be having or have recently had surgery

Some MEDICINES MAY INTERACT with Aptivus Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Certain antiarrhythmics (eg, amiodarone, bepridil, flecainide, propafenone, quinidine), astemizole, certain benzodiazepines (eg, midazolam, triazolam), certain HMG-CoA reductase inhibitors (eg, lovastatin, simvastatin), cisapride, ergot derivatives (eg, ergonovine, ergotamine), pimozide, serotonin 5-HT₁ receptor antagonists (eg, eletriptan, sumatriptan), or terfenadine because the risk of side effects, including heart or blood vessel problems, muscle problems, or severe breathing problems, may be increased
• Rifampin or St. John’s wort because they may decrease Aptivus Solution’s effectiveness
• Other HIV protease inhibitors (eg, saquinavir) because their effectiveness may be decreased by Aptivus Solution
• Anticoagulants (eg, warfarin), antiplatelet medicines (eg, clopidogrel), and many prescription and nonprescription medicines (eg, used for aches and pains, asthma, erectile dysfunction, diabetes, high blood pressure, high cholesterol, HIV, immune system suppression, infections, inflammation, irregular heartbeat, nasal allergies, seizures), multivitamin products, and herbal or dietary supplements (eg, coenzyme Q10, garlic, ginkgo, ginseng, herbal teas, St. John’s wort) may interact with Aptivus Solution, increasing the risk of side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Aptivus Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Aptivus Solution:

Use Aptivus Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Aptivus Solution. Talk to your pharmacist if you have questions about this information.
• Take Aptivus Solution by mouth with or without food.
• Aptivus Solution is administered along with another medicine called ritonavir. Be sure to follow your doctor’s instructions for taking ritonavir along with Aptivus Solution.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• If you are also taking didanosine, do not take it within 2 hours of taking Aptivus Solution. Check with your doctor if you have questions.
• Taking Aptivus Solution at the same time each day will help you remember to take it.
• Take Aptivus Solution on a regular schedule to get the most benefit from it.
• Consult your doctor before including grapefruit or grapefruit juice in your diet.
• Continue to use Aptivus Solution even if you feel well. Do not miss any doses. Failure to do so may decrease the effectiveness of Aptivus Solution and increase the risk that your HIV will no longer be sensitive to Aptivus Solution or to other similar medicines.
• If you miss a dose of Aptivus Solution, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Aptivus Solution.

Important safety information:

• Aptivus Solution may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Aptivus Solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Tell your doctor or dentist that you take Aptivus Solution before you receive any medical or dental care, emergency care, or surgery.
• Changes in body fat (eg, an increased amount of fat in the upper back, neck, breast, and trunk, and loss of fat from the legs, arms, and face) may occur in some patients taking Aptivus Solution. The cause and long-term effects of these changes are not known. Discuss any concerns with your doctor.
• Aptivus Solution may improve immune system function. This may reveal hidden infections in some patients. Tell your doctor right away if you notice symptoms of infection (eg, cough, fever, shortness of breath, sore throat, weakness) after you start Aptivus Solution.
• When your medicine supply is low, get more from your doctor or pharmacist as soon as you can. Do not stop taking Aptivus Solution, even for a short period of time. If you do, the virus may grow resistant to the medicine and become harder to treat.
• Aptivus Solution is not a cure for HIV infection. Patients may still get illnesses and infections associated with HIV. Remain under the care of your doctor.
• Aptivus Solution does not stop the spread of HIV to others through blood or sexual contact. Use barrier methods of birth control (eg, condoms) if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors.
• Aptivus Solution may increase triglyceride and lipid levels. The long-term chance of complications from these increased triglyceride and lipid levels, such as heart attack and stroke, are not known at this time.
• Hemophilia patients – Report all bleeding episodes to your doctor.
• Aptivus Solution may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
• Diabetes patients – Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
• Aptivus Solution may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Aptivus Solution. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
• Hormonal birth control (eg, birth control pills) may not work as well while you are using Aptivus Solution. To prevent pregnancy, use an extra form of birth control (eg, condoms).
• Women who take estrogens for birth control or hormone replacement may have an increased risk of rash from Aptivus Solution. Contact your doctor if you develop a rash.
• Lab tests, including viral load, CD4 count, triglyceride and lipid levels, and liver function, may be performed while you use Aptivus Solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Aptivus Solution with caution in the ELDERLY; they may be more sensitive to its effects.
• Use Aptivus Solution with extreme caution in CHILDREN younger than 2 years; safety and effectiveness in these children have not been confirmed.
• PREGNANCY AND BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risk of using Aptivus Solution while you are pregnant. It is not known if Aptivus Solution is found in breast milk. Mothers infected with HIV should not breast-feed. There is a risk of passing the HIV infection or Aptivus Solution to the baby.

Possible side effects of Aptivus Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Cough; diarrhea; headache; nausea; tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); body fat changes; confusion; dark urine; depression; difficulty urinating; dizziness; excessive hunger, thirst, or urination; fast heartbeat; fever, chills, or sore throat; flu-like symptoms; fruity breath odor; itching; joint pain or stiffness; loss of appetite; mental or mood changes; mouth sores or ulcers; muscle pain; numbness or tingling; pale stools; red, blistered, swollen, or peeling skin; severe or persistent nausea; slurred speech or one-sided weakness; stomach pain or tenderness; throat tightness; unusual bruising or bleeding; unusual drowsiness or tiredness; unusual weakness; vision changes; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Aptivus Solution:

Store Aptivus Solution at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Do not refrigerate or freeze. Aptivus Solution must be used within 60 days after opening the bottle. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Aptivus Solution out of the reach of children and away from pets.

General information:

• If you have any questions about Aptivus Solution, please talk with your doctor, pharmacist, or other health care provider.
• Aptivus Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Aptivus Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Urea (you-REE-ah)
Brand Name: Examples include Aqua Care and Carmol 20

Aqua Care Cream is used for:

Moisturizing and softening dry, cracked, calloused, rough, and hardened skin of feet, hands, or elbows. It may also be used for certain other skin conditions as determined by your doctor.

Aqua Care Cream is a debriding agent. It works by helping the breakdown of dead skin and pus, which helps to loosen and shed hard and scaly skin.

Do NOT use Aqua Care Cream if:

• you are allergic to any ingredient in Aqua Care Cream

Contact your doctor or health care provider right away if any of these apply to you.

Before using Aqua Care Cream:

Some medical conditions may interact with Aqua Care Cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Aqua Care Cream. Because little, if any, of Aqua Care Cream is absorbed into the blood, the risk of it interacting with another medicine is low.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Aqua Care Cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Aqua Care Cream:

Use Aqua Care Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Aqua Care Cream is for external use only.
• Wash hands before and after using Aqua Care Cream unless your hands are part of the treated area.
• Apply a small amount of medicine to the affected area. Rub in thoroughly.
• If you miss a dose of Aqua Care Cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Aqua Care Cream.

Important safety information:

• Aqua Care Cream is for external use only. Do not get it in the eyes, nose, or mouth. If you get Aqua Care Cream in the eyes, rinse them immediately with a generous amount of cool water.
• Do not apply to broken or severely irritated skin.
• Do not exceed the recommended dose, use Aqua Care Cream for longer than prescribed, or use Aqua Care Cream for other skin conditions without checking with your doctor.
• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Aqua Care Cream, discuss with your doctor the benefits and risks of using Aqua Care Cream during pregnancy. It is unknown if Aqua Care Cream is excreted in breast milk. If you are or will be breast-feeding while you are using Aqua Care Cream, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Aqua Care Cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild skin irritation; temporary burning, stinging, or itching.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); redness; severe or persistent irritation.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Aqua Care Cream:

Store Aqua Care Cream at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Protect from freezing. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Aqua Care Cream out of the reach of children and away from pets.

General information:

• If you have any questions about Aqua Care Cream, please talk with your doctor, pharmacist, or other health care provider.
• Aqua Care Cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Aqua Care Cream. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: vitamin e (Oral route)

VYE-ta-min E

Commonly used brand name(s):

In the U.S.

• Alpha-E
• Aqua Gem-E
• Aquasol E
• D-Alpha Gems
• E-400
• E-600
• E-Gems
• Formula E 400
• Gamma E-Gems
• Gamma E Plus
• Key-E
• Natural Vitamin Blend E-400IU
• Nutr-E-Sol

Available Dosage Forms:

• Liquid
• Solution
• Tablet
• Capsule, Liquid Filled
• Tablet, Chewable
• Powder for Solution
• Capsule

Therapeutic Class: Nutritive Agent

Pharmacologic Class: Vitamin E (class)

Uses For Aqua Gem-E

Vitamins are compounds that you must have for growth and health. They are needed in only small amounts and are available in the foods that you eat. Vitamin E prevents a chemical reaction called oxidation, which can sometimes result in harmful effects in your body. It is also important for the proper function of nerves and muscles.

Some conditions may increase your need for vitamin E. These include:

• Intestine disease
• Liver disease
• Pancreas disease
• Surgical removal of stomach

Increased need for vitamin E should be determined by your health care professional.

Infants who are receiving a formula that is not fortified with vitamin E may be likely to have a vitamin E deficiency. Also, diets high in polyunsaturated fatty acids may increase your need for vitamin E.

Claims that vitamin E is effective for treatment of cancer and for prevention or treatment of acne, aging, loss of hair, bee stings, liver spots on the hands, bursitis, diaper rash, frostbite, stomach ulcer, heart attacks, labor pains, certain blood diseases, miscarriage, muscular dystrophy, poor posture, sexual impotence, sterility, infertility, menopause, sunburn, and lung damage from air pollution have not been proven. Although vitamin E is being used to prevent certain types of cancer, there is not enough information to show that this is effective.

Lack of vitamin E is extremely rare, except in people who have a disease in which it is not absorbed into the body.

Vitamin E is available without a prescription.

Importance of Diet

For good health, it is important that you eat a balanced and varied diet. Follow carefully any diet program your health care professional may recommend. For your specific dietary vitamin and/or mineral needs, ask your health care professional for a list of appropriate foods. If you think that you are not getting enough vitamins and/or minerals in your diet, you may choose to take a dietary supplement.

Vitamin E is found in various foods including vegetable oils (corn, cottonseed, soybean, safflower), wheat germ, whole-grain cereals, and green leafy vegetables. Cooking and storage may destroy some of the vitamin E in foods.

Vitamin supplements alone will not take the place of a good diet and will not provide energy. Your body also needs other substances found in food such as protein, minerals, carbohydrates, and fat. Vitamins themselves often cannot work without the presence of other foods. For example, small amounts of fat are needed so that vitamin E can be absorbed into the body.

The daily amount of vitamin E needed is defined in several different ways.

• For U.S.—
• Recommended Dietary Allowances (RDAs) are the amount of vitamins and minerals needed to provide for adequate nutrition in most healthy persons. RDAs for a given nutrient may vary depending on a person’s age, sex, and physical condition (e.g., pregnancy).
• Daily Values (DVs) are used on food and dietary supplement labels to indicate the percent of the recommended daily amount of each nutrient that a serving provides. DV replaces the previous designation of United States Recommended Daily Allowances (USRDAs).

• For Canada—
• Recommended Nutrient Intakes (RNIs) are used to determine the amounts of vitamins, minerals, and protein needed to provide adequate nutrition and lessen the risk of chronic disease.

Vitamin E is available in various forms, including d- or dl-alpha tocopheryl acetate, d- or dl-alpha tocopherol, and d- or dl-alpha tocopheryl acid succinate. In the past, the RDA for vitamin E have been expressed in Units. This term has been replaced by alpha tocopherol equivalents (alpha-TE) or milligrams (mg) of d-alpha tocopherol. One Unit is equivalent to 1 mg of dl-alpha tocopherol acetate or 0.6 mg d-alpha tocopherol. Most products available in stores continue to be labeled in Units.

Normal daily recommended intakes in milligrams (mg) of alpha tocopherol equivalents (mg alpha-TE) and Units for vitamin E are generally defined as follows:

Persons	U.S.	Canada
mg alpha-TE	Units	mg alpha-TE	Units
Infants and children Birth to 3 years of age	3–6	5–10	3–4	5–6.7
4 to 6 years of age	7	11.7	5	8.3
7 to 10 years of age	7	11.7	6–8	10–13
Adolescent and adult males	10	16.7	6–10	10–16.7
Adolescent and adult females	8	13	5–7	8.3–11.7
Pregnant females	10	16.7	8–9	13–15
Breast-feeding females	11–12	18–20	9–10	15–16.7

Before Using Aqua Gem-E

If you are taking this dietary supplement without a prescription, carefully read and follow any precautions on the label. For this supplement, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Problems in children have not been reported with intake of normal daily recommended amounts. You should check with your health care professional if you are giving your baby an unfortified formula. In that case, the baby must get the vitamins needed some other way. Some studies have shown that premature infants may have low levels of vitamin E. Your health care professional may recommend a vitamin E supplement.

Geriatric

Problems in older adults have not been reported with intake of normal daily recommended amounts.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	A	Adequate studies in pregnant women have not shown an increased risk of fetal abnormalities.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using this dietary supplement with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Dicumarol

Using this dietary supplement with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this dietary supplement. Make sure you tell your doctor if you have any other medical problems, especially:

• Bleeding problems—Vitamin E, when taken in doses greater than 800 Units a day for long periods of time, may make this condition worse

Proper Use of vitamin e

This section provides information on the proper use of a number of products that contain vitamin e. It may not be specific to Aqua Gem-E. Please read with care.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral solution dosage form:
  • To prevent the following deficiencies in infants:
    • Infants receiving a formula high in polyunsaturated fatty acids—15 to 25 Units per day or 7 Units per 32 ounces of formula.
    • Infants with certain colon problems—15 to 25 Units per kilogram (kg) (6.8 to 11 Units per pound) of body weight per day. The water-soluble form of vitamin E must be used.
    • Infants of normal birthweight—5 Units per 32 ounces of formula.
• For oral dosage forms (capsules, tablets, oral solution):
  • To prevent deficiency for individuals (other than infants), the amount taken by mouth is based on normal daily recommended intakes:
    • For the U.S.
    • Adult and teenage males—10 milligrams (mg) of alpha tocopherol equivalents (mg alpha-TE) or 16.7 Units per day.
    • Adult and teenage females—8 mg alpha-TE or 13 Units per day.
    • Pregnant females—10 mg alpha-TE or 16.7 Units per day.
    • Breast-feeding females—11 to 12 mg alpha-TE or 18 to 20 Units per day.
    • Children 4 to 10 years of age—7 mg alpha-TE or 11.7 Units per day.
    • Children birth to 3 years of age—3 to 6 mg alpha-TE or 5 to 10 Units per day.
    • For Canada
    • Adult and teenage males—6 to 10 mg alpha-TE or 10 to 16.7 Units per day.
    • Adult and teenage females—5 to 7 mg alpha-TE or 8.3 to 11.7 Units per day.
    • Pregnant females—8 to 9 mg alpha-TE or 13 to 15 Units per day.
    • Breast-feeding females—9 to 10 mg alpha-TE or 15 to 16.7 Units per day.
    • Children 7 to 10 years of age—6 to 8 mg alpha-TE or 10 to 13 Units per day.
    • Children 4 to 6 years of age—5 mg alpha-TE or 8.3 Units per day.
    • Children birth to 3 years of age—3 to 4 mg alpha-TE or 5 to 6.7 Units per day.
  • To treat deficiency:
    • Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on the severity of deficiency.

For individuals taking the oral liquid form of this dietary supplement:

• This preparation should be taken by mouth even though it comes in a dropper bottle.
• This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.

Missed Dose

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the dietary supplement in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Aqua Gem-E Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

With doses greater than 400 Units a day and long-term use

• Blurred vision
• diarrhea
• dizziness
• headache
• nausea or stomach cramps
• unusual tiredness or weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided “AS IS” and “as available” for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

Generic Name: pamabrom (PAM a brom)
Brand Names: Aqua-Ban, Aqua-Ban with Pamabrom

What is Aqua-Ban (pamabrom)?

Pamabrom is a diuretic (water pill). It works by increasing urination.

Pamabrom is used to treat bloating, puffiness, and other signs of water weight gain related to menstrual symptoms.

Pamabrom may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Aqua-Ban (pamabrom)?

Do not use this medication if you are allergic to pamabrom or if you are unable to urinate.

Before using pamabrom, tell your doctor if you take any other diuretic (water pill), or if you have high blood pressure, heart disease, or kidney disease. If you have any of these conditions, you may need a dose adjustment or special tests to safely take pamabrom.

Use this medication as directed on the label, or as your doctor has prescribed. Do not use the medication in larger amounts or for longer than recommended.

Do not take more than 4 tablets in one day (24 hours).

What should I discuss with my health care provider before taking Aqua-Ban (pamabrom)?

Do not use this medication if you are allergic to pamabrom or if you are unable to urinate.

Before taking pamabrom, tell your doctor if you have high blood pressure, heart disease, or kidney disease. If you have any of these conditions, you may need a dose adjustment or special tests to safely take pamabrom.

Pamabrom may or may not be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while you are taking this medication. It is not known whether pamabrom passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Aqua-Ban (pamabrom)?

Use this medication exactly as directed on the label, or as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended.

The usual dose of pamabrom is 1 tablet taken 4 times per day.

Do not take more than 4 tablets in one day (24 hours).

Pamabrom will cause you to urinate more than usual. This is a sign that the medication is working.

Store pamabrom at room temperature away from moisture and heat.

What happens if I miss a dose?

Since pamabrom is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

What should I avoid while taking Aqua-Ban (pamabrom)?

Follow your doctor’s instructions about any restrictions on food, beverages, or activity while you are using pamabrom.

Aqua-Ban (pamabrom) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Aqua-Ban (pamabrom)?

Ask your doctor before taking pamabrom if you also take any other diuretic (often used as blood pressure medication).

Diuretics include amiloride (Midamor, Moduretic), bumetanide (Bumex), chlorothiazide (Diuril), chlorthalidone (Hygroton, Thalitone), ethacrynic acid (Edecrin), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar, Vasoretic, Zestoretic), indapamide (Lozol), metolazone (Mykrox, Zaroxolyn), spironolactone (Aldactazide, Aldactone), triamterene (Dyrenium, Maxzide, Dyazide), torsemide (Demadex), and others.

This list is not complete and there may be other drugs that can interact with pamabrom. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about pamabrom.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 1.03. Revision Date: 4/12/2009 4:41:24 PM.

Generic Name: pamabrom (PAM a brom)
Brand Names: Aqua-Ban, Aqua-Ban with Pamabrom

What is Aqua-Ban with Pamabrom (pamabrom)?

Pamabrom is a diuretic (water pill). It works by increasing urination.

Pamabrom is used to treat bloating, puffiness, and other signs of water weight gain related to menstrual symptoms.

Pamabrom may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Aqua-Ban with Pamabrom (pamabrom)?

Do not use this medication if you are allergic to pamabrom or if you are unable to urinate.

Before using pamabrom, tell your doctor if you take any other diuretic (water pill), or if you have high blood pressure, heart disease, or kidney disease. If you have any of these conditions, you may need a dose adjustment or special tests to safely take pamabrom.

Use this medication as directed on the label, or as your doctor has prescribed. Do not use the medication in larger amounts or for longer than recommended.

Do not take more than 4 tablets in one day (24 hours).

What should I discuss with my health care provider before taking Aqua-Ban with Pamabrom (pamabrom)?

Do not use this medication if you are allergic to pamabrom or if you are unable to urinate.

Before taking pamabrom, tell your doctor if you have high blood pressure, heart disease, or kidney disease. If you have any of these conditions, you may need a dose adjustment or special tests to safely take pamabrom.

Pamabrom may or may not be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while you are taking this medication. It is not known whether pamabrom passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Aqua-Ban with Pamabrom (pamabrom)?

Use this medication exactly as directed on the label, or as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended.

The usual dose of pamabrom is 1 tablet taken 4 times per day.

Do not take more than 4 tablets in one day (24 hours).

Pamabrom will cause you to urinate more than usual. This is a sign that the medication is working.

Store pamabrom at room temperature away from moisture and heat.

What happens if I miss a dose?

Since pamabrom is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

What should I avoid while taking Aqua-Ban with Pamabrom (pamabrom)?

Follow your doctor’s instructions about any restrictions on food, beverages, or activity while you are using pamabrom.

Aqua-Ban with Pamabrom (pamabrom) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Aqua-Ban with Pamabrom (pamabrom)?

Ask your doctor before taking pamabrom if you also take any other diuretic (often used as blood pressure medication).

Diuretics include amiloride (Midamor, Moduretic), bumetanide (Bumex), chlorothiazide (Diuril), chlorthalidone (Hygroton, Thalitone), ethacrynic acid (Edecrin), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar, Vasoretic, Zestoretic), indapamide (Lozol), metolazone (Mykrox, Zaroxolyn), spironolactone (Aldactazide, Aldactone), triamterene (Dyrenium, Maxzide, Dyazide), torsemide (Demadex), and others.

This list is not complete and there may be other drugs that can interact with pamabrom. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about pamabrom.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 1.03. Revision Date: 4/12/2009 4:41:24 PM.