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E Pherol

30/06/10

Generic Name: vitamin E (VYE ta min E)
Brand Names: Amino-Opti-E, Aqua-E, Aquasol E, Aquavite-E, Aqueous Vitamin E, E Pherol, E-400 Clear, Vita-Plus E Natural

What is E Pherol (vitamin E)?

Vitamin E is an antioxidant that occurs naturally in foods such as nuts, seeds, and leafy green vegetables. Vitamin E is important for many processes in the body.

Vitamin E is used to prevent and to treat a deficiency vitamin E. People with certain diseases may need extra vitamin E.

Vitamin E may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about E Pherol (vitamin E)?

Before using vitamin E, tell your healthcare provider if you have liver disease, diabetes, active bleeding, a vitamin K deficiency, retinitis pigmentosa, chronic diarrhea, if you are being treated for cancer, or if you have a history of heart attack, stroke, blood clot, or recent surgery.

Do not use this product without a doctor’s advice your doctor if you are pregnant or breast-feeding. Your dose needs may be different during pregnancy or while you are nursing a baby. Do not take vitamin E without a doctor’s advice if you are using any type of medication to treat or prevent blood clots.

There are many other drugs that can interact with or be made less effective by vitamin E. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Stop taking vitamin E and call your doctor at once if you have any unusual bleeding or bruising, or if you feel like you might pass out.

What should I discuss with my healthcare provider before taking E Pherol (vitamin E)?

Before using vitamin E, talk to your doctor, pharmacist, herbalist, or other healthcare provider. You may not be able to take vitamin E if you have certain medical conditions.

You may need a dose adjustment or special tests if you have:

liver disease;
diabetes;
active or uncontrolled bleeding;
a vitamin K deficiency;
retinitis pigmentosa;
short bowel syndrome;
chronic diarrhea;
a history of heart attack, stroke, or blood clot;
if you have recently had surgery; or
if you are receiving cancer treatment (chemotherapy or radiation).

It is not known whether vitamin E is harmful to an unborn baby. Your dose needs may be different during pregnancy. Do not use this product without a doctor’s advice if you are pregnant or plan to become pregnant while using vitamin E. It is not known whether vitamin E passes into breast milk or if it could harm a nursing baby. Your dose needs may be different while you are nursing. Do not use this product without a doctor’s advice if you are breast-feeding a baby.

How should I take E Pherol (vitamin E)?

Take exactly as directed on the label, or as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended.

Take vitamin E with a full glass of water.

The chewable tablet must be chewed completely before you swallow it.

Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

You may take vitamin E with or without food. You do not need to eat extra fat to help your body absorb vitamin E.

The recommended dietary allowance of vitamin E increases with age. Follow your healthcare provider’s instructions. You may also consult the National Academy of Sciences “Dietary Reference Intake” or the U.S. Department of Agriculture’s “Dietary Reference Intake” (formerly “Recommended Daily Allowances” or RDA) listings for more information.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include unusual bleeding or bruising.

What should I avoid while taking E Pherol (vitamin E)?

Avoid taking other vitamins, mineral supplements, or nutritional products without your doctor’s advice.

E Pherol (vitamin E) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop taking vitamin E and call your doctor at once if you have a serious side effect such as:

feeling like you might pass out;
easy bruising; or
unusual bleeding (nose, mouth, vagina, or rectum).

Less serious side effects may include:

nausea, diarrhea, stomach cramps;
tired feeling;
headache;
blurred vision; or
mild rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect E Pherol (vitamin E)?

Do not take vitamin E without a doctor’s advice if you are using any type of medication to treat or prevent blood clots, such as:

heparin, warfarin (Coumadin);
alteplase (Activase), tenecteplase (TNKase), urokinase (Abbokinase);
argatroban (Acova), bivalirudin (Angiomax), lepirudin (Refludan);
dalteparin (Fragmin), enoxaparin (Lovenox), fondaparinux (Arixtra); or
abciximab (ReoPro), anagrelide (Agrylin), cilostazol (Pletal), clopidogrel (Plavix), dipyridamole (Persantine, Aggrenox), eptifibatide (Integrelin), prasugrel (Effient), ticlopidine (Ticlid), tirofiban (Aggrastat).

The following drugs can interact with or be made less effective by vitamin E. Tell your doctor if you are using any of these:

cyclosporine (Gengraf, Neoral, Sandimmune);
diazepam (Valium) and other sedatives;
fluoxetine (Prozac) and other antidepressants;
mineral oil, orlistat (alli, Xenical);
an antibiotic such as clarithromycin (Biaxin), doxycycline (Doryx, Vibramycin), trimethoprim (Bactrim, Septra, SMX-TMP), and others;
antifungal medication such as itraconazole (Sporanox) or ketoconazole (Extina, Ketozole, Nizoral, Xolegal);
cholesterol-lowering medicines such as atorvastatin (Lipitor), cholestyramine (Questran), colestipol (Colestid), simvastatin (Zocor, Simcor), lovastatin (Mevacor, Advicor), pravastatin (Pravachol), niacin (Niaspan, Slo-Niacin), and others;
heart or blood pressure medications such as diltiazem (Cartia, Cardizem), losartan (Cozaar), propranolol (Inderal), verapamil (Calan, Covera, Isoptin), and others;
HIV medicines such as fosamprenavir (Lexiva), ritonavir (Norvir, Kaletra), and others;
narcotic medication such as fentanyl (Actiq, Duragesic, Fentora);
seizure medication such as carbamazepine (Carbatrol, Tegretol), phenobarbital (Solfoton), phenytoin (Dilantin), and others; or
stomach acid reducers such as cimetidine (Tagamet), omeprazole (Prilosec), lansoprazole (Prevacid), and others.

This list is not complete and there are many other drugs that can interact with vitamin E. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about vitamin E.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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E-400

30/06/10

Generic Name: vitamin e (Oral route)

VYE-ta-min E

Commonly used brand name(s):

In the U.S.

Alpha-E
Aqua Gem-E
Aquasol E
D-Alpha Gems
E-400
E-600
E-Gems
Formula E 400
Gamma E-Gems
Gamma E Plus
Key-E
Natural Vitamin Blend E-400IU
Nutr-E-Sol

Available Dosage Forms:

Liquid
Solution
Tablet
Capsule, Liquid Filled
Tablet, Chewable
Powder for Solution
Capsule

Therapeutic Class: Nutritive Agent

Pharmacologic Class: Vitamin E (class)

Uses For E-400

Vitamins are compounds that you must have for growth and health. They are needed in only small amounts and are available in the foods that you eat. Vitamin E prevents a chemical reaction called oxidation, which can sometimes result in harmful effects in your body. It is also important for the proper function of nerves and muscles.

Some conditions may increase your need for vitamin E. These include:

Intestine disease
Liver disease
Pancreas disease
Surgical removal of stomach

Increased need for vitamin E should be determined by your health care professional.

Infants who are receiving a formula that is not fortified with vitamin E may be likely to have a vitamin E deficiency. Also, diets high in polyunsaturated fatty acids may increase your need for vitamin E.

Claims that vitamin E is effective for treatment of cancer and for prevention or treatment of acne, aging, loss of hair, bee stings, liver spots on the hands, bursitis, diaper rash, frostbite, stomach ulcer, heart attacks, labor pains, certain blood diseases, miscarriage, muscular dystrophy, poor posture, sexual impotence, sterility, infertility, menopause, sunburn, and lung damage from air pollution have not been proven. Although vitamin E is being used to prevent certain types of cancer, there is not enough information to show that this is effective.

Lack of vitamin E is extremely rare, except in people who have a disease in which it is not absorbed into the body.

Vitamin E is available without a prescription.

Importance of Diet

For good health, it is important that you eat a balanced and varied diet. Follow carefully any diet program your health care professional may recommend. For your specific dietary vitamin and/or mineral needs, ask your health care professional for a list of appropriate foods. If you think that you are not getting enough vitamins and/or minerals in your diet, you may choose to take a dietary supplement.

Vitamin E is found in various foods including vegetable oils (corn, cottonseed, soybean, safflower), wheat germ, whole-grain cereals, and green leafy vegetables. Cooking and storage may destroy some of the vitamin E in foods.

Vitamin supplements alone will not take the place of a good diet and will not provide energy. Your body also needs other substances found in food such as protein, minerals, carbohydrates, and fat. Vitamins themselves often cannot work without the presence of other foods. For example, small amounts of fat are needed so that vitamin E can be absorbed into the body.

The daily amount of vitamin E needed is defined in several different ways.

For U.S.—
Recommended Dietary Allowances (RDAs) are the amount of vitamins and minerals needed to provide for adequate nutrition in most healthy persons. RDAs for a given nutrient may vary depending on a person’s age, sex, and physical condition (e.g., pregnancy).
Daily Values (DVs) are used on food and dietary supplement labels to indicate the percent of the recommended daily amount of each nutrient that a serving provides. DV replaces the previous designation of United States Recommended Daily Allowances (USRDAs).

For Canada—
Recommended Nutrient Intakes (RNIs) are used to determine the amounts of vitamins, minerals, and protein needed to provide adequate nutrition and lessen the risk of chronic disease.

Vitamin E is available in various forms, including d- or dl-alpha tocopheryl acetate, d- or dl-alpha tocopherol, and d- or dl-alpha tocopheryl acid succinate. In the past, the RDA for vitamin E have been expressed in Units. This term has been replaced by alpha tocopherol equivalents (alpha-TE) or milligrams (mg) of d-alpha tocopherol. One Unit is equivalent to 1 mg of dl-alpha tocopherol acetate or 0.6 mg d-alpha tocopherol. Most products available in stores continue to be labeled in Units.

Normal daily recommended intakes in milligrams (mg) of alpha tocopherol equivalents (mg alpha-TE) and Units for vitamin E are generally defined as follows:

Persons	U.S.	Canada
mg alpha-TE	Units	mg alpha-TE	Units
Infants and children Birth to 3 years of age	3–6	5–10	3–4	5–6.7
4 to 6 years of age	7	11.7	5	8.3
7 to 10 years of age	7	11.7	6–8	10–13
Adolescent and adult males	10	16.7	6–10	10–16.7
Adolescent and adult females	8	13	5–7	8.3–11.7
Pregnant females	10	16.7	8–9	13–15
Breast-feeding females	11–12	18–20	9–10	15–16.7

Before Using E-400

If you are taking this dietary supplement without a prescription, carefully read and follow any precautions on the label. For this supplement, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Problems in children have not been reported with intake of normal daily recommended amounts. You should check with your health care professional if you are giving your baby an unfortified formula. In that case, the baby must get the vitamins needed some other way. Some studies have shown that premature infants may have low levels of vitamin E. Your health care professional may recommend a vitamin E supplement.

Geriatric

Problems in older adults have not been reported with intake of normal daily recommended amounts.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	A	Adequate studies in pregnant women have not shown an increased risk of fetal abnormalities.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using this dietary supplement with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Dicumarol

Using this dietary supplement with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of vitamin e

This section provides information on the proper use of a number of products that contain vitamin e. It may not be specific to E-400. Please read with care.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral solution dosage form:
- To prevent the following deficiencies in infants:
  - Infants receiving a formula high in polyunsaturated fatty acids—15 to 25 Units per day or 7 Units per 32 ounces of formula.
  - Infants with certain colon problems—15 to 25 Units per kilogram (kg) (6.8 to 11 Units per pound) of body weight per day. The water-soluble form of vitamin E must be used.
  - Infants of normal birthweight—5 Units per 32 ounces of formula.
For oral dosage forms (capsules, tablets, oral solution):
- To prevent deficiency for individuals (other than infants), the amount taken by mouth is based on normal daily recommended intakes:
  - For the U.S.
  - Adult and teenage males—10 milligrams (mg) of alpha tocopherol equivalents (mg alpha-TE) or 16.7 Units per day.
  - Adult and teenage females—8 mg alpha-TE or 13 Units per day.
  - Pregnant females—10 mg alpha-TE or 16.7 Units per day.
  - Breast-feeding females—11 to 12 mg alpha-TE or 18 to 20 Units per day.
  - Children 4 to 10 years of age—7 mg alpha-TE or 11.7 Units per day.
  - Children birth to 3 years of age—3 to 6 mg alpha-TE or 5 to 10 Units per day.
  - For Canada
  - Adult and teenage males—6 to 10 mg alpha-TE or 10 to 16.7 Units per day.
  - Adult and teenage females—5 to 7 mg alpha-TE or 8.3 to 11.7 Units per day.
  - Pregnant females—8 to 9 mg alpha-TE or 13 to 15 Units per day.
  - Breast-feeding females—9 to 10 mg alpha-TE or 15 to 16.7 Units per day.
  - Children 7 to 10 years of age—6 to 8 mg alpha-TE or 10 to 13 Units per day.
  - Children 4 to 6 years of age—5 mg alpha-TE or 8.3 Units per day.
  - Children birth to 3 years of age—3 to 4 mg alpha-TE or 5 to 6.7 Units per day.
- To treat deficiency:
  - Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on the severity of deficiency.

For individuals taking the oral liquid form of this dietary supplement:

This preparation should be taken by mouth even though it comes in a dropper bottle.
This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.

Missed Dose

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the dietary supplement in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

E-400 Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

With doses greater than 400 Units a day and long-term use

Blurred vision
diarrhea
dizziness
headache
nausea or stomach cramps
unusual tiredness or weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided “AS IS” and “as available” for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

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E-400 Clear

30/06/10

Generic Name: vitamin E (VYE ta min E)
Brand Names: Amino-Opti-E, Aqua-E, Aquasol E, Aquavite-E, Aqueous Vitamin E, E Pherol, E-400 Clear, Vita-Plus E Natural

What is E-400 Clear (vitamin E)?

Vitamin E is an antioxidant that occurs naturally in foods such as nuts, seeds, and leafy green vegetables. Vitamin E is important for many processes in the body.

Vitamin E is used to prevent and to treat a deficiency vitamin E. People with certain diseases may need extra vitamin E.

Vitamin E may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about E-400 Clear (vitamin E)?

Stop taking vitamin E and call your doctor at once if you have any unusual bleeding or bruising, or if you feel like you might pass out.

What should I discuss with my healthcare provider before taking E-400 Clear (vitamin E)?

Before using vitamin E, talk to your doctor, pharmacist, herbalist, or other healthcare provider. You may not be able to take vitamin E if you have certain medical conditions.

You may need a dose adjustment or special tests if you have:

liver disease;
diabetes;
active or uncontrolled bleeding;
a vitamin K deficiency;
retinitis pigmentosa;
short bowel syndrome;
chronic diarrhea;
a history of heart attack, stroke, or blood clot;
if you have recently had surgery; or
if you are receiving cancer treatment (chemotherapy or radiation).

How should I take E-400 Clear (vitamin E)?

Take exactly as directed on the label, or as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended.

Take vitamin E with a full glass of water.

The chewable tablet must be chewed completely before you swallow it.

Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

You may take vitamin E with or without food. You do not need to eat extra fat to help your body absorb vitamin E.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include unusual bleeding or bruising.

What should I avoid while taking E-400 Clear (vitamin E)?

Avoid taking other vitamins, mineral supplements, or nutritional products without your doctor’s advice.

E-400 Clear (vitamin E) side effects

feeling like you might pass out;
easy bruising; or
unusual bleeding (nose, mouth, vagina, or rectum).

Less serious side effects may include:

nausea, diarrhea, stomach cramps;
tired feeling;
headache;
blurred vision; or
mild rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect E-400 Clear (vitamin E)?

Do not take vitamin E without a doctor’s advice if you are using any type of medication to treat or prevent blood clots, such as:

heparin, warfarin (Coumadin);
alteplase (Activase), tenecteplase (TNKase), urokinase (Abbokinase);
argatroban (Acova), bivalirudin (Angiomax), lepirudin (Refludan);
dalteparin (Fragmin), enoxaparin (Lovenox), fondaparinux (Arixtra); or
abciximab (ReoPro), anagrelide (Agrylin), cilostazol (Pletal), clopidogrel (Plavix), dipyridamole (Persantine, Aggrenox), eptifibatide (Integrelin), prasugrel (Effient), ticlopidine (Ticlid), tirofiban (Aggrastat).

The following drugs can interact with or be made less effective by vitamin E. Tell your doctor if you are using any of these:

cyclosporine (Gengraf, Neoral, Sandimmune);
diazepam (Valium) and other sedatives;
fluoxetine (Prozac) and other antidepressants;
mineral oil, orlistat (alli, Xenical);
an antibiotic such as clarithromycin (Biaxin), doxycycline (Doryx, Vibramycin), trimethoprim (Bactrim, Septra, SMX-TMP), and others;
antifungal medication such as itraconazole (Sporanox) or ketoconazole (Extina, Ketozole, Nizoral, Xolegal);
cholesterol-lowering medicines such as atorvastatin (Lipitor), cholestyramine (Questran), colestipol (Colestid), simvastatin (Zocor, Simcor), lovastatin (Mevacor, Advicor), pravastatin (Pravachol), niacin (Niaspan, Slo-Niacin), and others;
heart or blood pressure medications such as diltiazem (Cartia, Cardizem), losartan (Cozaar), propranolol (Inderal), verapamil (Calan, Covera, Isoptin), and others;
HIV medicines such as fosamprenavir (Lexiva), ritonavir (Norvir, Kaletra), and others;
narcotic medication such as fentanyl (Actiq, Duragesic, Fentora);
seizure medication such as carbamazepine (Carbatrol, Tegretol), phenobarbital (Solfoton), phenytoin (Dilantin), and others; or
stomach acid reducers such as cimetidine (Tagamet), omeprazole (Prilosec), lansoprazole (Prevacid), and others.

Where can I get more information?

Your pharmacist can provide more information about vitamin E.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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E-600

30/06/10

Generic Name: vitamin e (Oral route)

VYE-ta-min E

Commonly used brand name(s):

In the U.S.

Alpha-E
Aqua Gem-E
Aquasol E
D-Alpha Gems
E-400
E-600
E-Gems
Formula E 400
Gamma E-Gems
Gamma E Plus
Key-E
Natural Vitamin Blend E-400IU
Nutr-E-Sol

Available Dosage Forms:

Liquid
Solution
Tablet
Capsule, Liquid Filled
Tablet, Chewable
Powder for Solution
Capsule

Therapeutic Class: Nutritive Agent

Pharmacologic Class: Vitamin E (class)

Uses For E-600

Some conditions may increase your need for vitamin E. These include:

Intestine disease
Liver disease
Pancreas disease
Surgical removal of stomach

Increased need for vitamin E should be determined by your health care professional.

Lack of vitamin E is extremely rare, except in people who have a disease in which it is not absorbed into the body.

Vitamin E is available without a prescription.

Importance of Diet

The daily amount of vitamin E needed is defined in several different ways.

For U.S.—
Recommended Dietary Allowances (RDAs) are the amount of vitamins and minerals needed to provide for adequate nutrition in most healthy persons. RDAs for a given nutrient may vary depending on a person’s age, sex, and physical condition (e.g., pregnancy).
Daily Values (DVs) are used on food and dietary supplement labels to indicate the percent of the recommended daily amount of each nutrient that a serving provides. DV replaces the previous designation of United States Recommended Daily Allowances (USRDAs).

For Canada—
Recommended Nutrient Intakes (RNIs) are used to determine the amounts of vitamins, minerals, and protein needed to provide adequate nutrition and lessen the risk of chronic disease.

Normal daily recommended intakes in milligrams (mg) of alpha tocopherol equivalents (mg alpha-TE) and Units for vitamin E are generally defined as follows:

Persons	U.S.	Canada
mg alpha-TE	Units	mg alpha-TE	Units
Infants and children Birth to 3 years of age	3–6	5–10	3–4	5–6.7
4 to 6 years of age	7	11.7	5	8.3
7 to 10 years of age	7	11.7	6–8	10–13
Adolescent and adult males	10	16.7	6–10	10–16.7
Adolescent and adult females	8	13	5–7	8.3–11.7
Pregnant females	10	16.7	8–9	13–15
Breast-feeding females	11–12	18–20	9–10	15–16.7

Before Using E-600

If you are taking this dietary supplement without a prescription, carefully read and follow any precautions on the label. For this supplement, the following should be considered:

Allergies

Pediatric

Geriatric

Problems in older adults have not been reported with intake of normal daily recommended amounts.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	A	Adequate studies in pregnant women have not shown an increased risk of fetal abnormalities.

Breast Feeding

Interactions with Medicines

Dicumarol

Warfarin

Interactions with Food/Tobacco/Alcohol

Proper Use of vitamin e

This section provides information on the proper use of a number of products that contain vitamin e. It may not be specific to E-600. Please read with care.

Dosing

For oral solution dosage form:
- To prevent the following deficiencies in infants:
  - Infants receiving a formula high in polyunsaturated fatty acids—15 to 25 Units per day or 7 Units per 32 ounces of formula.
  - Infants with certain colon problems—15 to 25 Units per kilogram (kg) (6.8 to 11 Units per pound) of body weight per day. The water-soluble form of vitamin E must be used.
  - Infants of normal birthweight—5 Units per 32 ounces of formula.
For oral dosage forms (capsules, tablets, oral solution):
- To prevent deficiency for individuals (other than infants), the amount taken by mouth is based on normal daily recommended intakes:
  - For the U.S.
  - Adult and teenage males—10 milligrams (mg) of alpha tocopherol equivalents (mg alpha-TE) or 16.7 Units per day.
  - Adult and teenage females—8 mg alpha-TE or 13 Units per day.
  - Pregnant females—10 mg alpha-TE or 16.7 Units per day.
  - Breast-feeding females—11 to 12 mg alpha-TE or 18 to 20 Units per day.
  - Children 4 to 10 years of age—7 mg alpha-TE or 11.7 Units per day.
  - Children birth to 3 years of age—3 to 6 mg alpha-TE or 5 to 10 Units per day.
  - For Canada
  - Adult and teenage males—6 to 10 mg alpha-TE or 10 to 16.7 Units per day.
  - Adult and teenage females—5 to 7 mg alpha-TE or 8.3 to 11.7 Units per day.
  - Pregnant females—8 to 9 mg alpha-TE or 13 to 15 Units per day.
  - Breast-feeding females—9 to 10 mg alpha-TE or 15 to 16.7 Units per day.
  - Children 7 to 10 years of age—6 to 8 mg alpha-TE or 10 to 13 Units per day.
  - Children 4 to 6 years of age—5 mg alpha-TE or 8.3 Units per day.
  - Children birth to 3 years of age—3 to 4 mg alpha-TE or 5 to 6.7 Units per day.
- To treat deficiency:
  - Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on the severity of deficiency.

For individuals taking the oral liquid form of this dietary supplement:

This preparation should be taken by mouth even though it comes in a dropper bottle.
This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.

Missed Dose

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the dietary supplement in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

E-600 Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

With doses greater than 400 Units a day and long-term use

Blurred vision
diarrhea
dizziness
headache
nausea or stomach cramps
unusual tiredness or weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Advanced,E

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E-Gems

30/06/10

Generic Name: vitamin e (Oral route)

VYE-ta-min E

Commonly used brand name(s):

In the U.S.

Alpha-E
Aqua Gem-E
Aquasol E
D-Alpha Gems
E-400
E-600
E-Gems
Formula E 400
Gamma E-Gems
Gamma E Plus
Key-E
Natural Vitamin Blend E-400IU
Nutr-E-Sol

Available Dosage Forms:

Liquid
Solution
Tablet
Capsule, Liquid Filled
Tablet, Chewable
Powder for Solution
Capsule

Therapeutic Class: Nutritive Agent

Pharmacologic Class: Vitamin E (class)

Uses For E-Gems

Some conditions may increase your need for vitamin E. These include:

Intestine disease
Liver disease
Pancreas disease
Surgical removal of stomach

Increased need for vitamin E should be determined by your health care professional.

Lack of vitamin E is extremely rare, except in people who have a disease in which it is not absorbed into the body.

Vitamin E is available without a prescription.

Importance of Diet

The daily amount of vitamin E needed is defined in several different ways.

For U.S.—
Recommended Dietary Allowances (RDAs) are the amount of vitamins and minerals needed to provide for adequate nutrition in most healthy persons. RDAs for a given nutrient may vary depending on a person’s age, sex, and physical condition (e.g., pregnancy).
Daily Values (DVs) are used on food and dietary supplement labels to indicate the percent of the recommended daily amount of each nutrient that a serving provides. DV replaces the previous designation of United States Recommended Daily Allowances (USRDAs).

For Canada—
Recommended Nutrient Intakes (RNIs) are used to determine the amounts of vitamins, minerals, and protein needed to provide adequate nutrition and lessen the risk of chronic disease.

Normal daily recommended intakes in milligrams (mg) of alpha tocopherol equivalents (mg alpha-TE) and Units for vitamin E are generally defined as follows:

Persons	U.S.	Canada
mg alpha-TE	Units	mg alpha-TE	Units
Infants and children Birth to 3 years of age	3–6	5–10	3–4	5–6.7
4 to 6 years of age	7	11.7	5	8.3
7 to 10 years of age	7	11.7	6–8	10–13
Adolescent and adult males	10	16.7	6–10	10–16.7
Adolescent and adult females	8	13	5–7	8.3–11.7
Pregnant females	10	16.7	8–9	13–15
Breast-feeding females	11–12	18–20	9–10	15–16.7

Before Using E-Gems

If you are taking this dietary supplement without a prescription, carefully read and follow any precautions on the label. For this supplement, the following should be considered:

Allergies

Pediatric

Geriatric

Problems in older adults have not been reported with intake of normal daily recommended amounts.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	A	Adequate studies in pregnant women have not shown an increased risk of fetal abnormalities.

Breast Feeding

Interactions with Medicines

Dicumarol

Warfarin

Interactions with Food/Tobacco/Alcohol

Proper Use of vitamin e

This section provides information on the proper use of a number of products that contain vitamin e. It may not be specific to E-Gems. Please read with care.

Dosing

For oral solution dosage form:
- To prevent the following deficiencies in infants:
  - Infants receiving a formula high in polyunsaturated fatty acids—15 to 25 Units per day or 7 Units per 32 ounces of formula.
  - Infants with certain colon problems—15 to 25 Units per kilogram (kg) (6.8 to 11 Units per pound) of body weight per day. The water-soluble form of vitamin E must be used.
  - Infants of normal birthweight—5 Units per 32 ounces of formula.
For oral dosage forms (capsules, tablets, oral solution):
- To prevent deficiency for individuals (other than infants), the amount taken by mouth is based on normal daily recommended intakes:
  - For the U.S.
  - Adult and teenage males—10 milligrams (mg) of alpha tocopherol equivalents (mg alpha-TE) or 16.7 Units per day.
  - Adult and teenage females—8 mg alpha-TE or 13 Units per day.
  - Pregnant females—10 mg alpha-TE or 16.7 Units per day.
  - Breast-feeding females—11 to 12 mg alpha-TE or 18 to 20 Units per day.
  - Children 4 to 10 years of age—7 mg alpha-TE or 11.7 Units per day.
  - Children birth to 3 years of age—3 to 6 mg alpha-TE or 5 to 10 Units per day.
  - For Canada
  - Adult and teenage males—6 to 10 mg alpha-TE or 10 to 16.7 Units per day.
  - Adult and teenage females—5 to 7 mg alpha-TE or 8.3 to 11.7 Units per day.
  - Pregnant females—8 to 9 mg alpha-TE or 13 to 15 Units per day.
  - Breast-feeding females—9 to 10 mg alpha-TE or 15 to 16.7 Units per day.
  - Children 7 to 10 years of age—6 to 8 mg alpha-TE or 10 to 13 Units per day.
  - Children 4 to 6 years of age—5 mg alpha-TE or 8.3 Units per day.
  - Children birth to 3 years of age—3 to 4 mg alpha-TE or 5 to 6.7 Units per day.
- To treat deficiency:
  - Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on the severity of deficiency.

For individuals taking the oral liquid form of this dietary supplement:

This preparation should be taken by mouth even though it comes in a dropper bottle.
This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.

Missed Dose

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the dietary supplement in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

E-Gems Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

With doses greater than 400 Units a day and long-term use

Blurred vision
diarrhea
dizziness
headache
nausea or stomach cramps
unusual tiredness or weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Advanced,E

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E-Mycin

30/06/10

Brand names: PCE, Erythromycin, Oral, E.E.S., E-Mycin, Eryc, Ery-Tab, Erythrocin

Why is E-Mycin prescribed?

Erythromycin is an antibiotic used to treat many kinds of infections, including:

Acute pelvic inflammatory disease
Gonorrhea
Intestinal parasitic infections
Legionnaires’ disease
Listeriosis
Pinkeye
Rectal infections
Reproductive tract infections
Skin infections
Syphilis
Upper and lower respiratory tract infections
Urinary tract infections
Whooping cough

Erythromycin is also prescribed to prevent rheumatic fever in people who are allergic to penicillin and sulfa drugs. It is prescribed before colorectal surgery to prevent infection.

Most important fact about E-Mycin

Erythromycin, like any other antibiotic, works best when there is a constant amount of drug in the blood. To help keep the drug amount constant, it is important not to miss any doses. Also, it is advisable to take the doses at evenly spaced times around the clock.

How should you take E-Mycin?

Some forms of erythromycin are most effective when taken on an empty stomach. Your doctor may advise you to take each dose at least 1/2 hour and preferably 2 hours before meals. Delayed release formulations may be taken with or without food. If the drug upsets your stomach, taking it with meals may help. Ask your doctor whether this is advisable for you.

Chewable forms of erythromycin should be crushed or chewed before being swallowed.

Delayed-release brands and tablets and capsules that are coated to slow their breakdown should be swallowed whole. Do not crush or break. If you are not sure about the form of erythromycin you are taking, ask your pharmacist.

The liquid should be shaken well before each use.

If you miss a dose…
Take it as soon as you remember. If it is almost time for your next dose, and you take 2 doses a day, space the missed dose and the next dose 5 to 6 hours apart; if you take 3 or more doses a day, space the missed dose and the next one 2 to 4 hours apart. Never take 2 doses at the same time.

Storage instructions…
The liquid form of erythromycin should be kept in the refrigerator; use E.E.S. within 10 days. Do not freeze. Store tablets and capsules at room temperature in a tightly closed container.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine whether it is safe to continue taking E-Mycin.

Side effects may include:
Abdominal pain, diarrhea, loss of appetite, nausea, vomiting

Why should E-Mycin not be prescribed?

You should not use erythromycin if you have ever had an allergic reaction to it or are sensitive to it.

Special warnings about E-Mycin

As with other antibiotics, treatment with erythromycin may result in a growth of bacteria that do not respond to E-Mycin and can cause a secondary infection.

If you have ever had liver disease, consult your doctor before taking erythromycin.

If a new infection (called superinfection) develops, talk to your doctor. You may need to be treated with a different antibiotic.

This drug may cause a severe form of intestinal inflammation. If you develop diarrhea, contact your doctor immediately. If you have myasthenia gravis (muscle weakness), it can be aggravated by erythromycin.

When erythromycin is used to treat syphilis in pregnant women, it does not prevent the disease from infecting their babies. The infants should be treated after birth with penicillin.

Prolonged or repeated use of erythromycin may result in the growth of bacteria or fungi that do not respond to E-Mycin and can cause a second infection.

Possible food and drug interactions when taking E-Mycin

Combining erythromycin with lovastatin can cause severe muscle wasting and damage to the kidneys. If you are taking both of these drugs, your doctor will monitor you closely for warning signs of this interaction.

If erythromycin is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining erythromycin with the following:

Benzodiazepines such as midazolam and triazolam
Blood-thinning drugs such as warfarin
Bromocriptine
Carbamazepine
Cyclosporine
Digoxin
Dihydroergotamine
Disopyramide
Ergotamine
Hexobarbital
Seizure medications such as phenytoin and valproic acid
Tacrolimus
Theophylline

Special information if you are pregnant or breastfeeding

There is no evidence that erythromycin will harm a developing baby, but the possibility has not been completely ruled out. If you are pregnant or plan to become pregnant, inform your doctor immediately.

Erythromycin appears in breast milk and could affect a nursing infant. If E-Mycin is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment is finished.

Recommended dosage

Dosage instructions are determined by the type (and severity) of infection being treated and may vary slightly for different brands of erythromycin. The following are recommended dosages for PCE, one of the most commonly prescribed brands.

ADULTS

Streptococcal Infections

The usual dose is 333 milligrams every 8 hours, or 500 milligrams every 12 hours. Depending on the severity of the infection, the dose may be increased to a total of 4 grams a day. However, when the daily dosage is larger than 1 gram, twice-a-day doses are not recommended, and the drug should be taken more often in smaller doses.

To treat streptococcal infections of the upper respiratory tract (tonsillitis or strep throat), erythromycin should be taken for at least 10 days.

To prevent repeated infections in people who have had rheumatic fever, the usual dosage is 250 milligrams twice a day.

Urinary Tract Infections Due to Chlamydia Trachomatis During Pregnancy

The usual dosage is 500 milligrams of erythromycin orally 4 times a day or 666 milligrams every 8 hours on an empty stomach for at least 7 days. For women who cannot tolerate this regimen, a decreased dose of 500 milligrams every 12 hours or 333 milligrams every 8 hours a day should be used for at least 14 days.

For Those with Uncomplicated Urinary, Reproductive Tract, or Rectal Infections Caused by Chlamydia Trachomatis When Tetracycline Cannot Be Taken

The usual oral dosage is 500 milligrams of erythromycin 4 times a day or 666 milligrams every 8 hours for at least 7 days.

For Those with Nongonococcal Urethral Infections When Tetracycline Cannot Be Taken

The usual dosage is 500 milligrams of erythromycin by mouth 4 times a day or 666 milligrams orally every 8 hours for at least 7 days.

Acute Pelvic Inflammatory Disease Caused by Neisseria Gonorrhoeae

The usual treatment is three days of intravenous erythromycin followed by 500 milligrams orally every 12 hours or 333 milligrams orally every 8 hours for 7 days.

Syphilis

The usual dosage is 30 to 40 grams divided into smaller doses over a period of 10 to 15 days.

Intestinal Infections

The usual dosage is 500 milligrams every 12 hours, or 333 milligrams every 8 hours, for 10 to 14 days.

Legionnaires’ Disease

The usual dosage ranges from 1 to 4 grams daily, divided into smaller doses.

CHILDREN

Age, weight, and severity of the infection determine the correct dosage.

The usual dosage is from 30 to 50 milligrams daily for each 2.2 pounds of body weight, divided into equal doses for 10 to 14 days. For pneumonia in infants due to chlamydia, treatment lasts at least 3 weeks.

For more severe infections, this dosage may be doubled, but it should not exceed 4 grams per day.

Children weighing over 44 pounds should follow the recommended adult dose schedule.

For prevention of bacterial endocarditis, the children’s dosage is 10 milligrams per 2.2 pounds of body weight 2 hours before dental work or surgery, followed by 5 milligrams per 2.2 pounds 6 hours later.

Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical help immediately.

Symptoms of erythromycin overdose may include:
Diarrhea, nausea, stomach cramps, vomiting

Detailed,E

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E-Pilo-1

30/06/10

Generic Name: epinephrine and pilocarpine ophthalmic (ep ih NEF rin and pie low CAR peen)
Brand Names: E-Pilo-1, E-Pilo-2, E-Pilo-4, E-Pilo-6, P1E1, P2E1, P3E1, P4E1, P6E1

What is E-Pilo-1 (epinephrine and pilocarpine ophthalmic)?

Epinephrine ophthalmic reduces congestion in the eye by constricting blood vessels in the eye. It also enlarges the pupil, and it reduces the amount of fluid in the eye in two ways: It reduces the production of fluid inside the eye, and it increases the amount of fluid that drains from the eye.

Pilocarpine ophthalmic also reduces pressure in the eye by increasing the amount of fluid that drains from the eye. In addition, pilocarpine causes the pupil to become smaller and reduces its response to light or dark conditions.

Together, epinephrine and pilocarpine are used to lower increased pressure in the eye that may be caused by conditions such as open-angle glaucoma and ocular (eye) hypertension (high pressure).

Epinephrine and pilocarpine ophthalmic is not commercially available in the United States.

Epinephrine and pilocarpine ophthalmic may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about E-Pilo-1 (epinephrine and pilocarpine ophthalmic)?

Contact your doctor immediately if you notice any decrease in vision or an increase in “floaters” in your visual field. Rarely, pilocarpine ophthalmic may cause retinal detachment. Retinal detachment can lead to blind spots, floaters in your visual field, and even blindness. Your doctor will want to check your retina before you use this medication to determine if you have an increased risk of retinal detachment.

Do not touch the dropper to any surface, including the eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in the eye.

Apply light pressure to the inside corner of the eye (near the nose) after each drop to prevent the fluid from draining down the tear duct.

What should I discuss with my healthcare provider before using E-Pilo-1 (epinephrine and pilocarpine ophthalmic)?

Epinephrine and pilocarpine ophthalmic should not be used to treat narrow- or shallow-angle glaucoma.

Rarely, pilocarpine ophthalmic may cause retinal detachment. Tell your doctor if you have any type of retinal disease, if you have had a retinal tear, if you are nearsighted, or if you have had cataract surgery. These conditions may increase the risk of retinal detachment.

Before using this medication, tell your doctor if you have

heart failure,
high or low blood pressure,
ever had a heart attack,
asthma,
a stomach ulcer or stomach spasms,
epilepsy,
hyperthyroidism (an overactive thyroid),
blockage of your urinary tract or difficulty urinating, or
Parkinson’s disease.

You may not be able to use epinephrine and pilocarpine ophthalmic, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

If you wear contact lenses, remove them before applying epinephrine and pilocarpine ophthalmic. Ask your doctor if contact lenses can be reinserted after application of the medication.

It is not known whether epinephrine and pilocarpine ophthalmic will be harmful to an unborn baby. Do not use epinephrine and pilocarpine ophthalmic without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether epinephrine and pilocarpine passes into breast milk. Do not use epinephrine and pilocarpine ophthalmic without first talking to your doctor if you are breast-feeding a baby.

How should I use E-Pilo-1 (epinephrine and pilocarpine ophthalmic)?

Use epinephrine and pilocarpine ophthalmic eye drops exactly as directed by your doctor. If you do not understand these instructions, ask your doctor, pharmacist, or nurse to explain them to you.

Wash your hands before and after using the eye drops.

If you wear contact lenses, remove them before applying epinephrine and pilocarpine ophthalmic. Ask your doctor if contact lenses can be reinserted after application of the medication.

To apply the eye drops:

Tilt the head back slightly and pull down on the lower eyelid. Position the dropper above the eye. Look up and away from the dropper. Squeeze out a drop and close the eye. Apply gentle pressure to the inside corner of the eye (near the nose) for about 1 minute to prevent the liquid from draining down the tear duct. If you are using more than 1 drop in the same eye, repeat the process with about 5 minutes between drops. Repeat the process in the other eye if needed.

Epinephrine and pilocarpine ophthalmic is usually used once or twice a day. Follow your doctor’s instructions.

Do not touch the dropper to any surface, including the eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in the eye. Do not use any eye drop that is discolored or has particles in it. Store epinephrine and pilocarpine ophthalmic at room temperature away from moisture and heat. Keep the bottle properly capped.

What happens if I miss a dose?

Apply the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and apply the next one as directed. Do not use a double dose of this medication.

What happens if I overdose?

The symptoms of an epinephrine and pilocarpine ophthalmic overdose are unknown. Sweating, nausea, vomiting, diarrhea, watering mouth, and tearing eyes may occur. If you suspect an overdose, or if the drops have been ingested, call an emergency room or poison control center for advice.

What should I avoid while using E-Pilo-1 (epinephrine and pilocarpine ophthalmic)?

Use caution when driving, operating machinery, or performing other hazardous activities. Epinephrine and pilocarpine ophthalmic may cause blurred or decreased night vision. If you experience blurred or decreased vision, avoid these activities. Do not touch the dropper to any surface, including your eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in your eye.

If you wear contact lenses, remove them before applying epinephrine and pilocarpine ophthalmic. Ask your doctor if contact lenses can be reinserted after application of the medication.

Do not use other eye medications during treatment with epinephrine and pilocarpine ophthalmic except under the direction of your doctor.

E-Pilo-1 (epinephrine and pilocarpine ophthalmic) side effects

If you experience any of the following serious side effects, stop using epinephrine and pilocarpine ophthalmic and seek emergency medical attention or contact your doctor immediately:

an allergic reaction (swelling of the lips, face, or tongue; difficulty breathing; shortness of breath; or hives);
high blood pressure (severe headache, blurred vision, or flushed skin); or
an irregular or fast heartbeat.

Other, less serious side effects may be more likely to occur. Continue to use epinephrine and pilocarpine ophthalmic and talk to your doctor if you experience

burning, stinging, redness, or tearing of the eye;
blurred vision;
headache or brow ache;
dizziness;
decreased vision in poor light;
nausea, vomiting, or diarrhea;
watering mouth;
sweating; or
increased urination.

Colored deposits (spots) on the inner lining of the eyelid or on the surface of the eye may develop during chronic treatment with epinephrine and pilocarpine ophthalmic. These deposits are harmless.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect E-Pilo-1 (epinephrine and pilocarpine ophthalmic)?

Before using this medication, tell your doctor if you are using another eye medication especially if it is a nonsteroidal anti-inflammatory drug (NSAID) such as flurbiprofen (Ocufen), suprofen (Profenal), diclofenac (Voltaren), or ketorolac (Acular).

Do not use other eye medications during treatment with epinephrine and pilocarpine ophthalmic except under the direction of your doctor.

Drugs other than those listed here may also interact with epinephrine and pilocarpine ophthalmic. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information?

Your pharmacist has additional information about epinephrine and pilocarpine ophthalmic written for health professionals that you may read.

What does my medication look like?

Epinephrine and pilocarpine ophthalmic is currently not available in the United States.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Concise,E

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Drugs & Medications:A-Z

Recent Posts

Blogroll

30/06/10

What is E Pherol (vitamin E)?

What is the most important information I should know about E Pherol (vitamin E)?

What should I discuss with my healthcare provider before taking E Pherol (vitamin E)?

How should I take E Pherol (vitamin E)?

What happens if I miss a dose?

What happens if I overdose?

What should I avoid while taking E Pherol (vitamin E)?

E Pherol (vitamin E) side effects

What other drugs will affect E Pherol (vitamin E)?

Where can I get more information?

30/06/10

Uses For E-400

Importance of Diet

Before Using E-400

Allergies

Pediatric

Geriatric

Pregnancy

Breast Feeding

Interactions with Medicines

Interactions with Food/Tobacco/Alcohol

Other Medical Problems

Proper Use of vitamin e

Dosing

Missed Dose

Storage

E-400 Side Effects

30/06/10

What is E-400 Clear (vitamin E)?

What is the most important information I should know about E-400 Clear (vitamin E)?

What should I discuss with my healthcare provider before taking E-400 Clear (vitamin E)?

How should I take E-400 Clear (vitamin E)?

What happens if I miss a dose?

What happens if I overdose?

What should I avoid while taking E-400 Clear (vitamin E)?

E-400 Clear (vitamin E) side effects

What other drugs will affect E-400 Clear (vitamin E)?

Where can I get more information?

30/06/10

Uses For E-600

Importance of Diet

Before Using E-600

Allergies

Pediatric

Geriatric

Pregnancy

Breast Feeding

Interactions with Medicines

Interactions with Food/Tobacco/Alcohol

Other Medical Problems

Proper Use of vitamin e

Dosing

Missed Dose

Storage

E-600 Side Effects

30/06/10

Uses For E-Gems

Importance of Diet

Before Using E-Gems

Allergies

Pediatric

Geriatric

Pregnancy

Breast Feeding

Interactions with Medicines

Interactions with Food/Tobacco/Alcohol

Other Medical Problems

Proper Use of vitamin e

Dosing

Missed Dose

Storage

E-Gems Side Effects

30/06/10

Why is E-Mycin prescribed?

Most important fact about E-Mycin

How should you take E-Mycin?