ep-roe-SAR-tan

Commonly used brand name(s):

In the U.S.

• Teveten

Available Dosage Forms:

• Tablet

Therapeutic Class: Cardiovascular Agent

Pharmacologic Class: Angiotensin II Receptor Antagonist

Uses For eprosartan

Eprosartan belongs to the class of medicines called angiotensin II inhibitors. It is used to treat high blood pressure (hypertension).

High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Eprosartan works by blocking the action of a substance in the body that causes blood vessels to tighten. As a result, eprosartan relaxes blood vessels. This lowers blood pressure.

eprosartan is available only with your doctor’s prescription.

Before Using eprosartan

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For eprosartan, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to eprosartan or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on eprosartan have been done only in adult patients, and there is no specific information comparing use of eprosartan in children with use in other age groups.

Geriatric

eprosartan has been tested in patients 65 years of age or older and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

	Pregnancy Category	Explanation
1st Trimester	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.
2nd Trimester	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.
3rd Trimester	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using eprosartan with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Aceclofenac
• Acemetacin
• Alclofenac
• Apazone
• Benoxaprofen
• Bromfenac
• Bufexamac
• Carprofen
• Celecoxib
• Clometacin
• Clonixin
• Dexketoprofen
• Diclofenac
• Diflunisal
• Dipyrone
• Droxicam
• Etodolac
• Etofenamate
• Felbinac
• Fenbufen
• Fenoprofen
• Fentiazac
• Floctafenine
• Flufenamic Acid
• Flurbiprofen
• Ibuprofen
• Indomethacin
• Indoprofen
• Isoxicam
• Ketoprofen
• Ketorolac
• Lornoxicam
• Meclofenamate
• Mefenamic Acid
• Meloxicam
• Nabumetone
• Naproxen
• Niflumic Acid
• Nimesulide
• Oxaprozin
• Oxyphenbutazone
• Phenylbutazone
• Pirazolac
• Piroxicam
• Pirprofen
• Propyphenazone
• Proquazone
• Rofecoxib
• Sulindac
• Suprofen
• Tenidap
• Tenoxicam
• Tiaprofenic Acid
• Tolmetin
• Valdecoxib
• Zomepirac

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of eprosartan. Make sure you tell your doctor if you have any other medical problems, especially:

• Congestive heart failure (severe)—Lowering of blood pressure by eprosartan may make this condition worse

• Dehydration or salt depletion—Blood pressure–lowering effects of eprosartan may be increased

• Kidney disease—Effects of eprosartan may make this condition worse

Proper Use of eprosartan

Take eprosartan only as directed by your doctor. Do not take more of it and do not take it more often than your doctor ordered. eprosartan also works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at the same time each day.

Dosing

The dose of eprosartan will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of eprosartan. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  • For high blood pressure:
    • Adults— 400 to 800 milligrams (mg) a day. The dose may be taken once a day or divided into two doses.
    • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of eprosartan, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using eprosartan

It is important that your doctor check your progress at regular visits to make sure that eprosartan is working properly and to check for unwanted effects.

Check with your doctor immediately if you think that you may be pregnant. Eprosartan may cause birth defects or other problems in the baby if taken during pregnancy.

Do not take other medicines unless they have been discussed with your doctor. This especially includes over-the-counter (nonprescription) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may increase your blood pressure.

Dizziness or light-headedness may occur, especially if you have been taking a diuretic (water pill). Make sure you know how you react to eprosartan before you drive, use machines, or do anything else that could be dangerous if you experience these effects.

Check with your doctor right away if you become sick while taking eprosartan, especially with severe or continuing nausea and vomiting or diarrhea. These conditions may cause you to lose too much water and lead to low blood pressure.

Dizziness, light-headedness, or fainting also may occur if you exercise or if the weather is hot. Heavy sweating can cause loss of too much water and result in low blood pressure. Use extra care during exercise or hot weather.

eprosartan Side Effects

Side Effects of eprosartan

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common

• Burning or painful urination or changes in urinary frequency
• cough, fever, or sore throat

Rare

• Dizziness, light-headedness, or fainting
• swollen face, lips, limbs, or tongue

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

• Abdominal pain
• joint pain
• unusual tiredness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Brand names: Teveten

Why is Eprosartan mesylate prescribed?

Teveten is used to treat high blood pressure. It is a member of the family of drugs called angiotensin II receptor blockers. The hormone angiotensin II makes the blood vessels constrict, causing blood pressure to rise. Teveten works by blocking the receptors that respond to angiotensin II. The drug may be prescribed alone or in combination with other medications that help lower blood pressure, such as water pills (diuretics) or calcium channel blockers.

Most important fact about Eprosartan mesylate

You must take Teveten regularly for it to be effective. Since blood pressure declines gradually, it may be several weeks before you get the full benefit of Teveten, and you must continue taking it even if you are feeling well. Teveten does not cure high blood pressure; it merely keeps it under control.

How should you take Eprosartan mesylate?

Teveten can be taken with or without food. Try to establish a regular routine by taking it at the same time each day, for example in the morning with breakfast. This reduces the chances that you’ll forget a dose.

• If you miss a dose…
  Take it as soon as possible. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule.

• Storage instructions…
  Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform you doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Teveten.

• Side effects may include:
  Cold, cough, runny nose, sore throat

Why should Eprosartan mesylate not be prescribed?

Do not take Teveten if you are pregnant, or if you have ever had an allergic reaction to it.

Special warnings about Eprosartan mesylate

When Teveten is combined with diuretics, it can cause excessively low blood pressure, especially when you first start taking it. If you develop warning signs such as light-headedness or faintness, call your doctor right away. You may need to have your dosage adjusted or discontinue the medication.

If you have kidney disease, Teveten should be used with caution. Be sure your doctor knows your medical history before you begin Eprosartan mesylate so you can be carefully monitored.

Possible food and drug interactions when taking Eprosartan mesylate

No interactions have been reported.

Special information if you are pregnant or breastfeeding

Drugs such as Teveten can cause injury or even death to an unborn child when used in the second or third trimester of pregnancy. Stop taking Teveten as soon as you know you are pregnant, and be sure to tell your doctor if you are pregnant or plan to become pregnant. Teveten may appear in breast milk and could affect the nursing infant. If Eprosartan mesylate is essential to your health, your doctor may advise you to stop breastfeeding while you are taking Teveten.

Recommended dosage for Eprosartan mesylate

ADULTS

The usual starting dose of Teveten is 600 milligrams taken once daily. Teveten may also be taken once or twice daily with total doses ranging from 400 to 800 milligrams. If your blood pressure does not go down as expected, your doctor may combine your dose with a diuretic or calcium channel blocker.

CHILDREN

The safety and effectiveness of Teveten have not been established in children.

Overdosage

Although there is limited information available on Teveten overdosage, remember that any medication taken in excess can have serious consequences. Extremely low blood pressure and abnormally slow or rapid heartbeat are possible signs of an overdose with this class of drugs. If you suspect an overdose, seek emergency medical treatment immediately.

Brand names: Teveten HCT

Why is Eprosartan mesylate and Hydrochlorothiazide prescribed?

Teveten HCT is a combination medication used in the treatment of high blood pressure. One component, eprosartan, belongs to a class of blood pressure medications that work by preventing the hormone angiotensin II from constricting the blood vessels, thus allowing blood to flow more freely and keeping blood pressure down. The other component, hydrochlorothiazide, is a diuretic that increases the output of urine, removing excess fluid from the body and thus lowering blood pressure.

Most important fact about Eprosartan mesylate and Hydrochlorothiazide

You must take Teveten HCT regularly for it to be effective. Since blood pressure declines gradually, it may be several weeks before you get the full benefit of Eprosartan mesylate and Hydrochlorothiazide, and you must continue to take it even if you are feeling well. Teveten HCT does not cure high blood pressure; it merely keeps it under control.

How should you take Eprosartan mesylate and Hydrochlorothiazide?

Take Teveten HCT regularly, once a day every day. Schedule it for the same time each day so that it’s easier to remember.

• If you miss a dose…
  Take the forgotten dose as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular schedule. Do not take two doses at once.

• Storage instructions…
  Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe to continue using Teveten HCT.

• Side effects may include:
  Back pain, dizziness, fatigue, headache

Many other rare side effects have been reported by people taking the individual components of Teveten HCT. Be sure to tell your doctor about any new or unusual symptoms you suffer.

Why should Eprosartan mesylate and Hydrochlorothiazide not be prescribed?

If you have ever had an allergic reaction to eprosartan, hydrochlorothiazide, or sulfa drugs, you should not take Eprosartan mesylate and Hydrochlorothiazide. Also avoid Teveten HCT if you are unable to urinate.

Special warnings about Eprosartan mesylate and Hydrochlorothiazide

Teveten HCT can cause an excessive drop in blood pressure, especially when you first begin taking it. If you feel light-headed or faint, let the doctor know about it. If you actually pass out, stop taking Teveten HCT and see your doctor immediately. The problem is more likely if you suffer from a lack of fluid, due either to inadequate intake or to excessive sweating, diarrhea, or vomiting.

Excessive fluid loss can also lead to a chemical imbalance in the body. Warning signs include dry mouth, thirst, diminished urination, weakness, lack of energy, drowsiness, restlessness, confusion, seizures, muscle pain, muscle fatigue, nausea, vomiting, and rapid heartbeat. Alert your doctor if you develop any of these symptoms.

If you have liver or kidney disease, diabetes, gout, or lupus erythematosus, Teveten HCT should be used with caution. This drug may bring out hidden diabetes. If you are already taking insulin or oral diabetes drugs, your dosage may have to be adjusted. If you have asthma or a history of allergies, you may be at greater risk of an allergic reaction to Eprosartan mesylate and Hydrochlorothiazide.

This drug is not approved for children.

Possible food and drug interactions when taking Eprosartan mesylate and Hydrochlorothiazide

Unless your doctor approves, avoid potassium supplements and potassium-containing salt substitutes while taking Teveten HCT.

If Teveten HCT is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Teveten HCT with the following:

Alcohol
Barbiturates such as phenobarbital and Seconal
Cholestyramine (Questran)
Colestipol (Colestid)
Diuretics that leave potassium in the body, including amiloride, spironolactone, and triamterene
Insulin
Lithium (Eskalith, Lithobid)
Narcotic painkillers such as Demerol, OxyContin, and Percodan
Nonsteroidal anti-inflammatory drugs such as Aleve, Anaprox, and Motrin
Other blood pressure medications such as Procardia XL and Tenormin
Oral diabetes drugs such as Diabinese, DiaBeta, and Glucotrol
Steroid medications such as prednisone

Special information if you are pregnant or breastfeeding

When used in the second or third trimester of pregnancy, Teveten HCT can cause injury or even death to the unborn child. Alert your doctor as soon as you learn you are pregnant. Teveten HCT should be discontinued as soon as possible.

This drug is not recommended if you plan to breastfeed.

Recommended dosage for Eprosartan mesylate and Hydrochlorothiazide

ADULTS

Teveten HCT comes in two strengths: 600/12.5 and 600/25 (600 milligrams of eprosartan and either 12.5 milligrams or 25 milligrams of hydrochlorothiazide). The usual starting dose is one 600/12.5 tablet per day. If your blood pressure remains too high, the doctor may increase the dose to one 600/25 tablet per day.

Overdosage

Little is known about overdosage with Teveten HCT. The most likely symptoms would be those of chemical imbalance triggered when the hydrochlorothiazide in the product flushes too much water from the system. These symptoms include thirst, diminished urination, weakness, drowsiness, restlessness, confusion, seizures, muscle pain, nausea, vomiting, and rapid heartbeat. If you suspect an overdose, seek medical attention immediately.

Eprosartan/

Hydrochlorothiazide

Generic Name: Eprosartan/Hydrochlorothiazide (EP-roe-SAR-tan/HYE-droe-KLOR-oh-THYE-a-zide)
Brand Name: Teveten HCT

Eprosartan/Hydrochlorothiazide is used for:

Treating high blood pressure. It may also be used for other conditions as determined by your doctor.

Eprosartan/Hydrochlorothiazide is a combination angiotensin II receptor blocker and diuretic. The angiotensin II receptor blocker works by relaxing the blood vessels. Exactly how the diuretic works to decrease blood pressure is unknown, but it helps the kidneys to eliminate fluid and sodium from the body.

Do NOT use Eprosartan/Hydrochlorothiazide if:

• you are allergic to any ingredient in Eprosartan/Hydrochlorothiazide or to any other sulfonamide medicine (eg, sulfamethoxazole)
• you are pregnant
• you have severe kidney problems or are unable to urinate
• you are taking dofetilide or ketanserin

Contact your doctor or health care provider right away if any of these apply to you.

Before using Eprosartan/Hydrochlorothiazide:

Some medical conditions may interact with Eprosartan/Hydrochlorothiazide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breastfeeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have ever had a severe allergic reaction (eg, swelling of the hands, face, lips, eyes, throat, or tongue; trouble swallowing or breathing; hoarseness) after taking any other angiotensin II receptor blocker or an angiotensin-converting enzyme (ACE) inhibitor (eg, captopril)
• if you have low blood sodium, chloride, potassium, or magnesium levels; low blood volume; or high blood calcium levels; or you are dehydrated
• if you have asthma; diabetes; gout; heart problems (eg, congestive heart failure); liver, gall bladder, or kidney problems; high blood cholesterol or lipid levels; or systemic lupus erythematosus
• if you have recently had nerve surgery

Some MEDICINES MAY INTERACT with Eprosartan/Hydrochlorothiazide. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Dofetilide or ketanserin because the risk of irregular heartbeat may be increased
• Adrenocorticotropic hormone (ACTH), barbiturates (eg, phenobarbital), corticosteroids (eg, prednisone), diuretics (eg, furosemide), narcotic pain medicines (eg, morphine), or other medicines for high blood pressure because they may increase the risk of Eprosartan/Hydrochlorothiazide’s side effects
• Cholestyramine, colestipol, or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because they may decrease Eprosartan/Hydrochlorothiazide’s effectiveness
• Diazoxide, digoxin, lithium, nondepolarizing muscle relaxants (eg, tubocurarine), potassium, or potassium-sparing diuretics (eg, spironolactone) because risk of their side effects and toxic effects may be increased by Eprosartan/Hydrochlorothiazide
• Diabetes medicine (eg, glipizide, metformin), insulin, or pressor amines (eg, norepinephrine) because their effectiveness may be decreased by Eprosartan/Hydrochlorothiazide

This may not be a complete list of all interactions that may occur. Ask your health care provider if Eprosartan/Hydrochlorothiazide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Eprosartan/Hydrochlorothiazide:

Use Eprosartan/Hydrochlorothiazide as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.

• Eprosartan/Hydrochlorothiazide may be taken with or without food.
• Drinking extra fluids while you are taking Eprosartan/Hydrochlorothiazide is recommended. Check with your doctor for instructions.
• Eprosartan/Hydrochlorothiazide may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
• If you take cholestyramine or colestipol, ask your doctor or pharmacist how to take it with Eprosartan/Hydrochlorothiazide.
• Continue to take Eprosartan/Hydrochlorothiazide even if you feel well. Do not miss any doses.
• If you miss a dose of Eprosartan/Hydrochlorothiazide, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Eprosartan/Hydrochlorothiazide.

Important safety information:

• Eprosartan/Hydrochlorothiazide may cause drowsiness, dizziness, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Eprosartan/Hydrochlorothiazide with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Eprosartan/Hydrochlorothiazide may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
• Report any lightheadedness or fainting to your doctor immediately. Your risk of lightheadedness or fainting may be increased if you experience diarrhea, vomiting, or excessive sweating, if you do not drink enough fluids, or if you are on a low-salt diet.
• Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel normal.” Tell your doctor if you develop any new symptoms.
• Eprosartan/Hydrochlorothiazide may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Eprosartan/Hydrochlorothiazide. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.Tell your doctor or dentist that you take Eprosartan/Hydrochlorothiazide before you receive any medical or dental care, emergency care, or surgery.
• If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.
• Your doctor may have also prescribed a potassium supplement for you. If so, follow the dosing carefully. Do not start taking additional potassium on your own or change your diet to include more potassium without first checking with your doctor.
• Check with your doctor before you use a salt substitute or a product that has potassium in it.
• Diabetes patients – Eprosartan/Hydrochlorothiazide may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
• Eprosartan/Hydrochlorothiazide may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
• Eprosartan/Hydrochlorothiazide may interfere with certain lab tests, including parathyroid function tests. Be sure your doctor and lab personnel know you are taking Eprosartan/Hydrochlorothiazide.
• Lab tests, including kidney function, blood pressure, and blood electrolytes, may be performed while you use Eprosartan/Hydrochlorothiazide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Eprosartan/Hydrochlorothiazide with caution in the ELDERLY; they may be more sensitive to its effects.
• Eprosartan/Hydrochlorothiazide should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: Eprosartan/Hydrochlorothiazide may cause birth defects or fetal death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. Eprosartan/Hydrochlorothiazide is found in breast milk. Do not breast-feed while taking Eprosartan/Hydrochlorothiazide.

Possible side effects of Eprosartan/Hydrochlorothiazide:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; dizziness; lightheadedness, especially when sitting up or standing.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; decrease in sexual ability; depression; drowsiness; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; decreased urination; hoarseness; muscle pain, tenderness, or cramps; red, swollen, blistered, or peeling skin; restlessness; seizures; severe or persistent dry mouth; shortness of breath; swelling of the arms or legs; unusual bruising or bleeding; unusual thirst, tiredness, or weakness; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include confusion; fainting; fast, slow, or irregular heartbeat; severe or unusual dizziness.

Proper storage of Eprosartan/Hydrochlorothiazide:

Store Eprosartan/Hydrochlorothiazide between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Eprosartan/Hydrochlorothiazide out of the reach of children and away from pets.

General information:

• If you have any questions about Eprosartan/Hydrochlorothiazide, please talk with your doctor, pharmacist, or other health care provider.
• Eprosartan/Hydrochlorothiazide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Eprosartan/Hydrochlorothiazide. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: magnesium sulfate (mag NEE see um SUL fate)
Brand Names: Epsom Salt

What is Epsom Salt (magnesium sulfate)?

Magnesium is a naturally occurring mineral. Magnesium is important for many systems in the body especially the muscles and nerves. Magnesium sulfate also increases water in the intestines, which may induce defecation.

Magnesium hydroxide is used as a laxative to relieve occasional constipation (irregularity).

Magnesium sulfate may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Epsom Salt (magnesium sulfate)?

Before taking magnesium sulfate, tell your doctor if you have any other medical conditions, allergies, or if you take other medicines or other herbal/health supplements. Magnesium sulfate may not be recommended in some situations.

Do not use magnesium sulfate as a laxative if you have stomach (abdominal) pain, nausea, or vomiting, unless directed by a doctor. If you notice a sudden change in bowel habits that persists over a period of 2 weeks, consult your healthcare provider before using a laxative. Magnesium sulfate should not be used for longer than one week, unless otherwise directed by your healthcare provider. Rectal bleeding or failure to have a bowel movement after use of a laxative may indicate a more serious condition; stop using magnesium sulfate and contact your healthcare provider.

What should I discuss with my healthcare provider before taking Epsom Salt (magnesium sulfate)?

Do not take magnesium sulfate without first talking to your doctor if you have kidney disease. Do not use magnesium sulfate as a laxative if you have stomach (abdominal) pain, nausea, or vomiting, unless directed by a doctor. If you notice a sudden change in bowel habits that persists over a period of 2 weeks, consult your healthcare provider before using a laxative. Magnesium sulfate should not be used for longer than one week, unless otherwise directed by your healthcare provider. Rectal bleeding or failure to have a bowel movement after use of a laxative may indicate a more serious condition; stop using magnesium sulfate and contact your healthcare provider.

Before taking magnesium sulfate, tell your doctor if you have any other medical conditions, allergies, or if you take other medicines or other herbal/health supplements. Magnesium sulfate may not be recommended in some situations.

It is not known whether magnesium sulfate will be harmful to an unborn baby. Do not take magnesium sulfate without first talking to your doctor if you are pregnant or planning a pregnancy. It is not known whether magnesium sulfate will be harmful to an nursing baby. Do not take magnesium sulfate without first talking to your doctor if you are breast-feeding a baby.

How should I take Epsom Salt (magnesium sulfate)?

Take magnesium sulfate exactly as directed by your doctor or as directed on the package. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Magnesium sulfate may be used orally or as a rectal enema. Follow your doctor’s instructions or the directions on the package.

Do not use magnesium sulfate as a laxative if you have stomach (abdominal) pain, nausea, or vomiting, unless directed by a doctor. If you notice a sudden change in bowel habits that persists over a period of 2 weeks, consult your healthcare provider before using a laxative. Magnesium sulfate should not be used for longer than one week, unless otherwise directed by your healthcare provider. Rectal bleeding or failure to have a bowel movement after use of a laxative may indicate a more serious condition; stop using magnesium sulfate and contact your healthcare provider. Do not take more magnesium sulfate than is directed. Store magnesium sulfate at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of an magnesium sulfate overdose include nausea, vomiting, flushing, low blood pressure, a slow heartbeat, drowsiness, coma, and death.

What should I avoid while taking Epsom Salt (magnesium sulfate)?

There are no restrictions on food, beverages, or activity while taking magnesium sulfate unless otherwise directed by your doctor.

Epsom Salt (magnesium sulfate) side effects

Stop taking magnesium sulfate and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Other, less serious side effects may be more likely to occur. Continue to take magnesium sulfate and talk to your doctor if you experience diarrhea or upset stomach.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Epsom Salt (magnesium sulfate)?

Before taking magnesium sulfate, talk to your doctor if you are taking

• a tetracycline antibiotic such as tetracycline (Sumycin, Achromycin V, and others), demeclocycline (Declomycin), doxycycline (Vibramycin, Monodox, Doxy, and others), minocycline (Minocin, Dynacin, and others), or oxytetracycline (Terramycin, and others);

• a fluoroquinolone antibiotic such as ciprofloxacin (Cipro), ofloxacin (Floxin), enoxacin (Penetrex), norfloxacin (Noroxin), sparfloxacin (Zagam), levofloxacin (Levaquin), lomefloxacin (Maxaquin), grepafloxacin (Raxar), and others;

• penicillamine (Cuprimine);

• digoxin (Lanoxin, Lanoxicaps); or

• nitrofurantoin (Macrodantin, Furadantin, others).

You not be able to take magnesium sulfate, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here can also interact with magnesium sulfate. Talk to your doctor and pharmacist before taking any over-the-counter or prescription medicines, including vitamins, minerals, and herbal products.

Where can I get more information?

• Your pharmacist has additional information about magnesium sulfate written for health professionals that you may read.

• Consultation with a licensed health care professional is advisable before using any herbal/health supplement. Remember, keep this and all other prescription drug products, over-the-counter drug products, and herbal/health supplements out of the reach of children.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 1.05. Revision Date: 4/12/2009 4:37:29 PM.

What is e.p.t. Pregnancy Test?

Early Home Pregnancy Test Kit.
99% Accurate at detecting the pregnancy hormone.
However, some pregnant women may not have detectable amounts of pregnancy hormone in their urine on the first day of the missed period or may have miscalculated the first day of their period.

How do I use e.p.t. Pregnancy Test?

1. Remove the e.p.t. Pregnancy test stick from its foil packet just prior to use.
2. Remove the purple cap to expose the absorbent tip.
3. Hold the test stick by its thumb grip. Point the absorbent tip downward.
4. Place the absorbent tip in the urine flow for just 5 seconds, or dip the absorbent tip into a clean container of urine for just 20 seconds. Keep the absorbent tip pointing downwards.
5. Place the test stick on a flat surface with the windows facing up for at least 2 minutes. (If you wish, replace the cap to cover the absorbent tip.) You may notice a light blue color moving across the windows.

Important: To avoid affecting the test result, wait at least 2 minutes before lifting the stick.

How to read the results of an Early Home Pregnancy Test:

Wait 2 minutes to read the result. A line will appear in the square window as a control to show that you have done the test correctly. Be sure to read the result before 10 minutes have passed.

Pregnant
A (+) sign in the round window indicates that you are pregnant. The lines that make up the plus sign can be different shades of blue. Please see your doctor to discuss your pregnancy and the next steps. Early prenatal care is important to ensure the health of you and your baby.

Not Pregnant
A (-) sign in the round window indicates that you are not pregnant. If your period does not start within a week, repeat the test. If you still get a negative result and your period has not started, please see your doctor.

Important:
If no line appears in the square window, the test result is invalid. Do not read the result. Call the toll-free number 1-800-378-1783 (1-800-EPT-1STEP).

Questions and Answers about e.p.t. Pregnancy Test

When can I use e.p.t Pregnancy Test?
e.p.t Pregnancy Test can be used as soon as you miss your period and any day thereafter. If you prefer to test early, e.p.t Pregnancy Test can be used as soon as four days before you expect your period to start. If you test early and get a “not pregnant” result, there is still a chance that you may be pregnant.

Do I have to use an early morning urine sample?
If you are testing before you expect your period to start, it is recommended that you test with your first urine of the day. Otherwise you can test at any time of the day. Avoid excess fluid intake before testing.

How does e.p.t Pregnancy Test work?
e.p.t Pregnancy Test detects hCG (human Chorionic Gonadotropin), a hormone present in urine only during pregnancy. e.p.t Pregnancy Test can detect tiny amounts of this hormone in your urine.

What if the lines in the round and square windows are different shades of blue?
As long as a (+) symbol appears in the round window and a single line appears in the square window, the result is positive. It does not matter if one line is fainter or darker than the other.

I have used the e.p.t Home Pregnancy Test but no blue lines have appeared. What should I do?
If there is no blue line in the square window within 10 minutes, the test is not working properly. This may be because too much or too little urine has been used. You should test again using a second test, carefully following the instructions.

What if I think the e.p.t. Pregnancy Test result is incorrect?
Following the instructions carefully should yield an accurate reading. If you think the result is incorrect, or if it is difficult to detect a (+) or (-)in the round window, repeat the test after one week with a new e.p.t Pregnancy Test stick.

Are there any factors that can affect the e.p.t. Pregnancy Test result?
Yes. Certain drugs which contain hCG or are used in combination with hCG (such as Humegon, Pregnyl, Profasi, Pergonal, APL), In addition, ovarian cysts, ectopic pregnancy and rare medical conditions can affect the result. If you repeat the test and continue to get an unexpected result, contact your doctor.

Using e.p.t Pregnancy test within 9 weeks of giving birth or having a miscarriage may cause a false positive result. The test may detect hCG still in your system from a previous pregnancy. You should ask your doctor for help in interpreting the result of your e.p.t Pregnancy test if you have recently been pregnant.

Factors which should not affect the test result include alcohol, analgesics (pain killers), antibiotics, birth control pills or hormone therapies containing clomiphene citrate (Clomid or Serophen).

Additional Information

Store at room temperature 2°-30°C (36°-86°F).

For In-Vitro Diagnostic Use (Not for Internal Use)

Keep Out of Reach of Children