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Lice-X

30/06/10

Generic Name: pyrethrum extract and piperonyl butoxide (Topical route)

pye-REE-thrum EX-trackt, PIP-er-oh-nil byoo-TOX-ide

Commonly used brand name(s):

In the U.S.

A200 Maximum Strength
A200 Time-Tested Formula
Lice-X
Licide
Medi-Lice Maximum Strength
Pronto Maximum Strength
Pyrinex
Pyrinyl
Rid
Tisit

Available Dosage Forms:

Gel/Jelly
Liquid
Shampoo
Kit
Foam

Therapeutic Class: Pediculicide

Chemical Class: Pyrethrums

Uses For Lice-X

Medicine containing pyrethrins is used to treat head, body, and pubic lice infections. This medicine is absorbed by the lice and destroys them by acting on their nervous systems. It does not affect humans in this way. The piperonyl butoxide is included to make the pyrethrins more effective in killing the lice. This combination medicine is known as a pediculicide.

This medicine is available without a prescription.

Before Using Lice-X

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no specific information comparing use of pyrethrins and piperonyl butoxide combination in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of pyrethrins and piperonyl butoxide combination medicine in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of pyrethrum extract and piperonyl butoxide

This section provides information on the proper use of a number of products that contain pyrethrum extract and piperonyl butoxide. It may not be specific to Lice-X. Please read with care.

Pyrethrins and piperonyl butoxide combination medicine usually comes with patient directions. Read them carefully before using this medicine.

Use this medicine only as directed. Do not use more of it and do not use it more often than recommended on the label. To do so may increase the chance of absorption through the skin and the chance of side effects.

Keep pyrethrins and piperonyl butoxide combination medicine away from the mouth and do not inhale it. This medicine is harmful if swallowed or inhaled.

To lessen the chance of inhaling this medicine, apply it in a well-ventilated room (for example, one with free flowing air or with a fan turned on).

Keep this medicine away from the eyes and other mucous membranes, such as the inside of the nose, mouth, or vagina, because it may cause irritation. If you accidentally get some in your eyes, flush them thoroughly with water at once.

Do not apply this medicine to the eyelashes or eyebrows . If they become infected with lice, check with your doctor.

To use the gel or solution form of this medicine:

Apply enough medicine to thoroughly wet the dry hair and scalp or skin. Allow the medicine to remain on the affected areas for exactly 10 minutes.
Then, thoroughly wash the affected areas with warm water and soap or regular shampoo. Rinse thoroughly and dry with a clean towel.

To use the shampoo form of this medicine:

Apply enough medicine to thoroughly wet the dry hair and scalp or skin. Allow the medicine to remain on the affected areas for exactly 10 minutes.
Then use a small amount of water and work shampoo into the hair and scalp or skin until a lather forms. Rinse thoroughly and dry with a clean towel.

After rinsing and drying, use a nit removal comb (special fine-toothed comb, usually included with this medicine) to remove the dead lice and eggs (nits) from hair.

Immediately after using this medicine, wash your hands to remove any medicine that may be on them.

This medicine should be used again in 7 to 10 days after the first treatment in order to kill any newly hatched lice.

Lice can easily move from one person to another by close body contact. This can happen also by direct contact with such things as clothing, hats, scarves, bedding, towels, washcloths, hairbrushes and combs, or the hair of infected persons. Therefore, all members of your household should be examined for lice and receive treatment if they are found to be infected.

To use this medicine for pubic (crab) lice:

Your sexual partner may also need to be treated, since the infection may spread to persons in close contact. If your partner is not being treated or if you have any questions about this, check with your doctor.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For topical dosage forms (gel, solution shampoo, and topical solution):
- For head, body, or pubic lice:
  - Adults and children—Use one time, then repeat one time in seven to ten days.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Lice-X

To prevent reinfection or spreading of the infection to other people, good health habits are also required. These include the following:

For head lice
- Machine wash all clothing (including hats, scarves, and coats), bedding, towels, and washcloths in very hot water and dry them by using the hot cycle of a dryer for at least 20 minutes. Clothing or bedding that cannot be washed should be dry-cleaned or sealed in a plastic bag for 2 weeks.
- Shampoo all wigs and hairpieces.
- Wash all hairbrushes and combs in very hot soapy water (above 130 °F) for 5 to 10 minutes and do not share them with other people.
- Clean the house or room by thoroughly vacuuming upholstered furniture, rugs, and floors.
For body lice
- Machine wash all clothing, bedding, towels, and washcloths in very hot water and dry them by using the hot cycle of a dryer for at least 20 minutes. Clothing or bedding that cannot be washed should be dry-cleaned or sealed in a plastic bag for 2 weeks.
- Clean the house or room by thoroughly vacuuming upholstered furniture, rugs, and floors.
For pubic lice
- Machine wash all clothing (especially underwear), bedding, towels, and washcloths in very hot water and dry them by using the hot cycle of a dryer for at least 20 minutes. Clothing or bedding that cannot be washed should be dry-cleaned or sealed in a plastic bag for 2 weeks.
- Scrub toilet seats frequently.

Lice-X Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common or rare

Skin irritation not present before use of this medicine
skin rash or infection
sneezing (sudden attacks of)
stuffy or runny nose
wheezing or difficulty in breathing

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided “AS IS” and “as available” for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

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Librium

30/06/10

Generic Name: chlordiazepoxide (klor dye az e POX ide)
Brand Names: Librium

What is Librium (chlordiazepoxide)?

Chlordiazepoxide is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Chlordiazepoxide affects chemicals in the brain that may become unbalanced and cause anxiety.

Chlordiazepoxide is used to treat anxiety disorders or alcohol withdrawal.

Chlordiazepoxide may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Librium (chlordiazepoxide)?

Do not use this medication if you are allergic to chlordiazepoxide or to other benzodiazepines, such as alprazolam (Xanax), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax). This medication can cause birth defects in an unborn baby. Do not use chlordiazepoxide if you are pregnant.

Before taking chlordiazepoxide, tell your doctor if you have any breathing problems, glaucoma, porphyria, kidney or liver disease, or a history of depression, suicidal thoughts, or addiction to drugs or alcohol.

Do not drink alcohol while taking chlordiazepoxide. This medication can increase the effects of alcohol.

Tell your doctor if you regularly use other medicines that make you sleepy. They can add to sleepiness caused by chlordiazepoxide.

What should I discuss with my healthcare provider before taking Librium (chlordiazepoxide)?

Before taking chlordiazepoxide, tell your doctor if you are allergic to any drugs, or if you have:

glaucoma;
asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems;
porphyria;
kidney or liver disease;
a history of depression or suicidal thoughts or behavior; or
a history of drug or alcohol addiction.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

Chlordiazepoxide may be habit-forming and should be used only by the person it was prescribed for. Chlordiazepoxide should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Chlordiazepoxide can cause birth defects in an unborn baby. Do not use chlordiazepoxide without your doctor’s consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication. Chlordiazepoxide may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. The sedative effects of chlordiazepoxide may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking chlordiazepoxide.

How should I take Librium (chlordiazepoxide)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Chlordiazepoxide should be used for only a short time. Do not take this medication for longer than 4 months without your doctor’s advice. Contact your doctor if this medicine seems to stop working as well in treating your symptoms. Do not stop using chlordiazepoxide suddenly, or you could have seizures or unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when you stop using chlordiazepoxide.

To be sure this medication is not causing harmful effects, your blood and liver function may need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.

Store chlordiazepoxide at room temperature away from moisture, heat, and light.

Keep track of how many pills have been used from each new bottle of this medicine. Benzodiazepines are drugs of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of chlordiazepoxide can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, excitation, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, or coma.

What should I avoid while taking Librium (chlordiazepoxide)?

Do not drink alcohol while taking chlordiazepoxide. This medication can increase the effects of alcohol. Chlordiazepoxide can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, or depression can add to sleepiness caused by chlordiazepoxide. Tell your doctor if you regularly use any of these medicines, or any other anxiety medications.

Librium (chlordiazepoxide) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

confusion;
depressed mood, thoughts of suicide or hurting yourself;
restless muscle movements in your eyes, tongue, jaw, or neck;
hyperactivity, agitation, hostility;
hallucinations; or
jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

drowsiness, tiredness;
swelling;
skin rash;
nausea, vomiting, constipation; or
irregular menstrual periods.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Librium (chlordiazepoxide)?

Before taking chlordiazepoxide, tell your doctor if you are using any of the following drugs:

a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Solfoton);
a blood thinner such as warfarin (Coumadin); or
an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate);
medicine to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil), pimozide (Orap), or thioridazine (Mellaril);
narcotic medication such as butorphanol (Stadol), codeine, hydrocodone (Lortab, Vicodin), levorphanol (Levo-Dromoran), meperidine (Demerol), methadone (Dolophine, Methadose), morphine (Kadian, MS Contin, Oramorph), naloxone (Narcan), oxycodone (OxyContin), propoxyphene (Darvon, Darvocet); or
an antidepressant such as amitriptyline (Elavil, Etrafon), amoxapine (Asendin), citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), paroxetine (Paxil), protriptyline (Vivactil), sertraline (Zoloft), or trimipramine (Surmontil).

This is not a complete list and there may be other drugs that can interact with chlordiazepoxide. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about chlordiazepoxide.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Librium Injection

30/06/10

Generic Name: Chlordiazepoxide (klor-DYE-aze-ee-POX-ide)
Brand Name: Librium

Librium Injection is used for:

Treating anxiety disorders and withdrawal symptoms due to alcoholism. It is also used to reduce fear and anxiety (nervous tension) before undergoing surgery. It may be used for other conditions as determined by your doctor.

Librium Injection is a benzodiazepine. It works by slowing down the movement of chemicals in the brain. This results in a reduction in nervous tension (anxiety) and muscle spasm, and also causes sedation.

Do NOT use Librium Injection if:

you are allergic to any ingredient in Librium Injection
you have acute narrow-angle glaucoma, severe liver disease, or a mental state where contact with reality is lost (psychosis)
you are taking sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Librium Injection:

Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have glaucoma or a predisposition for glaucoma, liver problems, lung problems or chronic obstructive pulmonary disease (COPD), muscle problems, depression, suicidal tendencies, the blood disorder porphyria, or a history of drug abuse or dependence

Some MEDICINES MAY INTERACT with Librium Injection. Tell your health care provider if you are taking any of the following medicines.

Rifampin because the effectiveness of Librium Injection may be decreased
Azole antifungals (eg, ketoconazole), clozapine, disulfiram, nefazodone, omeprazole, sodium oxybate (GHB), or valproic acid because side effects such as increased sedation may occur
Clozapine, hydantoins (eg, phenytoin), or sodium oxybate (GHB) because the actions and side effects of these medicines may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Librium Injection may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Librium Injection:

Use Librium Injection as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Librium Injection is usually administered as an injection at your doctor’s office, hospital, or clinic.
If you are using Librium Injection at home, carefully follow the injection procedures taught to you by your health care provider.
If the medicine contains particles or is discolored, or if the vial/container is cracked or damaged in any way, do not use it.
Try to stay in bed for 3 hours after taking Librium Injection.
Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when full.
If you miss a dose of Librium Injection and you are using it regularly, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Librium Injection.

Important safety information:

Librium Injection may cause dizziness, drowsiness, or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Librium Injection. Using Librium Injection alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks for up to 48 hours after use.
Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Librium Injection. Librium Injection will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
Use Librium Injection with extreme caution in CHILDREN; safety and effectiveness have not been confirmed.
PREGNANCY and BREAST-FEEDING: Librium Injection has been shown to cause harm to the fetus. Avoid becoming pregnant while taking Librium Injection. If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using Librium Injection during pregnancy. Librium Injection is excreted in breast milk. Do not breast-feed while taking Librium Injection.

When used for long periods of time or at high doses, Librium Injection may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Librium Injection stops working well. Do not take more than prescribed.

Librium Injection may be habit-forming and lead to DEPENDENCE if used in high doses or for a long period of time. If you are on long-term or high dosage therapy, you may have WITHDRAWAL symptoms (eg, convulsions, tremor, stomach and muscle cramps, vomiting, sweating) if you suddenly stop taking Librium Injection. Do not stop therapy abruptly or change dosage without asking your pharmacist or doctor. Discuss overuse with your doctor or pharmacist.

Possible side effects of Librium Injection:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; clumsiness; confusion; dizziness; drowsiness; dry mouth; headache; pain, swelling, or redness at the injection site; short-term memory loss; unusual weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); birth defects; increased anxiety symptoms (excitement, stimulation, rage).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include confusion; clumsiness; deep sleep; diminished reflexes; drowsiness; impaired coordination; loss of consciousness; slow reflexes.

Proper storage of Librium Injection:

Store the powder at room temperature (59 to 77 degrees F) (15 to 25 degrees C). Store away from heat and light. Do not store in the bathroom. Store the special liquid used for mixing in the refrigerator (36 to 46 degrees F; 2 to 8 degrees C). Do not freeze. Prepare solution immediately before using. Throw away any unused solution. Librium Injection may not be prepared and stored for later use. Keep Librium Injection, as well as needles and syringes, out of the reach of children and away from pets.

General information:

If you have any questions about Librium Injection, please talk with your doctor, pharmacist, or other health care provider.
Librium Injection is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Librium Injection. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: May 5, 2010

Database Edition 10.2.1.002

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Librax

30/06/10

Generic Name: chlordiazepoxide and clidinium (klor dye az e POX ide and kli DI nee um)
Brand Names: Librax

What is chlordiazepoxide and clidinium?

Chlordiazepoxide is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Chlordiazepoxide affects chemicals in the brain that may become unbalanced and cause anxiety.

Clidinium reduces stomach acid and decreases intestinal spasms.

The combination of chlordiazepoxide and clidinium is used to treat stomach ulcers, irritable bowel syndrome, and intestinal infections.

Chlordiazepoxide and clidinium may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about chlordiazepoxide and clidinium?

Do not use this medication if you are allergic to chlordiazepoxide or clidinium, or to other benzodiazepines, such as alprazolam (Xanax), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax). This medication can cause birth defects in an unborn baby. Do not use chlordiazepoxide and clidinium if you are pregnant.

Before taking chlordiazepoxide and clidinium, tell your doctor if you have any breathing problems, glaucoma, porphyria, kidney or liver disease, or a history of depression, suicidal thoughts, or addiction to drugs or alcohol.

Do not drink alcohol while taking chlordiazepoxide and clidinium. This medication can increase the effects of alcohol. Chlordiazepoxide and clidinium can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. This medication may be habit-forming and should be used only by the person it was prescribed for. Chlordiazepoxide and clidinium should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

What should I discuss with my health care provider before taking chlordiazepoxide and clidinium?

Do not take chlordiazepoxide and clidinium if you have:

narrow-angle glaucoma;
an enlarged prostate;
a bladder obstruction; or
problems with urination.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take this medication:

asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems;
open-angle glaucoma;
myasthenia gravis;
ulcerative colitis, or a blockage in your intestines;
kidney or liver disease;
a history of depression or suicidal thoughts or behavior; or
a history of drug or alcohol addiction.

Chlordiazepoxide can cause birth defects in an unborn baby. Do not use chlordiazepoxide and clidinium without your doctor’s consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication. Chlordiazepoxide and clidinium may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. The sedative effects of chlordiazepoxide may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking chlordiazepoxide and clidinium.

How should I take chlordiazepoxide and clidinium?

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Take this medicine with a full glass of water.

Chlordiazepoxide and clidinium is usually taken before meals and at bedtime. Follow your doctor’s instructions.

Chlordiazepoxide may be habit-forming and should be used only by the person it was prescribed for. Chlordiazepoxide and clidinium should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Contact your doctor if this medicine seems to stop working as well in treating your symptoms. Do not stop using chlordiazepoxide and clidinium suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely. Store this medication at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of chlordiazepoxide can be fatal.

Overdose symptoms may include extreme drowsiness, dry mouth, blurred vision, confusion, muscle weakness, slow or shallow breathing, feeling light-headed, or fainting.

What should I avoid while taking chlordiazepoxide and clidinium??

Chlordiazepoxide and clidinium side effects

confusion;
depressed mood, thoughts of suicide or hurting yourself;
restless muscle movements in your eyes, tongue, jaw, or neck;
hyperactivity, agitation, hostility;
hallucinations;
jaundice (yellowing of the skin or eyes); or
urinating less than usual or not at all.

Less serious side effects may include:

drowsiness, tiredness;
swelling;
skin rash;
blurred vision;
dry mouth;
nausea, vomiting, constipation; or
irregular menstrual periods.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect chlordiazepoxide and clidinium?

Before taking chlordiazepoxide and clidinium, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by chlordiazepoxide and clidinium.

Before taking chlordiazepoxide and clidinium, tell your doctor if you are using any of the following drugs:

a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton);
a blood thinner such as warfarin (Coumadin);
an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate);
medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), pimozide (Orap), or thioridazine (Mellaril);
narcotic medications such as butorphanol (Stadol), codeine, hydrocodone (Lortab, Vicodin), levorphanol (Levo-Dromoran), meperidine (Demerol), methadone (Dolophine, Methadose), morphine (Kadian, MS Contin, Oramorph), naloxone (Narcan), oxycodone (OxyContin), propoxyphene (Darvon, Darvocet); or
antidepressants such as amitriptyline (Elavil, Etrafon), amoxapine (Ascendin), citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), paroxetine (Paxil), protriptyline (Vivactil), sertraline (Zoloft), or trimipramine (Surmontil).

This list is not complete and there may be other drugs that can interact with chlordiazepoxide and clidinium. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist has information about chlordiazepoxide and clidinium.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Concise,L

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Librax Capsules

30/06/10

Generic Name: Chlordiazepoxide/Clidinium (KLOR-dye-az-e-POX-ide/kli-DIN-ee-um)
Brand Name: Librax

Librax Capsules is used for:

Treating stomach or bowel problems such as ulcers, irritability, or inflammation.

Librax Capsules is a benzodiazepine and anticholinergic combination. It works by relieving anxiety and reducing digestive secretions. This helps to improve certain stomach or bowel conditions.

Do NOT use Librax Capsules if:

you are allergic to any ingredient in Librax Capsules
you have problems swallowing, or other severe esophagus problems (eg, inflammation, reflux)
you have severe stomach or bowel problems (eg, blockage, inflammation, loss of muscle tone)
you have a blockage of your bladder, an enlarged prostate, glaucoma, myasthenia gravis, or severe liver problems
you have severe mental problems (eg, psychosis)
you are taking sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Librax Capsules:

Some medical conditions may interact with Librax Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have kidney or liver problems
if you have problems urinating
if you have a history of blood problems (eg, porphyria), glaucoma, increased pressure in the eye, or abnormal electroencephalograms (EEGs)
if you have a history of heart problems (eg, irregular heartbeat, congestive heart failure), hernia, lung or breathing problems (eg, chronic obstructive pulmonary disease [COPD]), or nerve and muscle problems
if you have a history of mood or mental problems (eg, anxiety, depression), suicidal thoughts or actions, or a history of alcohol or other substance dependence or abuse
if you have been very ill

Some MEDICINES MAY INTERACT with Librax Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

Clozapine, methadone, or sodium oxybate (GHB) because delirium, severe drowsiness, severe breathing problems, or serious low blood pressure may occur
Anticoagulants (eg, warfarin) because changes in blood clotting may occur
Azole antifungals (eg, ketoconazole), disulfiram, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), nefazodone, omeprazole, or phenothiazines (eg, thioridazine) because they may increase the risk of Librax Capsules’s side effects
Rifampin because it may decrease Librax Capsules’s effectiveness
Hydantoins (eg, phenytoin) because the risk of their side effects may be increased by Librax Capsules

This may not be a complete list of all interactions that may occur. Ask your health care provider if Librax Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Librax Capsules:

Use Librax Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Librax Capsules by mouth with or without food.
If you miss a dose of Librax Capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Librax Capsules.

Important safety information:

Librax Capsules may cause drowsiness. This effect may be worse if you take it with alcohol or certain medicines. Use Librax Capsules with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Librax Capsules; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
Lab tests, including liver function and complete blood cell counts, may be performed while you use Librax Capsules. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
Use Librax Capsules with caution in the ELDERLY; they may be more sensitive to its effects, especially confusion, drowsiness, and loss of coordination.
Librax Capsules should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
PREGNANCY and BREAST-FEEDING: Librax Capsules may cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Librax Capsules while you are pregnant. Librax Capsules is found in breast milk. Do not breast-feed while taking Librax Capsules.

Some people who use Librax Capsules for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction.

If you stop taking Librax Capsules suddenly, you may have WITHDRAWAL symptoms. These may include unpleasant feelings. In more severe cases, you may have stomach and muscle cramps, vomiting, sweating, and shakiness. Seizures may rarely occur. If you take Librax Capsules for more than 1 to 2 weeks, do not stop taking it without talking to your doctor.

Possible side effects of Librax Capsules:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; constipation; drowsiness; dry mouth.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); behavior changes (eg, excessive anger or rage); changes in sexual desire; changes in the menstrual period; confusion; difficulty urinating; excitability; fainting; loss of coordination; sore throat or fever; swelling; yellowing of the skin or eyes.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include confusion; extreme drowsiness; loss of consciousness; slowed reflexes.

Proper storage of Librax Capsules:

Store Librax Capsules at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Keep Librax Capsules out of the reach of children and away from pets.

General information:

If you have any questions about Librax Capsules, please talk with your doctor, pharmacist, or other health care provider.
Librax Capsules is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Librax Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: May 5, 2010

Database Edition 10.2.1.002

L,Med-facts

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Libritabs

30/06/10

Generic Name: chlordiazepoxide hydrochloride (Oral route)

klor-dye-az-e-POX-ide hye-droe-KLOR-ide

Commonly used brand name(s):

In the U.S.

Librium

Available Dosage Forms:

Capsule
Tablet

Therapeutic Class: Antianxiety

Pharmacologic Class: Chlordiazepoxide

Uses For Libritabs

Chlordiazepoxide is used to relieve symptoms of anxiety, including nervousness or anxiety that happens before a surgery. It may also be used to treat symptoms of alcohol withdrawal.

Chlordiazepoxide is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor’s prescription.

Before Using Libritabs

Allergies

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of chlordiazepoxide in children below 6 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of chlordiazepoxide in the elderly. However, severe drowsiness, dizziness, confusion, clumsiness, or unsteadiness are more likely to occur in the elderly, who are usually more sensitive than younger adults to the effects of chlordiazepoxide. Elderly patients may require a lower dose to help reduce unwanted effects.

Breast Feeding

Interactions with Medicines

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Alfentanil
Amobarbital
Anileridine
Aprobarbital
Butabarbital
Butalbital
Carisoprodol
Chloral Hydrate
Chlorzoxazone
Codeine
Dantrolene
Ethchlorvynol
Fentanyl
Fospropofol
Hydrocodone
Hydromorphone
Levorphanol
Meperidine
Mephenesin
Mephobarbital
Meprobamate
Metaxalone
Methocarbamol
Methohexital
Morphine
Morphine Sulfate Liposome
Oxycodone
Oxymorphone
Pentobarbital
Phenobarbital
Primidone
Propoxyphene
Remifentanil
Secobarbital
Sodium Oxybate
Sufentanil
Tapentadol
Thiopental
Zolpidem

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Ketoconazole
St John’s Wort
Theophylline

Interactions with Food/Tobacco/Alcohol

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Ethanol

Proper Use of chlordiazepoxide hydrochloride

This section provides information on the proper use of a number of products that contain chlordiazepoxide hydrochloride. It may not be specific to Libritabs. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Dosing

For oral dosage form (capsules):
- For anxiety:
  - Adults—5 to 25 milligrams (mg) three or four times a day.
  - Older adults—5 milligrams (mg) two to four times a day.
  - Children 6 years of age and older—At first, 5 milligrams (mg) two to four times a day. Your doctor may increase your dose if needed.
  - Children younger than 6 years of age—Use and dose must be determined by your doctor.
- For apprehension and anxiety before a surgery:
  - Adults—5 to 10 milligrams (mg) three or four times a day, taken several days before the surgery.
  - Children—Use and dose must be determined by your doctor.
- For symptoms of alcohol withdrawal:
  - Adults—At first, 50 to 100 milligrams (mg). The dose may be repeated until agitation is controlled. However, the dose is usually not more than 300 mg per day.
  - Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Libritabs

It is very important that your doctor check the progress of you or your child at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

This medicine may cause some people, especially older persons, to become drowsy, dizzy, lightheaded, clumsy or unsteady, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert or able to think or see well.

This medicine will add to the effects of alcohol and other central nervous system (CNS) depressants. CNS depressants are medicines that slow down the nervous system, which may cause drowsiness or make you less alert. Some examples of CNS depressants are antihistamines or medicine for hay fever, allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates (used for seizures); muscle relaxants; or anesthetics (numbing medicines), including some dental anesthetics. This effect may last for a few days after you stop taking this medicine. Check with your doctor before taking any of the above while you are using this medicine.

If you develop any unusual and strange thoughts or behavior while you are taking chlordiazepoxide, be sure to discuss it with your doctor. Some changes that have occurred in people taking this medicine are like those seen in people who drink alcohol and then act in a manner that is not normal. Other changes may be more unusual and extreme, such as confusion, worsening of depression, hallucinations (seeing, hearing, or feeling things that are not there), suicidal thoughts, and unusual excitement, nervousness, or irritability.

Do not stop taking it without checking with your doctor first.. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent a worsening of your condition and reduce the possibility of withdrawal symptoms, such as convulsions (seizures), stomach or muscle cramps, tremors, or unusual behavior.

This medicine is for short-term use only (usually 7 to 10 days). If your condition does not improve or if it becomes worse, check with your doctor.

Libritabs Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Fainting
mood or mental changes
shakiness and unsteady walk
unsteadiness, trembling, or other problems with muscle control or coordination

Incidence not known

Abdominal and muscle cramps
chills
clay-colored stools
convulsions
cough or hoarseness
dark urine
difficulty in speaking
dizziness
drooling
fever with or without chills
general feeling of tiredness or weakness
headache
itching
light-colored stools
loss of appetite
loss of balance control
lower back or side pain
muscle trembling, jerking, or stiffness
nausea and vomiting
painful or difficult urination
pale skin
rash
restlessness
shakiness in the legs, arms, hands, or feet
shuffling walk
sleeplessness
sore throat
sores, ulcers, or white spots on the lips or in the mouth
stiffness of the limbs
stomach pain
sweating
swelling
trouble sleeping
twisting movements of the body
unable to sleep
uncontrolled movements, especially of the face, neck, and back
unpleasant breath odor
unusual bruising or bleeding
unusual tiredness or weakness
vomiting of blood
yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Change in consciousness
lack of coordination
loss of consciousness
sleepiness or unusual drowsiness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Decreased interest in sexual intercourse
difficulty having a bowel movement (stool)
inability to have or keep an erection
increased in sexual ability, desire, drive, or performance
increased interest in sexual intercourse
loss in sexual ability, desire, drive, or performance
menstrual changes
skin blisters

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Advanced,L

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Lialda

30/06/10

Generic Name: mesalamine (oral) (me SAL a meen)
Brand Names: Apriso, Asacol, Asacol HD, Lialda, Pentasa

What is mesalamine oral?

Mesalamine affects a substance in the body that causes inflammation, tissue damage, and diarrhea.

Mesalamine is used to treat ulcerative colitis, proctitis, and proctosigmoiditis. Mesalamine is also used to prevent the symptoms of ulcerative colitis from recurring.

Mesalamine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about mesalamine oral?

You should not use this medication if you are allergic to mesalamine or to aspirin or other salicylates (such as Disalcid, Doan’s Pills, Dolobid, Salflex, Tricosal, and others). Before you take mesalamine, tell your doctor if you have kidney or liver disease, a stomach condition called pyloric stenosis, a heart condition such as congestive heart failure, or a history of allergy to sulfasalazine (Azulfidine). Do not crush, break, or chew a mesalamine tablet or capsule. Swallow the pill whole. It is specially formulated to release the medicine after it has passed through your stomach into your intestines.

Call your doctor if you find undissolved tablets in your stool.

Stop using mesalamine and call your doctor at once if you have severe stomach pain, cramping, fever, headache, and bloody diarrhea.

What should I discuss with my healthcare provider before taking mesalamine oral?

You should not use this medication if you are allergic to mesalamine or to aspirin or other salicylates (such as Disalcid, Doan’s Pills, Dolobid, Salflex, Tricosal, and others).

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take mesalamine:

a stomach condition called pyloric stenosis;
a history of allergy to sulfasalazine (Azulfidine);
a heart condition such as congestive heart failure;
kidney disease; or
liver disease.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Mesalamine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take mesalamine oral?

Take mesalamine with a full glass of water.

Mesalamine can usually be taken with or without food. Follow your doctor’s instructions.

Mesalamine extended-release capsules(Lialda) should be taken with a meal. Do not crush, break, or chew a mesalamine tablet or capsule. Swallow the pill whole.

The extended-release capsule is specially formulated to release the medicine after it has passed through your stomach into your intestines. Breaking the pill may cause the drug to be released too early in the digestive tract.

The enteric-coated tablet has a special coating to protect your stomach. Breaking the pill could damage this coating.

Call your doctor if you find undissolved tablets in your stool.

Store mesalamine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include ringing in your ears, dizziness, headache, confusion, drowsiness, sweating, shortness of breath, vomiting, and diarrhea.

What should I avoid while taking mesalamine oral?

Follow your doctor’s instructions about any restrictions on food, beverages, or activity while you are using mesalamine.

Mesalamine oral side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using mesalamine and call your doctor at once if you have any of these serious side effects:

severe stomach pain, cramping, fever, headache, and bloody diarrhea.

Less serious side effects may include:

mild nausea, vomiting, stomach cramps, diarrhea, gas;
fever, sore throat, or other flu symptoms;
constipation;
headache or dizziness;
tired feeling; or
skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect mesalamine oral?

Before taking mesalamine, tell your doctor if you are using any of the following drugs:

azathioprine (Imuran) or mercaptopurine (Purinethol);
pentamidine (Nebupent, Pentam);
tacrolimus (Prograf);
amphotericin B (Fungizone, AmBisome, Amphotec, Abelcet);
antibiotics such as capreomycin (Capastat), rifampin (Rifadin, Rimactane, Rifater), vancomycin (Vancocin, Vancoled);
antiviral medicines such as acyclovir (Zovirax), adefovir (Hepsera), cidofovir (Vistide), or foscarnet (Foscavir);
cancer medicine such as aldesleukin (Proleukin), carmustine (BiCNU, Gliadel), cisplatin (Platinol), ifosfamide (Ifex), oxaliplatin (Eloxatin), streptozocin (Zanosar), or tretinoin (Vesanoid); or
aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel).

This list is not complete and there may be other drugs that can interact with mesalamine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about mesalamine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Concise,L

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Lialda Delayed-Release Tablets

30/06/10

Generic Name: Mesalamine (me-SAL-a-meen)
Brand Name: Examples include Asacol and Lialda

Lialda Delayed-Release Tablets are used for:

Treating and causing remission of various forms of mild to moderate ulcerative colitis (inflammation of the colon). Lialda Delayed-Release Tablets may also be used for other conditions as determined by your doctor.

Lialda Delayed-Release Tablets are a 5-aminosalicylic acid (5-ASA). It works by preventing the production of substances that cause inflammation of the colon.

Do NOT use Lialda Delayed-Release Tablets if:

you are allergic to any ingredient in Lialda Delayed-Release Tablets, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, naproxen), or salicylates (eg, aspirin)
you are younger than 18 years of age and you have the flu or chickenpox, or you have received a live vaccine (eg, varicella, influenza) within the past 6 weeks
you are taking probenecid or sulfinpyrazone

Contact your doctor or health care provider right away if any of these apply to you.

Before using Lialda Delayed-Release Tablets:

Some medical conditions may interact with Lialda Delayed-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines (including sulfasalazine), foods, or other substances
if you have had a stroke, bleeding in the brain, or an aneurysm
if you have a history of liver or kidney problems, certain stomach problems (pyloric stenosis), pancreas problems (eg, pancreatitis), Kawasaki syndrome, or a rheumatic (inflammatory) disease (eg, rheumatoid arthritis)
if you have a history of heart problems (eg, inflammation of the sac around your heart)
if you have the flu or chickenpox or have recently received a live vaccine (eg, varicella, influenza)

Some MEDICINES MAY INTERACT with Lialda Delayed-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

Gingko biloba extract because side effects, such as increased bleeding, may occur
Corticosteroids (eg, prednisone) because they may decrease Lialda Delayed-Release Tablets’s effectiveness
Carbonic anhydrase inhibitors (eg, acetazolamide), insulin, meglitinide antidiabetics (eg, repaglinide), sulfonylureas (eg, glipizide), or valproic acid because the risk of their side effects may be increased by Lialda Delayed-Release Tablets
Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), anticoagulants (eg, warfarin), beta-blockers (eg, propranolol), probenecid, spironolactone, or sulfinpyrazone because their effectiveness may be decreased by Lialda Delayed-Release Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Lialda Delayed-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Lialda Delayed-Release Tablets:

Use Lialda Delayed-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Lialda Delayed-Release Tablets by mouth with or without food. If stomach upset occurs, take with food or milk to reduce stomach irritation.
Swallow Lialda Delayed-Release Tablets whole. Do not break, crush, or chew before swallowing.
Continue to take Lialda Delayed-Release Tablets even if you feel well. Do not miss any doses.
If you miss a dose of Lialda Delayed-Release Tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Lialda Delayed-Release Tablets.

Important safety information:

Lialda Delayed-Release Tablets may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Lialda Delayed-Release Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Lialda Delayed-Release Tablets may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Lialda Delayed-Release Tablets. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
You may notice undissolved parts of Lialda Delayed-Release Tablets in your stool with some brands of Lialda Delayed-Release Tablets. If this occurs repeatedly, contact your doctor.
Some patients may experience an intolerance reaction to Lialda Delayed-Release Tablets. Signs of intolerance are very similar to symptoms of inflammatory bowel disease. They may include severe or persistent stomach pain or cramping, bloody diarrhea, fever, headache, or rash. If you experience any of these symptoms, contact your doctor right away.
Salicylates have been linked to a serious illness called Reye syndrome. Do not give Lialda Delayed-Release Tablets to a child or teenager who has the flu, chickenpox, or a viral infection. Contact your doctor with any questions or concerns.
Lab tests, including kidney function, liver function, and complete blood cell counts, may be performed while you use Lialda Delayed-Release Tablets. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
Use Lialda Delayed-Release Tablets with caution in the ELDERLY; they may be more sensitive to its effects, especially blood problems.
Lialda Delayed-Release Tablets should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Lialda Delayed-Release Tablets while you are pregnant. Lialda Delayed-Release Tablets are found in breast milk. If you are or will be breast-feeding while you use Lialda Delayed-Release Tablets, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Lialda Delayed-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; gas; headache; mild stomach discomfort or pain; nausea; runny or stuffy nose.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine; bloody diarrhea; bloody or coffee ground-like vomit; change in the amount of urine; chest pain; dark urine; fever, chills, or persistent sore throat; severe or persistent headache; severe or sudden stomach pain or cramping; shortness of breath; unusual bruising or bleeding; yellowing of the skin or eyes.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include confusion; diarrhea; dizziness; drowsiness; fast or difficult breathing; fever; headache; hearing loss; ringing in the ears; seizures; sweating; vomiting of blood; weakness.

Proper storage of Lialda Delayed-Release Tablets:

Store Lialda Delayed-Release Tablets at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Lialda Delayed-Release Tablets out of the reach of children and away from pets.

General information:

If you have any questions about Lialda Delayed-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.
Lialda Delayed-Release Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Lialda Delayed-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: May 5, 2010

Database Edition 10.2.1.002

L,Med-facts

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Lexxel

30/06/10

Generic Name: enalapril and felodipine (en AL a pril and fe LOE di peen)
Brand Names: Lexxel

What is Lexxel (enalapril and felodipine)?

Enalapril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme.

Felodipine is in a group of drugs called calcium channel blockers. It works by relaxing the muscles of your heart and blood vessels.

The combination of enalapril and felodipine is used to treat high blood pressure (hypertension). It is usually given after other blood pressure medications have been tried without successful treatment of hypertension.

Enalapril and felodipine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Lexxel (enalapril and felodipine)?

Do not use this medication without telling your doctor if you are pregnant or planning a pregnancy. Enalapril and felodipine could cause birth defects in the baby if you take the medication during pregnancy. Use an effective form of birth control. Stop using this medication and tell your doctor right away if you become pregnant during treatment.

Vomiting, diarrhea, or heavy sweating can cause you to become dehydrated. This can lead to very low blood pressure, electrolyte disorders, or kidney failure while you are taking enalapril and felodipine. Drink plenty of water each day while you are taking this medication.

What should I discuss with my healthcare provider before taking Lexxel (enalapril and felodipine)?

Do not use this medication if you are allergic to enalapril and felodipine or to any other ACE inhibitor, such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik).

Before using enalapril and felodipine, tell your doctor if you are allergic to any drugs, or if you have:

kidney disease (or if you are on dialysis);
liver disease;
heart disease or congestive heart failure;
low sodium levels in your body (hyponatremia);
diabetes; or
a history of stroke or heart attack.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

FDA pregnancy category D. Do not use this medication without telling your doctor if you are pregnant or planning a pregnancy. Enalapril and felodipine could cause birth defects in the baby if you take the medication during pregnancy. Use an effective form of birth control. Stop using this medication and tell your doctor right away if you become pregnant during treatment. Enalapril and felodipine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Lexxel (enalapril and felodipine)?

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Enalapril and felodipine should be taken without food or with a light meal.

Do not crush, chew, or break the extended-release tablet. Swallow the pill whole. Breaking or crushing the pill may cause too much of the drug to be released at one time.

To be sure this medication is helping your condition, your blood pressure will need to be checked on a regular basis. Your kidney function may also need to be tested. Do not miss any scheduled visits to your doctor.

If you need to have any type of surgery, tell the surgeon ahead of time that you are taking enalapril and felodipine. You may need to stop using the medicine for a short time.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms, so you may not know when your blood pressure is high. You may need to use blood pressure medication for the rest of your life.

Store enalapril and felodipine at room temperature away from moisture, heat, and light.

See also: Lexxel dosage in more detail

What happens if I miss a dose?

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include feeling extremely dizzy or light-headed, or fainting.

What should I avoid while taking Lexxel (enalapril and felodipine)?

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Do not use salt substitutes or potassium supplements while taking enalapril and felodipine, unless your doctor has told you to.

Grapefruit and grapefruit juice may interact with felodipine and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

Lexxel (enalapril and felodipine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

feeling like you might pass out;
chest pain;
swelling in your hands or feet;
fast, pounding, or uneven heartbeats;
fever, chills, body aches, flu symptoms; or
nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

cough;
headache;
dizziness;
swelling in your gums;
feeling tired or weak;
warmth, redness, or tingling under your skin;
dry mouth, sore throat; or
diarrhea, constipation, upset stomach.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect Lexxel (enalapril and felodipine)?

Before taking enalapril and felodipine, tell your doctor if you are taking any of the following drugs:

cimetidine (Tagamet);
lithium (Lithobid, Eskalith);
a diuretic (water pill).
aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), diclofenac (Voltaren), etodolac (Lodine), indomethacin (Indocin), naproxen (Aleve, Naprosyn), and others;
HIV/AIDS medicine such as nelfinavir (Viracept) or ritonavir (Norvir);
an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., E-Mycin, Ery-Tab, Erythrocin), itraconazole (Sporanox), ketoconazole (Nizoral), or troleandomycin (Tao);
seizure medication such as phenytoin (Dilantin), carbamazepine (Carbatrol, Tegretol), or phenobarbital (Solfoton);
an “SSRI” antidepressant such as fluoxetine (Prozac), fluvoxamine (Luvox), or paroxetine (Paxil); or
a tricyclic antidepressant such as amitriptyline (Elavil, Etrafon), amoxapine (Ascendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or trimipramine (Surmontil).

This list is not complete and there may be other drugs that can interact with enalapril and felodipine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about enalapril and felodipine.

Remember, keep this and all other medicines out of the reach of children. Never share your medicines with others and only use this medication for the condition prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Concise,L

Comments (0)

Lexiva

30/06/10

Generic Name: fosamprenavir (FOS am pren a veer)
Brand Names: Lexiva

What is fosamprenavir?

Fosamprenavir is an antiviral medication in a group of HIV medicines called protease (PRO-tee-ayz) inhibitors. Fosamprenavir prevents human immunodeficiency virus (HIV) cells from multiplying in your body.

Fosamprenavir is used to treat HIV, which causes acquired immunodeficiency syndrome (AIDS). Fosamprenavir is not a cure for HIV or AIDS.

Fosamprenavir may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about fosamprenavir?

Do not take fosamprenavir with cisapride (Propulsid), pimozide (Orap), midazolam (Versed), triazolam (Halcion), or an ergot medicine such as Ergomar, Cafergot, Wigraine, D.H.E. 45, Migranal, Methergine, and others. Fosamprenavir should not be taken together with ritonavir (Norvir) if you are also using a heart rhythm medication called flecainide (Tambocor) or propafenone (Rythmol). Ask your doctor about taking a different medication for your heart rhythm disorder. These drugs can cause life-threatening side effects if you use them while you are taking fosamprenavir.

There are many other medicines that can cause serious interactions if you use them while taking fosamprenavir. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors.

HIV/AIDS is usually treated with a combination of different drugs. To best treat your condition, use all of your medications as directed by your doctor. Do not change your doses or medication schedule without advice from your doctor.

Avoid having unprotected sex or sharing needles, razors, or toothbrushes. Taking this medication will not prevent you from passing HIV to other people. Talk with your doctor about safe methods of preventing HIV transmission during sex.

What should I discuss with my healthcare provider before taking fosamprenavir?

Do not take this medication if you are allergic to fosamprenavir or a similar drug called amprenavir (Agenerase).

Do not take fosamprenavir together with cisapride (Propulsid), pimozide (Orap), midazolam (Versed), triazolam (Halcion), or ergot medicines such as ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine). Fosamprenavir should not be taken together with ritonavir (Norvir) if you are also using a heart rhythm medication called flecainide (Tambocor) or propafenone (Rythmol). Ask your doctor about taking a different medication for your heart rhythm disorder. These drugs can cause life-threatening side effects if you use them while you are taking fosamprenavir.

If you have any of these other conditions, you may need a fosamprenavir dose adjustment or special tests:

liver disease;
kidney disease;
diabetes;
a bleeding disorder such as hemophilia;
heart disease, history of heart attack;
high cholesterol or triglycerides; or
if you have ever used a protease inhibitor in the past.

FDA pregnancy category C. It is not known whether fosamprenavir will harm an unborn baby. Tell your doctor if you are pregnant. HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.

Your name may need to be listed on an antiviral pregnancy registry when you start using this medication.

Taking fosamprenavir together with another HIV medicine called ritonavir (Norvir) and also using birth control pills can increase you risk of liver problems. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking fosamprenavir and ritonavir. Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

How should I take fosamprenavir?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Fosamprenavir tablets can be taken with or without food.

Fosamprenavir liquid should be taken with food in children and without food in adults.

Shake the oral suspension (liquid) well just before you measure a dose. Measure the liquid with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Use fosamprenavir regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

To be sure this medicine is helping your condition and is not causing harmful effects, your blood will need to be tested often. Your liver function may also need to be tested. Visit your doctor regularly.

HIV/AIDS is usually treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor’s advice. Every person with HIV or AIDS should remain under the care of a doctor.

Store fosamprenavir tablets at room temperature away from moisture and heat. You may store fosamprenavir liquid in the refrigerator but do not allow it to freeze.

See also: Lexiva dosage in more detail

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking fosamprenavir?

Taking this medication will not prevent you from passing HIV to other people. Avoid having unprotected sex or sharing razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

Fosamprenavir side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking fosamprenavir and call your doctor at once if you have any of these serious side effects:

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
pale or yellowed skin, dark colored urine, fever, confusion or weakness;
increased urination or extreme thirst;
sudden and severe pain in your lower back or side, blood in your urine, pain or burning when you urinate;
signs of a new infection, such as fever or chills, cough, or flu symptoms;
easy bruising or bleeding; or
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash.

Less serious side effects of fosamprenavir may include:

mild nausea, vomiting, diarrhea, stomach pain;
numbness or tingling, especially around your mouth;
headache, mood changes; or
changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect fosamprenavir?

Many other drugs can cause serious or life-threatening drug interactions if you use them while taking fosamprenavir. Tell your doctor if you are also using:

itraconazole (Sporanox) or ketoconazole (Nizoral);
heart rhythm medicine such as amiodarone (Cordarone), lidocaine, or quinidine (Quinaglute, Quinidex);
an antidepressant such as amitriptyline (Elavil, Etrafon), imipramine (Janimine, Tofranil), or paroxetine (Paxil);
rifampin (Rifadin, Rimactane, Rifater);
steroid medicine such as dexamethasone (Decadron, Hexadrol) or fluticasone (Advair, Flonase, Flovent);
St. John’s wort;
a blood thinner such as warfarin (Coumadin);
a calcium channel blocker such as amlodipine (Caduet, Lotrel, Norvasc), diltiazem (Tiazac, Cartia, Dilacor), felodipine (Plendil), nifedipine (Procardia, Adalat), or verapamil (Calan, Covera, Isoptin, Verelan);
cholesterol-lowering medicine such as atorvastatin (Lipitor), lovastatin (Mevacor, Altocor), or simvastatin (Zocor);
drugs that weaken the immune system, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf);
other HIV /AIDS medicine such as delavirdine (Rescriptor), efavirenz (Sustiva), nevirapine (Viramune), or lopinavir/ritonavir (Kaletra);
insulin or diabetes medication you take by mouth;
medicines to treat erectile dysfunction, such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra);
seizure medications such as carbamazepine (Carbatrol, Tegretol), phenobarbital (Luminal, Solfoton), or phenytoin (Dilantin); or
stomach acid reducers such as cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), or ranitidine (Zantac).

This list is not complete and there are many other drugs that can interact with fosamprenavir. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about fosamprenavir.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Concise,L

Comments (0)

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Drugs & Medications:A-Z

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30/06/10

Uses For Lice-X

Before Using Lice-X

Allergies

Pediatric

Geriatric

Pregnancy

Breast Feeding

Interactions with Medicines

Interactions with Food/Tobacco/Alcohol

Other Medical Problems

Proper Use of pyrethrum extract and piperonyl butoxide

Dosing

Storage

Precautions While Using Lice-X

Lice-X Side Effects

30/06/10

What is Librium (chlordiazepoxide)?

What is the most important information I should know about Librium (chlordiazepoxide)?

What should I discuss with my healthcare provider before taking Librium (chlordiazepoxide)?

How should I take Librium (chlordiazepoxide)?

What happens if I miss a dose?

What happens if I overdose?

What should I avoid while taking Librium (chlordiazepoxide)?

Librium (chlordiazepoxide) side effects

What other drugs will affect Librium (chlordiazepoxide)?

Where can I get more information?

30/06/10

Librium Injection is used for:

Do NOT use Librium Injection if:

Before using Librium Injection:

How to use Librium Injection:

Important safety information:

Possible side effects of Librium Injection:

If OVERDOSE is suspected:

General information:

30/06/10

What is chlordiazepoxide and clidinium?

What is the most important information I should know about chlordiazepoxide and clidinium?

What should I discuss with my health care provider before taking chlordiazepoxide and clidinium?

How should I take chlordiazepoxide and clidinium?

What happens if I miss a dose?

What happens if I overdose?

What should I avoid while taking chlordiazepoxide and clidinium??

Chlordiazepoxide and clidinium side effects

What other drugs will affect chlordiazepoxide and clidinium?

Where can I get more information?

30/06/10

Librax Capsules is used for:

Do NOT use Librax Capsules if:

Before using Librax Capsules:

How to use Librax Capsules:

Important safety information:

Possible side effects of Librax Capsules:

If OVERDOSE is suspected:

General information:

30/06/10

Uses For Libritabs

Before Using Libritabs

Allergies

Pediatric

Geriatric

Breast Feeding

Interactions with Medicines

Interactions with Food/Tobacco/Alcohol

Other Medical Problems

Proper Use of chlordiazepoxide hydrochloride

Dosing

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Precautions While Using Libritabs

Libritabs Side Effects

30/06/10

What is mesalamine oral?

What is the most important information I should know about mesalamine oral?

What should I discuss with my healthcare provider before taking mesalamine oral?

How should I take mesalamine oral?