Generic Name: tranexamic acid (Oral route)

tran-ex-AM-ik AS-id

Commonly used brand name(s):

In the U.S.

• Lysteda

Available Dosage Forms:

• Tablet
• Syrup

Therapeutic Class: Hemostatic

Uses For Lysteda

Tranexamic acid is used to treat heavy menstrual bleeding in women. This medicine may be used by teenage females, but is not recommended before the start of menstruation.

Tranexamic acid is an antifibrinolytic agent. It works by blocking the breakdown of blood clots, which prevents bleeding.

This medicine is available only with your doctor’s prescription.

Before Using Lysteda

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of tranexamic acid in children or teenage females below 18 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies on the relationship of age to the effects of tranexamic acid have not been performed in the geriatric population. This medicine is not recommended for use in women who are no longer having menstrual bleeding (postmenopausal).

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Anti-Inhibitor Coagulant Complex
• Chlorpromazine
• Tretinoin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Blood clots, active or history of or
• Deep vein thrombosis (blood clot in the leg) or
• Pulmonary embolism (blood clot in the lung) or
• Retinal artery or vein occlusion (blood clot in the eye) or
• Stroke (blood clot in the brain)—Should not be used in patients with these conditions.

• Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of Lysteda

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Do not take this medicine when you do not have your period. You should wait until your monthly period has started before taking this medicine.

This medicine comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.

You may take this medicine with or without food.

Swallow the tablet whole. Do not break, crush, or chew it.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  • To treat heavy menstrual bleeding:
    • Adults—Two tablets (650 milligrams per tablet) three times a day in the morning, afternoon, and evening. The tablets should not be taken more than 5 days in a row for each monthly period.
    • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you take a dose that is late, wait at least six hours before you take your next dose.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Lysteda

It is very important that your doctor check your progress while you are using this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

Tell your doctor if you are using birth control pills or other types of birth control (e.g., patch, vaginal ring, or intrauterine device). Using these medicines together may increase your chance of having a blood clot, heart attack, or stroke.

This medicine may cause serious allergic reactions including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have shortness of breath; trouble breathing; chest tightness; flushing of the face; trouble swallowing; or any swelling of your hands, face, or mouth while you are using this medicine.

Stop taking this medicine and call your doctor right away if you have any eye problems, such as a change in your vision. Your doctor will want you to have your eyes checked by an ophthalmologist (eye doctor).

If this medicine does not reduce your bleeding after two menstrual cycles or if it seems to stop working, check with your doctor.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Lysteda Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Pale skin
• troubled breathing with exertion
• unusual bleeding or bruising
• unusual tiredness or weakness

Incidence not known

• Anxiety
• blurred or loss of vision
• chest pain
• confusion
• cough
• difficulty with swallowing
• disturbed color perception
• dizziness or lightheadedness
• double vision
• fainting
• fast heartbeat
• hives
• itching
• night blindness
• numbness of the hands
• overbright appearance of lights
• pain, redness, or swelling in the arm or leg
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• seeing halos around lights
• seeing shades of colors differently than before
• shortness of breath
• skin rash
• sudden shortness of breath or troubled breathing
• tightness in the chest
• tunnel vision
• wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Abdominal or stomach pain, discomfort, or tenderness
• back pain
• chills
• difficulty with moving
• fever
• flushing
• headache
• headache, severe and throbbing
• increased sensitivity to sunlight
• itching, pain, redness, or swelling of the eye or eyelid
• joint pain
• muscle aching or cramping
• muscle pains or stiffness
• pain or tenderness around the eyes and cheekbones
• severe skin rash or hives
• stuffy or runny nose
• swollen glands
• swollen joints
• watering of the eyes

Incidence not known

• Diarrhea
• nausea
• vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided “AS IS” and “as available” for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

Generic Name: lysine (LYE seen)
Brand Names:

What is lysine?

Lysine is an essential amino acid. Essential means that it is not produced by the body and therefore it must be taken in either by diet or by taking supplements. Lysine is found in foods such as yogurt, fish, cheese, brewer’s yeast, wheat germ, pork, and other meats.

Lysine has been used to treat or prevent herpes infections (genital herpes and cold sores) and canker sores. It has also been used to treat symptoms of Bell’s palsy, and to improve calcium use in the body.

Lysine has not been approved by the FDA to treat any disease, and it should not be substituted for prescription medications.

Lysine may also have uses other than those listed in this product guide.

What is the most important information I should know about lysine?

Lysine has not been approved by the FDA to treat any disease, and it should not be substituted for prescription medications.

Lysine has not been evaluated by the FDA for safety, effectiveness, or purity. All potential risks and/or advantages of this product may not be known. Additionally, there are no regulated manufacturing standards in place for these compounds. Some marketed herbal supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

What should I discuss with my healthcare provider before taking lysine?

Before taking lysine, talk to your doctor, pharmacist, herbalist, or other healthcare provider. You may not be able to use this product if you have liver or kidney disease, or certain other medical conditions or allergies. Do not take lysine without telling your doctor if you are pregnant or could become pregnant. It is not known whether lysine will be harmful to an unborn baby. Do not take lysine without telling your doctor if you are breast-feeding a baby. It is not known whether lysine will be harmful to a nursing infant.

How should I take lysine?

Lysine has not been evaluated by the FDA for safety, effectiveness, or purity. All potential risks and/or advantages of this product may not be known. Additionally, there are no regulated manufacturing standards in place for these compounds. Some marketed herbal supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

If you choose to take lysine, use it exactly as directed on the label, or as prescribed by your doctor, pharmacist, or other healthcare provider.

Store lysine at room temperature, away from heat, light, and moisture.

What happens if I miss a dose?

No information is available regarding a missed dose of lysine. Ask your doctor, pharmacist, or healthcare professional for instructions if you miss a dose.

What happens if I overdose?

An overdose of lysine is unlikely to threaten life. Call an emergency room or poison control center for advice if you think you have taken too much.

What should I avoid while taking lysine?

Do not give any herbal/health supplement to a child without a doctor’s advice.

Lysine side effects

Stop taking lysine and seek emergency medical attention if you experience symptoms of a serious allergic reaction including difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives.

Side effects other than those listed here may also occur. Talk to your doctor, pharmacist, or healthcare provider about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect lysine?

The following drugs may become toxic if you take them together with lysine. Tell your healthcare provider if you are using any of these:

• gentamicin (Garamycin);

• tobramycin (Nebcin, TOBI);

• amikacin (Amikin);

• kanamycin (Kantrex);

• netilmicin (Netromycin);

• neomycin (Mycifradin, Neo-Fradin, Neo-Tab);

• netilmicin (Netromycin);

• streptomycin; or

• tobramycin (Nebcin, Tobi).

If you are using any of these drugs, you may not be able to take lysine, or you may need dosage adjustments or special tests during treatment.

This list is not complete and there may be other drugs that can interact with lysine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

• Your doctor, pharmacist, herbalist, or healthcare provider can provide more information about lysine.

• Before using any herbal supplement, consult with a licensed healthcare professional or a practitioner trained in the uses of herbal supplements. It is important to keep all of your care providers informed about the treatments and medications you are using. Remember, keep all medicines out of the reach of children, never share your medicines with others, and use this product only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 1.06. Revision Date: 4/12/2009 4:37:30 PM.

Generic Name: Vitamins with Lipotropics (VYE-ta-mins/lye-po-TROE-piks)
Brand Name: Examples include Geravine and Lysiplex

Lysiplex Elixir is used for:

Providing vitamins and certain other nutrients as a supplement to the diet. It may also be used for other conditions as determined by your doctor.

Lysiplex Elixir is a combination of vitamins and lipotropic factors. It works by providing vitamins to the body. Exactly how the lipotropics work is unknown.

Do NOT use Lysiplex Elixir if:

• you are allergic to any ingredient in Lysiplex Elixir

Contact your doctor or health care provider right away if any of these apply to you.

Before using Lysiplex Elixir:

Some medical conditions may interact with Lysiplex Elixir. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have anemia

Some MEDICINES MAY INTERACT with Lysiplex Elixir. However, no specific interactions with Lysiplex Elixir are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Lysiplex Elixir may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Lysiplex Elixir:

Use Lysiplex Elixir as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Lysiplex Elixir with regard to food as directed on the package labeling or by your doctor.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• If you miss a dose of Lysiplex Elixir, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Lysiplex Elixir.

Important safety information:

• Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children younger than 6 years of age. Keep this product out of the reach of children. If an accidental overdose does occur, seek immediate medical attention or call a poison control center.
• Do not take large doses of vitamins (megadoses or megavitamin therapy) unless directed to do so by your doctor.
• Some vitamin supplements contain vitamin C (ascorbic acid). If your brand contains vitamin C, it may cause incorrect test results with some urine glucose tests. If you have diabetes, check with your doctor before adjusting the dose of your diabetes medicine or changing your diet.
• If your brand contains vitamin C, it may also cause incorrect test results with kits used to check for blood in the stool. Check with your doctor if you are taking Lysiplex Elixir when using this test kit.
• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Lysiplex Elixir, discuss with your doctor the benefits and risks of using Lysiplex Elixir during pregnancy. Lysiplex Elixir is excreted in breast milk. If you are or will be breast-feeding while you are using Lysiplex Elixir, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Lysiplex Elixir:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild breath odor; upset stomach.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Lysiplex Elixir:

Store Lysiplex Elixir at room temperature, below 86 degrees F (30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Lysiplex Elixir out of the reach of children and away from pets.

General information:

• If you have any questions about Lysiplex Elixir, please talk with your doctor, pharmacist, or other health care provider.
• Lysiplex Elixir is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Lysiplex Elixir. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: mitotane (MYE toe tane)
Brand Names: Lysodren

What is Lysodren (mitotane)?

Mitotane is a cancer medication. That interferes with the growth of cancer cells and slows their growth and spread in the body.

Mitotane is used to treat cancer of the adrenal gland (adrenal cortical carcinoma).

Mitotane may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Lysodren (mitotane)?

You may receive your first few doses of mitotane in a hospital setting where you can be monitored in case the medication causes serious side effects. You should not use this medication if you are allergic to mitotane.

Before taking mitotane, tell your doctor if you have liver disease, or if you have had a recent infection, surgery, or trauma.

Always wear rubber gloves when handling mitotane tablets. The medicine from a crushed or broken tablet can be dangerous if it gets on your skin.

You may need to take steroid medication along with mitotane to best treat your condition. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor.

If you have any type of infection, serious injury or medical emergency, you may need to stop taking this medication for a short time. Your doctor will determine when you can start taking mitotane again.

Carry an ID card or wear a medical alert bracelet stating that you are taking mitotane, in case of an emergency. Any doctor, dentist, or emergency medical care provider who treats you should know that you are using mitotane.

You must remain under the care of a doctor while taking mitotane. Do not miss any scheduled appointments.

It may take up to several months of using mitotane before your symptoms improve. Talk with your doctor if your symptoms do not improve or if they get worse.

What should I discuss with my healthcare provider before taking Lysodren (mitotane)?

You should not use this medication if you are allergic to mitotane.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:

• recent infection, surgery, or trauma;

• liver disease.

FDA pregnancy category C. It is not known whether mitotane is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether mitotane passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Lysodren (mitotane)?

You may receive your first few doses of mitotane in a hospital setting where you can be monitored in case the medication causes serious side effects.

Take mitotane exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

You may take mitotane with or without food.

Always wear rubber gloves when handling mitotane tablets. Do not crush or break a tablet, or use a tablet that has been accidentally broken. The medicine from a crushed or broken tablet can be dangerous if it gets on your skin. If skin contact occurs, wash the area with soap and water. Ask your doctor or pharmacist how to safely dispose of the broken tablet.

Your doctor may occasionally change your dose to make sure you get the best results from this medication. You may also need to take steroid medication to best treat your condition. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor.

Contact your doctor at once if you develop signs of infection such as fever, chills, sore throat, flu symptoms, loss of appetite, nausea and vomiting, mouth sores, or unusual weakness.

If you have any type of infection, serious injury or medical emergency, you may need to stop taking this medication for a short time. Your doctor will determine when you can start taking mitotane again.

Carry an ID card or wear a medical alert bracelet stating that you are taking mitotane, in case of an emergency. Any doctor, dentist, or emergency medical care provider who treats you should know that you are using mitotane.

To be sure this medication is helping your condition and is not causing harmful effects, your doctor will need to check your progress on a regular basis. You must remain under the care of a doctor while taking mitotane. Do not miss any scheduled appointments.

It may take up to several months of using mitotane before your symptoms improve. For best results, keep using your medications as directed. Talk with your doctor if your symptoms do not improve or if they get worse. Store mitotane at room temperature away from moisture and heat.

See also: Lysodren dosage in more detail

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a mitotane overdose are not known.

What should I avoid while taking Lysodren (mitotane)?

Avoid being near people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection.

Avoid activities that may increase your risk of trauma or injury.

Mitotane can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Lysodren (mitotane) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• feeling like you might pass out;

• fast or pounding heartbeats;

• warmth, redness, or tingly feeling under your skin;

• sweating, cold or clammy skin;

• high fever, chills, uncontrolled shaking;

• blurred or double vision;

• confusion, problems with speech, balance, or walking;

• pain or burning when you urinate;

• blood in your urine; or

• unexpected weight loss.

Less serious side effects may include:

• dizziness, spinning sensation;

• drowsiness, tired feeling;

• depressed mood;

• mild skin rash;

• nausea, vomiting, diarrhea; or

• loss of appetite.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Lysodren (mitotane)?

Before using mitotane, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by mitotane.

Tell your doctor about all other medications you use, especially:

• a blood thinner such as warfarin (Coumadin);

• spironolactone (Aldactone).

This list is not complete and there may be other drugs that can interact with mitotane. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about mitotane.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 3.01. Revision Date: 06/08/2009 11:16:39 AM.

Generic Name: Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine)
Brand Name: Atgam

Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine) is used for:

Treating rejection in kidney transplant patients. It is also used with other medicines to delay the onset of kidney transplant rejection. Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine) is also used to treat moderate to severe aplastic anemia in certain patients who cannot have a bone marrow transplant.

Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine) is a lymphocyte-selective immunosuppressant. It works by decreasing the action of certain types of blood cells (T lymphocytes), which are part of the body’s immune system.

Do NOT use Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine) if:

• you are allergic to Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine), any ingredient in Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine), or any other gamma globulin made from horse serum
• you have a severe decrease in white blood cell counts or severely decreased blood platelets

Contact your doctor or health care provider right away if any of these apply to you.

Before using Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine):

Some medical conditions may interact with Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine). Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine). However, no specific interactions with Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine) are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine) may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine):

Use Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine) is usually administered as an injection at your doctor’s office, hospital, or clinic.
• If Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine) contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
• Keep this product, as well as syringes and needles, out of the reach of children. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
• If you miss a dose of Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine), contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine).

Important safety information:

• Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine) CONTAINS ALBUMIN, which comes from human blood. There is an extremely rare risk of developing a viral disease or a central nervous system disease called Creutzfeldt-Jakob disease. No cases of viral diseases or Creutzfeldt-Jakob disease from albumin have been identified.
• Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine) may cause dizziness or lightheadedness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine). Using Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine) alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• A skin test is normally performed before the first dose to check for possible allergy to horse serum.
• LAB TESTS, including blood cell counts, liver function tests, and kidney function tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
• Caution is advised when using Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine) in CHILDREN because they may be more sensitive to its effects.
• PREGNANCY and BREAST-FEEDING: It is unknown if Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine) can cause harm to the fetus. If you become pregnant while taking Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine), discuss with your doctor the benefits and risks of using Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine) during pregnancy. It is unknown if Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine) is excreted in breast milk. If you are or will be breast-feeding while you are using Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine), check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine):

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; headache; joint pain; nausea; night sweats; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); back pain; chest pain; confusion or disorientation; decreased urination or dark urine; fast, slow, or irregular heartbeat; fever, chills, or sore throat; irritation or sores in the mouth; muscle pain; pain, redness, or swelling at the injection site; pain or swelling in the legs; pain or swelling in the neck or under the arms; red, swollen, or blistered skin; seizures; severe dizziness, lightheadedness, or headache; stomach pain; unusual bleeding or bruising; unusual skin sensations (eg, burning or tingling).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine):

Store Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine) in the refrigerator between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Keep Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine) out of the reach of children and away from pets.

General information:

• If you have any questions about Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine), please talk with your doctor, pharmacist, or other health care provider.
• Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine) is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine). If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: vancomycin (VAN koe MYE sin)
Brand Names: Lyphocin, Vancocin HCl, Vancocin HCl Pulvules

What is Lyphocin (vancomycin)?

Vancomycin is an antibiotic. It fights bacteria in the body.

Vancomycin is used to treat infections of the intestines that cause colitis (inflammation of the large intestine).

Vancomycin may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Lyphocin (vancomycin)?

Before using vancomycin, tell your doctor if you are allergic to any drugs, or if you have kidney disease, problems with your hearing, or an intestinal disorder such as inflammatory bowel disease, Crohn’s disease, or ulcerative colitis.

Vancomycin can cause temporary or permanent hearing loss. Stop using this medication and call your doctor at once if you have any hearing problems or ringing in your ears.

To be sure this medication is not causing harmful effects, your hearing will need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Vancomycin will not treat a viral infection such as the common cold or flu.

What should I discuss with my healthcare provider before using Lyphocin (vancomycin)?

Do not take this medication if you are allergic to vancomycin.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take vancomycin:

• kidney disease,

• hearing problems; or

• an intestinal disorder such as inflammatory bowel disease, Crohn’s disease, or ulcerative colitis.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Vancomycin can pass into breast milk and may harm a nursing baby. Do not take this medication without telling your doctor if you are breast-feeding a baby.

How should I take Lyphocin (vancomycin)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Vancomycin can cause temporary or permanent hearing loss. To be sure this medication is not causing harmful effects, your hearing will need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.

Take the oral medicine with a full glass of water.

Vancomycin should be taken at evenly spaced intervals.

Shake the oral suspension (liquid) well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Vancomycin will not treat a viral infection such as the common cold or flu. Store vancomycin capsules at room temperature, away from heat and moisture. Store vancomycin oral liquid in the refrigerator, but do not allow it to freeze.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a vancomycin overdose are not known.

What should I avoid while using Lyphocin (vancomycin)?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, stop using this medication and call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Lyphocin (vancomycin) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using vancomycin and call your doctor at once if you have any of these serious side effects:

• hearing loss, ringing in your ears;

• urinating less than usual or not at all;

• fever, chills, body aches, flu symptoms;

• feeling light-headed, fainting;

• skin rash, redness, bruising, severe tingling, numbness, pain, muscle weakness; or

• severe stomach pain, diarrhea that is watery or bloody.

Less serious side effects may include:

• dizziness;

• nausea;

• back pain; or

• muscle pain or tightness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Lyphocin (vancomycin)?

Before using vancomycin, tell your doctor if you are using any of these other antibiotics, especially:

• amikacin (Amikin);

• gentamicin (Garamycin);

• kanamycin (Kantrex);

• neomycin (Mycifradin, Neo-Fradin, Neo-Tab);

• streptomycin; or

• tobramycin (Nebcin, Tobi).

This list is not complete and there may be other drugs that can interact with vancomycin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about vancomycin.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 3.04. Revision Date: 08/12/2009 9:50:52 AM.

Generic name: Pregabalin
Brand names: Lyrica

Why is Lyrica prescribed?

Lyrica is used to treat nerve pain associated with diabetes and the after-effects of shingles (herpes zoster infection). It is also used together with other drugs to treat a form of epilepsy characterized by partial seizures.

Most important fact about Lyrica

Lyrica can cause dizziness, sleepiness, and blurred or double vision. To prevent injury to yourself and others, use caution when driving, operating machinery, or engaging in hazardous activities until you know how the drug affects you.

How should you take Lyrica?

Take Lyrica exactly as your doctor prescribes, with or without food, at about the same time every day. Do not stop taking Lyrica suddenly or change your dose without your doctor’s approval. If not tapered slowly over the course of at least a week, discontinuing treatment with Lyrica can cause headaches, nausea, diarrhea, or trouble sleeping.

• If you miss a dose…
  Take the forgotten dose as soon as you remember. However, if it is almost time for you next dose, skip the one you missed and return to your regular schedule. Do not take two doses at once.

• Storage instructions…
  Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe to continue using Lyrica.

• Side effects may include:
  Blurry vision, dizziness, dry mouth, sleepingess, swelling of hands and feet, trouble concentrating, weight gain

Why should Lyrica not be prescribed?

Do not take Lyrica if you are allergic to any of its ingredients.

Special warnings about Lyrica

Lyrica should be used with caution if you are over 65 years, or if you have kidney disease, heart disease including heart failure, or a bleeding disorder.

Contact your doctor right away if you develop swelling of the hands and feet, muscle pain or weakness, or skin sores.

Men who plan to father a child, or whose female partners have become pregnant, must seek expert medical advice about the risks associated with Lyrica.

Possible food and drug interactions when taking Lyrica

If Lyrica is taken with certain drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Lyrica with any of the following:

Antihistamines
Anxiety medication
Diabetes medication such as pioglitazone or rosiglitazone
Narcotic pain medication
Seizure medications
Sleep medications
Tranquilizers

Drinking alcohol while taking Lyrica can make you dizzy or sleepy and should be avoided.

Special information if you are pregnant or breastfeeding

The effects of taking Lyrica during pregnancy have not been studied. Lyrica taken by a male partner may affect an unborn baby. If you are pregnant or plan to become pregnant, contact your doctor immediately.

It is not known whether Lyrica appears in breast milk; talk to your doctor if you plan to breastfeed.

Recommended dosage for Lyrica

ADULTS

Nerve Pain Due to Diabetic Peripheral Neuropathy
The usual starting dose is 50 milligrams taken three times a day. Depending on your response, the doctor may increase your dose to 100 milligrams three times daily. You may be prescribed a lower dose if you have kidney problems.

Nerve Pain Due to Shingles
The usual starting dose is 75 to 150 milligrams taken two times a day, or 50 to 100 milligrams taken three times a day. You may be prescribed a lower dose if you have kidney problems.

Epilepsy (partial seizures)
The usual starting dose is 50 milligrams taken three times a day, or 75 milligrams taken two times a day. Depending on your response, the doctor may increase the total daily dose up to 600 milligrams a day. You may be prescribed a lower dose if you have kidney problems.

Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose, seek emergency treatment immediately.

Generic Name: ferrous sulfate (FER us SUL fate)
Brand Names: Feosol, Fer Iron, Fer-Gen-Sol, Fer-in-Sol, Fer-In-Sol, Feratab, FeroSul, Ferra T.D. Caps, Ferro-Bob, Lydia E. Pinkham, MyKidz Iron 10, Slow Fe, Slow Release Iron

What is Lydia E. Pinkham (ferrous sulfate)?

Ferrous sulfate is a type of iron. You normally get iron from the foods you eat. In your body, iron becomes a part of your hemoglobin (HEEM o glo bin) and myoglobin (MY o glo bin). Hemoglobin carries oxygen through your blood to tissues and organs. Myoglobin helps your muscle cells store oxygen.

Ferrous sulfate is used to treat iron deficiency anemia (a lack of red blood cells caused by having too little iron in the body).

Ferrous sulfate may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Lydia E. Pinkham (ferrous sulfate)?

Ask a doctor or pharmacist if it is safe for you to take this medication if you have iron overload syndrome, hemolytic anemia (a lack of red blood cells), porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system), thalassemia (a genetic disorder of red blood cells), if you are an alcoholic, or if you receive regular blood transfusions.

Avoid taking any other multivitamin or mineral product within 2 hours before or after you take ferrous sulfate. Taking similar mineral products together at the same time can result in a mineral overdose or serious side effects. Seek emergency medical attention if you think you have used too much of this medicine, or if anyone has accidentally swallowed it. An overdose of iron can be fatal, especially in a young child.

Overdose symptoms may include nausea, severe stomach pain, bloody diarrhea, coughing up blood or vomit that looks like coffee grounds, shallow breathing, weak and rapid pulse, pale skin, blue lips, and seizure (convulsions).

Take ferrous sulfate on an empty stomach, at least 1 hour before or 2 hours after a meal. Avoid taking antacids or antibiotics within 2 hours before or after taking ferrous sulfate.

Ferrous sulfate is only part of a complete program of treatment that may also include a special diet. It is very important to follow the diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you should eat to make sure you get enough iron from both your diet and your medication.

What should I discuss before taking Lydia E. Pinkham (ferrous sulfate)?

Ask a doctor or pharmacist if it is safe for you to take this medication if you have:

• iron overload syndrome;

• hemolytic anemia (a lack of red blood cells);

• porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system);

• thalassemia (a genetic disorder of red blood cells);

• if you are an alcoholic; or

• if you receive regular blood transfusions.

It is not known whether this medication could be harmful to an unborn baby. Tell your doctor if you become pregnant during treatment. It is not known whether ferrous sulfate passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not give ferrous sulfate to a child without the advice of a doctor.

How should I take Lydia E. Pinkham (ferrous sulfate)?

Use this medication exactly as directed on the label, or as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended.

Take ferrous sulfate on an empty stomach, at least 1 hour before or 2 hours after a meal. Avoid taking antacids or antibiotics within 2 hours before or after taking ferrous sulfate . Take this medication with a full glass of water. Do not crush, chew, break, or open an extended-release tablet or capsule. Swallow the pill whole. Breaking or opening the pill may cause too much of the drug to be released at one time. Shake the oral suspension (liquid) well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Ferrous sulfate can stain your teeth, but this effect is temporary. To prevent tooth staining, mix the liquid form of ferrous sulfate with water or fruit juice (not with milk) and drink the mixture through a straw. You may also clean your teeth with baking soda once per week to treat any tooth staining.

Ferrous sulfate is only part of a complete program of treatment that may also include a special diet. It is very important to follow the diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you should eat to make sure you get enough iron from both your diet and your medication.

Store ferrous sulfate at room temperature, away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine, or if a child has accidentally swallowed it. An overdose of ferrous sulfate can be fatal to a child.

Overdose symptoms may include nausea, severe stomach pain, bloody diarrhea, coughing up blood or vomit that looks like coffee grounds, shallow breathing, weak and rapid pulse, pale skin, blue lips, and seizure (convulsions).

What should I avoid while taking Lydia E. Pinkham (ferrous sulfate)?

Avoid taking any other multivitamin or mineral product within 2 hours before or after you take ferrous sulfate. Taking similar mineral products together at the same time can result in a mineral overdose or serious side effects.

Avoid taking an antibiotic medicine within 2 hours before or after you take ferrous sulfate. This is especially important if you are taking an antibiotic such as ciprofloxacin (Cipro), demeclocycline (Declomycin), doxycycline (Adoxa, Doryx, Oracea, Vibramycin), levofloxacin (Levaquin), lomefloxacin (Maxaquin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), norfloxacin (Noroxin), ofloxacin (Floxin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

Certain foods can also make it harder for your body to absorb ferrous sulfate. Avoid taking this medication within 1 hour before or 2 hours after eating fish, meat, liver, and whole grain or “fortified” breads or cereals.

Avoid using antacids without your doctor’s advice. Use only the specific type of antacid your doctor recommends. Antacids contain different medicines and some types can make it harder for your body to absorb ferrous sulfate.

Lydia E. Pinkham (ferrous sulfate) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include:

• constipation;

• upset stomach;

• black or dark-colored stools; or

• temporary staining of the teeth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Lydia E. Pinkham (ferrous sulfate)?

The following drugs can interact with ferrous sulfate. Tell your doctor if you use any of these:

• acetohydroxamic acid (Lithostat);

• chloramphenicol;

• cimetidine (Tagamet);

• etidronate (Didronel);

• dimercaprol (an injection used to treat poisoning by arsenic, lead, or mercury);

• levodopa (Larodopa, Dopar, Sinemet);

• methyldopa (Aldomet); or

• penicillamine (Cuprimine).

This list is not complete and there may be other drugs that can interact with ferrous sulfate. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about ferrous sulfate.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 3.02. Revision Date: 10/14/2009 11:35:06 AM.

lyme dis-EEZ VAX-een (re-KOM-bin-ant ospa)

Available Dosage Forms:

• Suspension

Therapeutic Class: Vaccine

Uses For lyme disease vaccine (recombinant ospa)

Lyme disease vaccine is an active immunizing agent used to prevent infection by Lyme disease bacteria. It works by causing your body to produce its own protection (antibodies) against the bacteria.

Lyme disease causes rash, fever, weakness, and joint and muscle pain. The disease is caused by bacteria passed to humans by the bite of infected ticks.

The risk of getting tick-borne infections can be lessened by such precautions as wearing long-sleeved shirts and long pants, tucking pants into socks, treating clothing with tick repellent, and checking for and removing attached ticks.

lyme disease vaccine (recombinant ospa) is no longer commercially available.

Before Using lyme disease vaccine (recombinant ospa)

In deciding to use a vaccine, the risks of taking the vaccine must be weighed against the good it will do. This is a decision you and your doctor will make. For this vaccine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to lyme disease vaccine (recombinant ospa) or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Lyme disease vaccine has not been tested in persons younger than 15 years of age. Use is not recommended in infants and children.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly as they do in younger adults. Although there is no specific information comparing use of Lyme disease vaccine in the elderly with use in other age groups, this vaccine is not expected to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of Lyme disease vaccine. Make sure you tell your doctor if you have any other medical problems.

Proper Use of lyme disease vaccine (recombinant ospa)

Dosing

The dose of lyme disease vaccine (recombinant ospa) will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of lyme disease vaccine (recombinant ospa). If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

This medication is not longer on the market

lyme disease vaccine (recombinant ospa) Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common

• Numbness
• tingling
• unusual tiredness or weakness

Less common

• Bone pain
• chills
• cough
• fever
• muscle aches
• runny or stuffy nose
• shivering
• skin rash, itching, redness, swelling, or other sign of irritation not present before vaccination
• sneezing
• sore throat
• sweating

Rare

• Difficulty swallowing
• dizziness
• fast heartbeat
• headache, severe
• puffiness or swelling around eyelids
• shortness of breath

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Back pain
• pain in joints and/or muscles

Less common

• Depression
• diarrhea
• dizziness
• feeling unusually cold

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided “AS IS” and “as available” for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.