Generic Name: insulin isophane and insulin regular (IN su lin EYE soe fane and IN su lin REG ue lar)
Brand Names: Humulin 50/50, Humulin 70/30, Humulin 70/30 Pen, Novolin 70/30, Novolin 70/30 Innolet, Novolin 70/30 PenFill, Relion Novolin 70/30 Innolet, ReliOn/Novolin 70/30

What is Humulin 50/50 (insulin isophane and insulin regular)?

Insulin isophane and insulin regular is a man-made form of a hormone that is produced in the body. It works by lowering levels of glucose (sugar) in the blood. Insulin isophane and insulin regular is a long-acting form of insulin that is slightly different from other forms of insulin that are not man-made.

Insulin isophane and insulin regular is used to treat diabetes.

Insulin isophane and insulin regular may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Humulin 50/50 (insulin isophane and insulin regular)?

Take care to keep your blood sugar from getting too low, causing hypoglycemia. Symptoms of low blood sugar may include headache, nausea, hunger, confusion, drowsiness, weakness, dizziness, blurred vision, fast heartbeat, sweating, tremor, or trouble concentrating. Carry a piece of non-dietetic hard candy or glucose tablets with you in case you have low blood sugar. Also be sure your family and close friends know how to help you in an emergency.

Also watch for signs of blood sugar that is too high (hyperglycemia). These symptoms include increased thirst, loss of appetite, increased urination, nausea, vomiting, drowsiness, dry skin, and dry mouth. Check your blood sugar levels and ask your doctor how to adjust your insulin doses if needed.

Never share an injection pen or cartridge with another person. Sharing injection pens or cartridges can allow disease such as hepatitis or HIV to pass from one person to another.

Insulin isophane and insulin regular is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

What should I discuss with my healthcare provider before using Humulin 50/50 (insulin isophane and insulin regular)?

Do not use this medication if you are allergic to insulin, or if you are having an episode of hypoglycemia (low blood sugar).

Before using insulin isophane and insulin regular, tell your doctor if you have liver or kidney disease.

Tell your doctor about all other medications you use, including any oral (by mouth) diabetes medications.

Insulin isophane and insulin regular is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

Your doctor will need to check your progress on a regular basis. Do not miss any scheduled appointments.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether insulin isophane and insulin regular passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use Humulin 50/50 (insulin isophane and insulin regular)?

Use this medication exactly as it was prescribed for you. Do not use it in larger amounts or for longer than recommended by your doctor. Follow the directions on your prescription label.

Insulin isophane and insulin regular is given as an injection (shot) under your skin. Your doctor, nurse, or pharmacist will give you specific instructions on how and where to inject this medicine. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

Choose a different place in your injection skin area each time you use this medication. Do not inject into the same place two times in a row.

Carefully shake or rotate the insulin vial (bottle) several times to thoroughly mix the insulin isophane and insulin regular before each use. Shake the mixture until it looks cloudy or milky. Do not use the mixture if has clumps or white particles in it after mixing, or if the white substance remains at the bottom of the vial. Call your doctor for a new prescription.

Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Some insulin needles can be used more than once, depending on needle brand and type. But a reused needle must be properly cleaned, recapped, and inspected for bending or breakage. Reusing needles also increases your risk of infection. Ask your doctor or pharmacist whether you are able to reuse your insulin needles.

Never share an injection pen or cartridge with another person. Sharing injection pens or cartridges can allow disease such as hepatitis or HIV to pass from one person to another.

Check your blood sugar carefully during a time of stress or illness, if you travel, exercise more than usual, or skip meals. These things can affect your glucose levels and your insulin dose needs may also change.

Watch for signs of blood sugar that is too high (hyperglycemia). These symptoms include increased thirst, loss of appetite, increased urination, nausea, vomiting, drowsiness, dry skin, and dry mouth. Check your blood sugar levels and ask your doctor how to adjust your insulin doses if needed.

Ask your doctor how to adjust your insulin isophane and insulin regular dose if needed. Do not change your dose without first talking to your doctor. Carry an ID card or wear a medical alert bracelet stating that you have diabetes, in case of emergency. Any doctor, dentist, or emergency medical care provider who treats you should know that you are diabetic. Storing unopened vials or injection pens: Keep in the carton and store in a refrigerator. Do not freeze. Throw away any insulin not used before the expiration date on the medicine label. Storing after your first use: Keep the “in-use” vials or injection pens at cool room temperature, away from heat and light, and use prior to the expiration date. Throw an in-use injection pen 10 days after the first use, even if there is still medicine left in it.

Do not freeze insulin isophane and insulin regular, and throw away the medication if it has become frozen.

What happens if I miss a dose?

Since insulin isophane and insulin regular is used before meals or snacks, you may not be on a timed dosing schedule. Whenever you use insulin isophane and insulin regular, be sure to eat a meal or snack within 30 to 60 minutes. Do not use extra insulin isophane and insulin regular to make up a missed dose.

It is important to keep insulin isophane and insulin regular on hand at all times. Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An insulin overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, seizure (convulsions), or coma.

What should I avoid while using Humulin 50/50 (insulin isophane and insulin regular)?

Do not change the brand of insulin isophane and insulin regular or syringe you are using without first talking to your doctor or pharmacist. Avoid drinking alcohol. Your blood sugar may become dangerously low if you drink alcohol while using insulin isophane and insulin regular.

Humulin 50/50 (insulin isophane and insulin regular) side effects

Get emergency medical help if you have any of these signs of insulin allergy: itching skin rash over the entire body, wheezing, trouble breathing, fast heart rate, sweating, or feeling like you might pass out.

Hypoglycemia, or low blood sugar, is the most common side effect of insulin isophane and insulin regular. Symptoms of low blood sugar may include headache, nausea, hunger, confusion, drowsiness, weakness, dizziness, blurred vision, fast heartbeat, sweating, tremor, trouble concentrating, confusion, or seizure (convulsions). Watch for signs of low blood sugar. Carry a piece of non-dietetic hard candy or glucose tablets with you in case you have low blood sugar.

Tell your doctor if you have itching, swelling, redness, or thickening of the skin where you inject insulin isophane and insulin regular.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Humulin 50/50 (insulin isophane and insulin regular)?

Using certain medicines can make it harder for you to tell when you have low blood sugar. Tell your doctor if you use any of the following:

• albuterol (Proventil, Ventolin);

• clonidine (Catapres);

• reserpine;

• guanethidine (Ismelin); or

• beta-blockers such as atenolol (Tenormin), bisoprolol (Zebeta), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), timolol (Blocadren), and others.

There are many other medicines that can increase or decrease the effects of insulin isophane and insulin regular on lowering your blood sugar. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about insulin isophane and insulin regular.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 5.01. Revision Date: 04/24/2009 11:45:38 AM.

Humulin 50/

50 Vials

Generic Name: Insulin Isophane (NPH)/Insulin Regular (IN-su-lin)
Brand Name: Examples include Humulin 50/50 and Novolin 70/30

Humulin 50/50 Vials are used for:

Treating diabetes mellitus.

Humulin 50/50 Vials are a combination of an intermediate-acting and a fast-acting form of the hormone insulin. It works by helping your body to use sugar properly. This lowers the amount of glucose in the blood, which helps to treat diabetes.

Do NOT use Humulin 50/50 Vials if:

• you are allergic to any ingredient in Humulin 50/50 Vials
• you are having an episode of low blood sugar

Contact your doctor or health care provider right away if any of these apply to you.

Before using Humulin 50/50 Vials:

Some medical conditions may interact with Humulin 50/50 Vials. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you drink alcoholic beverages or smoke
• if you have kidney or liver problems; nerve problems; adrenal, pituitary, or thyroid problems; or diabetic ketoacidosis
• if you use 3 or more insulin injections per day
• if you are fasting, have high blood sodium levels, or are on a low-salt diet

Some MEDICINES MAY INTERACT with Humulin 50/50 Vials. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Beta-blockers (eg, propranolol), clonidine, guanethidine, lithium, or reserpine because they may increase the risk of high or low blood sugar or may hide the signs and symptoms of low blood sugar, if it occurs
• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), disopyramide, fenfluramine, fibrates (eg, clofibrate, gemfibrozil), fluoxetine, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), oral medicines for diabetes (eg, glipizide, metformin, nateglinide), pentamidine, propoxyphene, salicylates (eg, aspirin), somatostatin analogs (eg, octreotide), or sulfonamide antibiotics (eg, sulfamethoxazole) because the risk of low blood sugar may be increased
• Corticosteroids (eg, prednisone), danazol, diuretics (eg, furosemide, hydrochlorothiazide), estrogen, hormonal contraceptives (eg, birth control pills), isoniazid, niacin, phenothiazines (eg, chlorpromazine), progesterones (eg, medroxyprogesterone), somatropin, sympathomimetics (eg, albuterol, epinephrine, terbutaline), or thyroid hormones (eg, levothyroxine) because they may decrease Humulin 50/50 Vials’s effectiveness, resulting in high blood sugar

This may not be a complete list of all interactions that may occur. Ask your health care provider if Humulin 50/50 Vials may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Humulin 50/50 Vials:

Use Humulin 50/50 Vials as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Humulin 50/50 Vials. Talk to your pharmacist if you have questions about this information.
• Use Humulin 50/50 Vials within 30 to 60 minutes before a meal, as directed by your doctor.
• If you will be using Humulin 50/50 Vials at home, a health care provider will teach you how to use it. Be sure you understand how to use Humulin 50/50 Vials. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
• Carefully rotate the vial as directed before each injection. This will ensure that the contents are evenly mixed. This combination insulin should look uniformly cloudy or milky.
• Do not use Humulin 50/50 Vials if it contains particles or clumps, is discolored, or if the vial is cracked or damaged.
• Do NOT dilute Humulin 50/50 Vials or mix it with other insulin. Do NOT use Humulin 50/50 Vials in an insulin pump.
• Use the proper technique taught to you by your doctor. Inject deep under the skin, NOT into a vein or muscle.
• Injection sites within an injection area (abdomen, thigh, upper arm) must be rotated from one injection to the next.
• Be sure you have purchased the correct insulin. Insulin comes in a variety of containers, including vials, cartridges, and pens. Make sure that you understand how to properly measure and prepare your dose. If you have any questions about measuring and preparing your dose, contact your doctor or pharmacist for information.
• Humulin 50/50 Vials begins lowering blood sugar within 30 to 60 minutes after an injection. The effect may last for up to 24 hours.
• Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
• It is very important to follow your insulin regimen exactly. Do NOT miss any doses. Ask your doctor for specific instructions to follow in case you ever miss a dose of insulin.

Ask your health care provider any questions you may have about how to use Humulin 50/50 Vials.

Important safety information:

• Drowsiness, dizziness, lightheadedness, or blurred vision may occur while you use Humulin 50/50 Vials. These effects may be worse if you take it with alcohol or certain medicines. Use Humulin 50/50 Vials with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do not drink alcohol without discussing it with your doctor. Drinking alcohol may increase the risk of developing high or low blood sugar.
• Do NOT take more than the recommended dose, use Humulin 50/50 Vials more often than prescribed, or change the type or dose of insulin you are using without checking with your doctor.
• Any change of insulin should be made cautiously and only under medical supervision. Changes in purity, strength, brand (manufacturer), type (regular, NPH, lente), species (beef, pork, beef-pork, human), and/or method of manufacture may require a change in dose.
• Illness, especially with nausea and vomiting, may cause your insulin requirements to change. Even if you are not eating, you still require insulin. You and your doctor should establish a sick day plan to use in case of illness. When you are sick, test your blood/urine frequently and call your doctor as instructed.
• Tell your doctor or dentist that you take Humulin 50/50 Vials before you receive any medical or dental care, emergency care, or surgery.
• If you will be traveling across time zones, consult your doctor concerning adjustments in your insulin schedule.
• Carry an ID card at all times that says you have diabetes.
• An insulin reaction resulting from low blood sugar levels (hypoglycemia) may occur if you take too much insulin, skip a meal, or exercise too much. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you more hungry. It is a good idea to carry a reliable source of glucose (eg, tablets or gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.
• Developing a fever or infection, eating significantly more than prescribed, or missing your dose of insulin may cause high blood sugar (hyperglycemia). High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell you doctor right away.
• Check with your doctor if you notice a depression in the skin or skin thickening at the injection site. You may need to change your injection technique.
• Proper diet, regular exercise, and regular testing of blood sugar are important for best results when using Humulin 50/50 Vials.
• Lab tests, including fasting blood glucose levels and hemoglobin A_1c, may be performed while you use Humulin 50/50 Vials. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Humulin 50/50 Vials with caution in the ELDERLY; if low blood sugar occurs, it may be more difficult to recognize in these patients.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Humulin 50/50 Vials while you are pregnant. It is not known if Humulin 50/50 Vials are found in breast milk. If you are or will be breast-feeding while you use Humulin 50/50 Vials, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Humulin 50/50 Vials:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Redness, swelling, itching, or mild pain at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; wheezing; muscle pain); changes in vision; chills; confusion; dizziness; drowsiness; fainting; fast or irregular heartbeat; headache; loss of consciousness; mood changes; seizures; slurred speech; swelling; tremor; trouble breathing; trouble concentrating; unusual hunger; unusual sweating; weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org) or emergency room immediately. Symptoms may include chills; dizziness; drowsiness; fainting; fast or irregular heartbeat; headache; loss of consciousness; nervousness; seizures; shakiness; sweating; tremor; vision changes; weakness.

Proper storage of Humulin 50/50 Vials:

Store new (unopened) vials in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Store used (open) vials in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). If refrigeration is not possible, store at room temperature, below 86 degrees F (30 degrees C). Store away from heat and light. If Humulin 50/50 Vials has been frozen or overheated, throw it away. Throw away unrefrigerated or opened vials after 28 days, even if they still contain medicine.

Do not leave Humulin 50/50 Vials in a car on a warm or sunny day. Do not use Humulin 50/50 Vials after the expiration date stamped on the label. Keep Humulin 50/50 Vials, as well as syringes and needles, out of the reach of children and away from pets.

General information:

• If you have any questions about Humulin 50/50 Vials, please talk with your doctor, pharmacist, or other health care provider.
• Humulin 50/50 Vials are to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Humulin 50/50 Vials. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Dextromethorphan/Guaifenesin (DEX-troe-meth-OR-fan/gwye-FEN-e-sin)
Brand Name: Examples include Coricidin HBP Congestion/Cough and Humibid CS

Humibid CS is used for:

Temporarily relieving cough due to the common cold, upper respiratory tract infections, sinus inflammation, sore throat, or bronchitis.

Humibid CS is a combination of an expectorant (guaifenesin) and a cough suppressant (dextromethorphan). It works by loosening mucus and lung secretions in the chest and making coughs more productive.

Do NOT use Humibid CS if:

• you are allergic to any ingredient in Humibid CS
• you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days
• you are taking a selective serotonin reuptake inhibitor (SSRI) (eg, fluoxetine)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Humibid CS:

Some medical conditions may interact with Humibid CS. Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of chronic cough, lung problems (eg, chronic bronchitis, emphysema), asthma, chronic obstructive pulmonary disease (COPD), or if your cough occurs with large amounts of mucus

Some MEDICINES MAY INTERACT with Humibid CS. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Furazolidone, MAOIs (eg, phenelzine), or SSRIs (eg, fluoxetine) because the risk of toxic side effects may be increased by Humibid CS

This may not be a complete list of all interactions that may occur. Ask your health care provider if Humibid CS may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Humibid CS:

Use Humibid CS as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Humibid CS by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
• To help Humibid CS work, drink plenty of extra fluids while taking Humibid CS, unless your health care provider instructed otherwise.
• If you miss a dose of Humibid CS and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Ask your health care provider any questions you may have about how to use Humibid CS.

Important safety information:

• Humibid CS may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Humibid CS with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• If your cough lasts for more than 1 week or comes back, or if you also have a fever, rash, or persistent headache, contact your health care provider. A persistent cough could be a sign of a serious condition.
• Humibid CS has dextromethorphan in it. Before you start any new medicine, check the label to see if it has dextromethorphan in it too. If it does or if you are not sure, check with your doctor or pharmacist.
• Humibid CS should not be used in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Humibid CS while you are pregnant. It is not known if Humibid CS is found in breast milk. Do not breast-feed while taking Humibid CS.

Possible side effects of Humibid CS:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; stomach upset.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include confusion; excitement; hallucinations; slowed breathing.

Proper storage of Humibid CS:

Store Humibid CS at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Humibid CS out of the reach of children and away from pets.

General information:

• If you have any questions about Humibid CS, please talk with your doctor, pharmacist, or other health care provider.
• Humibid CS is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Humibid CS. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Dextromethorphan/Guaifenesin/Potassium Guaiacolsulfonate (dex-troe-meth-OR-fan/gwye-FEN-eh-sin/poe-TASS-ee-um gwye-a-kole-SUL-foe-nate)
Brand Name: Humibid DM

Humibid DM Sustained-Release Capsules are used for:

Relieving symptoms of cough and mucus in the chest due to respiratory infections, asthma, colds, or hay fever. It may also be used for other conditions as determined by your doctor.

Humibid DM Sustained-Release Capsules are a combination of a cough suppressant and 2 expectorants. The cough suppressant works in the brain to reduce the cough reflex. The expectorants loosen mucus and lung secretions in the chest and make coughs more productive.

Do NOT use Humibid DM Sustained-Release Capsules if:

• you are allergic to any ingredient in Humibid DM Sustained-Release Capsules
• you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Humibid DM Sustained-Release Capsules:

Some medical conditions may interact with Humibid DM Sustained-Release Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of a chronic cough that occurs with smoking, asthma, chronic bronchitis, or emphysema, or if cough occurs with large amounts of mucus

Some MEDICINES MAY INTERACT with Humibid DM Sustained-Release Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Furazolidone or MAO inhibitors (eg, phenelzine) because the risk of serious side effects such as low blood pressure, fever, severe muscle problems, and possibly death may be increased by Humibid DM Sustained-Release Capsules

This may not be a complete list of all interactions that may occur. Ask your health care provider if Humibid DM Sustained-Release Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Humibid DM Sustained-Release Capsules:

Use Humibid DM Sustained-Release Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Humibid DM Sustained-Release Capsules may be taken with or without food.
• Drinking extra fluids while you are taking Humibid DM Sustained-Release Capsules are recommended. Check with your doctor for instructions.
• Swallow Humibid DM Sustained-Release Capsules whole. Do not break, crush, or chew before swallowing.
• If you miss a dose of Humibid DM Sustained-Release Capsules and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Humibid DM Sustained-Release Capsules.

Important safety information:

• Humibid DM Sustained-Release Capsules may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Humibid DM Sustained-Release Capsules. Using Humibid DM Sustained-Release Capsules alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
• If cough persists for more than 1 week or is accompanied by a fever, contact your health care provider. A persistent cough could be a sign of a serious condition.
• Humibid DM Sustained-Release Capsules contains dextromethorphan. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains dextromethorphan. If it does or if you are uncertain, contact your doctor or pharmacist.
• Humibid DM Sustained-Release Capsules may interfere with some lab tests. Make sure your doctor and lab personnel know you are taking Humibid DM Sustained-Release Capsules.
• Use Humibid DM Sustained-Release Capsules with caution in the ELDERLY because they may be more sensitive to its effects.
• Use Humibid DM Sustained-Release Capsules with extreme caution in CHILDREN younger than 12 years of age. Safety and effectiveness in this age group have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Humibid DM Sustained-Release Capsules during pregnancy. It is unknown if Humibid DM Sustained-Release Capsules are excreted in breast milk. If you are or will be breast-feeding while you are using Humibid DM Sustained-Release Capsules, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Humibid DM Sustained-Release Capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; headache; nausea; upset stomach; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); lower back or side pain.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Humibid DM Sustained-Release Capsules:

Store Humibid DM Sustained-Release Capsules at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Humibid DM Sustained-Release Capsules out of the reach of children and away from pets.

General information:

• If you have any questions about Humibid DM Sustained-Release Capsules, please talk with your doctor, pharmacist, or other health care provider.
• Humibid DM Sustained-Release Capsules are to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Humibid DM Sustained-Release Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Guaifenesin/Potassium Guaiacolsulfonate (gwye-FEN-eh-sin/poe-TASS-ee-um gwye-a-kole-SUL-foe-nate)
Brand Name: Allfen and Humibid LA

Humibid LA is used for:

Relieving symptoms of cough and mucus in the chest due to respiratory infections, asthma, colds, or hay fever. It may also be used for other conditions as determined by your doctor.

Humibid LA is a combination of 2 expectorants. It works by thinning mucus (phlegm) in the lungs and making it less sticky and easier to cough up. This reduces chest congestion by making coughs more productive.

Do NOT use Humibid LA if:

• you are allergic to any ingredient in Humibid LA

Contact your doctor or health care provider right away if any of these apply to you.

Before using Humibid LA:

Some medical conditions may interact with Humibid LA. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a chronic cough that occurs with smoking, asthma, chronic bronchitis, or emphysema, or if cough occurs with large amounts of mucus

Some MEDICINES MAY INTERACT with Humibid LA. Tell your health care provider if you are taking any other medicines. However, no specific interactions with Humibid LA are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Humibid LA may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Humibid LA:

Use Humibid LA as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Humibid LA may be taken with or without food.
• Drinking extra fluids while you are taking Humibid LA is recommended. Check with your doctor for instructions.
• Swallow Humibid LA whole. Do not break, crush, or chew before swallowing.
• If you miss a dose of Humibid LA and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Humibid LA.

Important safety information:

• Humibid LA may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Humibid LA. Using Humibid LA alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
• If cough persists for more than 1 week or is accompanied by a fever, contact your health care provider. A persistent cough could be a sign of a serious condition.
• Humibid LA may interfere with some lab tests. Make sure your doctor and lab personnel know you are taking Humibid LA.
• Use Humibid LA with extreme caution in CHILDREN younger than 12 years of age. Safety and effectiveness in this age group have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Humibid LA during pregnancy. It is unknown if Humibid LA is excreted in breast milk. If you are or will be breast-feeding while you are using Humibid LA, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Humibid LA:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; headache; nausea; upset stomach; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); lower back or side pain.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Humibid LA:

Store Humibid LA at room temperature between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Humibid LA out of the reach of children and away from pets.

General information:

• If you have any questions about Humibid LA, please talk with your doctor, pharmacist, or other health care provider.
• Humibid LA is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Humibid LA. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic name: Adalimumab
Brand names: Humira

Why is Humira prescribed?

Humira is a medicine that is used in people with moderate-to-severe rheumatoid arthritis (RA) or with psoriatic arthritis (PsA). RA is an inflammatory disease of the joints, and PsA is an inflammatory disease of the joints and skin.

Most important fact about Humira

There is a risk of tuberculosis infection or fungal infection with the use of Humira. You should be tested and, if positive, treated for tuberculosis before beginning treatment with Humira.

How should you take Humira?

Your doctor will administer your first injection of Humira in your front thigh or abdomen. If you would like to self-administer, or have a caregiver administer your injection, have the doctor explain the proper injection and discarding technique.

• If you miss a dose…
  If you forget to take Humira when you are supposed to, inject the next dose right away. Then, take your next dose when your next scheduled dose is due.

• Storage instructions…
  Store in a refrigerator, away from light. Do not freeze Humira.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Humira.

• Side effects may include:
  Reaction at site of injection (bruising, itching, rash, redness, swelling)

Usually, the rash will go away within a few days. If the skin around the area where you injected Humira still hurts or is swollen, try using a towel soaked with cold water on the injection site. If you have pain, redness or swelling around the injection site that doesn’t go away within a few days or gets worse, call your doctor right away.

Why should Humira not be prescribed?

Do not begin treatment with Humira if you have an allergy to any of its ingredients. The needle cover on the prefilled syringe contains dry natural rubber, so tell your doctor if you have any allergies to rubber or latex.

Special warnings about Humira

Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Humira.

Also, talk to your doctor about your complete medical history, especially if you have a history of infection (including an open cut or sore), or an infection that is in your whole body (such as the flu); if you have ever had tuberculosis or have been in close contact with someone who has had it; or if you experience any numbness or tingling or have ever had a disease that affects your nervous system, such as multiple sclerosis.

Tell your doctor if you are scheduled to have surgery or a vaccination.

Possible food and drug interactions when taking Humira

If Humira is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Humira with the RA drug anakinra.

Special information if you are pregnant or breastfeeding

The effects of Humira during pregnancy and breastfeeding are unknown. Talk with your doctor before taking Humira if you are pregnant, plan to become pregnant, or are breastfeeding.

Recommended dosage for Humira

ADULTS

The recommended dose of Humira is one 40-milligram injection every other week.

Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

Generic Name: somatropin (soe ma TROE pin)
Brand Names: Genotropin, Genotropin Miniquick, Humatrope, Norditropin, Norditropin Cartridge, Norditropin FlexPro Pen, Norditropin Nordiflex Pen, Nutropin, Nutropin AQ, Omnitrope, Saizen, Serostim, Tev-tropin, Zorbtive

What is Humatrope (somatropin)?

Somatropin is a form of human growth hormone. Human growth hormone is important in the body for the growth of bones and muscles.

Somatropin is used to treat growth failure in children and adults who lack natural growth hormone, and in those with chronic kidney failure, Noonan syndrome, Turner syndrome, short stature at birth with no catch-up growth, and other causes. Somatropin is also used to prevent severe weight loss in people with AIDS, or to treat short bowel syndrome.

Somatropin may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Humatrope (somatropin)?

Before you receive somatropin, tell your doctor about all your past and present medical conditions, especially allergies, trauma, surgery, diabetes, cancer, breathing problems, liver or kidney disease, scoliosis, high blood pressure, pancreas disorder, underactive thyroid, or a brain tumor.

Also tell your doctor about all other medications you use, especially steroids or diabetes medications. Your dosages of these medicines may need to be changed when you start using somatropin. Do not stop using a steroid suddenly or change any of your medication doses without your doctor’s advice.

If you have Prader-Willi syndrome and are using somatropin, call your doctor promptly if you develop signs of lung or breathing problems such as shortness of breath, coughing, or new or increased snoring.

Call your doctor at once if you have sudden and severe pain or tenderness in your upper stomach, with nausea, vomiting, sweating, fever, fast heartbeat, and yellowing of the skin or eyes. You should also call your doctor promptly if you have vision changes and sudden, severe pain behind your eyes.

What should I discuss with my healthcare provider before using Humatrope (somatropin)?

Before you receive somatropin, tell your doctor if you have ever had an allergic reaction to a growth hormone medicine, or to drug preservatives such as benzyl alcohol, metacresol or glycerin.

You should not use this medication if you are allergic to somatropin, or if you have:

• diabetic retinopathy (a serious eye condition caused by diabetes);

• cancer; or

• Prader-Willi syndrome and are also overweight or have sleep apnea or severe respiratory (lung) problems.

You should also not use somatropin if you have a serious medical condition after having:

• open heart surgery or stomach surgery;

• trauma or other medical emergency; or

• breathing problems (such as lung failure).

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before using somatropin, tell your doctor if you have:

• liver disease;
• kidney disease (or if you are on dialysis);

• diabetes;

• scoliosis;

• high blood pressure (hypertension);

• a pancreas disorder;

• a history of cancer;

• carpal tunnel syndrome;

• underactive thyroid; or

• a brain tumor or lesion.

FDA pregnancy category B. Some brands of somatropin are not expected to harm an unborn baby, including Genotropin, Omnitrope, Saizen, Serostim, and Zorbtive. FDA pregnancy category C. It is not known whether certain other brands of somatropin will harm an unborn baby, including Humatrope, Norditropin,Nutropihn, and Tev-tropin. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether somatropin passes into breast milk or if it could harm a nursing baby. Do not use somatropin without telling your doctor if you are breast-feeding a baby.

How should I use Humatrope (somatropin)?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your dose and brand of somatropin, and how often you give it will depend on what you are being treated for. Follow the directions on your prescription label.

Somatropin is injected into a muscle or under the skin. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

Use a different place on your body each time you give the injection. Your care provider will show you the best places on your body to inject the medication. Do not inject into the same place two times in a row. Do not inject this medicine into skin or muscle that is red, sore, infected, or injured.

Do not shake the medication bottle or you may ruin the medicine. When mixing somatropin with a diluent (liquid), use a gentle swirling motion. Do not use the medication if it has changed colors or has particles in it. Call your doctor for a new prescription.

Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

To be sure this medication is helping your condition and not causing harm, your blood and growth progress will need to be tested on a regular basis. Your eyes may also need to be checked. Visit your doctor regularly.

If you are being treated for short bowel syndrome, follow the diet plan created for you by your doctor or nutrition counselor to help control your condition. Somatropin is not a cure for short bowel syndrome.

If you use a form of somatropin that comes in a cartridge for use with an injection pen, use only the pen injection system provided with the somatropin brand you use.

How you store this medicine will depend on what brand you are using and what diluent you are mixing somatropin with. After mixing somatropin, you may need to use it right away or you may be able to store it for later use. Read and carefully follow the instructions provided with your medicine about proper storage of somatropin before and after it has been mixed. Ask your pharmacist if you have any questions about proper storage of your medication.

Throw away any somatropin left over after the expiration date on the label has passed.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

Call your doctor if you miss more than 3 doses in a row.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose can cause tremors or shaking, cold sweats, increased hunger, headache, drowsiness, weakness, dizziness, fast heartbeat, and nausea. Long-term overdose may cause excessive growth.

What should I avoid while using Humatrope (somatropin)?

If you use Zorbtive to treat short bowel syndrome, avoid drinking fruit juices or soda beverages. Follow the instructions of your doctor or nutrition counselor about what types of liquids you should drink while using Zorbtive.

Avoid drinking alcohol if you have short bowel syndrome. Alcohol can irritate your stomach and could make your condition worse.

Humatrope (somatropin) side effects

If you have Prader-Willi syndrome, call your doctor promptly if you develop signs of lung or breathing problems such as shortness of breath, coughing, or new or increased snoring. Rare cases of serious breathing problems have occurred in patients with Prader-Willi syndrome who use somatropin.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• sudden and severe pain or tenderness in your upper stomach;

• nausea, vomiting, sweating, fever, fast heartbeat, yellowing of the skin or eyes;

• increased thirst and urination;

• sudden and severe pain behind your eyes, vision changes;

• swelling in your head, face, hands, or feet; or

• numbness or tingling in your wrist, hand, or fingers.

Less serious side effects may include:

• headache;

• redness, soreness, swelling, skin rash, itching, pain, or bruising where the medicine was injected;

• breast swelling;

• joint pain, swelling, or stiffness; or

• mild nausea, stomach pain, gas.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Humatrope (somatropin)?

Before using somatropin, tell your doctor if you use insulin or take oral (by mouth) medicine to treat diabetes. Somatropin may affect blood sugar levels and you may need to adjust your dose of the diabetes medication. Do not change the dose of your diabetes medication without your doctor’s advice.

Tell your doctor if you use any type of steroid medicine such as cortisone, dexamethasone, methylprednisolone, prednisone, and others. Steroids can make somatropin less effective and your doses may need to be adjusted. Do not stop using a steroid suddenly. Follow your doctor’s instructions.

Tell your doctor about all other medications you use, especially cyclosporine (Gengraf, Neoral, Sandimmune), seizure medication, birth control pills, anabolic steroids, or hormone replacement medications for men or women.

This list is not complete and other drugs may interact with somatropin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about somatropin.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 9.01. Revision Date: 04/14/2010 1:58:00 PM.

Generic Name: Somatropin (rDNA origin – Refrigerated) (SOE-ma-TROE-pin)
Brand Name: Humatrope

Humatrope Vial is used for:

Treating certain children or adults when the body does not produce enough growth hormone. It is also used to treat certain children who are not growing normally because of Turner syndrome or certain other conditions (eg, idiopathic short stature). It may also be used for other conditions as determined by your doctor.

Humatrope Vial is a growth hormone. It works by stimulating growth in patients who do not make enough natural growth hormone.

Do NOT use Humatrope Vial if:

• you are allergic to any ingredient in Humatrope Vial or in the diluent
• you have active or recurring cancer or a brain tumor
• you have severe breathing problems (eg, respiratory failure) or a serious illness caused by complications from a surgery or injury
• you have a certain type of eye problem caused by diabetes (diabetic retinopathy)
• the patient is a child who has Prader-Willi syndrome and is severely overweight or has a history of severe breathing problems (eg, airway blockage, respiratory infection, sleep apnea)
• the patient is a child who has epiphyseal closure (bone growth is complete)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Humatrope Vial:

Some medical conditions may interact with Humatrope Vial. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of lung or breathing problems (eg, airway blockage, respiratory infection, sleep apnea), an underactive thyroid, heart problems, high blood pressure, ear or hearing problems (eg, repeated ear infections), or endocrine problems (eg, pituitary or adrenal gland problems)
• if you have a history of diabetes or high blood sugar levels, or if a member of your family has had diabetes
• if you have a history of leukemia, other types of cancer (eg, skin cancer), or any unusual growths or tumors (especially in the brain)
• if you have curvature of the spine (scoliosis) or Prader-Willi syndrome
• if you are very overweight or have had a recent major surgery or injury

Some MEDICINES MAY INTERACT with Humatrope Vial. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Corticosteroids (eg, prednisone) or estrogens because they may decrease Humatrope Vial’s effectiveness
• Anticonvulsants (eg, carbamazepine) or cyclosporine because the risk of their side effects may be increased by Humatrope Vial
• Insulin or other medicines for diabetes because their effectiveness may be decreased by Humatrope Vial

This may not be a complete list of all interactions that may occur. Ask your health care provider if Humatrope Vial may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Humatrope Vial:

Use Humatrope Vial as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Humatrope Vial. Talk to your pharmacist if you have questions about this information.
• Humatrope Vial is given as an injection under the skin. A health care provider will teach you how to use it. Be sure you understand how to use Humatrope Vial. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
• Do NOT shake Humatrope Vial.
• Humatrope Vial should be clear and colorless. Do not use Humatrope Vial if it contains particles, is cloudy or discolored, or if the container is cracked or damaged.
• Be sure to rotate your injection site as directed to help avoid thickening or hardening of the skin.
• Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
• If you miss a dose of Humatrope Vial, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Humatrope Vial.

Important safety information:

• Severe and sometimes fatal lung and breathing problems have occurred with the use of Humatrope Vial in certain children with Prader-Willi syndrome. These children were usually either very overweight or had severe breathing problems (eg, airway blockage, sleep apnea, lung or airway infection). The risk may be greater in boys. Children with Prader-Willi syndrome should have certain breathing tests before they start Humatrope Vial. They should be monitored for signs of lung or airway infection. They should also have effective weight control. Contact the doctor at once if the patient develops irregular breathing during sleep, new or increased snoring, or symptoms of lung or airway infection (eg, fever, coughing, sore throat, shortness of breath, chest pain or discomfort).
• Rarely, children using Humatrope Vial have experienced a slipped growth plate in the hip. Contact the doctor right away if the patient develops hip or knee pain or a limp.
• Diabetes patients – Humatrope Vial may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
• Lab tests, including blood sugar levels and thyroid function, may be performed while you use Humatrope Vial. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Humatrope Vial with caution in the ELDERLY; they may be more sensitive to its effects.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Humatrope Vial while you are pregnant. It is not known if Humatrope Vial is found in breast milk. If you are or will be breast-feeding while you use Humatrope Vial, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Humatrope Vial:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; headache; increased cough; mild flu-like symptoms; mild swelling (eg, of the hands or feet); muscle or joint pain; prickling sensation of the skin; redness or itching at the injection site; sore throat; stuffy nose.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); breast enlargement in males; burning, tingling, itching, or numbness in the palm of the hand, fingers, or wrist; change in appearance or size of a mole; confusion; ear pain, discharge, or discomfort; fever; hearing problems; hip or knee pain; limp; nausea or vomiting; new growth on the skin; one-sided weakness; persistent or severe cough or sore throat; persistent or unusual stomach pain; severe or persistent muscle or joint pain; severe or persistent swelling of the hands, ankles, or feet; shortness of breath; slurred speech; snoring or irregular breathing during sleep; sudden, severe, or persistent headache or dizziness; symptoms of high blood sugar (eg, increased thirst, hunger, or urination; unusual weakness); thickened or hardened skin at the injection site; trouble breathing; unusual bruising; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include dizziness; excessive thirst or hunger; fainting; fast heartbeat; frequent urination.

Proper storage of Humatrope Vial:

Store new (unopened) vials in the refrigerator between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Protect from light. Do not use Humatrope Vial past the expiration date on the product label.

After mixing with the provided diluent, store vials in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Throw away mixed vials after 14 days, even if they still contain medicine. If you mix Humatrope Vial with sterile water or bacteriostatic water for injection, check with your doctor or pharmacist about how to store Humatrope Vial.

Contact your pharmacist if you have any questions about how to properly store Humatrope Vial. Keep Humatrope Vial out of the reach of children and away from pets.

General information:

• If you have any questions about Humatrope Vial, please talk with your doctor, pharmacist, or other health care provider.
• Humatrope Vial is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Humatrope Vial. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Somatropin (rDNA origin – Refrigerated) (SOE-ma-TROE-pin)
Brand Name: Humatrope

Humatrope Cartridge is used for:

Treating certain children or adults when the body does not produce enough growth hormone. It is also used to treat certain children who are not growing normally because of Turner syndrome or certain other conditions (eg, idiopathic short stature). It may also be used for other conditions as determined by your doctor.

Humatrope Cartridge is a growth hormone. It works by stimulating growth in patients who do not make enough natural growth hormone.

Do NOT use Humatrope Cartridge if:

• you are allergic to any ingredient in Humatrope Cartridge or in the diluent, including metacresol or glycerin
• you have active or recurring cancer or a brain tumor
• you have severe breathing problems (eg, respiratory failure) or a serious illness caused by complications from a surgery or injury
• you have a certain type of eye problem caused by diabetes (diabetic retinopathy)
• the patient is a child who has Prader-Willi syndrome and is severely overweight or has a history of severe breathing problems (eg, airway blockage, respiratory infection, sleep apnea)
• the patient is a child who has epiphyseal closure (bone growth is complete)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Humatrope Cartridge:

Some medical conditions may interact with Humatrope Cartridge. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of lung or breathing problems (eg, airway blockage, respiratory infection, sleep apnea), an underactive thyroid, heart problems, high blood pressure, ear or hearing problems (eg, repeated ear infections), or endocrine problems (eg, pituitary or adrenal gland problems)
• if you have a history of diabetes or high blood sugar levels, or if a member of your family has had diabetes
• if you have a history of leukemia, other types of cancer (eg, skin cancer), or any unusual growths or tumors (especially in the brain)
• if you have curvature of the spine (scoliosis) or Prader-Willi syndrome
• if you are very overweight or have had a recent major surgery or injury

Some MEDICINES MAY INTERACT with Humatrope Cartridge. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Corticosteroids (eg, prednisone) or estrogens because they may decrease Humatrope Cartridge’s effectiveness
• Anticonvulsants (eg, carbamazepine) or cyclosporine because the risk of their side effects may be increased by Humatrope Cartridge
• Insulin or other medicines for diabetes because their effectiveness may be decreased by Humatrope Cartridge

This may not be a complete list of all interactions that may occur. Ask your health care provider if Humatrope Cartridge may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Humatrope Cartridge:

Use Humatrope Cartridge as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Humatrope Cartridge. Talk to your pharmacist if you have questions about this information.
• Humatrope Cartridge is given as an injection under the skin. A health care provider will teach you how to use it. Be sure you understand how to use Humatrope Cartridge. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
• Humatrope Cartridge should only be used with a certain kind of pen device. Ask your health care provider if you have any questions.
• Do NOT shake Humatrope Cartridge.
• Humatrope Cartridge should be clear and colorless. Do not use Humatrope Cartridge if it contains particles, is cloudy or discolored, or if the container is cracked or damaged.
• Be sure to rotate your injection site as directed to help avoid thickening or hardening of the skin.
• Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
• If you miss a dose of Humatrope Cartridge, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Humatrope Cartridge.

Important safety information:

• Severe and sometimes fatal lung and breathing problems have occurred with the use of Humatrope Cartridge in certain children with Prader-Willi syndrome. These children were usually either very overweight or had severe breathing problems (eg, airway blockage, sleep apnea, lung or airway infection). The risk may be greater in boys. Children with Prader-Willi syndrome should have certain breathing tests before they start Humatrope Cartridge. They should be monitored for signs of lung or airway infection. They should also have effective weight control. Contact the doctor at once if the patient develops irregular breathing during sleep, new or increased snoring, or symptoms of lung or airway infection (eg, fever, coughing, sore throat, shortness of breath, chest pain or discomfort).
• Rarely, children using Humatrope Cartridge have experienced a slipped growth plate in the hip. Contact the doctor right away if the patient develops hip or knee pain or a limp.
• Diabetes patients – Humatrope Cartridge may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
• Lab tests, including blood sugar levels and thyroid function, may be performed while you use Humatrope Cartridge. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Humatrope Cartridge with caution in the ELDERLY; they may be more sensitive to its effects.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Humatrope Cartridge while you are pregnant. It is not known if Humatrope Cartridge is found in breast milk. If you are or will be breast-feeding while you use Humatrope Cartridge, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Humatrope Cartridge:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; headache; increased cough; mild flu-like symptoms; mild swelling (eg, of the hands or feet); muscle or joint pain; prickling sensation of the skin; redness or itching at the injection site; sore throat; stuffy nose.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); breast enlargement in males; burning, tingling, itching, or numbness in the palm of the hand, fingers, or wrist; change in appearance or size of a mole; confusion; ear pain, discharge, or discomfort; fever; hearing problems; hip or knee pain; limp; nausea or vomiting; new growth on the skin; one-sided weakness; persistent or severe cough or sore throat; persistent or unusual stomach pain; severe or persistent muscle or joint pain; severe or persistent swelling of the hands, ankles, or feet; shortness of breath; slurred speech; snoring or irregular breathing during sleep; sudden, severe, or persistent headache or dizziness; symptoms of high blood sugar (eg, increased thirst, hunger, or urination; unusual weakness); thickened or hardened skin at the injection site; trouble breathing; unusual bruising; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include dizziness; excessive thirst or hunger; fainting; fast heartbeat; frequent urination.

Proper storage of Humatrope Cartridge:

Store new (unopened) cartridges in the refrigerator between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Protect from light. Do not use Humatrope Cartridge past the expiration date on the product label.

After mixing, store cartridges in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Store without the needle attached. Throw away cartridges after 28 days, even if they still contain medicine.

Contact your pharmacist if you have any questions about how to properly store Humatrope Cartridge. Keep Humatrope Cartridge out of the reach of children and away from pets.

General information:

• If you have any questions about Humatrope Cartridge, please talk with your doctor, pharmacist, or other health care provider.
• Humatrope Cartridge is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Humatrope Cartridge. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: paromomycin (PAR oh moe MYE sin)
Brand Names: Paromycin

What is Humatin (paromomycin)?

Paromomycin is an antibiotic.

Paromomycin is used in the treatment of various intestinal infections. Paromomycin is also used in the treatment of certain liver problems.

Paromomycin may also be used for purposes other than those listed here.

What is the most important information I should know about Humatin (paromomycin)?

Use caution when driving, operating machinery, or performing other hazardous activities. Paromomycin may cause dizziness. If you experience dizziness, avoid these activities and contact your doctor.

What should I discuss with my healthcare provider before taking Humatin (paromomycin)?

Before taking paromomycin, tell your doctor if you have

• stomach or intestinal problems such as stomach ulcer, inflammatory bowel disease, or intestinal blockage (obstruction);

• kidney disease; or
• liver disease.

You may not be able to take paromomycin, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Do not take paromomycin without first talking to your doctor if you are pregnant or could become pregnant during treatment. Do not take paromomycin without first talking to your doctor if you are breast-feeding a baby.

How should I take Humatin (paromomycin)?

Take paromomycin exactly as directed by your doctor. If you do not understand these instructions, ask your doctor, nurse, or pharmacist to explain them to you.

Take each dose with a full glass of water. Take paromomycin with food.

It is important to take paromomycin regularly to get the most benefit.

Store paromomycin at room temperature away from moisture, heat, and direct light.

See also: Humatin dosage in more detail

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose. Do not take a double dose unless otherwise directed by your doctor.

What happens if I overdose?

Seek emergency medical attention if an overdose is suspected.

Symptoms of a paromomycin overdose are not known.

What should I avoid while taking Humatin (paromomycin)?

Use caution when driving, operating machinery, or performing other hazardous activities. Paromomycin may cause dizziness. If you experience dizziness, avoid these activities and contact your doctor.

Humatin (paromomycin) side effects

If you experience any of the following serious side effects, seek emergency medical attention or contact your doctor immediately:

• an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

• decreased hearing or ringing in the ears;

• little or no urine production; or

• dizziness.

Other less serious side effects may be more likely to occur. Continue to take paromomycin and talk to your doctor if you experience

• nausea or vomiting;

• diarrhea; or

• itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Humatin (paromomycin)?

Talk to your doctor before taking any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products, during treatment with paromomycin.

Where can I get more information?

• Your pharmacist has additional information about paromomycin written for healthcare professionals that you may read.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 1.04. Revision Date: 4/12/2009 4:39:05 PM.