Generic name: Linezolid
Brand names: Zyvox

Why is Zyvox prescribed?

Zyvox is a member of a new class of antibiotics called oxazolidinones. It is used to treat certain types of pneumonia, some forms of skin infection, and infections involving certain strains of a germ called Enterococcus faecium.

Most important fact about Zyvox

Antibiotic treatment can cause a type of diarrhea that, in rare cases, becomes extremely severe. If you develop diarrhea after starting Zyvox, be sure to notify your doctor immediately.

If you need to take Zyvox for more than two weeks, your doctor will perform blood tests to check for blood abnormalities. Blood tests are also needed if you tend to bleed easily or are taking medications that increase your chance of bleeding.

Zyvox could cause a very rare—but potentially fatal—side effect known as lactic acidosis, especially if the treatment lasts longer than the recommended 28 days. It is caused by a buildup of lactic acid in the blood. Lactic acidosis is a medical emergency that must be treated in a hospital. Notify your doctor immediately if you experience repeated nausea and vomiting or any of the following:

• Symptoms of lactic acidosis may include:
  Dizziness, extreme weakness or tiredness, light-headedness, low body temperature, rapid breathing or trouble breathing, sleepiness, slow or irregular heartbeat, unexpected or unusual stomach discomfort, unusual muscle pain

How should you take Zyvox?

Zyvox should be taken twice a day, every 12 hours, until the prescription is finished. Do not stop taking the medicine when you start to feel better. If you discontinue it too soon, surviving germs may cause a relapse. Zyvox may be taken with or without food.

If you are taking the liquid formulation of Zyvox, gently mix it before each use by turning the bottle upside down and upright 3 to 5 times. Do not shake the bottle.

Your doctor will only prescribe Zyvox to treat a bacterial infection; it will not cure a viral infection, such as the common cold. It’s important to take the full dosage schedule of Zyvox, even if you’re feeling better in a few days. Not completing the full dosage schedule may decrease the drug’s effectiveness and increase the chances that the bacteria may become resistant to Zyvox and similar antibiotics.

• If you miss a dose…
  Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.

• Storage instructions…
  Both Zyvox tablets and Zyvox liquid can be stored at room temperature. Keep the bottles tightly closed and protect from light and moisture. The liquid formulation should be used within 21 days.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Zyvox.

• Side effects reported in adults may include:
  Diarrhea, headache, nausea, vomiting

• Side effects reported in children may include:
  Anemia, blood infection, diarrhea, fever, rash, upper respiratory infection, vomiting

Why should Zyvox not be prescribed?

If Zyvox gives you an allergic reaction, you won’t be able to use it.

Special warnings about Zyvox

Let the doctor know if you have high blood pressure. Zyvox has not been tested under these conditions.

If you’re taking Zyvox with a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs), there is a chance of developing serotonin syndrome. Symptoms include euphoria, drowsiness, rapid muscle contraction and relaxation, restlessness, dizziness, sweating, coordination problems, and fever. If you experience these symptoms, seek medical attention immediately.

Vision problems─including blurred vision, change in color perception, and problems with depth perception─may be caused by Zyvox treatment that lasts for more than 28 days. If this occurs, contact your doctor right away.

If you have a condition called phenylketonuria and must avoid the amino acid phenylalanine, it’s important to know that the liquid formulation of Zyvox contains this substance.

Possible food and drug interactions when taking Zyvox

If Zyvox is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Zyvox with the following:

Serotonin-boosting antidepressants
Decongestants
Over-the-counter cold medicines and cough syrups that contain pseudoephedrine

While taking Zyvox, it’s important to avoid eating large amounts of foods that contain a chemical called tyramine. Food products high in tyramine include aged cheese, fermented or air-dried meats such as dry sausage, sauerkraut, soy sauce, red wine, tap beers, and any protein-rich food that has been improperly refrigerated.

Special information if you are pregnant or breastfeeding

Zyvox has not been studied in pregnant women or nursing mothers. Because the possibility of harm to the developing baby has not been ruled out, Zyvox should be used during pregnancy only if the potential benefit outweighs the possible risk. If you wish to breastfeed your infant, discuss your treatment options with your doctor.

Recommended dosage for Zyvox

ADULTS AND ADOLESCENTS 12 AND OLDER

Pneumonia and Complicated Skin Infections

The usual dosage is 600 milligrams every 12 hours for 10 to 14 days.

Uncomplicated Skin Infections

Adults: The usual dosage is 400 milligrams every 12 hours for 10 to 14 days.

Adolescents 12 years and older: The usual dosage is 600 milligrams every 12 hours for 10 to 14 days.

Enterococcus faecium Infections

The usual dosage is 600 milligrams every 12 hours for 14 to 28 days.

CHILDREN (BIRTH TO 11 YEARS OLD)

Pneumonia and Complicated Skin Infections

The usual dosage is 10 milligrams for every 2.2 pounds of body weight taken every 8 hours for 10 to 14 days.

Uncomplicated Skin Infections

Children under 5 years old: The usual dosage is 10 milligrams for every 2.2 pounds of body weight taken every 8 hours for 10 to 14 days.

Children 5 to 11 years old: The usual dosage is 10 milligrams for every 2.2 pounds of body weight taken every 12 hours for 10 to 14 days.

Enterococcus faecium Infections

The usual dosage is 10 milligrams for every 2.2 pounds of body weight taken every 8 hours for 14 to 28 days.

Overdosage

Little is known about the effects of a Zyvox overdose. However, any medication taken in excess can have serious consequences, so if you suspect an overdose, seek medical attention immediately.

Generic name: Cetirizine hydrochloride
Brand names: Zyrtec

Why is Zyrtec prescribed?

Zyrtec is an antihistamine. It is prescribed to treat the sneezing; itchy, runny nose; and itchy, red, watery eyes caused by seasonal allergies such as hay fever. Zyrtec also relieves the symptoms of year-round allergies due to dust, mold, and animal dander. This medication is also used in the treatment of chronic itchy skin and hives.

Most important fact about Zyrtec

Zyrtec may cause drowsiness. Be especially careful driving or operating dangerous machinery or participating in any hazardous activity that requires full mental alertness until you know how you react to Zyrtec.

How should you take Zyrtec?

Take Zyrtec once a day, exactly as prescribed. This medication can be taken with or without food.

Zyrtec may make your mouth dry. Sucking hard candy, chewing a stick of gum, or melting bits of ice in your mouth can provide relief.

• If you miss a dose…
  If you are taking Zyrtec on a regular schedule, take the forgotten dose as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at once.

• Storage instructions…
  Store the tablets and syrup at room temperature. The syrup may be refrigerated.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Zyrtec.

• Side effects in adults may include:
  Drowsiness, dry mouth, fatigue

• Side effects in children aged 6 to 11 may include:
  Abdominal pain, coughing, diarrhea, headache, nosebleed, sleepiness, sore throat, wheezing

Why should Zyrtec not be prescribed?

Avoid Zyrtec if it causes a reaction, or if you have ever had a reaction to similar drugs.

Special warnings about Zyrtec

If you have kidney or liver disease, be sure to tell your doctor. Your dose of Zyrtec may have to be reduced.

Possible food and drug interactions when taking Zyrtec

You should avoid drinking alcohol or taking sedatives, tranquilizers, sleeping pills, or muscle relaxants while using Zyrtec. They can lead to increased drowsiness and reduced mental alertness. Among the products to avoid are the following:

Antidepressants
Muscle relaxants
Pain-relieving narcotics
Sedatives such as phenobarbital
Sleeping pills
High doses of theophylline

Special information if you are pregnant or breastfeeding

The effects of Zyrtec during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, tell your doctor immediately. Zyrtec appears in breast milk and should not be used if you are breastfeeding.

Recommended dosage for Zyrtec

ADULTS AND CHILDREN 12 YEARS AND OLDER

The usual starting dose is 5 or 10 milligrams once a day, depending on the severity of your symptoms. If you have a kidney or liver condition, the doctor will probably prescribe 5 milligrams daily.

CHILDREN 6 TO 11 YEARS

The usual starting dose is 5 or 10 milligrams (1 or 2 teaspoonfuls of syrup) once a day. If your child has a kidney or liver condition, the doctor will probably prescribe the lower dose.

CHILDREN 2 TO 5 YEARS

The usual starting dose is 2.5 milligrams (one-half teaspoonful) once a day. Dosage may be increased to a maximum of 5 milligrams (1 teaspoonful) once daily or 2.5 milligrams (one-half teaspoonful) every 12 hours. If the child has a kidney or liver condition, Zyrtec should not be given.

CHILDREN 6 TO 23 MONTHS

The usual starting dose is 2.5 milligrams (one-half teaspoonful) once a day. In children 12 to 23 months old, the dose can be increased to a maximum of 5 milligrams a day, given as 2.5 milligrams (one-half teaspoonful) every 12 hours. Zyrtec should not be used if your child has kidney or liver problems.

Overdosage

Any medication taken in excess can have serious consequences. In adults, the primary symptom of a Zyrtec overdose is extreme sleepiness. In children, restlessness and irritability may precede drowsiness. If you suspect an overdose, seek medical treatment immediately.

Generic name: Olanzapine
Brand names: Zyprexa

Why is Zyprexa prescribed?

Zyprexa helps manage symptoms of schizophrenia, the manic phase of bipolar disorder, and other psychotic disorders. It is thought to work by opposing the action of serotonin and dopamine, two of the brain’s major chemical messengers. The drug is available as Zyprexa tablets and Zyprexa Zydis, which dissolves rapidly with or without liquid.

Most important fact about Zyprexa

At the start of Zyprexa therapy, the drug can cause extreme low blood pressure, increased heart rate, dizziness, and, in rare cases, a tendency to faint when first standing up. These problems are more likely if you are dehydrated, have heart disease, or take blood pressure medicine. To avoid such problems, your doctor may start with a low dose of Zyprexa and increase the dosage gradually.

How should you take Zyprexa?

Zyprexa should be taken once a day with or without food. To use Zyprexa Zydis, open the sachet, peel back the foil on the blister pack, remove the tablet, and place the entire tablet in the mouth. Do not push the tablet through the foil. The medication can be taken with or without water; the saliva in your mouth will cause the tablet to dissolve.

• If you miss a dose…
  Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at once.

• Storage instructions…
  Store at room temperature away from light and moisture.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Zyprexa.

• Side effects may include:
  Agitation, change in personality, constipation, dizziness, dry mouth, increased appetite, indigestion, low blood pressure upon standing, sleepiness, tremor, weakness, weight gain

Why should Zyprexa not be prescribed?

If Zyprexa gives you an allergic reaction, you cannot take the drug.

Special warnings about Zyprexa

Certain antipsychotic drugs, including Zyprexa, are associated with an increased risk of developing high blood sugar, which on rare occasions has led to coma or death. See your doctor right away if you develop signs of high blood sugar, including dry mouth, unusual thirst, increased urination, and tiredness. If you have diabetes or have a high risk of developing it, see your doctor regularly for blood sugar testing.

Use Zyprexa with caution if you have any of the following conditions: Parkinson’s disease, trouble swallowing, narrow angle glaucoma (high pressure in the eye), an enlarged prostate, heart irregularities, heart disease, heart failure, liver disease, or a history of heart attack, seizures, or intestinal blockage.

Zyprexa should not be used to treat elderly patients who have dementia because the drug could increase the risk of stroke. In addition, antipsychotic drug treatment has been associated with swallowing and breathing problems in older people and those with Alzheimer’s disease.

Drugs such as Zyprexa sometimes cause a condition called Neuroleptic Malignant Syndrome (NMS). Symptoms include high fever, muscle rigidity, irregular pulse or blood pressure, rapid heartbeat, excessive sweating, and changes in heart rhythm. If these symptoms appear, contact your doctor right away. You’ll have to discontinue using Zyprexa while the condition is under treatment.

There is also a risk of developing tardive dyskinesia, a condition marked by slow, rhythmical, involuntary movements. This problem is more likely to surface in older adults, especially elderly women. When it does, use of Zyprexa is usually stopped.

Animal studies suggest that Zyprexa may increase the risk of breast cancer, although human studies have not confirmed such a risk. If you have a history of breast cancer, see your doctor regularly for checkups.

People at high risk of suicide attempts should be prescribed the lowest dose possible to reduce the risk of intentional overdose.

Zyprexa sometimes causes drowsiness and can impair your judgment, thinking, and motor skills. Use caution while driving and don’t operate dangerous machinery until you know how the drug affects you.

Medicines such as Zyprexa can interfere with regulation of the body’s temperature. Do not get overheated or become dehydrated while taking Zyprexa. Avoid extreme heat and drink plenty of fluids.

Zyprexa can cause low blood pressure upon standing, resulting in dizziness, rapid heartbeat, and fainting, especially at the start of therapy. Let the doctor know if you develop this problem; your dosage can be adjusted to reduce the symptoms.

If you have phenylketonuria and must avoid the amino acid phenylalanine, you should not take Zyprexa Zydis, which contains this substance.

The safety and effectiveness of Zyprexa have not been studied in children.

Possible food and drug interactions when taking Zyprexa

Avoid alcohol while taking Zyprexa. The combination can cause a sudden drop in blood pressure.

If Zyprexa is taken with certain other drugs, the effects of either can be increased, decreased, or altered. Ask your doctor before taking any prescription or over-the-counter drugs. It is especially important to check before combining Zyprexa with the following:

Blood pressure medications
Benzodiazepines
Carbamazepine
Diazepam
Drugs that boost the effect of dopamine, such as Parkinson’s medications
Fluvoxamine
Levodopa
Omeprazole
Rifampin

Special information if you are pregnant or breastfeeding

If you are pregnant or plan to become pregnant, inform your doctor immediately. Zyprexa should be used during pregnancy only if absolutely necessary. The drug may appear in breast milk; do not breastfeed while on Zyprexa therapy.

Recommended dosage for Zyprexa

ADULTS

Schizophrenia

The usual starting dose is 5 to 10 milligrams once a day. If you start at the lower dose, after a few days the doctor will increase it to 10. After that, the dosage will be increased no more than once a week, 5 milligrams at a time, up to a maximum of 20 milligrams a day.

Those most likely to start at 5 milligrams are people who are weak, people prone to low blood pressure, and nonsmoking women over 65 (because they tend to have a slow metabolism).

Manic Episodes in Bipolar Disorder

The usual starting dose is 10 to 15 milligrams once a day. If needed, the dose can be increased every 24 hours by 5 milligrams a day, up to a maximum daily dose of 20 milligrams. After the person is stabilized, the doctor may continue maintenance therapy at a dosage range of 5 to 20 milligrams a day. If Zyprexa is being combined with lithium or valproate, the usual starting dose is 10 milligrams once a day.

Overdosage

An overdose of Zyprexa is usually not life-threatening, but fatalities have been reported. If you suspect an overdose, seek medical attention immediately.

• Symptoms of Zyprexa overdose may include:
  Agitation, drowsiness, rapid or irregular heartbeat, slurred or disrupted speech, stupor

Overdoses of Zyprexa have also led to breathing difficulties, changes in blood pressure, excessive perspiration, fever, muscle rigidity, cardiac arrest, coma, and convulsions.

Generic name: Zileuton
Brand names: Zyflo

Why is Zyflo prescribed?

Zyflo tablets prevent and relieve the symptoms of chronic asthma. The drug works by relaxing the muscles in the walls of your airways, allowing them to open wider, and by reducing inflammation, swelling, and mucus secretion in the lungs.

Most important fact about Zyflo

Zyflo has been known to cause liver damage. Be sure to see your doctor every few months for liver function tests.

How should you take Zyflo?

Zyflo should be taken 4 times a day. Although you can take it with or without meals, it may be easier to remember if you take it with meals and at bedtime. Take Zyflo exactly as prescribed, even when symptoms subside.

While taking Zyflo, you should continue taking all other asthma medications your doctor has prescribed, unless directed otherwise. Do not decrease the dose or stop taking any of these drugs.

• If you miss a dose…
  Take the forgotten dose as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.

• Storage instructions…
  Store at room temperature, away from light.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Zyflo.

• Side effects may include:
  Abdominal pain, headache, indigestion, loss of strength, muscle aches, nausea, pain

Why should Zyflo not be prescribed?

If you have liver disease, you should not take Zyflo. You should also avoid Zyflo if you have ever had an allergic reaction to it or its ingredients.

Special warnings about Zyflo

Zyflo will not help an acute asthma attack in which immediate opening of the airways is needed.

If you find that you have to use your other asthma medications—such as an inhaler—more often, report this to your doctor.

Because Zyflo can affect the liver, make sure your doctor is aware of any problems you’ve had in the past. Warn the doctor, too, if you’re a heavy drinker. Your liver function will be tested before you start Zyflo, and regularly thereafter. Be sure to go in for these tests. If they reveal liver damage, you’ll have to stop taking Zyflo. Also be sure to tell your doctor immediately if you develop any symptoms of liver disease. These include pain in the upper right abdomen, nausea, fatigue, lethargy, itching, general discomfort, and jaundice (yellowing of the skin and eyes).

Possible food and drug interactions when taking Zyflo

If Zyflo is taken with certain other drugs, the effects of either could be increased, decreased, or altered. You should check with your doctor before stopping or starting any prescription or nonprescription medicine. This is especially important with the following:

Astemizole
Beta blockers (a type of heart and blood pressure medication)
Calcium channel blockers (another type of heart and blood pressure medication)
Cisapride
Cyclosporin
Terfenadine
Theophylline
Warfarin

While you are taking Zyflo, your theophylline dosage may need to be lowered, and your theophylline levels will have to be carefully watched. Dosages of propanolol may also need reduction, and warfarin dosages may need adjustment as well.

Special information if you are pregnant or breastfeeding

The effects of Zyflo in pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, ask your doctor whether you should continue taking Zyflo. It is not certain that the drug appears in breast milk, but taking Zyflo while nursing is not recommended. Discuss with your doctor whether it’s best to stop taking the drug or to give up breastfeeding.

Recommended dosage for Zyflo

ADULTS

The recommended dosage is one 600-milligram tablet 4 times a day.

CHILDREN

The safety and effectiveness of Zyflo in children under 12 years of age have not been established.

Overdosage

Because Zyflo is a relatively new drug, little is known about overdosage. However, any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical treatment immediately.

Generic name: Acyclovir
Brand names: Zovirax

Why is Zovirax prescribed?

Zovirax liquid, capsules, and tablets are used in the treatment of certain infections with herpes viruses. These include genital herpes, shingles, and chickenpox. This drug may not be appropriate for everyone, and its use should be thoroughly discussed with your doctor. Zovirax ointment is used to treat initial episodes of genital herpes and certain herpes simplex infections of the skin and mucous membranes. Zovirax cream is used for herpes cold sores on the lips and face only.

Some doctors use Zovirax, along with other drugs, in the treatment of AIDS, and for unusual herpes infections such as those following kidney and bone marrow transplants.

Most important fact about Zovirax

Zovirax does not cure herpes. However, it does reduce pain and may help the sores caused by herpes to heal faster. Genital herpes is a sexually transmitted disease. To reduce the chance of infecting your partner, forgo intercourse and other sexual contact while you have sores or any other symptom.

How should you take Zovirax?

Your medication should not be shared with others, and the prescribed dose should not be exceeded. You can take Zovirax with or without food.

Zovirax ointment should not be used in or near the eyes. To reduce the risk of spreading the infection, use a rubber glove to apply the ointment.

Zovirax cream should not be used in or near the eyes, or inside the nose or mouth. The medication can, however, be applied on the outside of the lips. Apply the cream with your fingers to clean, dry skin. Be sure to wash your hands before and after applying Zovirax cream, and avoid bathing or swimming afterward to prevent it from washing off. Do not cover the cold sore with a bandage or make-up unless your doctor approves.

• If you miss a dose…
  Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.

If you are using the ointment, apply it as soon as you remember and continue your regular schedule.

• Storage instructions…
  Store Zovirax at room temperature in a dry place.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Zovirax.

• Side effects may include:
  Diarrhea, general feeling of bodily discomfort, nausea, vomiting

• Side effects of Zovirax ointment may include:
  Burning, itching, mild pain, skin rash, stinging, vaginal inflammation

• Side effects of Zovirax cream may include:
  Allergic reactions, burning, dry or cracked lips, dry or flaky skin, eczema (inflamed, irritated patches of skin), hives, inflammation, itchy spots, stinging

Why should Zovirax not be prescribed?

If you are sensitive to or have ever had an allergic reaction to Zovirax or similar drugs, you should not take Zovirax. Make sure that your doctor is aware of any drug reactions that you have experienced.

Special warnings about Zovirax

If you are being treated for a kidney disorder, consult your doctor before taking Zovirax. The drug has been known to cause kidney failure.

If you develop unusual bruising or bleeding under the skin, be sure to alert your doctor. It could signal a dangerous blood disorder.

Possible food and drug interactions when taking Zovirax

If Zovirax is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Zovirax with the following:

Cyclosporine
Interferon
Probenecid
Zidovudine

Special information if you are pregnant or breastfeeding

Zovirax seems relatively safe during pregnancy. Nevertheless, it should be used only if its benefits outweigh the potential risk to the baby. If you are pregnant or plan to become pregnant, inform your doctor immediately. Zovirax appears in breast milk and could affect a nursing infant. If Zovirax is essential to your health, your doctor may advise you to discontinue breastfeeding your baby until your treatment with Zovirax is finished.

Recommended dosage for Zovirax

ADULTS

For Genital Herpes

The usual dose is one 200-milligram capsule or 1 teaspoonful of liquid every 4 hours, 5 times daily for 10 days. If the herpes is recurrent, the usual adult dose is 400 milligrams (two 200-milligram capsules, one 400-milligram tablet or 2 teaspoonfuls) 2 times daily for up to 12 months.

If genital herpes is intermittent, the usual adult dose is one 200-milligram capsule or 1 teaspoon of liquid every 4 hours, 5 times a day for 5 days. Therapy should be started at the earliest sign or symptom.

Ointment: Apply ointment to affected area every 3 hours, 6 times per day, for 7 days. Use enough ointment (approximately one-half inch ribbon of ointment per 4 square inches of surface area) to cover the affected area.

For Herpes Cold Sores

Apply Zovirax cream to the affected area 5 times a day for 4 days. Therapy should begin as soon as possible after the first sign of a cold sore such as a bump, tingling, redness, or itchiness.

For Herpes Zoster (Shingles)

The usual adult dose is 800 milligrams (one 800-milligram tablet or 4 teaspoonfuls of liquid) every 4 hours, 5 times daily for 7 to 10 days.

For Chickenpox:

The usual adult dose is 800 milligrams 4 times a day for 5 days.

If you have a kidney disorder, the dose will need to be adjusted by your doctor.

CHILDREN

The usual dose for chickenpox in children 2 years of age and older is 20 milligrams per 2.2 pounds of body weight taken orally 4 times daily, for a total of 80 milligrams per 2.2 pounds, for 5 days. A child weighing more than 88 pounds should take the adult dose.

The safety and effectiveness of oral Zovirax have not been established in children under 2 years of age. However, your doctor may decide that the benefits of Zovirax outweigh the potential risks. The safety and effectiveness of Zovirax ointment in children have not been established. Zovirax cream has not been studied in children less than 12 years old.

OLDER ADULTS

Your doctor will start you at the low end of the dosage range, since older adults are more apt to have kidney problems or other disease, or to be taking other medications.

Overdosage

Zovirax is generally safe. However, any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

• Symptoms of Zovirax overdose may include:
  Agitation, kidney failure, lethargy, coma, seizures

Brand names: Zonegran

Why is Zonisamide prescribed?

Zonegran helps reduce the frequency of partial epileptic seizures, a form of epilepsy in which neural disturbances are limited to a specific region of the brain and the victim remains conscious throughout the attack. The drug is used in combination with other antiseizure medications, not by itself.

Most important fact about Zonisamide

Do not stop taking Zonisamide on your own. If the doctor decides to discontinue Zonegran, he will tell you how to taper off slowly. Abrupt discontinuation of Zonegran can cause seizures.

How should you take Zonisamide?

Zonegran capsules should be swallowed whole and can be taken with or without food.

• If you miss a dose…
  Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.

• Storage instructions…
  Store at room temperature in a dry place. Protect from light.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Zonegran.

• Side effects may include:
  Abdominal pain, agitation, confusion, depression, diarrhea, difficulty concentrating, difficulty with memory, dizziness, double vision and other visual disturbances, drowsiness, fatigue, flu syndrome, headache, insomnia, irritability, loss of appetite, loss of muscle coordination, mental slowing, nausea, prickling or burning skin, rash, speech abnormalities, tiredness

Why should Zonisamide not be prescribed?

Do not take Zonegran if you are allergic to sulfa drugs.

Special warnings about Zonisamide

If you develop a rash while taking Zonegran, call your physician immediately. It could be a sign of an allergic reaction.

Zonegran may cause drowsiness. Do not drive a car or operate dangerous machinery until you know how the drug affects you.

People who take Zonegran are prone to develop kidney stones. To reduce the risk of stone formation, be sure to drink plenty of fluids. Call your doctor immediately if you develop symptoms of kidney stones such as back pain, abdominal pain, painful urination, or blood in the urine.

Call your doctor if you start to bruise easily or develop a fever, a sore throat, or blisters in the mouth. These could be signs of anemia or other blood problems that Zonegran has been known to trigger in very rare cases.

Contact your doctor immediately if you develop severe muscle pain or weakness.

Contact your doctor immediately if your seizures worsen.

Zonegran may interfere with a child’s ability to perspire and control body temperature, leading to a medical emergency. Zonegran is not approved for use in children under 16.

Possible food and drug interactions when taking Zonisamide

If Zonegran is taken with certain other drugs, the effects if either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Zonegran with the following:

Carbamazepine
Phenobarbital
Phenytoin
Valproate

Special information if you are pregnant or breastfeeding

In most cases, Zonegran should not be taken by pregnant women because there is a chance that it could harm the developing baby. If you are pregnant or plan to become pregnant, tell your doctor immediately.

It is not known whether Zonegran appears in breast milk, but because it could cause a serious reaction if it did, you’ll probably need to make a choice between breastfeeding and continuing your Zonegran therapy. Be sure to discuss the question with your doctor.

Recommended dosage for Zonisamide

ADULTS

The recommended starting dose for adults over the age of 16 is 100 milligrams daily as your doctor directs.

Your physician may wish to increase the dose by 100 milligrams every 2 weeks to a maximum of 600 milligrams per day. Larger doses can be divided into two smaller doses taken twice a day.

Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

• Symptoms of Zonegran overdose may include:
  Diminished breathing, loss of consciousness, low blood pressure, slow heartbeat

Generic name: Zonisamide
Brand names: Zonegran

Why is Zonegran prescribed?

Zonegran helps reduce the frequency of partial epileptic seizures, a form of epilepsy in which neural disturbances are limited to a specific region of the brain and the victim remains conscious throughout the attack. The drug is used in combination with other antiseizure medications, not by itself.

Most important fact about Zonegran

Do not stop taking Zonegran on your own. If the doctor decides to discontinue Zonegran, he will tell you how to taper off slowly. Abrupt discontinuation of Zonegran can cause seizures.

How should you take Zonegran?

Zonegran capsules should be swallowed whole and can be taken with or without food.

• If you miss a dose…
  Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.

• Storage instructions…
  Store at room temperature in a dry place. Protect from light.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Zonegran.

• Side effects may include:
  Abdominal pain, agitation, confusion, depression, diarrhea, difficulty concentrating, difficulty with memory, dizziness, double vision and other visual disturbances, drowsiness, fatigue, flu syndrome, headache, insomnia, irritability, loss of appetite, loss of muscle coordination, mental slowing, nausea, prickling or burning skin, rash, speech abnormalities, tiredness

Why should Zonegran not be prescribed?

Do not take Zonegran if you are allergic to sulfa drugs.

Special warnings about Zonegran

If you develop a rash while taking Zonegran, call your physician immediately. It could be a sign of an allergic reaction.

Zonegran may cause drowsiness. Do not drive a car or operate dangerous machinery until you know how the drug affects you.

People who take Zonegran are prone to develop kidney stones. To reduce the risk of stone formation, be sure to drink plenty of fluids. Call your doctor immediately if you develop symptoms of kidney stones such as back pain, abdominal pain, painful urination, or blood in the urine.

Call your doctor if you start to bruise easily or develop a fever, a sore throat, or blisters in the mouth. These could be signs of anemia or other blood problems that Zonegran has been known to trigger in very rare cases.

Contact your doctor immediately if you develop severe muscle pain or weakness.

Contact your doctor immediately if your seizures worsen.

Zonegran may interfere with a child’s ability to perspire and control body temperature, leading to a medical emergency. Zonegran is not approved for use in children under 16.

Possible food and drug interactions when taking Zonegran

If Zonegran is taken with certain other drugs, the effects if either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Zonegran with the following:

Carbamazepine
Phenobarbital
Phenytoin
Valproate

Special information if you are pregnant or breastfeeding

In most cases, Zonegran should not be taken by pregnant women because there is a chance that it could harm the developing baby. If you are pregnant or plan to become pregnant, tell your doctor immediately.

It is not known whether Zonegran appears in breast milk, but because it could cause a serious reaction if it did, you’ll probably need to make a choice between breastfeeding and continuing your Zonegran therapy. Be sure to discuss the question with your doctor.

Recommended dosage for Zonegran

ADULTS

The recommended starting dose for adults over the age of 16 is 100 milligrams daily as your doctor directs.

Your physician may wish to increase the dose by 100 milligrams every 2 weeks to a maximum of 600 milligrams per day. Larger doses can be divided into two smaller doses taken twice a day.

Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

• Symptoms of Zonegran overdose may include:
  Diminished breathing, loss of consciousness, low blood pressure, slow heartbeat

Generic name: Zolmitriptan
Brand names: Zomig

Why is Zomig prescribed?

Zomig relieves migraine headaches. It is effective whether or not the headache is preceded by an aura (visual disturbances such as halos and flickering lights). For most people Zomig provides relief within 2 hours, but it will not abort an attack or reduce the number of headaches you experience.

Migraines are thought to be caused by expansion and inflammation of blood vessels in the head. Zomig ends a migraine attack by constricting these blood vessels and reducing inflammation.

Most important fact about Zomig

Zomig is for use only on common and classic migraine headaches. It should not be used for other types of headache, including certain unusual types of migraine. It has not been tested for cluster headaches, a type of severe headache more common among men.

How should you take Zomig?

Take Zomig as soon as your first symptoms appear. If the headache comes back after your first dose, you may take a second one 2 hours later. However, if the first dose has no effect at all, do not take a second one unless your doctor advises it, and never take more than 10 milligrams in a day. If taking an orally disintegrating Zomig ZMT tablet, do not remove it from the blister pack until just before use, then immediately place it on your tongue, where it will dissolve in the saliva. Do not break the tablet. Throw away any unused tablets already removed from the blister packaging.

• If you miss a dose…
  Zomig is not for regular use. Take it only when you are having a migraine attack.

• Storage instructions…
  Store Zomig at room temperature, away from heat, light, and moisture. Throw away any remaining tablets after the expiration date printed on the package. Also discard any leftover medicine if your doctor decides to stop treatment with Zomig.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Zomig.

• Side effects may include:
  Chest pain or tightness, cold sensation, dizziness, drowsiness, dry mouth, feeling of heaviness in the chest or elsewhere, indigestion, jaw pain or tightness, nausea, neck pain or tightness, pain, skin tingling, sweating, throat pain or tightness, warm sensation, weakness

Why should Zomig not be prescribed?

You should not take Zomig if you have certain types of heart disease, including angina (chest pain), a history of heart attack, and certain heart irregularities. Also avoid the drug if you have uncontrolled high blood pressure.

Do not use Zomig within 24 hours of taking an ergotamine-based migraine medication or a drug in the same class as Zomig.

Avoid using Zomig within 2 weeks of taking a drug classified as an MAO inhibitor, such as antidepressants.

If Zomig gives you an allergic reaction, do not take it again.

Special warnings about Zomig

If the first dose of Zomig does not relieve your symptoms, ask your doctor to re-evaluate you; migraine may not be the problem.

Although the danger is very remote, this type of medication has been known to trigger serious and even life-threatening heart problems in people with heart disease. If you have a heart disorder, make sure the doctor knows about it. Do not take Zomig if you suffer from irregular heartbeat.

Very rarely, Zomig has caused serious intestinal problems. See your doctor immediately if you have bloody diarrhea or stomach pain.

If you have risk factors for heart disease, your doctor may ask you to take your first dose of Zomig in the office, and may want to monitor you carefully thereafter. Risk factors that signal the need for caution include high blood pressure, high cholesterol, smoking, excess weight, diabetes, and a strong family history of heart disease or hardening of the arteries. Heart disease is also more likely in postmenopausal women and men over 40.

Use Zomig with caution if you have liver or kidney disease. These conditions could alter the effect of the drug. If you have a history of seizures, make sure the doctor is aware of it. Also, if you develop any trouble with your eyes, alert your doctor. There is a possibility the problem could be related to Zomig.

If you experience pain or tightness in your chest or throat when using Zomig, tell your doctor. If the chest pain is severe or does not go away, seek medical attention immediately. These pains could be symptoms of a previously undetected heart condition.

If you develop shortness of breath, wheezing, a throbbing heartbeat, swelling of the eyelids, face, or lips, or a skin rash, skin lumps, or hives after taking Zomig, call your doctor immediately, and do not take any more of the drug without your doctor’s approval.

If a headache feels different from your usual migraine, check with your doctor before using Zomig.

If you must avoid phenylalanine, do not use the orally disintegrating Zomig ZMT tablets, which contain this substance.

Possible food and drug interactions when taking Zomig

Remember that Zomig should never be combined with the following drugs (see “Why should Zomig not be prescribed?”):

Ergotamine-type drugs
MAO inhibitors such as antidepressant drugs
Sumatriptan

If Zomig is taken with certain other drugs, the effects of either may be increased, decreased, or altered. It is especially important to check with your doctor before combining Zomig with the following:

Acetaminophen
Cimetidine
Fluoxetine
Fluvoxamine
Oral contraceptives
Paroxetine
Propranolol
Sertraline

Special information if you are pregnant or breastfeeding

The effects of Zomig during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. Although researchers have not confirmed it, Zomig may appear in breast milk and could affect a nursing infant. Check with your doctor before using Zomig while breastfeeding.

Recommended dosage for Zomig

ADULTS

The recommended starting dose is no more than 2.5 milligrams. Higher doses have little additional effect, but tend to cause more side effects. If the headache returns, the dose may be repeated after 2 hours. Do not exceed 10 milligrams in a day.

If you have liver disease, your doctor will prescribe a lower dose and closely monitor your blood pressure.

CHILDREN AND OLDER ADULTS

The safety and effectiveness of Zomig have not been established in children and adults over 65.

Overdosage

The only known symptom of Zomig overdose is drowsiness. However, any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

Brand names: Ambien

Why is Zolpidem tartrate prescribed?

Ambien is used for short-term treatment of insomnia (difficulty falling asleep or staying asleep, or early awakening). A relatively new drug, it is chemically different from other common sleep medications such as Halcion and Dalmane.

Most important fact about Zolpidem tartrate

Sleep problems are usually temporary and require medication for a week or two at most. Insomnia that lasts longer could be a sign of another medical problem. If you find that you need this medicine for more than 7 to 10 days, be sure to check with your doctor.

How should you take Zolpidem tartrate?

Ambien works very quickly. Take it just before going to bed. Take only the prescribed dose, exactly as instructed by your doctor.

• If you miss a dose…
  Take Ambien only as needed. Never double the dose.

• Storage instructions…
  Store at room temperature. Protect from extreme heat.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor immediately. Only your doctor can determine whether it is safe to continue taking Ambien.

• Side effects may include:
  Allergy, daytime drowsiness, dizziness, drugged feeling, headache, indigestion, nausea

Why should Zolpidem tartrate not be prescribed?

There are no known situations in which Ambien cannot be used.

Special warnings about Zolpidem tartrate

When sleep medications are used every night for more than a few weeks, some may lose their effectiveness. Remember, too, that you can become dependent on some sleep medications if you use them for a long time or at high doses.

Some people using Ambien—especially those taking serotonin-boosting antidepressants—have experienced unusual changes in their thinking and/or behavior. Alert your doctor if you notice a change.

Ambien and other sleep medicines can cause a special type of memory loss. It should not be taken on an overnight airplane flight of less than 7 to 8 hours, since “traveler’s amnesia” may occur.

When you first start taking Ambien, until you know whether the medication will have any “carry over” effect the next day, use extreme care while doing anything that requires complete alertness, such as driving a car or operating machinery. Older adults, in particular, should be aware that they may be more apt to fall.

Use Ambien cautiously if you have liver problems. It will take longer for its effects to wear off.

If you take Ambien for more than 1 or 2 weeks, consult your doctor before stopping. Sudden discontinuation of a sleep medicine can bring on withdrawal symptoms ranging from unpleasant feelings to vomiting and cramps.

When taking Ambien, do not drink alcohol. It can increase the drug’s side effects.

If you have breathing problems, they may become worse when you use Ambien.

Possible food and drug interactions when taking Zolpidem tartrate

If Ambien is used with certain other drugs, the effects of either drug could be increased, decreased, or altered. It is especially important to check with your doctor before combining Ambien with the following:

The antidepressant drug imipramine
The antipsychotic drug chlorpromazine
Serotonin-boosting antidepressants such as fluoxetine hydrochloride, paroxetine hydrochloride, and sertraline
Drugs that depress the central nervous system, including acetaminophen, diazepam, diphenhydramine, oxycodone hydrochloride, and pseudoephedrine hydrochloride

Special information if you are pregnant or breastfeeding

If you are pregnant or plan to become pregnant, inform your doctor immediately. Babies whose mothers take some sedative/hypnotic drugs may have withdrawal symptoms after birth and may seem limp and flaccid. Ambien is not recommended for use by nursing mothers.

Recommended dosage for Zolpidem tartrate

ADULTS

The recommended dosage for adults is 10 milligrams right before bedtime. Your doctor will prescribe a smaller dose if you are likely to be sensitive to the drug or have a liver problem. Never take more than 10 milligrams of Ambien per day.

CHILDREN

Safety and effectiveness have not been established in children below the age of 18.

OLDER ADULTS

Because older people and those in a weakened condition may be more sensitive to Ambien’s effects, the recommended starting dosage is 5 milligrams just before bedtime.

Overdosage

People who take too much Ambien may become excessively sleepy or even go into a light coma. The symptoms of overdose are more severe if the person is also taking other drugs that depress the central nervous system. Some cases of multiple overdose have been fatal.

If you suspect an overdose, seek medical attention immediately.

Generic name: Sertraline
Brand names: Zoloft

Why is Zoloft prescribed?

Zoloft is prescribed for major depression—a persistently low mood that interferes with everyday living. Symptoms may include loss of interest in your usual activities, disturbed sleep, change in appetite, constant fidgeting or lethargic movement, fatigue, feelings of worthlessness or guilt, difficulty thinking or concentrating, and recurrent thoughts of suicide.

Zoloft is also used to treat the following:

Premenstrual dysphoric disorder (PMDD), a condition marked by a depressed mood, anxiety or tension, emotional instability, and anger or irritability in the two weeks preceding menstruation.

Obsessive-compulsive disorder (unwanted thoughts that won’t go away and an irresistible urge to keep repeating certain actions, such as hand-washing or counting).

Panic disorder (unexpected attacks of overwhelming anxiety, accompanied by fear of their return).

Social anxiety disorder (extreme shyness in social situations that interferes with an individual’s work and social life).

Post-traumatic stress disorder (re-experiencing a dangerous or life-threatening event through intrusive thoughts, flashbacks, and intense psychological distress).

Zoloft belongs to a class of drugs called selective serotonin re-uptake inhibitors (SSRIs). Serotonin is one of the chemical messengers believed to govern moods. Ordinarily, it is quickly reabsorbed after its release at the junctures between nerves. Re-uptake inhibitors such as Zoloft slow this process, thereby boosting the levels of serotonin available in the brain.

Most important fact about Zoloft

Do not take Zoloft within 2 weeks of taking any drug classified as an MAO inhibitor. Drugs in this category include the antidepressants Marplan, Nardil, and Parnate. When serotonin boosters such as Zoloft are combined with MAO inhibitors, serious and sometimes fatal reactions can occur. In addition, you should not combine Zoloft with the drug pimozide (Orap).

How should you take Zoloft?

Take Zoloft exactly as prescribed: once a day, in either the morning or the evening.

Zoloft is available in capsule and oral concentrate forms. To prepare Zoloft oral concentrate, use the dropper provided. Measure out the amount of concentrate prescribed by your doctor and mix it with 4 ounces of water, ginger ale, lemon/lime soda, lemonade, or orange juice. (Do not mix the concentrate with any other type of beverage.) Drink the mixture immediately; do not prepare it in advance for later use. At times, a slight haze may appear after mixing, but this is normal.

Improvement with Zoloft may not be seen for several days to a few weeks. You should expect to keep taking it for at least several months.

Zoloft may make your mouth dry. For temporary relief suck a hard candy, chew gum, or melt bits of ice in your mouth.

• If you miss a dose…
  Take the forgotten dose as soon as you remember. If several hours have passed, skip the dose. Never try to “catch up” by doubling the dose.

• Storage instructions…
  Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Zoloft.

• Side effects may include:
  Abdominal pain, agitation, anxiety, constipation, decreased sex drive, diarrhea or loose stools, difficulty with ejaculation, dizziness, dry mouth, fatigue, gas, headache, decreased appetite, increased sweating, indigestion, insomnia, nausea, nervousness, pain, rash, sleepiness, sore throat, tingling or pins and needles, tremor, vision problems, vomiting

Many people lose a pound or two of body weight while taking Zoloft. This usually poses no problem but may be a concern if your depression has already caused you to lose a great deal of weight.

In a few people, Zoloft may trigger the grandiose, inappropriate, out-of-control behavior called mania or the similar, but less dramatic, “hyper” state called hypomania.

Why should Zoloft not be prescribed?

Do not use Zoloft while taking an MAO inhibitor or the drug pimozide (see “Most important fact about Zoloft”). Avoid Zoloft if it causes an allergic-type reaction.

Special warnings about Zoloft

In clinical studies, antidepressants increased the risk of suicidal thinking and behavior in children and adolescents with depression and other psychiatric disorders. Anyone considering the use of Zoloft or any other antidepressant in a child or adolescent must balance this risk with the clinical need. Zoloft is only approved for treating obsessive-compulsive disorder in children 6 years and older.

Additionally, the progression of major depression is associated with a worsening of symptoms and/or the emergence of suicidal thinking or behavior in both adults and children, whether or not they are taking antidepressants. Individuals being treated with Zoloft and their caregivers should watch for any change in symptoms or any new symptoms that appear suddenly—especially agitation, anxiety, hostility, panic, restlessness, extreme hyperactivity, and suicidal thinking or behavior—and report them to the doctor immediately. Be especially observant at the beginning of treatment or whenever there is a change in dose.

Use Zoloft cautiously and under close medical supervision if you have a history of kidney or liver disorders, heart disease, seizures, or bleeding problems. Your doctor may limit your dosage if you have one of these conditions.

Zoloft could cause weight loss in children. The manufacturer recommends regular monitoring of weight and growth during long-term treatment in children.

SSRI antidepressants could potentially cause stomach bleeding, especially when combined with nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, naproxen, and ketoprofen. Consult your doctor before combining Zoloft with NSAIDs or blood-thinning medications.

Like all antidepressants, Zoloft could trigger a manic episode. Let the doctor know if you’ve ever had this problem.

Zoloft has not been found to impair the ability to drive or operate machinery. Nevertheless, the manufacturer recommends caution until you know how the drug affects you.

As with other SSRIs, Zoloft therapy should be slowly tapered instead of abruptly stopped. If abruptly discontinued, drowsiness, irritability, agitation, anxiety, headache, and insomnia may occur.

If you are sensitive to latex, use caution when handling the dropper provided with the oral concentrate.

Possible food and drug interactions when taking Zoloft

Remember that Zoloft must never be combined with pimozide or an MAO inhibitor (see “Most important fact about Zoloft”).

You should not drink alcoholic beverages while taking Zoloft. Use over-the-counter remedies with caution. Although none is known to interact with Zoloft, interactions remain a possibility.

If Zoloft is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Zoloft with the following:

Antidepressants that boost serotonin
Other antidepressants, including tricyclics
Cimetidine
Diazepam
Digitoxin
Flecainide
Lithium
Over-the-counter drugs such as cold remedies
Propafenone
Sumatriptan
Tolbutamide
Warfarin

If you are using the oral concentrate form of Zoloft, do not take disulfiram.

Special information if you are pregnant or breastfeeding

If you are pregnant or plan to become pregnant, inform your doctor immediately. There have been reports of newborns experiencing complications such as respiratory problems, bluish coloring of the skin, irregular breathing, muscular problems, vomiting, and constant crying after exposure to SSRI antidepressants late in the third trimester. Zoloft should be used during pregnancy only if absolutely necessary.

Zoloft should be taken during pregnancy only if it is clearly needed. It is not known whether Zoloft appears in breast milk. Caution is advised when using Zoloft during breastfeeding.

Recommended dosage for Zoloft

ADULTS

Depression or Obsessive Compulsive Disorder

The usual starting dose is 50 milligrams once a day, taken either in the morning or in the evening. The doctor may increase your dose depending upon your response. The maximum dose is 200 milligrams in a day.

Premenstrual Dysphoric Disorder

Doses may be prescribed throughout the menstrual cycle or limited to the 2 weeks preceding menstruation. The starting dose is 50 milligrams a day. If this proves insufficient, the doctor will increase the dose in 50-milligram steps at the start of each new menstrual cycle up to a maximum of 100 milligrams per day in the 2-week regimen or 150 milligrams per day in the full-cycle regimen. (During the first 3 days of the 2-week regimen, doses are always limited to 50 milligrams.)

Panic Disorder, Post-traumatic Stress Disorder, and Social Anxiety Disorder

During the first week, the usual dose is 25 milligrams once a day. After that, the dose increases to 50 milligrams once a day. Depending on your response, you’re the doctor may continue to increase your dose up to a maximum of 200 milligrams a day.

CHILDREN 6 TO 17 YEARS OLD

Obsessive-Compulsive Disorder

The starting dose for children aged 6 to 12 is 25 milligrams and for adolescents aged 13 to 17, 50 milligrams. The doctor will adjust the dose as necessary.

Safety and effectiveness have not been established for children under 6.

DOSAGE ADJUSTMENT

The doctor will need to reduce the dosage if you have liver disease.

Overdosage

Any medication taken in excess can have serious consequences. An overdose of Zoloft can be fatal. If you suspect an overdose, seek medical attention immediately.

• Common symptoms of Zoloft overdose include:
  Agitation, dizziness, nausea, rapid heartbeat, sleepiness, tremor, vomiting

Other possible symptoms include coma, stupor, fainting, convulsions, delirium, hallucinations, mania, high or low blood pressure, and slow, rapid, or irregular heartbeat