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Guaifenesin Granules

30/06/10

Generic Name: Guaifenesin (gwye-FEN-eh-sin)
Brand Name: Examples include Mucinex Children’s and Mucinex Junior Strength

Guaifenesin Granules are used for:

Relieving symptoms of cough and mucus in the chest due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Guaifenesin Granules are an expectorant. It works by thinning mucus (phlegm) in the lungs and making it less sticky and easier to cough up. This reduces chest congestion by making coughs more productive.

Do NOT use Guaifenesin Granules if:

you are allergic to any ingredient in Guaifenesin Granules

Contact your doctor or health care provider right away if any of these apply to you.

Before using Guaifenesin Granules:

Some medical conditions may interact with Guaifenesin Granules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have a persistent cough that occurs with smoking, asthma, chronic bronchitis, or emphysema, or if your cough occurs with large amounts of mucus
if you have phenylketonuria

Some MEDICINES MAY INTERACT with Guaifenesin Granules. Tell your health care provider if you are taking any other medicines. However, no specific interactions with Guaifenesin Granules are known at this time.

Ask your health care provider if Guaifenesin Granules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Guaifenesin Granules:

Use Guaifenesin Granules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Guaifenesin Granules by mouth with or without food.
Drinking extra fluids while you are taking Guaifenesin Granules are recommended. Check with your doctor for instructions.
Empty the entire contents of the packet onto the tongue and swallow. For best taste, do not chew before swallowing.
If you miss a dose of Guaifenesin Granules and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Guaifenesin Granules.

Important safety information:

If cough persists for more than 1 week or is accompanied by a fever, contact your health care provider. A persistent cough could be a sign of a serious condition.
Some of these products contain phenylalanine. If you must have a diet that is low in phenylalanine, ask your pharmacist if it is in your product.
Different brands of Guaifenesin Granules may have different dosing instructions for CHILDREN. Follow the dosing instructions on the package labeling. If your doctor has given you instructions, follow those. If you are unsure of the dose to give a child, check with your doctor or pharmacist.
PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Guaifenesin Granules while you are pregnant. It is not known if Guaifenesin Granules are found in breast milk. If you are or will be breast-feeding while you use Guaifenesin Granules, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Guaifenesin Granules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Guaifenesin Granules:

Store Guaifenesin Granules at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Guaifenesin Granules out of the reach of children and away from pets.

General information:

If you have any questions about Guaifenesin Granules, please talk with your doctor, pharmacist, or other health care provider.
Guaifenesin Granules are to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Guaifenesin Granules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: May 5, 2010

Database Edition 10.2.1.002

G,Med-facts

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Guaifenesin AC Liquid

30/06/10

Generic Name: codeine and guaifenesin (KOE deen and gwye FEN a sin)
Brand Names: Allfen CD, Allfen CDX, Brontex, Cheracol with Codeine, Cheratussin AC, Dex-Tuss, Diabetic Tussin C, Duraganidin NR, ExeClear-C, Guaiatussin AC, Guaifen-C, Guiatuss AC, Guiatussin with Codeine, Iophen-C NR, M-Clear WC, Mar-cof CG, Mytussin AC, Robafen AC, Robitussin-AC, Tussi-Organidin NR, Tussi-Organidin-S NR, Tussiden C, Tusso-C

What is Guaifenesin AC Liquid (codeine and guaifenesin)?

Codeine is in a group of drugs called narcotics. It is a cough suppressant that affects the signals in the brain that trigger cough reflex.

Guaifenesin is an expectorant. It helps loosen mucus congestion in your chest and throat, making it easier to cough out through your mouth.

The combination of codeine and guaifenesin is used to treat cough and to reduce chest congestion caused by upper respiratory infections or the common cold.

Codeine and guaifenesin will not treat a cough that is caused by smoking, asthma, or emphysema.

Codeine and guaifenesin may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Guaifenesin AC Liquid (codeine and guaifenesin)?

Do not use any other over-the-counter cough or cold medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains guaifenesin. This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Codeine may be habit-forming and should be used only by the person it was prescribed for. This medication should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

What should I discuss with my healthcare provider before taking Guaifenesin AC Liquid (codeine and guaifenesin)?

You should not take this medication if you are allergic to codeine or guaifenesin.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take codeine and guaifenesin:

heart disease, heart rhythm disorder;
asthma, COPD, emphysema, or other breathing disorders;
a history of head injury or brain tumor;
epilepsy or other seizure disorder;
a stomach or intestinal disorder;
Addison’s disease or other adrenal gland disorders;
curvature of the spine;
a thyroid disorder;
liver or kidney disease;
enlarged prostate; or
a history of depression, mental illness, or drug addiction;

FDA pregnancy category C. This medication may be harmful to an unborn baby, and could cause addiction or withdrawal symptoms in a newborn. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Codeine can pass into breast milk and may harm a nursing baby. The use of codeine by some nursing mothers may lead to life-threatening side effects in the baby. Do not use this medication if you are breast-feeding a baby. Codeine may be habit-forming and should be used only by the person it was prescribed for. Codeine should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Older adults may be more likely to have side effects from this medication.

Liquid forms of this medication may contain sugar or artificial sweetener (phenylalanine). Talk to your doctor before using this form of codeine and guaifenesin if you have diabetes or phenylketonuria (PKU).

How should I take Guaifenesin AC Liquid (codeine and guaifenesin)?

Take this medication exactly as it has been prescribed by your doctor. Do not use the medication in larger amounts, or use it for longer than recommended. Follow the directions on your prescription label. Cough or cold medicine is usually taken only for a short time until your symptoms clear up.

Always ask a doctor before giving cough or cold medicine to a child. Death can occur from the misuse of cough or cold medicine in very young children. Take codeine and guaifenesin with food if it upsets your stomach. Drink extra fluids to help loosen the congestion and lubricate your throat while you are taking this medication.

Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Call your doctor if your symptoms do not improve after 7 days of treatment, or if you also have a fever, headache, or skin rash.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using codeine and guaifenesin.

Do not stop using this medication suddenly after long-term use or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication. Store codeine and guaifenesin at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use. Keep track of how much of this medicine has been used from each new bottle. Codeine is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

What happens if I miss a dose?

Since cough medicine is usually taken only as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of codeine can be fatal.

Overdose symptoms may include extreme dizziness or drowsiness, nausea, vomiting, sweating, confusion, hallucinations, cold and clammy skin, blue-colored lips or fingernails, weak or limp muscles, pinpoint pupils, weak pulse, slow breathing, fainting, or seizures (convulsions).

What should I avoid while taking Guaifenesin AC Liquid (codeine and guaifenesin)?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Do not use any other over-the-counter cough or cold medication without first asking your doctor or pharmacist. Guaifenesin is contained in many medicines available over the counter. If you take certain products together you may accidentally take too much of a certain drug. Read the label of any other medicine you are using to see if it contains guaifenesin.

Avoid drinking alcohol. It can increase some of the side effects of this medication.

Guaifenesin AC Liquid (codeine and guaifenesin) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking this medication and call your doctor at once if you have any of these serious side effects:

severe dizziness or drowsiness;
confusion, hallucinations, unusual thoughts or behavior;
urinating less than usual or not at all; or
slow heart rate, weak pulse, fainting, weak or shallow breathing.

Less serious side effects include:

dizziness, drowsiness, headache;
warmth, redness, or tingling under your skin;
nausea, vomiting, upset stomach;
constipation; or
skin rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Guaifenesin AC Liquid (codeine and guaifenesin)?

Before taking this medication, tell your doctor if you regularly use other medicines that make you sleepy (such as allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by codeine and guaifenesin.

Also tell your doctor if you are using any of the following drugs:

cimetidine (Tagamet);
quinidine (Quinaglute, Quinidex, Quin-Release);
naloxone (Narcan); or
naltrexone (Vivitrol).

This list is not complete and there may be other drugs that can interact with codeine and guaifenesin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about codeine and guaifenesin.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Concise,G

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guaifenesin and hydrocodone

30/06/10

Generic Name: guaifenesin and hydrocodone (gwye FEN e sin and HYE droe KOE done)
Brand names: A-Cof DH, Canges-XP, Codiclear DH, Condasin, Cotuss V, Execlear, Extendryl HC, Hycotuss Expectorant, Hydrocod-GF, Kwelcof, Monte-G HC, Narcof, Pancof XP, Pneumotussin 2.5, Relasin-HCX, Touro HC, Tussicle, Tusso-DF, Vi-Q-Tuss, Vitussin Expectorant, Xpect-HC, Z-Cof HCX, …show all 47 brand names.

What is guaifenesin and hydrocodone?

Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.

Hydrocodone is a narcotic cough suppressant.

Guaifenesin and hydrocodone is used to treat cough and reduce chest congestion caused by the common cold, flu, or allergies.

Guaifenesin and hydrocodone may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about guaifenesin and hydrocodone?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It may increase drowsiness and dizziness caused by guaifenesin and hydrocodone. Tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by guaifenesin and hydrocodone. Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. Hydrocodone should never be given to another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

What should I discuss with my healthcare provider before taking guaifenesin and hydrocodone?

Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. Hydrocodone should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Do not use this medicine if you are allergic to hydrocodone or guaifenesin.

Before taking this medication, tell your doctor if you have:

kidney disease;
liver disease;
asthma;
urination problems;
an enlarged prostate;
a thyroid disorder;
seizures or epilepsy;
gallbladder disease;
a head injury; or
Addison’s disease.

If you have any of these conditions, you may not be able to take guaifenesin and hydrocodone, or you may need a dose adjustment or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Guaifenesin and hydrocodone passes into breast milk and may be harmful to a nursing baby. Do not take guaifenesin and hydrocodone without telling your doctor if you are breast-feeding a baby.

How should I take guaifenesin and hydrocodone?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Guaifenesin and hydrocodone can be taken with or without food.

Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Do not take more of this medication or take it for longer than is recommended. Call your doctor if your symptoms do not improve, or if they get worse. Store guaifenesin and hydrocodone at room temperature away from moisture and heat. Keep track of how many pills have been used from each new bottle of this medicine. Hydrocodone is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include extreme drowsiness, sweating, pinpoint pupils, nausea, vomiting, dry mouth, confusion, cold and clammy skin, muscle weakness, fainting, weak pulse, slow heart rate, seizure (convulsions), weak or shallow breathing, or breathing that stops.

What should I avoid while taking guaifenesin and hydrocodone?

Do not take other over-the-counter cough, cold, allergy, pain, or sleep medications without first asking your doctor or pharmacist. Guaifenesin is contained in many medicines available over the counter. If you take certain products together you may accidentally take too much guaifenesin. Read the label of any other medicine you are using to see if it contains guaifenesin.

Guaifenesin and hydrocodone side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

slow heart rate, weak or shallow breathing;
feeling like you might pass out;
confusion, fear, unusual thoughts or behavior;
seizure (convulsions); or
urinating less than usual or not at all.

Less serious side effects may include:

dizziness, drowsiness;
nausea, vomiting, upset stomach;
blurred vision;
constipation;
dry mouth; or
sweating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Guaifenesin and hydrocodone Dosing Information

Usual Adult Dose for Cough:

1 extended release tablet (1200 mg-20 mg) orally every 12 hours (maximum dose is 2 tablets/day)
2 extended release tablets (575 mg-5 mg) orally every 12 hours (maximum dose is 6 tablets/day)
1 to 2 extended release tablet(s) (600 mg-5 mg) orally every 12 hours
1 to 1.5 tablet(s) (300 mg-5 mg) orally 4 times a day
1 to 2 tablet(s) (300 mg-2.5 mg) orally 4 times a day (maximum dose is 8 tablets/day)
5 mL syrup (100 mg-5 mg/5 mL) orally every 4 after meals and at bedtime
10 mL syrup (200 mg-2.5 mg/5 mL) orally every 4 to 6 hours (maximum dose is 40 mL/day)
10 mL syrup (100 mg-2.5 mg/5 mL) orally every 4 to 6 hours (maximum dose is 60 mL/day)
5 mL to 10 mL syrup (90 mg-3 mg/5 mL) orally every 4 to 6 hours
1 or 2 capsule(s) (300 mg-5 mg) orally every 8 hours
1 extended release tablet (1000 mg-10 mg) orally every 12 hours (maximum dose is 2 tablets/day)
5 mL syrup (100 mg-3.5 mg/5 mL) orally every 4 after meals and at bedtime (not to exceed 30 mL in a 24 hour period). Treatment should be initiated with 5 mL and subsequent doses, up to a maximum single dose of 15 mL, adjusted as required.
10 mL liquid (150 mg-5 mg/5 mL) orally every 6 hours (not to exceed 40 mL in 24 hours)
5 mL syrup (300 mg-3.5 mg/5 mL) orally every 4 to 6 hours (not to exceed 30 mL in 24 hours)
5 mL liquid (100 mg-4 mg/5 mL) orally every 4 to 6 hours
5 mL to 7.5 mL liquid (200 mg-7.5 mg/5 mL) orally every 6 hours

Usual Pediatric Dose for Cough:

2 years to under 6 years:
2.5 mL syrup (90 mg-3 mg/5 mL) orally every 4 to 6 hours
2.5 mL liquid (150 mg-5 mg/5 mL) orally every 6 hours (not to exceed 10 mL in 24 hours)
1.25 mL liquid (100 mg-4 mg/5 mL) orally every 4 to 6 hours

3 years to under 6 years:
2.5 mL syrup (100 mg-2.5 mg/5 mL) orally every 4 to 6 hours (maximum dose is 15 mL/day)
1.25 mL liquid (200 mg-7.5 mg/5 mL) orally every 6 hours

over 6 years to 12 years:
2.5 mL to 5 mL syrup (100 mg-5 mg/5 mL) orally 4 times a day.
2.5 mL to 5 mL syrup (90 mg-3 mg/5 mL) orally 4 times a day
5 mL syrup (200 mg-2.5 mg/5 mL) orally every 4 to 6 hours (maximum dose is 20 mL/day)
5 mL syrup (100 mg-2.5 mg/5 mL) orally every 4 to 6 hours (maximum dose is 30 mL/day)
1/2 to 1 extended release tablets (600 mg-5 mg) orally every 12 hours
1 capsule (300 mg-5 mg) orally every 8 hours
1/2 extended release tablet (1000 mg-10 mg) orally every 12 hours (maximum dose is 1 tablet/day)
5 mL liquid (150 mg-5 mg/5 mL) orally every 6 hours (not to exceed 20 mL in 24 hours)
2.5 mL liquid (100 mg-4 mg/5 mL) orally every 4 to 6 hours
2.5 mL liquid (200 mg-7.5 mg/5 mL) orally every 6 hours

over 12 years:
10 ml liquid (150 mg-5 mg/5 mL) orally every 6 hours (not to exceed 40 mL in 24 hours)
5 mL syrup (300 mg-3.5 mg/5 mL) orally every 4 to 6 hours (not to exceed 30 mL in 24 hours
5 mL syrup (100 mg-5 mg/5 mL) orally 4 times a day
1 extended release tablet (1200 mg-20 mg) orally every 12 hours (maximum dose is 2 tablets/day)
10 mL syrup (200 mg-2.5 mg/5 mL) orally every 4 to 6 hours (maximum dose is 40 mL/day)
10 mL syrup (100 mg-2.5 mg/5 mL) orally every 4 to 6 hours (maximum dose is 60 mL/day)
5 mL to 10 mL syrup (90 mg-3 mg/5 mL) orally 4 times a day
1 to 2 extended release tablets (600 mg-5 mg) orally every 12 hours
2 extended release tablets (575 mg-5 mg) orally every 12 hours (maximum dose is 6 tablets/day)
1 or 2 capsule(s) (300 mg-5 mg) orally every 8 hours
1 extended release tablet (100 mg-10 mg) orally every 12 hours (maximum dose is 2 tablets/day)
5 mL syrup (100 mg-3.5 mg/5 mL) orally every 4 after meals and at bedtime. Maximum single dose is 10 mL.
5 mL liquid (100 mg-4 mg/5 mL) orally every 4 to 6 hours
5 mL to 7.5 mL liquid (200 mg-7.5 mg/5 mL) orally every 6 hours

What other drugs will affect guaifenesin and hydrocodone?

Before taking this medication, tell your doctor if you are using any of the following drugs:

antidepressants such as amitriptyline (Elavil, Etrafon), clomipramine (Anafranil), imipramine (Janimine, Tofranil), and others;
atropine (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), glycopyrrolate (Robinul), mepenzolate (Cantil), methscopolamine (Pamine), or scopolamine (Transderm-Scop);
bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);
a bronchodilator such as ipratropium (Atrovent) or tiotropium (Spiriva); or
irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin, and others), or propantheline (Pro-Banthine).

This list is not complete and there may be other drugs that can interact with guaifenesin and hydrocodone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about guaifenesin and hydrocodone.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Concise,G

Comments (0)

guaifenesin and phenylephrine

30/06/10

Generic Name: guaifenesin and phenylephrine (gwye FEN e sin and FEN il EFF rin)
Brand names: Amitex LA, Crantex, Deconex, Deconsal II, Despec, Duraphen II, Duratuss PE, Genexa LA, Gentex LA, Guaifed Caps, Liquibid-D, Lusonex, Nasex-G, Nescon-PD, Phenavent, Prolex D, Rescon-GG, Robitussin Head & Chest Congestion, Sina-12X, Sinupan, SINUvent PE, Sudafed PE Non-Drying Sinus, Triaminic Chest & Nasal Congestion, Visonex, Wellbid-D, Xedec, …show all 101 brand names.

What is guaifenesin and phenylephrine?

Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of guaifenesin and phenylephrine is used to treat stuffy nose and sinus congestion, and to reduce chest congestion caused by the common cold or flu.

Guaifenesin and phenylephrine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about guaifenesin and phenylephrine?

There are many brands and forms of guaifenesin and phenylephrine available and not all brands are listed on this leaflet.

Do not give this medication to a child younger than 2 years old. Always ask a doctor before giving cough or cold medicine to a child. Death can occur from the misuse of cough or cold medicine in very young children. Do not use any other over-the-counter cough or cold medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of a certain drug. Read the label of any other medicine you are using to see if it contains a decongestant or expectorant.

What should I discuss with my healthcare provider before taking guaifenesin and phenylephrine?

Do not use this medication if you are allergic to guaifenesin or phenylephrine, or to other decongestants, diet pills, stimulants, or ADHD medications. Do not use a cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), o tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body.

Ask a doctor or pharmacist if it is safe for you to take this medication if you have:

heart disease or high blood pressure;
diabetes;
a thyroid disorder;
circulation problems;
glaucoma;
overactive thyroid; or
enlarged prostate or problems with urination.

It is not known if this medication may be harmful to an unborn baby. Do not use this medication without your doctor’s advice if you are pregnant. This medication passes into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Artificially-sweetened liquid forms of cold medicine may contain phenylalanine. This would be important to know if you have phenylketonuria (PKU). Check the ingredients and warnings on the medication label if you are concerned about phenylalanine.

How should I take guaifenesin and phenylephrine?

Use this medication exactly as directed on the label, or as it has been prescribed by your doctor. Do not use the medication in larger amounts, or use it for longer than recommended. Cold medicine is usually taken only for a short time until your symptoms clear up.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving cough or cold medicine to a child. Death can occur from the misuse of cough or cold medicine in very young children.

Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Do not crush, chew, break, or open a controlled-release, delayed-release, or extended-release tablet or capsule. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time. Take guaifenesin and phenylephrine with food if it upsets your stomach. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash. Drink extra fluids to help loosen the congestion and lubricate your throat while you are taking this medication.

What happens if I miss a dose?

Since cough or cold medicine is usually taken only as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include nausea, vomiting, numbness or tingly feeling, dizziness, and feeling restless or nervous.

What should I avoid while taking guaifenesin and phenylephrine?

Avoid drinking alcohol while you are taking this medicine. Do not use any other over-the-counter cough or cold medication without first asking your doctor or pharmacist. Guaifenesin and phenylephrine are contained in many medicines available over the counter. If you take certain products together you may accidentally take too much of a certain drug. Read the label of any other medicine you are using to see if it contains a decongestant or expectorant.

Avoid taking this medication with diet pills, caffeine pills, or other stimulants (such as ADHD medications). Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Guaifenesin and phenylephrine side effects

fast, pounding, or uneven heartbeat;
severe dizziness, anxiety, restless feeling, or nervousness;
easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;
increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

Less serious side effects may include:

nausea, vomiting, upset stomach, loss of appetite;
warmth, tingling, or redness under your skin;
feeling excited or restless;
sleep problems (insomnia);
skin rash or itching;
headache; or
dizziness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Guaifenesin and phenylephrine Dosing Information

Usual Adult Dose for Cough and Nasal Congestion:

Tablets:
Guaifenesin 550 mg-phenylephrine 8.5 mg: 1 tablet orally every 6 to 8 hours, not to exceed 4 tablets a day.
Guaifenesin 380 mg-phenylephrine 10 mg: 1 tablet orally every 4 hours, not to exceed 6 tablets a day.
Guaifenesin 200 mg-phenylephrine 5 mg: 2 tablets orally every 4 hours, not to exceed 12 tablets a day.

Liquid:
Guaifenesin 75 mg-phenylephrine 7.5 mg/5 mL: 10 mL orally every 4 to 6 hours, up to 40 mL a day.
Guaifenesin 100 mg-phenylephrine 5 mg/5 mL or guaifenesin 200 mg-phenylephrine 7.5 mg/5 mL: 10 mL orally every 4 to 6 hours, up to 40 mL a day.
Guaifenesin 100 mg-phenylephrine 7.5 mg/5 mL: 5 to 10 mL orally every 4 to 6 hours, up to 40 mL a day.
Guaifenesin 200 mg-phenylephrine 5 mg/5 mL: 5 to 10 mL orally every 4 to 6 hours, up to 60 mL a day.

Tablets, extended-release:
Guaifenesin 275 mg-phenylephrine 25 mg: 1 to 2 tablets orally every 12 hours, up to 4 tablets a day.
Guaifenesin 600 mg-phenylephrine 18 mg, or guaifenesin 300 mg-phenylephrine 20 mg, or guaifenesin 600 mg-phenylephrine 15 mg, or guaifenesin 315 mg-phenylephrine 20 mg: 2 tablets orally every 12 hours.
Guaifenesin 600 mg-phenylephrine 10 mg or guaifenesin 600 mg-phenylephrine 25 mg: 1 to 2 tablets orally every 12 hours.
Guaifenesin 600 mg-phenylephrine 20 mg: 1 to 2 tablets orally every 12 hours, up to 2 tablets a day.
Guaifenesin 600 mg-phenylephrine 30 mg, or guaifenesin 600 mg-phenylephrine 40 mg, or guaifenesin 650 mg-phenylephrine 40 mg: 1 tablet orally every 12 hours.
Guaifenesin 650 mg-henylephrine 23.75 mg, or guaifenesin 650 mg-phenylephrine 25 mg: 1 tablet orally every 12 hours not to exceed 2 tablets a day.
Guaifenesin 800 mg-phenylephrine 20 mg: 1 tablet orally every 8 hours not to exceed 3 tablets a day.
Guaifenesin 800 mg-phenylephrine 30 mg, or guaifenesin 800 mg-phenylephrine 40 mg, or guaifenesin 835 mg-phenylephrine 25 mg, or guaifenesin 835 mg-phenylephrine 30 mg or guaifenesin 900 mg-phenylephrine 25 mg, or guaifenesin 900 mg- phenylephrine 30 mg, or guaifenesin 1000 mg-phenylephrine 30 mg, or guaifenesin 1000 mg-phenylephrine 40 mg, or guaifenesin 1050 mg-phenylephrine 30 mg, or guaifenesin 1200 mg-phenylephrine 25 mg, or guaifenesin 1100 mg-phenylephrine 30 mg, or guaifenesin 1200 mg-phenylephrine 20 mg, or guaifenesin 1200 mg-phenylephrine 30 mg, or guaifenesin 1200 mg-phenylephrine 35 mg: 1 tablet orally every 12 hours not to exceed 2 tablets a day.
Guaifenesin 600 mg-phenylephrine 12.5 mg: 1 to 2 tablets orally every 12 hours or 1 tablet every 8 hours not to exceed 4 tablets a day.

Capsule, extended-release:
Guaifenesin 200 mg-phenylephrine 7.5 mg, or guaifenesin 300 mg-phenylephrine 10 mg: 1 to 2 capsules orally every 12 hours.
Guaifenesin 375 mg-phenylephrine 20 mg: 1 to 2 capsules orally every 12 hours, up to 3 capsules a day.
Guaifenesin 400 mg-phenylephrine 15 mg: 1 capsule orally every 12 hours.

Usual Pediatric Dose for Cough and Nasal Congestion:

guaifenesin-phenylephrine 20 mg-1.5 mg/ mL:
2 years to 5 years: 1 mL orally every 4 to 6 hours as needed. Do not exceed 4 doses in 24 hours.
6 years to 12 years: 2 mL orally every 4 to 6 hours as needed. Do not exceed 4 doses in 24 hours.

guaifenesin 100 mg-phenylephrine 5 mg/5 mL or guaifenesin 200 mg-phenylephrine 7.5 mg/5 mL or guaifenesin 75 mg – phenylephrine 7.5 mg/5 mL:
2 years to 6 years: 2.5 mL orally every 4 to 6 hours, up to 4 doses/day.
6 years to 11 years: 5 mL orally every 4 to 6 hours, up to 4 doses/day.

guaifenesin 50 mg-phenylephrine 2.5 mg/5 mL or guaifenesin 100 mg-phenylephrine 2.5 mg/5 mL:
2 years to 5 years: 5 mL orally every 4 hours, up to 6 doses a day.
6 years to 11 years: 10 mL orally every 4 hours, up to 6 doses a day.

guaifenesin 200 mg-phenylephrine 5 mg/5 mL:
2 years to 5 years: 2.5 mL orally every 4 hours, up to 6 doses a day.
6 years to 11 years: 5 mL orally every 4 hours, up to 6 doses a day.

6 years to 11 years:
Guaifenesin 550 mg-phenylephrine 8.5 mg: 1/2 tablet orally every 6 to 8 hours, not to exceed 2 tablets a day.

Tablets, extended-release:
Guaifenesin 600 mg-phenylephrine 10 mg or guaifenesin 600 mg-phenylephrine 25 mg: 1/2 to 1 tablet orally every 12 hours.
Guaifenesin 600 mg-phenylephrine 18 mg or guaifenesin 600 mg-phenylephrine 15 mg: 2 tablets orally every 12 hours.
Guaifenesin 650 mg-phenylephrine 40 mg: 1/2 tablet orally every 12 hours.
Guaifenesin 800 mg-phenylephrine 20 mg: 1/2 tablet orally every 8 hours not to exceed 1.5 tablets a day.
Guaifenesin 900 mg-phenylephrine 30 mg, or guaifenesin 650 mg-phenylephrine 23.75 mg: 1/2 tablet orally every 12 hours not to exceed 2 tablets a day.
Guaifenesin 800 mg-phenylephrine 40 mg, or guaifenesin 315 mg-phenylephrine 15 mg: 1 tablet orally every 12 hours not to exceed 2 tablets a day.
Guaifenesin 800 mg-phenylephrine 30 mg, or guaifenesin 650 mg-phenylephrine 25 mg, or guaifenesin 835 mg-phenylephrine 25 mg, or guaifenesin 835 mg-phenylephrine 30 mg, or guaifenesin 900 mg-phenylephrine 25 mg, or guaifenesin 1000 mg-phenylephrine 30 mg, or guaifenesin 1000 mg-phenylephrine 40 mg, or guaifenesin 1050 mg-phenylephrine 30 mg, or guaifenesin 1100 mg-phenylephrine 30 mg, guaifenesin 1200 mg-phenylephrine 20 mg, or guaifenesin 1200 mg-phenylephrine 30 mg: 1/2 tablet orally every 12 hours not to exceed 1 tablet a day.

12 yrs and older:
Guaifenesin 100 mg-phenylephrine 5 mg/5 mL: 10 mL orally every 4 to 6 hours, up to 4 doses a day.
Guaifenesin 550 mg-phenylephrine 8.5 mg: 1 tablet orally every 6 to 8 hours, not to exceed 4 tablets a day.
Guaifenesin 380 mg-phenylephrine 10 mg: 1 tablet orally every 4 hours, not to exceed 6 tablets a day.
Guaifenesin 200 mg-phenylephrine 5 mg: 2 tablets orally every 4 hours, not to exceed 12 tablets a day.

Tablets, extended-release:
Guaifenesin 800 mg-phenylephrine 20 mg: 1 tablet every 8 hours not to exceed 3 tablets a day.
Guaifenesin 275 mg-phenylephrine 25 mg or guaifenesin 600 mg-phenylephrine 15 mg: 1 tablet orally every 12 hours.
Guaifenesin 600 mg-phenylephrine 10 mg or guaifenesin 600 mg-phenylephrine 25 mg: 1 to 2 tablets orally every 12 hours.
Guaifenesin 600 mg-phenylephrine 18 mg, or guaifenesin 315 mg-phenylephrine 20 mg: 2 tablets orally every 12 hours.
Guaifenesin 600 mg-phenylephrine 40 mg: 1 tablet orally every 12 hours.
Guaifenesin 650 mg-phenylephrine 23.75 mg, or guaifenesin 650 mg-phenylephrine 25 mg, or guaifenesin 800 mg-phenylephrine 30 mg, or guaifenesin 800 mg-phenylephrine 40 mg, or guaifenesin 835 mg-phenylephrine 25 mg, or guaifenesin 835 mg-phenylephrine 30 mg, or guaifenesin 900 mg-phenylephrine 25 mg, or guaifenesin 900 mg-phenylephrine 30 mg, or guaifenesin 1000 mg-phenylephrine 40 mg, or guaifenesin 1050 mg-phenylephrine 30 mg, or guaifenesin 1100 mg-phenylephrine 30 mg, or guaifenesin 1200 mg-phenylephrine 20 mg, or guaifenesin 1200 mg-phenylephrine 25 mg, or guaifenesin 1200 mg-phenylephrine 30 mg, or guaifenesin 1200 mg-phenylephrine 35 mg: 1 tablet orally every 12 hours not to exceed 2 tablets a day.
Guaifenesin 600 mg-phenylephrine 12.5 mg: 1 to 2 tablets orally every 12 hours or 1 tablet every 8 hours not to exceed 4 tablets a day.

Capsules, extended-release:
Guaifenesin 200 mg-phenylephrine 7.5 mg: 1 to 2 capsules orally every 12 hours.
Guaifenesin 300 mg-phenylephrine 10 mg or Guaifenesin 400 mg – phenylephrine 15 mg: 1 capsule orally every 12 hours.
Guaifenesin 375 mg-phenylephrine 20 mg: 1 to 2 capsules orally every 12 hours, up to 3 a day.

What other drugs will affect guaifenesin and phenylephrine?

Ask a doctor or pharmacist if it is safe for you to take guaifenesin and phenylephrine if you are also using any of the following drugs:

medicines to treat high blood pressure;
a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others; or
an antidepressant such as amitriptyline (Elavil, Vanatrip), doxepin (Sinequan), desipramine (Norpramin), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), and others.

This list is not complete and there may be other drugs that can interact with guaifenesin and phenylephrine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about guaifenesin and phenylephrine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Concise,G

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guaifenesin and phenylpropanolamine

30/06/10

Generic Name: guaifenesin and phenylpropanolamine (gwye FEN e sin/fen ill proe pa NOLE a meen)
Brand names: Ami-Tex LA, Banex-LA, Coldloc-LA, Dayquil Sinus Pressure and Congestion, Despec, Entex LA, Exgest LA, G-Vent, Guaifenex PPA 75, Guaivent, Guiatex LA, Naldecon-EX Pediatric, Nasahist LA, Phentex-LA, Phenylfenesin LA, Poly-Vent, Profen LA, Stamoist LA, Triaminic Expectorant, Vanex-LA, …show all 40 brand names.

What is guaifenesin and phenylpropanolamine?

Guaifenesin is an expectorant. It is used to break up congestion and mucous to make breathing easier. Guaifenesin thins mucous, increases lubrication of the respiratory tract (lungs, nose and throat), and increases the removal of mucous.

Phenylpropanolamine is a decongestant. It constricts (shrinks) blood vessels (veins and arteries), which reduces swelling of mucous membranes in areas such as the nose and sinuses.

Guaifenesin and phenylpropanolamine is used to treat the symptoms of the common cold and of infections of the sinuses, lungs, and throat.

Phenylpropanolamine, an ingredient in this product, has been associated with an increased risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food and Drug Administration (FDA) recommends that consumers not use any products that contain phenylpropanolamine.

Guaifenesin and phenylpropanolamine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about guaifenesin and phenylpropanolamine?

Drink plenty of extra fluids while taking this medication. Do not crush or chew the tablets. Swallow them whole or break them in half where they are scored to make them easier to swallow if needed.

Who should not take guaifenesin and phenylpropanolamine?

Do not take guaifenesin and phenylpropanolamine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Before taking this medication, tell your doctor if you have

high blood pressure or any other type of heart disease,
diabetes,
a peripheral vascular disorder (poor circulation),
glaucoma or increased pressure in the eyes,
an overactive thyroid, or
difficulty urinating or an enlarged prostate.

You may not be able to take guaifenesin and phenylpropanolamine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Guaifenesin and phenylpropanolamine is in the FDA pregnancy category C. This means that it is not known whether guaifenesin and phenylpropanolamine will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. This medication passes into breast milk and may harm a nursing baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby. If you are over 65 years of age, you may be more likely to experience side effects from guaifenesin and phenylpropanolamine. You may require a lower dose of this medication. Guaifenesin and phenylpropanolamine has not been approved for use by children younger than 6 years of age.

How should I take guaifenesin and phenylpropanolamine?

Take guaifenesin and phenylpropanolamine exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Increasing fluid intake during the day may help relieve congestion. Take guaifenesin and phenylpropanolamine with food if it causes stomach upset. Do not crush or chew the tablets. Swallow them whole or break them in half where they are scored to make them easier to swallow if needed. Store guaifenesin and phenylpropanolamine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a guaifenesin and phenylpropanolamine overdose include vomiting, high blood pressure (headache, redness of face, blurred vision), an irregular heartbeat, and numbness of the fingers or toes.

What should I avoid while taking guaifenesin and phenylpropanolamine?

Use caution when driving, operating machinery, or performing other hazardous activities. Guaifenesin and phenylpropanolamine may cause dizziness. If you experience dizziness, avoid these activities.

Guaifenesin and phenylpropanolamine side effects

No serious side effects from guaifenesin and phenylpropanolamine are expected. Seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Other, less serious side effects may be more likely to occur. Continue to take guaifenesin and phenylpropanolamine and talk to your doctor if you experience

dizziness or headache;
nervousness, restlessness, or insomnia;
nausea or stomach upset; or
difficulty urinating.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Guaifenesin and phenylpropanolamine Dosing Information

Usual Adult Dose for Cough and Nasal Congestion:

5 mL to 10 mL (100 mg-12.5 mg/5 mL) orally every 4 hours.

-or-

20 mL (50 mg-6.25 mg/5 mL) orally every 4 hours.

-or-

Extended release: 1 tablet (40 mg to 50 mg phenylpropanolamine) orally every 12 hours.

Maximum is 150 mg phenylpropanolamine or 2.4 grams of guaifenesin/day.

Usual Pediatric Dose for Cough and Nasal Congestion:

6 to 12 years:

1 mL (50 mg-6.25mg/mL) orally every 4 hours. (Drops – Note concentration).

-or-

1 mL (30 mg-6.25mg/mL) orally every 4 hours. (Drops – Note concentration).

-or-

5mL (100 mg-6.25mg/5mL) orally every 4 hours.

Maximum is 75 mg phenylpropanolamine or 1.2 grams of guaifenesin/day.

> 12 years:

10 mL (100 mg-6.25 mg/5 mL) orally every 4 hours.

Maximum is 150 mg phenylpropanolamine or 2.4 grams of guaifenesin/day.

What other drugs will affect guaifenesin and phenylpropanolamine?

Heart medications such as methyldopa (Aldomet), reserpine (Serpalan, Serpasil), and guanethidine (Ismelin) may have decreased effects. Talk to your doctor before taking guaifenesin and phenylpropanolamine if you are taking any of these medications.

Do not take other over-the-counter cough, cold, allergy, diet, or sleep aids while taking guaifenesin and phenylpropanolamine without first talking to your doctor or pharmacist. Other medications may also contain guaifenesin, phenylpropanolamine, or other similar drugs. You may accidentally take too much of these medicines.

Drugs other than those listed here may also interact with guaifenesin and phenylpropanolamine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

Your pharmacist has additional information about guaifenesin and phenylpropanolamine written for health professionals that you may read.

What does my medication look like?

Guaifenesin and phenylpropanolamine is available with a prescription under several brand names. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

Entex LA, 400 mg of guaifenesin and 75 mg of phenylpropanolamine–orange, scored tablets
Exgest LA, 400 mg of guaifenesin and 75 mg of phenylpropanolamine–white, oval-shaped, scored, long-acting tablets with blue speckles
Dura-Vent, 600 mg of guaifenesin and 75 mg of phenylpropanolamine–white, scored tablets

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Concise,G

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Guaifed Caps

30/06/10

Generic Name: guaifenesin and phenylephrine (gwye FEN e sin and FEN il EFF rin)
Brand Names: Amitex LA, Crantex, Deconex, Deconsal II, Despec, Duraphen II, Duratuss PE, Genexa LA, Gentex LA, Guaifed Caps, Liquibid-D, Lusonex, Nasex-G, Nescon-PD, Phenavent, Prolex D, Rescon-GG, Robitussin Head & Chest Congestion, Sina-12X, Sinupan, SINUvent PE, Sudafed PE Non-Drying Sinus, Triaminic Chest & Nasal Congestion, Visonex, Wellbid-D, Xedec

What is Guaifed Caps (guaifenesin and phenylephrine)?

Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of guaifenesin and phenylephrine is used to treat stuffy nose and sinus congestion, and to reduce chest congestion caused by the common cold or flu.

Guaifenesin and phenylephrine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Guaifed Caps (guaifenesin and phenylephrine)?

There are many brands and forms of guaifenesin and phenylephrine available and not all brands are listed on this leaflet.

What should I discuss with my healthcare provider before taking Guaifed Caps (guaifenesin and phenylephrine)?

Ask a doctor or pharmacist if it is safe for you to take this medication if you have:

heart disease or high blood pressure;
diabetes;
a thyroid disorder;
circulation problems;
glaucoma;
overactive thyroid; or
enlarged prostate or problems with urination.

How should I take Guaifed Caps (guaifenesin and phenylephrine)?

Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

What happens if I miss a dose?

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include nausea, vomiting, numbness or tingly feeling, dizziness, and feeling restless or nervous.

What should I avoid while taking Guaifed Caps (guaifenesin and phenylephrine)?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Guaifed Caps (guaifenesin and phenylephrine) side effects

fast, pounding, or uneven heartbeat;
severe dizziness, anxiety, restless feeling, or nervousness;
easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;
increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

Less serious side effects may include:

nausea, vomiting, upset stomach, loss of appetite;
warmth, tingling, or redness under your skin;
feeling excited or restless;
sleep problems (insomnia);
skin rash or itching;
headache; or
dizziness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Guaifed Caps (guaifenesin and phenylephrine)?

Ask a doctor or pharmacist if it is safe for you to take guaifenesin and phenylephrine if you are also using any of the following drugs:

medicines to treat high blood pressure;
a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others; or
an antidepressant such as amitriptyline (Elavil, Vanatrip), doxepin (Sinequan), desipramine (Norpramin), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), and others.

Where can I get more information?

Your pharmacist can provide more information about guaifenesin and phenylephrine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Concise,G

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Guaifen DM

30/06/10

Generic Name: dextromethorphan and guaifenesin (DEX troe me THOR fan and gwye FEN e sin)
Brand Names: Allfen DM, Altarussin DM, Aquatab DM, Benylin Expectorant, Drituss DM, Extuss LA, Fenesin DM IR, Glycotuss-DM, Guaifen DM, Mucinex Children’s Cough, Mucinex DM, MucusRelief DM, Naldecon DX Liquigel, Relacon LAX, Respa-DM, Robitussin Cough & Congestion, Tussi-Bid, Tussi-Organidin DM NR, Vicks 44E

What is Guaifen DM (dextromethorphan and guaifenesin)?

Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.

The combination of dextromethorphan and guaifenesin is used to treat cough and chest congestion caused by the common cold, infections, or allergies.

Dextromethorphan will not treat a cough that is caused by smoking, asthma, or emphysema.

Dextromethorphan and guaifenesin may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Guaifen DM (dextromethorphan and guaifenesin)?

Do not give this medication to a child younger than 2 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body. Do not use any other over-the-counter cough or cold medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains dextromethorphan or guaifenesin. Dextromethorphan will not treat a cough that is caused by smoking, asthma, or emphysema.

What should I discuss with my healthcare provider before taking Guaifen DM (dextromethorphan and guaifenesin)?

Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body.

Ask a doctor or pharmacist if it is safe for you to take this medication if you have emphysema or chronic bronchitis.

FDA pregnancy category C. It is not known whether dextromethorphan and guaifenesin is harmful to an unborn baby. Before you take this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether this medication passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Guaifen DM (dextromethorphan and guaifenesin)?

Use this medication exactly as directed on the label, or as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Cold medicine is usually taken only for a short time until your symptoms clear up.

Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Do not crush, chew, or break an extended-release tablet. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking the pill would cause too much of the drug to be released at one time.

Dextromethorphan and guaifenesin granules should be sprinkled directly onto the tongue and swallowed right away.

Drink extra fluids to help loosen the congestion and lubricate your throat while you are taking this medication. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

If you need to have any type of surgery, tell the surgeon ahead of time if you have taken a cold medicine within the past few days.

Store this medicine at room temperature, away from heat, light, and moisture.

What happens if I miss a dose?

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include feeling restless or nervous.

What should I avoid while taking Guaifen DM (dextromethorphan and guaifenesin)?

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor’s advice. Taking a stimulant together with cough or cold medicine can increase your risk of unpleasant side effects.

Do not use any other over-the-counter cough or cold medication without first asking your doctor or pharmacist. Dextromethorphan and guaifenesin are contained in many medicines available over the counter. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains dextromethorphan or guaifenesin.

Guaifen DM (dextromethorphan and guaifenesin) side effects

severe dizziness, anxiety, restless feeling, or nervousness;
confusion, hallucinations; or
slow, shallow breathing.

Less serious side effects may include:

dizziness;
headache;
skin rash or itching; or
nausea, vomiting, or stomach upset.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Guaifen DM (dextromethorphan and guaifenesin)?

Before taking this medication, tell your doctor if you are using any of the following drugs:

celecoxib (Celebrex);
cinacalcet (Sensipar);
darifenacin (Enablex);
imatinib (Gleevec);
quinidine (Quinaglute, Quinidex);
ranolazine (Ranexa);
ritonavir (Norvir);
sibutramine (Meridia);
terbinafine (Lamisil);
medicines to treat high blood pressure; or
an antidepressant such as amitriptyline (Elavil, Etrafon), bupropion (Wellbutrin, Zyban), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), imipramine (Janimine, Tofranil), paroxetine (Paxil), sertraline (Zoloft), and others.

This list is not complete and there may be other drugs that can interact with dextromethorphan and guaifenesin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about dextromethorphan and guaifenesin.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Concise,G

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Guaifen-C

30/06/10

What is Guaifen-C (codeine and guaifenesin)?

Codeine is in a group of drugs called narcotics. It is a cough suppressant that affects the signals in the brain that trigger cough reflex.

Guaifenesin is an expectorant. It helps loosen mucus congestion in your chest and throat, making it easier to cough out through your mouth.

The combination of codeine and guaifenesin is used to treat cough and to reduce chest congestion caused by upper respiratory infections or the common cold.

Codeine and guaifenesin will not treat a cough that is caused by smoking, asthma, or emphysema.

Codeine and guaifenesin may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Guaifen-C (codeine and guaifenesin)?

What should I discuss with my healthcare provider before taking Guaifen-C (codeine and guaifenesin)?

You should not take this medication if you are allergic to codeine or guaifenesin.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take codeine and guaifenesin:

heart disease, heart rhythm disorder;
asthma, COPD, emphysema, or other breathing disorders;
a history of head injury or brain tumor;
epilepsy or other seizure disorder;
a stomach or intestinal disorder;
Addison’s disease or other adrenal gland disorders;
curvature of the spine;
a thyroid disorder;
liver or kidney disease;
enlarged prostate; or
a history of depression, mental illness, or drug addiction;

How should I take Guaifen-C (codeine and guaifenesin)?

Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Call your doctor if your symptoms do not improve after 7 days of treatment, or if you also have a fever, headache, or skin rash.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using codeine and guaifenesin.

What happens if I miss a dose?

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of codeine can be fatal.

What should I avoid while taking Guaifen-C (codeine and guaifenesin)?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid drinking alcohol. It can increase some of the side effects of this medication.

Guaifen-C (codeine and guaifenesin) side effects

severe dizziness or drowsiness;
confusion, hallucinations, unusual thoughts or behavior;
urinating less than usual or not at all; or
slow heart rate, weak pulse, fainting, weak or shallow breathing.

Less serious side effects include:

dizziness, drowsiness, headache;
warmth, redness, or tingling under your skin;
nausea, vomiting, upset stomach;
constipation; or
skin rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Guaifen-C (codeine and guaifenesin)?

Also tell your doctor if you are using any of the following drugs:

cimetidine (Tagamet);
quinidine (Quinaglute, Quinidex, Quin-Release);
naloxone (Narcan); or
naltrexone (Vivitrol).

Where can I get more information?

Your pharmacist can provide more information about codeine and guaifenesin.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Concise,G

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guaifenesin (Oral route)

30/06/10

gwye-FEN-e-sin

Commonly used brand name(s):

In the U.S.

Allfen
Altarussin
Amibid LA
Antitussin
Bidex 400
Diabetic Siltussin DAS-Na
Diabetic Tussin EX
Drituss G
Guaifenex G
Guaifenex LA
Mucinex
Robitussin

In Canada

Benylin-E
Benylin E Extra Strength Chest Congestion
Broncho-Grippex Expectorant
Robitussin Extra Strength

Available Dosage Forms:

Tablet, Extended Release
Solution
Capsule, Extended Release
Packet
Liquid
Tablet
Capsule
Elixir
Syrup

Therapeutic Class: Expectorant

Uses For guaifenesin

Guaifenesin is used to help clear mucus or phlegm (pronounced flem) from the chest when you have congestion from a cold or flu. It works by thinning the mucus or phlegm in the lungs.

guaifenesin is available both over-the-counter (OTC) and with your doctor’s prescription.

Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years of age. Using these medicines in very young children might cause serious or possibly life-threatening side effects .

Before Using guaifenesin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For guaifenesin, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to guaifenesin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no specific information comparing use of guaifenesin in children with use in other age groups, guaifenesin is not expected to cause different side effects or problems in children than it does in adults. However, check with your doctor before using guaifenesin in children who have a chronic cough, such as occurs with asthma, or who have an unusually large amount of mucus or phlegm with the cough. Children with these conditions may need a different kind of medicine. Also, guaifenesin should not be given to children and infants younger than 2 years of age unless you are directed to do so by your doctor.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of guaifenesin in the elderly with use in other age groups, guaifenesin is not expected to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of guaifenesin

Drinking plenty of water while taking guaifenesin may help loosen mucus or phlegm in the lungs.

For patients taking the extended-release capsule form of guaifenesin:

Swallow the capsule whole, or open the capsule and sprinkle the contents on soft food such as applesauce, jelly, or pudding and swallow without crushing or chewing.

For patients taking the extended-release tablet form of guaifenesin:

If the tablet has a groove in it, you may carefully break it into two pieces along the groove. Then swallow the pieces whole, without crushing or chewing them.
If the tablet does not have a groove, it must be swallowed whole. Do not break, crush, or chew it before swallowing.

Dosing

The dose of guaifenesin will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of guaifenesin. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For regular (short-acting) oral dosage forms (capsules, oral solution, syrup, or tablets):
- For cough:
  - Adults—200 to 400 milligrams (mg) every four hours.
  - Children 6 to 12 years of age—100 to 200 mg every four hours.
  - Children 4 to 6 years of age—50 to 100 mg every four hours.
  - Children and infants up to 4 years of age—Use is not recommended .
For long-acting oral dosage forms (extended-release capsules or tablets):
- For cough:
  - Adults—600 to 1200 mg every twelve hours.
  - Children 6 to 12 years of age—600 mg every twelve hours.
  - Children 4 to 6 years of age—300 mg every twelve hours.
  - Children and infants up to 4 years of age—Use is not recommended .

Missed Dose

If you miss a dose of guaifenesin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using guaifenesin

If your cough has not improved after 7 days or if you have a fever, skin rash, continuing headache, or sore throat with the cough, check with your doctor. These signs may mean that you have other medical problems.

guaifenesin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

Diarrhea
dizziness
headache
hives
nausea or vomiting
skin rash
stomach pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided “AS IS” and “as available” for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

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Guaifenesin Immediate-Release Capsules

30/06/10

Generic Name: Guaifenesin (gwye-FEN-eh-sin)
Brand Name: Examples include Hytuss and Organidin NR

Guaifenesin Immediate-Release Capsules are used for:

Relieving symptoms of an unproductive cough and mucus in the chest due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Guaifenesin Immediate-Release Capsules are an expectorant. It works by thinning mucus (phlegm) in the lungs and making it less sticky and easier to cough up. This reduces chest congestion by making coughs more productive.

Do NOT use Guaifenesin Immediate-Release Capsules if:

you are allergic to any ingredient in Guaifenesin Immediate-Release Capsules

Contact your doctor or health care provider right away if any of these apply to you.

Before using Guaifenesin Immediate-Release Capsules:

Some medical conditions may interact with Guaifenesin Immediate-Release Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have a chronic cough that occurs with smoking, asthma, chronic bronchitis, or emphysema, or if your cough occurs with large amounts of mucus

Some MEDICINES MAY INTERACT with Guaifenesin Immediate-Release Capsules. Tell your health care provider if you are taking any other medicines. However, no specific interactions with Guaifenesin Immediate-Release Capsules are known at this time.

Ask your health care provider if Guaifenesin Immediate-Release Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Guaifenesin Immediate-Release Capsules:

Use Guaifenesin Immediate-Release Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Guaifenesin Immediate-Release Capsules by mouth with or without food.
Drinking extra fluids while you are taking Guaifenesin Immediate-Release Capsules are recommended. Check with your doctor for instructions.
If you miss a dose of Guaifenesin Immediate-Release Capsules and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Guaifenesin Immediate-Release Capsules.

Important safety information:

If cough persists for more than 1 week or is accompanied by a fever, contact your health care provider. A persistent cough could be a sign of a serious condition.
Some of these products contain phenylalanine. If you must have a diet that is low in phenylalanine, ask your pharmacist if it is in your product.
Different brands of Guaifenesin Immediate-Release Capsules may have different dosing instructions for CHILDREN. Follow the dosing instructions on the package labeling. If your doctor has given you instructions, follow those. If you are unsure of the dose to give a child, check with your doctor or pharmacist.
PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Guaifenesin Immediate-Release Capsules while you are pregnant. It is not known if Guaifenesin Immediate-Release Capsules are found in breast milk. If you are or will be breast-feeding while you are using Guaifenesin Immediate-Release Capsules, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Guaifenesin Immediate-Release Capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Guaifenesin Immediate-Release Capsules:

Store Guaifenesin Immediate-Release Capsules at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Guaifenesin Immediate-Release Capsules out of the reach of children and away from pets.

General information:

If you have any questions about Guaifenesin Immediate-Release Capsules, please talk with your doctor, pharmacist, or other health care provider.
Guaifenesin Immediate-Release Capsules are to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Guaifenesin Immediate-Release Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: May 5, 2010

Database Edition 10.2.1.002

G,Med-facts

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30/06/10

Guaifenesin Granules are used for:

Do NOT use Guaifenesin Granules if:

Before using Guaifenesin Granules:

How to use Guaifenesin Granules:

Important safety information:

Possible side effects of Guaifenesin Granules:

If OVERDOSE is suspected:

General information:

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What is Guaifed Caps (guaifenesin and phenylephrine)?

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30/06/10

What is Guaifen DM (dextromethorphan and guaifenesin)?

What is the most important information I should know about Guaifen DM (dextromethorphan and guaifenesin)?

What should I discuss with my healthcare provider before taking Guaifen DM (dextromethorphan and guaifenesin)?

How should I take Guaifen DM (dextromethorphan and guaifenesin)?

What happens if I miss a dose?

What happens if I overdose?

What should I avoid while taking Guaifen DM (dextromethorphan and guaifenesin)?

Guaifen DM (dextromethorphan and guaifenesin) side effects