Generic Name: guanadrel (GWAH na drel)
Brand Names: Hylorel

What is Hylorel (guanadrel)?

Guanadrel lowers blood pressure by decreasing the levels of certain chemicals in the blood. This allows the blood vessels (veins and arteries) to relax (widen).

Guanadrel is used to treat hypertension (high blood pressure).

Guanadrel may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Hylorel (guanadrel)?

Do not stop taking guanadrel suddenly without first talking to your doctor. This could cause severely high blood pressure, nervousness, and anxiety. Use caution when driving, operating machinery, or performing other hazardous activities. Guanadrel may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Use caution when rising from a sitting or lying position, especially first thing in the morning. Dizziness may occur while taking guanadrel and may result in a fall.

What should I discuss with my healthcare provider before taking Hylorel (guanadrel)?

Do not take guanadrel without first talking to your doctor if you

• have congestive heart failure;

• have pheochromocytoma; or

• are taking a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate).

Before taking this medication, tell your doctor if you have

• peptic ulcer disease (stomach ulcers);

• ulcerative colitis;

• kidney disease; or

• asthma.

You may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Guanadrel is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not take guanadrel without first talking to your doctor if you are pregnant or could become pregnant during treatment. Guanadrel passes into breast milk and it may be harmful to a nursing infant. Do not take guanadrel without first talking to your doctor if you are breast-feeding a baby.

How should I take Hylorel (guanadrel)?

Take guanadrel exactly as directed. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Take guanadrel with food or milk if it causes stomach upset.

It is important to take guanadrel regularly to get the most benefit.

Do not stop taking guanadrel suddenly without first talking to your doctor. This could cause severely high blood pressure, nervousness, and anxiety.

Your doctor may want you to have blood pressure monitoring or other medical evaluations during treatment with guanadrel to monitor progress and side effects.

Store this medication at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention if an overdose is suspected.

Symptoms of a guanadrel overdose include low blood pressure (fainting, dizziness, weakness); a slow pulse; low body temperature; diarrhea; and slow breathing.

What should I avoid while taking Hylorel (guanadrel)?

Use caution when driving, operating machinery, or performing other hazardous activities. Guanadrel may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Use caution when rising from a sitting or lying position, especially first thing in the morning. Dizziness may occur while taking guanadrel and may result in a fall.

Avoid alcohol while taking guanadrel. It may increase drowsiness an dizziness caused by guanadrel. Use caution even with small amounts of alcohol.

Guanadrel may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if guanadrel is taken with any of these medications. Tell your doctor about all medicines that you are taking, and do not take any medicine without first talking to your doctor.

Avoid becoming overheated in hot weather or during exercise. Also avoid standing for long periods of time and use caution if you have a fever. These situations increase the effects of guanadrel in the body and may cause dizziness.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Hylorel (guanadrel) side effects

If you experience any of the following serious side effects, stop taking guanadrel and seek emergency medical attention or contact your doctor immediately:

• an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

• irregular heartbeats;

• heart failure (shortness of breath, swelling of ankles or legs, sudden weight gain of 5 pounds or more); or

• chest pain.

Other, less serious side effects are more likely to occur. Continue to take guanadrel and talk to your doctor if you experience

• unusual fatigue or drowsiness;

• dizziness (avoid standing up to quickly and use caution when performing hazardous activities);

• anxiety, depression, or nightmares;

• diarrhea, nausea, or vomiting (take guanadrel with food or milk if it upsets your stomach);

• a stuffy nose or a dry mouth (sucking on ice chips or sugarless hard candy may relieve a dry mouth);

• blurred vision;

• weight gain; or

• impotence or difficulty ejaculating.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Hylorel (guanadrel)?

Do not take guanadrel without first talking to your doctor if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days

Before taking guanadrel, tell your doctor if you are taking any of the following medicines:

• a respiratory medicine such as albuterol (Ventolin, Proventil, Volmax, others), pirbuterol (Maxair), salmeterol (Serevent), and others;

• a beta-blocker such as atenolol (Tenormin), acebutolol (Sectral), bisoprolol (Zebeta), carteolol (Cartrol), carvedilol (Coreg), labetalol (Trandate, Normodyne), metoprolol (Lopressor), nadolol (Corgard), propranolol (Inderal), pindolol (Visken), and timolol (Blocadren);

• a phenothiazine such as chlorpromazine (Thorazine), prochlorperazine (Compazine), perphenazine (Trilafon), fluphenazine (Prolixin), thioridazine (Mellaril), and others;

• other heart medications such as hydralazine (Apresoline) or minoxidil (Loniten); or

• a tricyclic antidepressant such as amitriptyline (Elavil, Endep), imipramine (Tofranil), doxepin (Sinequan), nortriptyline (Pamelor), and others.

You may require special monitoring or a dosage adjustment if you are taking any of the medicines listed above.

Guanadrel may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine without first talking to your doctor.

Drugs other than those listed here may also interact with guanadrel or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information?

• Your pharmacist has additional information about guanadrel written for health professionals that you may read.

What does my medication look like?

Guanadrel is available with a prescription under the brand name Hylorel. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Hylorel 10 mg–light-orange, elliptical, scored tablets

• Hylorel 25 mg–white, elliptical, scored tablets

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 6.02. Revision Date: 2/13/04 4:00:59 PM.

Generic Name: Hyoscyamine (HYE-oh-SYE-a-meen)
Brand Name: Hyosyne

Hyoscyamine Elixir is used for:

Treating certain stomach, intestinal, and bladder conditions, including spasms. It is used to control stomach secretions and cramps. It is used to relieve the symptoms of colic, runny nose, and Parkinson-like problems. It is used to treat excessive sweating or saliva production. It may also be used for other conditions as determined by your doctor.

Hyoscyamine Elixir is an anticholinergic agent. It works by decreasing the motion of muscles in the stomach, intestines, and bladder. It also decreases the production of stomach acid.

Do NOT use Hyoscyamine Elixir if:

• you are allergic to any ingredient in Hyoscyamine Elixir
• you have severe esophagus problems (eg, irritation, narrowing); a blockage of the stomach, bowel, or bladder; bowel motility problems; or severe bowel problems (eg, severe ulcerative colitis, toxic megacolon)
• you have glaucoma, myasthenia gravis, or heart problems caused by severe bleeding

Contact your doctor or health care provider right away if any of these apply to you.

Before using Hyoscyamine Elixir:

Some medical conditions may interact with Hyoscyamine Elixir. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have nerve problems, prostate problems, esophagus problems (eg, reflux), stomach or bowel problems, heart or blood vessel problems (eg, fast or irregular heartbeat, heart failure, coronary heart disease), hiatal hernia, kidney problems, an overactive thyroid, high blood pressure, urinary problems, paralysis, or brain damage, or if you are at risk for glaucoma
• if you have diarrhea or fever, have been very ill, or are in poor health

Some MEDICINES MAY INTERACT with Hyoscyamine Elixir. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Amantadine, antihistamines (eg, diphenhydramine), haloperidol, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), other anticholinergics (eg, scopolamine), phenothiazines (eg, thioridazine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Hyoscyamine Elixir’s side effects
• Narcotic pain medicines (eg, codeine) or potassium chloride because the risk of their side effects may be increased by Hyoscyamine Elixir
• Ketoconazole or metoclopramide because their effectiveness may be decreased by Hyoscyamine Elixir

This may not be a complete list of all interactions that may occur. Ask your health care provider if Hyoscyamine Elixir may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Hyoscyamine Elixir:

Use Hyoscyamine Elixir as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Hyoscyamine Elixir is usually taken 30 to 60 minutes before a meal. Follow your doctor’s instructions for taking Hyoscyamine Elixir.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• If you also take antacids, take Hyoscyamine Elixir before meals and the antacid after meals, unless directed otherwise by your doctor.
• If you miss a dose of Hyoscyamine Elixir, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Hyoscyamine Elixir.

Important safety information:

• Hyoscyamine Elixir may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Hyoscyamine Elixir with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Hyoscyamine Elixir; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
• Do not become overheated or dehydrated in hot weather or while you are being active; heatstroke may occur.
• Drink plenty of fluids, maintain good oral hygiene, and suck on sugarless hard candy to relieve dry mouth.
• Proper dental care is important while you are taking Hyoscyamine Elixir. Brush and floss your teeth and visit the dentist regularly.
• Hyoscyamine Elixir may make your eyes more sensitive to sunlight. It may help to wear sunglasses.
• Tell your doctor or dentist that you take Hyoscyamine Elixir before you receive any medical or dental care, emergency care, or surgery.
• Use Hyoscyamine Elixir with caution in the ELDERLY; they may be more sensitive to its effects, especially constipation, trouble urinating, dry mouth, drowsiness, agitation, confusion, excitability, or memory problems.
• Caution is advised when using Hyoscyamine Elixir in CHILDREN; they may be more sensitive to its effects, including excitability.
• Hyoscyamine Elixir should be used with extreme caution in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: It is not known if Hyoscyamine Elixir can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Hyoscyamine Elixir while you are pregnant. Hyoscyamine Elixir is found in breast milk. If you are or will be breast-feeding while taking Hyoscyamine Elixir, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Hyoscyamine Elixir:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bloated feeling; blurred vision; constipation; decreased sweating; dizziness; drowsiness; dry mouth; enlarged pupils; excitability; headache; nausea; nervousness; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; behavior changes; confusion; decreased sexual ability; diarrhea; difficulty focusing eyes; disorientation; exaggerated sense of well-being; fast or irregular heartbeat; hallucinations; loss of consciousness; loss of coordination; memory loss; mental or mood changes; severe or persistent trouble sleeping; speech changes; taste changes or loss; trouble urinating; unusual tiredness or weakness; vision changes; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include disorientation; excessive thirst or excitability; fever; hot, dry skin; seizures; severe dry mouth; severe or persistent blurred vision, dizziness, headache, nausea, or vomiting; trouble breathing or swallowing.

Proper storage of Hyoscyamine Elixir:

Store Hyoscyamine Elixir at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Hyoscyamine Elixir out of the reach of children and away from pets.

General information:

• If you have any questions about Hyoscyamine Elixir, please talk with your doctor, pharmacist, or other health care provider.
• Hyoscyamine Elixir is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Hyoscyamine Elixir. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Hyoscyamine (HYE-oh-SYE-a-meen)
Brand Name: Symax Duotab

Hyoscyamine Controlled-Release Tablets are used for:

Treating certain stomach, intestinal, and bladder conditions, including spasms. It is used to control stomach secretions and cramps. It is used to relieve the symptoms of colic or runny nose. It may also be used for other conditions as determined by your doctor.

Hyoscyamine Controlled-Release Tablets are an anticholinergic agent. It works by decreasing the motion of muscles in the stomach, intestines, and bladder. It also decreases the production of stomach acid.

Do NOT use Hyoscyamine Controlled-Release Tablets if:

• you are allergic to any ingredient in Hyoscyamine Controlled-Release Tablets
• you have severe esophagus problems (eg, irritation, narrowing); a blockage of the stomach, bowel, or bladder; bowel motility problems; or severe bowel problems (eg, severe ulcerative colitis, toxic megacolon)
• you have glaucoma, myasthenia gravis, or heart problems caused by severe bleeding

Contact your doctor or health care provider right away if any of these apply to you.

Before using Hyoscyamine Controlled-Release Tablets:

Some medical conditions may interact with Hyoscyamine Controlled-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have nerve problems, prostate problems, esophagus problems (eg, reflux), stomach or bowel problems, heart or blood vessel problems (eg, fast or irregular heartbeat, heart failure, coronary heart disease), hiatal hernia, kidney problems, an overactive thyroid, high blood pressure, urinary problems, paralysis, or brain damage, or if you are at risk for glaucoma
• if you have diarrhea or fever, have been very ill, or are in poor health

Some MEDICINES MAY INTERACT with Hyoscyamine Controlled-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Amantadine, antihistamines (eg, diphenhydramine), haloperidol, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), other anticholinergics (eg, scopolamine), phenothiazines (eg, thioridazine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Hyoscyamine Controlled-Release Tablets’s side effects
• Narcotic pain medicines (eg, codeine) or potassium chloride because the risk of their side effects may be increased by Hyoscyamine Controlled-Release Tablets
• Ketoconazole or metoclopramide because their effectiveness may be decreased by Hyoscyamine Controlled-Release Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Hyoscyamine Controlled-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Hyoscyamine Controlled-Release Tablets:

Use Hyoscyamine Controlled-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Hyoscyamine Controlled-Release Tablets are usually taken 30 to 60 minutes before a meal. Follow your doctor’s instructions for taking Hyoscyamine Controlled-Release Tablets.
• Swallow Hyoscyamine Controlled-Release Tablets whole. Do not break, crush, or chew before swallowing.
• If you also take antacids, ask your doctor or pharmacist how to take them with Hyoscyamine Controlled-Release Tablets.
• If you miss a dose of Hyoscyamine Controlled-Release Tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Hyoscyamine Controlled-Release Tablets.

Important safety information:

• Hyoscyamine Controlled-Release Tablets may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Hyoscyamine Controlled-Release Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Hyoscyamine Controlled-Release Tablets; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
• Do not become overheated or dehydrated in hot weather or while you are being active; heatstroke may occur.
• Drink plenty of fluids, maintain good oral hygiene, and suck on sugarless hard candy to relieve dry mouth.
• Proper dental care is important while you are taking Hyoscyamine Controlled-Release Tablets. Brush and floss your teeth and visit the dentist regularly.
• Hyoscyamine Controlled-Release Tablets may make your eyes more sensitive to sunlight. It may help to wear sunglasses.
• Tell your doctor or dentist that you take Hyoscyamine Controlled-Release Tablets before you receive any medical or dental care, emergency care, or surgery.
• Use Hyoscyamine Controlled-Release Tablets with caution in the ELDERLY; they may be more sensitive to its effects, especially constipation, trouble urinating, dry mouth, drowsiness, agitation, confusion, excitability, or memory problems.
• Caution is advised when using Hyoscyamine Controlled-Release Tablets in CHILDREN; they may be more sensitive to its effects, including excitability.
• Hyoscyamine Controlled-Release Tablets should be used with extreme caution in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: It is not known if Hyoscyamine Controlled-Release Tablets can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Hyoscyamine Controlled-Release Tablets while you are pregnant. Hyoscyamine Controlled-Release Tablets are found in breast milk. If you are or will be breast-feeding while taking Hyoscyamine Controlled-Release Tablets, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Hyoscyamine Controlled-Release Tablets:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bloated feeling; blurred vision; constipation; decreased sweating; dizziness; drowsiness; dry mouth; enlarged pupils; excitability; headache; nausea; nervousness; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; behavior changes; confusion; decreased sexual ability; diarrhea; difficulty focusing eyes; disorientation; exaggerated sense of well-being; fast or irregular heartbeat; hallucinations; loss of consciousness; loss of coordination; memory loss; mental or mood changes; severe or persistent trouble sleeping; speech changes; taste changes or loss; trouble urinating; unusual tiredness or weakness; vision changes; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( http://www.aapcc.org), or emergency room immediately. Symptoms may include disorientation; excessive thirst or excitability; fever; hot, dry skin; seizures; severe dry mouth; severe or persistent blurred vision, dizziness, headache, nausea, or vomiting; trouble breathing or swallowing.

Proper storage of Hyoscyamine Controlled-Release Tablets:

Store Hyoscyamine Controlled-Release Tablets at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Hyoscyamine Controlled-Release Tablets out of the reach of children and away from pets.

General information:

• If you have any questions about Hyoscyamine Controlled-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.
• Hyoscyamine Controlled-Release Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Hyoscyamine Controlled-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Hyoscyamine (HYE-oh-SYE-a-meen)
Brand Name: Levsin

Hyoscyamine is used for:

Treating certain stomach or bowel problems (eg, ulcers, spasms or cramping, irritable bowel syndrome, symptoms of colic), certain bladder problems (eg, spastic bladder, cystitis), and excessive secretions caused by inflammation of the pancreas, and for aiding in certain medical procedures or surgery. It may also be used for other conditions as determined by your doctor.

Hyoscyamine is an anticholinergic agent. It works by decreasing the motion of the stomach and intestines and the secretion of stomach fluids, including acid.

Do NOT use Hyoscyamine if:

• you are allergic to any ingredient in Hyoscyamine
• you have severe esophagus problems (eg, irritation, narrowing); a blockage of the stomach, bowel, or bladder; bowel motility problems; or severe bowel problems (eg, severe ulcerative colitis, toxic megacolon)
• you have glaucoma, myasthenia gravis, or heart problems caused by severe bleeding

Contact your doctor or health care provider right away if any of these apply to you.

Before using Hyoscyamine:

Some medical conditions may interact with Hyoscyamine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have nerve problems, prostate problems, esophagus problems (eg, reflux), stomach or bowel problems, heart or blood vessel problems (eg, fast or irregular heartbeat, heart failure, coronary heart disease), hiatal hernia, kidney problems, an overactive thyroid, high blood pressure, urinary problems, paralysis, or brain damage, or if you are at risk for glaucoma
• if you have diarrhea or fever, have been very ill, or are in poor health

Some MEDICINES MAY INTERACT with Hyoscyamine. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Amantadine, antihistamines (eg, diphenhydramine), haloperidol, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), other anticholinergics (eg, scopolamine), phenothiazines (eg, thioridazine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Hyoscyamine’s side effects
• Narcotic pain medicines (eg, codeine) or potassium chloride because the risk of their side effects may be increased by Hyoscyamine
• Ketoconazole or metoclopramide because their effectiveness may be decreased by Hyoscyamine

This may not be a complete list of all interactions that may occur. Ask your health care provider if Hyoscyamine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Hyoscyamine:

Use Hyoscyamine as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.

• Hyoscyamine is usually given as an injection at your doctor’s office, hospital, or clinic. If you will be using Hyoscyamine at home, a health care provider will teach you how to use it. Be sure you understand how to use Hyoscyamine. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
• Do not use Hyoscyamine if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
• Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
• If you miss a dose of Hyoscyamine, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Hyoscyamine.

Important safety information:

• Hyoscyamine may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Hyoscyamine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Hyoscyamine; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
• Do not become overheated or dehydrated in hot weather or while you are being active; heatstroke may occur.
• Drink plenty of fluids, maintain good oral hygiene, and suck on sugarless hard candy to relieve dry mouth.
• Proper dental care is important while you are taking Hyoscyamine. Brush and floss your teeth and visit the dentist regularly.
• Hyoscyamine may make your eyes more sensitive to sunlight. It may help to wear sunglasses.
• Tell your doctor or dentist that you take Hyoscyamine before you receive any medical or dental care, emergency care, or surgery.
• Use Hyoscyamine with caution in the ELDERLY; they may be more sensitive to its effects, especially constipation, trouble urinating, dry mouth, drowsiness, agitation, confusion, excitability, or memory problems.
• Caution is advised when using Hyoscyamine in CHILDREN; they may be more sensitive to its effects, including excitability.
• Hyoscyamine should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Hyoscyamine while you are pregnant. Hyoscyamine is found in breast milk. Do not breast-feed while taking Hyoscyamine.

Possible side effects of Hyoscyamine:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bloated feeling; blurred vision; constipation; decreased sweating; dizziness; drowsiness; dry mouth; enlarged pupils; excitability; headache; nausea; nervousness; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; behavior changes; confusion; decreased sexual ability; diarrhea; difficulty focusing eyes; disorientation; exaggerated sense of well-being; fast or irregular heartbeat; hallucinations; loss of consciousness; loss of coordination; memory loss; mental or mood changes; severe or persistent trouble sleeping; speech changes; taste changes or loss; trouble urinating; unusual tiredness or weakness; vision changes; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include blurred vision; difficulty breathing; difficulty swallowing; disorientation; dizziness; dry mouth; dry skin; enlarged pupils; excessive thirst; excitability; headache; muscle weakness; nausea; rapid heartbeat with weak pulse; seizures; vomiting.

Proper storage of Hyoscyamine:

Hyoscyamine is usually handled and stored by a health care provider. If you are using Hyoscyamine at home, store Hyoscyamine as directed by your pharmacist or health care provider. Keep Hyoscyamine out of the reach of children and away from pets.

General information:

• If you have any questions about Hyoscyamine, please talk with your doctor, pharmacist, or other health care provider.
• Hyoscyamine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Hyoscyamine. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Hyoscyamine (HYE-oh-SYE-a-meen)
Brand Name: Levsinex

Hyoscyamine Extended-Release Capsules are used for:

Treating certain stomach, intestinal, and bladder conditions, including spasms. It is used to control stomach secretions and cramps. It is used to relieve the symptoms of colic, runny nose, and Parkinson-like problems. It is used to treat excessive sweating or saliva production. It may also be used for other conditions as determined by your doctor.

Hyoscyamine Extended-Release Capsules are an anticholinergic agent. It works by decreasing the motion of muscles in the stomach, intestines, and bladder. It also decreases the production of stomach acid.

Do NOT use Hyoscyamine Extended-Release Capsules if:

• you are allergic to any ingredient in Hyoscyamine Extended-Release Capsules
• you have severe esophagus problems (eg, irritation, narrowing); a blockage of the stomach, bowel, or bladder; bowel motility problems; or severe bowel problems (eg, severe ulcerative colitis, toxic megacolon)
• you have glaucoma, myasthenia gravis, or heart problems caused by severe bleeding

Contact your doctor or health care provider right away if any of these apply to you.

Before using Hyoscyamine Extended-Release Capsules:

Some medical conditions may interact with Hyoscyamine Extended-Release Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have nerve problems, prostate problems, esophagus problems (eg, reflux), stomach or bowel problems, heart or blood vessel problems (eg, fast or irregular heartbeat, heart failure, coronary heart disease), hiatal hernia, kidney problems, an overactive thyroid, high blood pressure, urinary problems, paralysis, or brain damage, or if you are at risk for glaucoma
• if you have diarrhea or fever, have been very ill, or are in poor health

Some MEDICINES MAY INTERACT with Hyoscyamine Extended-Release Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Amantadine, antihistamines (eg, diphenhydramine), haloperidol, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), other anticholinergics (eg, scopolamine), phenothiazines (eg, thioridazine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Hyoscyamine Extended-Release Capsules’s side effects
• Narcotic pain medicines (eg, codeine) or potassium chloride because the risk of their side effects may be increased by Hyoscyamine Extended-Release Capsules
• Ketoconazole or metoclopramide because their effectiveness may be decreased by Hyoscyamine Extended-Release Capsules

This may not be a complete list of all interactions that may occur. Ask your health care provider if Hyoscyamine Extended-Release Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Hyoscyamine Extended-Release Capsules:

Use Hyoscyamine Extended-Release Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Hyoscyamine Extended-Release Capsules are usually taken 30 to 60 minutes before a meal. Follow your doctor’s instructions for taking Hyoscyamine Extended-Release Capsules.
• Swallow Hyoscyamine Extended-Release Capsules whole. Do not break, crush, or chew before swallowing.
• If you also take antacids, ask your doctor or pharmacist how to take them with Hyoscyamine Extended-Release Capsules.
• If you miss a dose of Hyoscyamine Extended-Release Capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Hyoscyamine Extended-Release Capsules.

Important safety information:

• Hyoscyamine Extended-Release Capsules may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Hyoscyamine Extended-Release Capsules with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Hyoscyamine Extended-Release Capsules; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
• Do not become overheated or dehydrated in hot weather or while you are being active; heatstroke may occur.
• Drink plenty of fluids, maintain good oral hygiene, and suck on sugarless hard candy to relieve dry mouth.
• Proper dental care is important while you are taking Hyoscyamine Extended-Release Capsules. Brush and floss your teeth and visit the dentist regularly.
• Hyoscyamine Extended-Release Capsules may make your eyes more sensitive to sunlight. It may help to wear sunglasses.
• Tell your doctor or dentist that you take Hyoscyamine Extended-Release Capsules before you receive any medical or dental care, emergency care, or surgery.
• Use Hyoscyamine Extended-Release Capsules with caution in the ELDERLY; they may be more sensitive to its effects, especially constipation, trouble urinating, dry mouth, drowsiness, agitation, confusion, excitability, or memory problems.
• Caution is advised when using Hyoscyamine Extended-Release Capsules in CHILDREN; they may be more sensitive to its effects, including excitability.
• Hyoscyamine Extended-Release Capsules should be used with extreme caution in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: It is not known if Hyoscyamine Extended-Release Capsules can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Hyoscyamine Extended-Release Capsules while you are pregnant. Hyoscyamine Extended-Release Capsules are found in breast milk. If you are or will be breast-feeding while taking Hyoscyamine Extended-Release Capsules, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Hyoscyamine Extended-Release Capsules:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bloated feeling; blurred vision; constipation; decreased sweating; dizziness; drowsiness; dry mouth; enlarged pupils; excitability; headache; nausea; nervousness; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; behavior changes; confusion; decreased sexual ability; diarrhea; difficulty focusing eyes; disorientation; exaggerated sense of well-being; fast or irregular heartbeat; hallucinations; loss of consciousness; loss of coordination; memory loss; mental or mood changes; severe or persistent trouble sleeping; speech changes; taste changes or loss; trouble urinating; unusual tiredness or weakness; vision changes; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include disorientation; excessive thirst or excitability; fever; hot, dry skin; seizures; severe dry mouth; severe or persistent blurred vision, dizziness, headache, nausea, or vomiting; trouble breathing or swallowing.

Proper storage of Hyoscyamine Extended-Release Capsules:

Store Hyoscyamine Extended-Release Capsules at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Hyoscyamine Extended-Release Capsules out of the reach of children and away from pets.

General information:

• If you have any questions about Hyoscyamine Extended-Release Capsules, please talk with your doctor, pharmacist, or other health care provider.
• Hyoscyamine Extended-Release Capsules are to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Hyoscyamine Extended-Release Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: hyaluronidase (Subcutaneous route, Injection route)

hye-al-ure-ON-i-dase

Commonly used brand name(s):

In the U.S.

• Amphadase
• Hydase
• Hylenex
• Vitrase

Available Dosage Forms:

• Powder for Solution
• Solution

Therapeutic Class: Tissue Permeability Modifier

Pharmacologic Class: Enzyme

Uses For Hylenex

Hyaluronidase is a natural substance found in the body. Hyaluronidase is collected from either cows or pigs. It is cleaned up to remove animal substances. Hyaluronidase is a spreading substance. Hyaluronidase is used with other drugs given under the skin to improve their uptake by the body. This method of drug delivery is only used when the drug cannot be given by injection into a vein.

This medicine is available only with your doctor’s prescription.

Before Using Hylenex

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

This medicine has been tested in children and, in effective doses, has not been shown to cause different side effects or problems than it does in adults.

Geriatric

This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Benzocaine
• Bupivacaine
• Butacaine
• Chloroprocaine
• Cocaine
• Dibucaine
• Etidocaine
• Lidocaine
• Mepivacaine
• Prilocaine
• Procaine
• Proparacaine
• Propoxycaine
• Ropivacaine
• Tetracaine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of hyaluronidase. Make sure you tell your doctor if you have any other medical problems.

Proper Use of hyaluronidase

This section provides information on the proper use of a number of products that contain hyaluronidase. It may not be specific to Hylenex. Please read with care.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For injection dosage form:
  • For better uptake of other drugs:
    • Adults—Use and dose must be determined by your doctor.
    • Children—Use and dose must be determined by your doctor.

Storage

Store in the refrigerator. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Hylenex

Some people may be allergic to this medicine. Tell your doctor if you develop red or itching skin or if you have trouble breathing after you receive hyaluronidase.

Hylenex Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

• Cough
• difficulty swallowing
• dizziness
• fast heartbeat
• hives or welts
• itching
• large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
• redness of skin
• shortness of breath
• skin rash
• tightness in chest
• unusual tiredness or weakness
• wheezing

Symptoms of Overdose

Get emergency help immediately if any of the following symptoms of overdose occur:

• Blurred vision
• chills
• confusion
• dizziness
• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
• fast, pounding, or irregular heartbeat or pulse
• flushing
• nausea
• redness of skin
• swelling
• unusually warm skin
• sweating
• unusual tiredness or weakness
• vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at injection site

Incidence not known

• Swelling

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided “AS IS” and “as available” for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.