FA-8
30/06/10
Generic Name: folic acid (Oral route, Injection route)
FOE-lik AS-id
Commonly used brand name(s):
In the U.S.
- FA-8
- Folacin-800
- Nature’s Blend Folic Acid
- ViloFane-Dp 7.5
Available Dosage Forms:
- Tablet
- Solution
- Injectable
- Capsule
Therapeutic Class: Nutritive Agent
Pharmacologic Class: Vitamin B
Uses For FA-8
Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Folic acid (vitamin B 9) is necessary for strong blood.
Lack of folic acid may lead to anemia (weak blood). Your health care professional may treat this by prescribing folic acid for you.
Some conditions may increase your need for folic acid. These include:
- Alcoholism
- Anemia, hemolytic
- Diarrhea (continuing)
- Fever (prolonged)
- Hemodialysis
- Illness (prolonged)
- Intestinal diseases
- Liver disease
- Stress (continuing)
- Surgical removal of stomach
In addition, infants smaller than normal, breast-fed infants, or those receiving unfortified formulas (such as evaporated milk or goat’s milk) may need additional folic acid.
Increased need for folic acid should be determined by your health care professional.
Some studies have found that folic acid taken by women before they become pregnant and during early pregnancy may reduce the chances of certain birth defects (neural tube defects).
Claims that folic acid and other B vitamins are effective for preventing mental problems have not been proven. Many of these treatments involve large and expensive amounts of vitamins.
Injectable folic acid is given by or under the direction of your health care professional. Another form of folic acid is available without a prescription.
Importance of Diet
For good health, it is important that you eat a balanced and varied diet. Follow carefully any diet program your health care professional may recommend. For your specific dietary vitamin and/or mineral needs, ask your health care professional for a list of appropriate foods. If you think that you are not getting enough vitamins and/or minerals in your diet, you may choose to take a dietary supplement.
Folic acid is found in various foods, including vegetables, especially green vegetables; potatoes; cereal and cereal products; fruits; and organ meats (for example, liver or kidney). It is best to eat fresh fruits and vegetables whenever possible since they contain the most vitamins. Food processing may destroy some of the vitamins. For example, heat may reduce the amount of folic acid in foods.
Vitamins alone will not take the place of a good diet and will not provide energy. Your body also needs other substances found in food such as protein, minerals, carbohydrates, and fat. Vitamins themselves often cannot work without the presence of other foods.
The daily amount of folic acid needed is defined in several different ways.
- For U.S.—
- Recommended Dietary Allowances (RDAs) are the amount of vitamins and minerals needed to provide for adequate nutrition in most healthy persons. RDAs for a given nutrient may vary depending on a person’s age, sex, and physical condition (e.g., pregnancy).
- Daily Values (DVs) are used on food and dietary supplement labels to indicate the percent of the recommended daily amount of each nutrient that a serving provides. DV replaces the previous designation of United States Recommended Daily Allowances (USRDAs).
- For Canada—
- Recommended Nutrient Intakes (RNIs) are used to determine the amounts of vitamins, minerals, and protein needed to provide adequate nutrition and lessen the risk of chronic disease.
Normal daily recommended intakes in micrograms (mcg) for folic acid are generally defined as follows:
| Persons | U.S. (mcg) |
Canada (mcg) |
| Infants and children Birth to 3 years of age |
25–100 | 50–80 |
| 4 to 6 years of age | 75–400 | 90 |
| 7 to 10 years of age | 100–400 | 125–180 |
| Adolescent and adult males | 150–400 | 150–220 |
| Adolescent and adult females | 150–400 | 145–190 |
| Pregnant females | 400–800 | 445–475 |
| Breast-feeding females | 260–800 | 245–275 |
Before Using FA-8
If you are taking this dietary supplement without a prescription, carefully read and follow any precautions on the label. For this supplement, the following should be considered:
In deciding to use folic acid, the risks of taking it must be weighed against the good it will do. This is a decision you and your health care professional will make. For folic acid, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Problems in children have not been reported with intake of normal daily recommended amounts.
Geriatric
Problems in older adults have not been reported with intake of normal daily recommended amounts.
Pregnancy
| Pregnancy Category | Explanation | |
|---|---|---|
| All Trimesters | A | Adequate studies in pregnant women have not shown an increased risk of fetal abnormalities. |
Breast Feeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Using this dietary supplement with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Phenytoin
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this dietary supplement. Make sure you tell your doctor if you have any other medical problems, especially:
- Pernicious anemia (a type of blood problem)—Taking folic acid while you have pernicious anemia may cause serious side effects. You should be sure that you do not have pernicious anemia before beginning folic acid supplementation
Proper Use of folic acid
This section provides information on the proper use of a number of products that contain folic acid. It may not be specific to FA-8. Please read with care.
Dosing
The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form (tablets):
- To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes:
- For the U.S.
- Adult and teenage males—150 to 400 micrograms (mcg) per day.
- Adult and teenage females—150 to 400 mcg per day.
- Pregnant females—400 to 800 mcg per day.
- Breast-feeding females—260 to 800 mcg per day.
- Children 7 to 10 years of age—100 to 400 mcg per day.
- Children 4 to 6 years of age—75 to 400 mcg per day.
- Children birth to 3 years of age—25 to 100 mcg per day.
- For Canada
- Adult and teenage males—150 to 220 mcg per day.
- Adult and teenage females—145 to 190 mcg per day.
- Pregnant females—445 to 475 mcg per day.
- Breast-feeding females—245 to 275 mcg per day.
- Children 7 to 10 years of age—125 to 180 mcg per day.
- Children 4 to 6 years of age—90 mcg per day.
- Children birth to 3 years of age—50 to 80 mcg per day.
- To treat deficiency:
- Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on the severity of deficiency.
- To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes:
Missed Dose
If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
Store the dietary supplement in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
FA-8 Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Rare
- Fever
- general weakness or discomfort
- reddened skin
- shortness of breath
- skin rash or itching
- tightness in chest
- troubled breathing
- wheezing
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.
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Fabrazyme
30/06/10
Generic Name: agalsidase beta (a GAL sih daze BAY tah)
Brand Names: Fabrazyme
What is agalsidase beta?
Agalsidase beta is a man-made form of the naturally-occurring enzyme a-galactosidase A. A deficiency of the enzyme a-galactosidase A is called Fabry disease. Agalsidase beta reduces deposits of globotriaosylceramide (GL-3) in the kidneys and other certain other cells in the body.
Agalsidase beta is used in the treatment of Fabry disease.
Agalsidase beta may also be used for purposes other than those listed here.
What is the most important information I should know about agalsidase beta?
Symptoms of allergic or infusion reactions including difficulty breathing; closing of the throat; hives; rash; itching; fever; shaking; chest tightness; high or low blood pressure; fast heartbeats; muscle pain; stomach pain; nausea or vomiting; dizziness; numbness or tingling; and headache have occurred upon injection of agalsidase beta in many patients. Most patients treated with agalsidase beta develop antibodies to agalsidase beta and many will develop symptoms of an infusion reaction. A slow rate of injection of the medication and pretreatment with other medications may decrease the severity of these symptoms. Emergency medical attention may be required if a severe allergic reaction is experienced.
What should I discuss with my health care provider before using agalsidase beta?
Before using agalsidase beta, tell your doctor if you have
-
had an allergic reaction to agalsidase beta or have antibodies to the medication; or
-
heart problems.
You may not be able to use agalsidase beta, or you may require a dosage adjustment or special monitoring during treatment.
Agalsidase beta is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not use agalsidase beta without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether agalsidase beta passes into breast milk. Do not use agalsidase beta without first talking to your doctor if you are breast-feeding a baby.
How should I use agalsidase beta?
Use agalsidase beta exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
Agalsidase beta is given by intravenous (into the vein) injection and will most likely be administered by a healthcare provider.
Your doctor may want you to have blood tests or other medical evaluations during treatment with agalsidase beta to monitor progress and side effects.
Your healthcare provider will store agalsidase beta as instructed by the manufacturer. If you are storing agalsidase beta at home, your healthcare provider will give you instructions regarding how to store the medication.
What happens if I miss a dose?
Contact your doctor if you miss a dose of agalsidase beta.
What happens if I overdose?
Contact your doctor, a hospital emergency room, or a poison control center if an overdose is suspected.
Although symptoms of an agalsidase beta overdose are not known, an overdose is unlikely to threaten life.
What should I avoid while taking agalsidase beta?
There are no restrictions on food, beverages, or activity during treatment with agalsidase beta.
Agalsidase beta side effects
Symptoms of allergic or infusion reactions including difficulty breathing; closing of the throat; hives; rash; itching; fever; shaking; chest tightness; high or low blood pressure; fast heartbeats; muscle pain; stomach pain; nausea or vomiting; dizziness; numbness or tingling; and headache have occurred upon injection of agalsidase beta in many patients. Most patients treated with agalsidase beta develop antibodies to agalsidase beta and many will develop symptoms of an infusion reaction. A slow rate of injection of the medication and pretreatment with other medications may decrease the severity of these symptoms. Emergency medical attention may be required if a severe allergic reaction is experienced.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect agalsidase beta?
Agalsidase beta is not known to interact with other medications. Talk to your doctor or pharmacist before taking other prescription or over-the-counter medications, including herbal products, during treatment with agalsidase beta.
Where can I get more information?
- Your pharmacist has more information about agalsidase beta written for health professionals that you may read.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 1.03. Revision Date: 4/12/2009 4:45:07 PM.
Factive
30/06/10
Generic Name: gemifloxacin (JEM i FLOX a sin)
Brand Names: Factive
What is Factive (gemifloxacin)?
Gemifloxacin is an antibiotic in a group of drugs called fluoroquinolones (flor-o-KWIN-o-lones). Gemifloxacin fights bacteria in the body.
Gemifloxacin is used to treat different types of bacterial infections.
Gemifloxacin may also be used for other purposes not listed in this medication guide.
What is the most important information I should know about moxifloxacin?
You should not use this medication if you are allergic to gemifloxacin or similar antibiotics such as ciprofloxacin (Cipro), levofloxacin (Levaquin), moxifloxacin (Avelox), ofloxacin (Floxin), norfloxacin (Noroxin), lomefloxacin (Maxaquin), and others.
Before taking gemifloxacin, tell your doctor if you have kidney disease, joint problems, a history of seizures, low levels of potassium or magnesium in your blood, a nerve disorder or history of circulation problems, or a personal or family history of “Long QT syndrome.”
Avoid taking antacids, vitamin or mineral supplements, sucralfate (Carafate), or didanosine (Videx) powder or chewable tablets within 3 hours before or 2 hours after you take gemifloxacin. These other medicines can make gemifloxacin much less effective when taken at the same time.
Taking gemifloxacin can make your skin more sensitive to sunlight. Avoid exposure to sunlight, sun lamps, or tanning beds.
Gemifloxacin may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles’ tendon of the heel. These effects may be more likely to occur if you are over 60, if you take an oral steroid medication, or if you have had a kidney, heart, or lung transplant. Stop taking gemifloxacin and call your doctor at once if you have sudden pain, swelling, tenderness, stiffness, or movement problems in any of your joints. Rest the joint until you receive medical care or instructions. Do not share this medication with another person (especially a child), even if they have the same symptoms you do.
What should I discuss with my healthcare provider before taking Factive (gemifloxacin)?
Do not use this medication if you are allergic to gemifloxacin or similar medications such as ciprofloxacin (Cipro), levofloxacin (Levaquin), ofloxacin (Floxin), moxifloxacin (Avelox), norfloxacin (Noroxin), lomefloxacin (Maxaquin), and others.
Before taking gemifloxacin, tell your doctor if you have a heart rhythm disorder, especially if you are being treated with one of these medications: quinidine (Cardioquin, Quinidex, Quinaglute), disopyramide (Norpace), bretylium (Bretylol), procainamide (Pronestyl, Procan SR), amiodarone (Cordarone, Pacerone), or sotalol (Betapace).
If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before you take gemifloxacin, tell your doctor if you have:
- a history of allergic reaction to an antibiotic;
-
joint problems;
- kidney disease;
-
epilepsy or a history of seizures;
-
low blood levels of potassium (hypokalemia) or magnesium (hypomagnesemia);
-
a nerve disorder or history of circulation problems; or
-
a personal or family history of “Long QT syndrome.”
FDA pregnancy category C: It is not known whether gemifloxacin is harmful to an unborn baby. Do not use gemifloxacin without telling your doctor if you are pregnant. Tell your doctor if you become pregnant during treatment. Gemifloxacin may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Gemifloxacin may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles’ tendon of the heel. These effects may be more likely to occur if you are over 60, if you take an oral steroid medication, or if you have had a kidney, heart, or lung transplant. Stop taking gemifloxacin and call your doctor at once if you have sudden pain, swelling, tenderness, stiffness, or movement problems in any of your joints. Rest the joint until you receive medical care or instructions. Do not share this medication with another person (especially a child), even if they have the same symptoms you do.
How should I take Factive (gemifloxacin)?
Take gemifloxacin exactly as it was prescribed for you. Do not take it in larger doses or for longer than recommended by your doctor. Follow the directions on your prescription label.
Take gemifloxacin with a full glass of water (8 ounces). Drink several extra glasses of fluid each day while you are taking gemifloxacin.
Gemifloxacin may be taken with or without food, but take it at the same time each day.
Take this medication for as many days as it has been prescribed for you even if you begin to feel better. Your symptoms may get better before the infection is completely treated. Gemifloxacin will not treat a viral infection such as the common cold or flu. Store gemifloxacin at room temperature away from moisture, heat, and light.
See also: Factive dosage in more detail
What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine.
Overdose symptoms may include weakness, chills, tremors, and seizure (convulsions).
What should I avoid while taking Factive (gemifloxacin)?
You may be taking certain other medicines that should not be taken at the same time as gemifloxacin. Avoid taking the following medicines within 3 hours before or 2 hours after you take gemifloxacin. These other medicines can make gemifloxacin much less effective when taken at the same time:
-
antacids that contain magnesium or aluminum (such as Maalox, Mylanta, or Rolaids);
-
the ulcer medicine sucralfate (Carafate);
-
didanosine (Videx) powder or chewable tablets; or
-
vitamin or mineral supplements that contain iron or zinc.
Avoid exposure to sunlight, sunlamps, or tanning beds. Gemifloxacin can make your skin more sensitive to sunlight, and a sunburn may result. Wear protective clothing and use a sunscreen (SPF-15 or higher) if you must be out in the sun. Call your doctor if you have severe burning, redness, itching, rash, or swelling after being in the sun.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.
Gemifloxacin can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
Factive (gemifloxacin) side effects
Stop using gemifloxacin and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using gemifloxacin and call your doctor at once if you have any of these serious side effects:
-
dizziness, fainting, fast or pounding heartbeat;
-
sudden pain, snapping or popping sound, bruising, loss of movement, or swelling near your joints (especially in your arm or ankle);
-
diarrhea that is watery or bloody;
-
confusion, hallucinations, depression, unusual thoughts or behavior;
-
seizure (convulsions);
-
pale or yellowed skin, dark colored urine, fever, weakness;
-
upper stomach pain, loss of appetite, clay-colored stools, jaundice (yellowing of the skin or eyes);
-
urinating less than usual or not at all;
-
easy bruising or bleeding;
-
numbness, burning, tingling, or unusual pain anywhere in your body;
-
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
-
the first sign of any skin rash, no matter how mild.
Less serious side effects may include:
-
nausea, vomiting;
-
dizziness or drowsiness;
-
blurred vision;
-
muscle pain;
-
feeling nervous, anxious, or restless; or
-
sleep problems (insomnia or nightmares).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Factive (gemifloxacin)?
Before taking gemifloxacin, tell your doctor if you are taking any of the following drugs:
-
probenecid (Benemid, Probalan);
-
a blood thinner such as warfarin (Coumadin);
-
a diuretic (water pill);
-
an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), or pentamidine (NebuPent, Pentam);
-
an antidepressant such as amitriptylline (Elavil, Vanatrip), clomipramine (Anafranil), or desipramine (Norpramin);
-
anti-malaria medications such as chloroquine (Arelan), mefloquine (Lariam), or halofantrine (Halfan);
-
medicine to prevent or treat nausea and vomiting, such as dolasetron (Anzemet) or ondansetron (Zofran);
-
medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (FazaClo, Clozaril), haloperidol (Haldol), pimozide (Orap), thioridazine (Mellaril), or ziprasidone (Geodon);
-
migraine headache medicine such as sumatriptan (Imitrex) or zolmitriptan (Zomig);
-
narcotic medication such as levomethadyl (Orlaam), or methadone (Dolophine, Methadose);
-
a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin, others), etodolac (Lodine), diclofenac (Cataflam, Voltaren), indomethacin (Indocin), naproxen (Aleve, Naprosyn, Anaprox), piroxicam (Feldene), and others; or
-
an oral steroid medication such as dexamethasone (Decadron, Dexpak), prednisolone (Orapred), prednisone (Meticorten, Sterapred), and others.
This list is not complete and there may be other drugs that can interact with gemifloxacin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Where can I get more information?
- Your pharmacist can provide more information about gemifloxacin.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
- Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 2.03. Revision Date: 4/12/2009 4:45:05 PM.
