Generic Name: methazolamide (meth a ZOLE a mide)
Brand Names: Glauctabs, MZM, Neptazane

What is MZM (methazolamide)?

Methazolamide is a carbonic anhydrase inhibitor. Carbonic anhydrase is a protein in the body. Methazolamide reduces the activity of this protein.

Methazolamide is used to treat glaucoma. By inhibiting the actions of carbonic anhydrase, methazolamide reduces the amount of fluid produced in the eyes and therefore also reduces pressure.

Methazolamide may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about MZM (methazolamide)?

Contact your doctor immediately if you experience a sore throat, fever, unusual bleeding or bruising, tingling or tremors in the hands or feet, pain in the side or groin, or a rash. These symptoms could be early signs of a serious side effect.

Use caution when driving, operating machinery, or performing other hazardous activities. Methazolamide may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Avoid prolonged exposure to sunlight. Methazolamide may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

What should I discuss with my healthcare provider before taking MZM (methazolamide)?

Tell your doctor if you have ever had an allergic reaction to a sulfa-based drug such as sulfamethoxazole (e.g., Bactrim, Septra, Gantanol). Methazolamide is also a sulfa-based drug, and you may have a similar reaction to it.

Before taking methazolamide, tell your doctor if you

• are on aspirin therapy,

• have liver disease,

• have kidney disease,

• have heart disease,

• have lung disease, or

• have a hormonal disease.

You may not be able to take methazolamide, or you may require a dosage adjustment special monitoring during treatment if you have any of the conditions listed above.

Methazolamide is in the FDA pregnancy category C. This means that it is not known whether methazolamide will be harm an unborn baby. Do not take methazolamide without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether methazolamide passes into breast . Do not take methazolamide without first talking to your doctor if you are breast-feeding a baby.

How should I take MZM (methazolamide)?

Take methazolamide exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Take methazolamide with food if it causes stomach upset.

It is important to take methazolamide regularly to get the most benefit.

Store methazolamide at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention if an overdose is suspected.

Symptoms of a methazolamide overdose include drowsiness, decreased appetite, nausea, vomiting, dizziness, numbness or tingling, shaking, and ringing in the ears.

What should I avoid while taking MZM (methazolamide)?

Use caution when driving, operating machinery, or performing other hazardous activities. Methazolamide may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Avoid prolonged exposure to sunlight. Methazolamide may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

MZM (methazolamide) side effects

If you experience any of the following serious side effects, stop taking methazolamide and seek emergency medical attention or contact your doctor immediately:

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• a sore throat or a fever;

• unusual bleeding or bruising;

• side or groin pain;

• tingling or tremors in the hands or feet; or

• a rash.

Other, less serious side effects may be more likely to occur. Continue to take methazolamide and talk to your doctor if you experience

• decreased appetite, nausea, vomiting, constipation, diarrhea, or changes in taste;

• drowsiness, dizziness, fatigue, or weakness;

• nervousness or tremor;

• headache or confusion;

• increased sensitivity of the skin to sunlight;

• worsening gout;

• loss of blood sugar control (if you are diabetic);

• ringing in your ears or hearing problems; or

• changes in vision.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect MZM (methazolamide)?

Before taking this medication, tell your doctor if you are taking any of the following medicines:

• cyclosporine (Sandimmune);

• primidone (Mysoline);

• diflunisal (Dolobid;

• aspirin, salsalate (Disalcid, Salflex, Salsitab, others), choline salicylate (Arthropan), magnesium salicylate (Doan’s, Magan, Mobidin), or other aspirin-like products (salicylates); or

• lithium (Lithobid, Eskalith, others).

You may not be able to take methazolamide, or you may require a dosage adjustment or special monitoring during treatment.

Drugs other than those listed here may also interact with methazolamide. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information?

• Your pharmacist has more information about methazolamide written for health professionals that you may read.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 4.03. Revision Date: 4/12/2009 4:37:51 PM.

Generic Name: codeine and guaifenesin (KOE deen and gwye FEN a sin)
Brand Names: Allfen CD, Allfen CDX, Brontex, Cheracol with Codeine, Cheratussin AC, Dex-Tuss, Diabetic Tussin C, Duraganidin NR, ExeClear-C, Guaiatussin AC, Guaifen-C, Guiatuss AC, Guiatussin with Codeine, Iophen-C NR, M-Clear WC, Mar-cof CG, Mytussin AC, Robafen AC, Robitussin-AC, Tussi-Organidin NR, Tussi-Organidin-S NR, Tussiden C, Tusso-C

What is Mytussin AC (codeine and guaifenesin)?

Codeine is in a group of drugs called narcotics. It is a cough suppressant that affects the signals in the brain that trigger cough reflex.

Guaifenesin is an expectorant. It helps loosen mucus congestion in your chest and throat, making it easier to cough out through your mouth.

The combination of codeine and guaifenesin is used to treat cough and to reduce chest congestion caused by upper respiratory infections or the common cold.

Codeine and guaifenesin will not treat a cough that is caused by smoking, asthma, or emphysema.

Codeine and guaifenesin may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Mytussin AC (codeine and guaifenesin)?

Do not use any other over-the-counter cough or cold medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains guaifenesin. This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Codeine may be habit-forming and should be used only by the person it was prescribed for. This medication should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

What should I discuss with my healthcare provider before taking Mytussin AC (codeine and guaifenesin)?

You should not take this medication if you are allergic to codeine or guaifenesin.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take codeine and guaifenesin:

• heart disease, heart rhythm disorder;

• asthma, COPD, emphysema, or other breathing disorders;

• a history of head injury or brain tumor;

• epilepsy or other seizure disorder;

• a stomach or intestinal disorder;

• Addison’s disease or other adrenal gland disorders;

• curvature of the spine;

• a thyroid disorder;

• liver or kidney disease;

• enlarged prostate; or

• a history of depression, mental illness, or drug addiction;

FDA pregnancy category C. This medication may be harmful to an unborn baby, and could cause addiction or withdrawal symptoms in a newborn. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Codeine can pass into breast milk and may harm a nursing baby. The use of codeine by some nursing mothers may lead to life-threatening side effects in the baby. Do not use this medication if you are breast-feeding a baby. Codeine may be habit-forming and should be used only by the person it was prescribed for. Codeine should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Older adults may be more likely to have side effects from this medication.

Liquid forms of this medication may contain sugar or artificial sweetener (phenylalanine). Talk to your doctor before using this form of codeine and guaifenesin if you have diabetes or phenylketonuria (PKU).

How should I take Mytussin AC (codeine and guaifenesin)?

Take this medication exactly as it has been prescribed by your doctor. Do not use the medication in larger amounts, or use it for longer than recommended. Follow the directions on your prescription label. Cough or cold medicine is usually taken only for a short time until your symptoms clear up.

Always ask a doctor before giving cough or cold medicine to a child. Death can occur from the misuse of cough or cold medicine in very young children. Take codeine and guaifenesin with food if it upsets your stomach. Drink extra fluids to help loosen the congestion and lubricate your throat while you are taking this medication.

Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Call your doctor if your symptoms do not improve after 7 days of treatment, or if you also have a fever, headache, or skin rash.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using codeine and guaifenesin.

Do not stop using this medication suddenly after long-term use or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication. Store codeine and guaifenesin at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use. Keep track of how much of this medicine has been used from each new bottle. Codeine is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

What happens if I miss a dose?

Since cough medicine is usually taken only as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of codeine can be fatal.

Overdose symptoms may include extreme dizziness or drowsiness, nausea, vomiting, sweating, confusion, hallucinations, cold and clammy skin, blue-colored lips or fingernails, weak or limp muscles, pinpoint pupils, weak pulse, slow breathing, fainting, or seizures (convulsions).

What should I avoid while taking Mytussin AC (codeine and guaifenesin)?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Do not use any other over-the-counter cough or cold medication without first asking your doctor or pharmacist. Guaifenesin is contained in many medicines available over the counter. If you take certain products together you may accidentally take too much of a certain drug. Read the label of any other medicine you are using to see if it contains guaifenesin.

Avoid drinking alcohol. It can increase some of the side effects of this medication.

Mytussin AC (codeine and guaifenesin) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking this medication and call your doctor at once if you have any of these serious side effects:

• severe dizziness or drowsiness;

• confusion, hallucinations, unusual thoughts or behavior;

• urinating less than usual or not at all; or

• slow heart rate, weak pulse, fainting, weak or shallow breathing.

Less serious side effects include:

• dizziness, drowsiness, headache;

• warmth, redness, or tingling under your skin;

• nausea, vomiting, upset stomach;

• constipation; or

• skin rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Mytussin AC (codeine and guaifenesin)?

Before taking this medication, tell your doctor if you regularly use other medicines that make you sleepy (such as allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by codeine and guaifenesin.

Also tell your doctor if you are using any of the following drugs:

• cimetidine (Tagamet);

• quinidine (Quinaglute, Quinidex, Quin-Release);

• naloxone (Narcan); or

• naltrexone (Vivitrol).

This list is not complete and there may be other drugs that can interact with codeine and guaifenesin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about codeine and guaifenesin.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 3.01. Revision Date: 10/09/2009 10:05:42 AM.

Generic Name: Codeine/Guaifenesin/Pseudoephedrine (KOE-deen/gwye-FEN-e-sin/SOO-doe-e-FED-rin)
Brand Name: Examples include Mytussin DAC and Robitussin DAC

Mytussin DAC Syrup is used for:

Relieving congestion and cough due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Mytussin DAC Syrup is a decongestant, cough suppressant, and expectorant combination. The decongestant works by constricting blood vessels and reducing swelling in the nasal passages. The cough suppressant works in the brain to help decrease the cough reflex to reduce a dry cough. The expectorant loosens mucus and lung secretions in the chest and makes coughs more productive.

Do NOT use Mytussin DAC Syrup if:

• you are allergic to any ingredient in Mytussin DAC Syrup or any other codeine- or morphine-related medicine (eg, oxycodone)
• you have severe high blood pressure, rapid heartbeat, or other severe heart problems (eg, heart blood vessel disease)
• you are having an asthma attack
• you are taking sodium oxybate (GHB) or if you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Mytussin DAC Syrup:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to morphine, codeine, or any other opiate (eg, hydrocodone, dihydrocodeine, oxycodone)
• if you have a history of glaucoma; an enlarged prostate gland or other prostate problems; heart problems; diabetes; high blood pressure; blood vessel problems; stroke; liver or kidney problems; blockage of the stomach, bowel, or bladder; adrenal gland problems; or thyroid problems
• if you have a history of constipation, stomach problems (eg, ulcers), bowel problems (eg, chronic inflammation or ulceration of the bowel), or gallbladder problems (eg, gallstones), or if you have had recent stomach, bowel, or urinary surgery
• if you have breathing or lung problems (eg, asthma, chronic bronchitis, emphysema), or chronic obstructive pulmonary disease (COPD), or if you have a cough that occurs with large amounts of mucus
• if you have a fever, severe drowsiness, recent head or brain injury, brain tumor, increased pressure in the brain, infection of the brain or nervous system, or a seizure disorder (eg, epilepsy)
• if you have very poor health or a history of alcohol abuse, other substance abuse, or suicidal thoughts or actions
• if you are taking medicine for high blood pressure or depression

Some MEDICINES MAY INTERACT with Mytussin DAC Syrup. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased
• Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), cimetidine, furazolidone, HIV protease inhibitors (eg, ritonavir), indomethacin, MAOIs (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Mytussin DAC Syrup’s side effects
• Naltrexone, quinidine, or rifamycins (eg, rifampin) because they may decrease Mytussin DAC Syrup’s effectiveness
• Bromocriptine or sodium oxybate (GHB) because the risk of their side effects may be increased by Mytussin DAC Syrup
• Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Mytussin DAC Syrup

This may not be a complete list of all interactions that may occur. Ask your health care provider if Mytussin DAC Syrup may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Mytussin DAC Syrup:

• Take Mytussin DAC Syrup by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
• Drink plenty of water while taking Mytussin DAC Syrup.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• If you miss a dose of Mytussin DAC Syrup, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Mytussin DAC Syrup.

Important safety information:

• Mytussin DAC Syrup may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Mytussin DAC Syrup with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Mytussin DAC Syrup; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
• Mytussin DAC Syrup may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
• Do not take diet or appetite control medicines while you are taking Mytussin DAC Syrup without checking with your doctor.
• Mytussin DAC Syrup has pseudoephedrine in it. Before you start any new medicine, check the label to see if it has pseudoephedrine in it too. If it does or if you are not sure, check with your doctor or pharmacist.
• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
• If your symptoms do not get better within 5 days, if they get worse, or if they go away and then come back, check with your doctor.
• If your symptoms occur along with fever, rash, or persistent headache, contact your doctor.
• Do not use Mytussin DAC Syrup for a cough with a lot of mucus. Do not use it for a long-term cough (eg, caused by asthma, emphysema, smoking). However, you may use it for these conditions if your doctor tells you to.
• Mytussin DAC Syrup may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Mytussin DAC Syrup. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
• Mytussin DAC Syrup may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Mytussin DAC Syrup.
• Tell your doctor or dentist that you take Mytussin DAC Syrup before you receive any medical or dental care, emergency care, or surgery.
• Some of these products contain phenylalanine. If you must have a diet that is low in phenylalanine, ask your pharmacist if it is in your product.
• Use Mytussin DAC Syrup with caution in the ELDERLY; they may be more sensitive to its effects, especially confusion, dizziness, drowsiness, low blood pressure, excitability, dry mouth, and trouble urinating.
• Caution is advised when using Mytussin DAC Syrup in CHILDREN; they may be more sensitive to its effects, especially excitability.
• Mytussin DAC Syrup should not be used in CHILDREN younger than 6 years old without first checking with the child’s doctor; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Mytussin DAC Syrup while you are pregnant. Mytussin DAC Syrup is found in breast milk. Do not breast-feed while taking Mytussin DAC Syrup.

Possible side effects of Mytussin DAC Syrup:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; excitability; headache; nausea; nervousness or anxiety; trouble sleeping; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; confusion; difficulty urinating; fainting; fast, slow, or irregular heartbeat; hallucinations; mental or mood changes; persistent trouble sleeping; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; shallow breathing; tremor; uncontrolled muscle movement.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; shallow or rapid breathing; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Mytussin DAC Syrup:

Store Mytussin DAC Syrup at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Mytussin DAC Syrup out of the reach of children and away from pets.

General information:

• If you have any questions about Mytussin DAC Syrup, please talk with your doctor, pharmacist, or other health care provider.
• Mytussin DAC Syrup is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Mytussin DAC Syrup. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Ambenonium (am-be-NOE-nee-um)
Brand Name: Mytelase

Mytelase is used for:

Treating myasthenia gravis. It may also be used for other conditions as determined by your doctor.

Mytelase is a cholinesterase inhibitor. It works by improving nerve impulses in muscles so that the muscles are better able to work.

Do NOT use Mytelase if:

• you are allergic to any ingredient in Mytelase
• you are taking quinine, quinidine, atropine, belladonna, ganglionic blocking agents (eg, mecamylamine), or cholinergic agents (eg, guanidine)
• you have a blockage of your stomach, intestine, or bladder

Contact your doctor or health care provider right away if any of these apply to you.

Before using Mytelase:

Some medical conditions may interact with Mytelase. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have heart problems (eg, heart block, slow heartbeat), Parkinson disease, a urinary tract infection, asthma, or kidney problems

Some MEDICINES MAY INTERACT with Mytelase. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Atropine, belladonna, ganglionic blocking agents (eg, mecamylamine), quinine, or quinidine because effectiveness of Mytelase may be decreased
• Cholinergic agents (eg, guanidine) because the risk of side effects may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Mytelase may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Mytelase:

Use Mytelase as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Mytelase may be taken with or without food. Take with food if it upsets your stomach.
• If you miss a dose of Mytelase, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Mytelase.

Important safety information:

• Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Mytelase.
• Use Mytelase with caution in the ELDERLY because they may be more sensitive to its effects.
• Use Mytelase with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Mytelase, discuss with your doctor the benefits and risks of using Mytelase during pregnancy. It is unknown if Mytelase is excreted in breast milk. Do not breast-feed while taking Mytelase.

Possible side effects of Mytelase:

All medicines may cause side effects, but many people have no, or minor, side effects. When used in small doses, no COMMON side effects have been reported with this product. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); diarrhea; fainting; increased production of saliva; increased sweating; muscle weakness; nausea; small pupils; stomach cramps; tremor; trouble speaking or swallowing; vision changes; vomiting; weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( http://www.aapcc.org), or emergency room immediately. Symptoms may include diarrhea; fainting; increased production of saliva; increased sweating; muscle weakness; nausea; small pupils; stomach cramps; tremor; trouble breathing; trouble speaking or swallowing; vision changes; vomiting; weakness.

Proper storage of Mytelase:

Store Mytelase at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Mytelase out of the reach of children and away from pets.

General information:

• If you have any questions about Mytelase, please talk with your doctor, pharmacist, or other health care provider.
• Mytelase is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Mytelase. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: ambenonium (am ben OH nee um)
Brand Names: Mytelase Chloride

What is Mytelase Chloride (ambenonium)?

Ambenonium affects chemicals in the body that are involved in the communication between nerve impulses and muscle movement.

Ambenonium is used to treat the symptoms of myasthenia gravis.

Ambenonium may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Mytelase Chloride (ambenonium)?

You should not use this medication if you are allergic to ambenonium, or if you are using certain medications.

Be sure your doctor knows if you use: mecamylamine, (Inversine), atropine (Atreza, Donnatal, Sal-Tropine, Lomotil, Lomocot, and others), blood pressure medications, or a diuretic (water pill).

Before using ambenonium, tell your doctor if you have asthma, Parkinson’s disease, or a bladder or bowel obstruction.

Your doctor may occasionally change your dose to make sure you get the best results from this medication. You may be asked to keep a daily record of when you took each dose and how long the effects lasted. This will help your doctor determine if your dose needs to be adjusted.

What should I discuss with my health care provider before taking Mytelase Chloride (ambenonium)?

You should not use this medication if you are allergic to ambenonium, or if you are using certain medications. Be sure your doctor knows if you use:

• mecamylamine, (Inversine);

• atropine (Atreza, Donnatal, Sal-Tropine, Lomotil, Lomocot, and others);

• blood pressure medications; or

• a diuretic (water pill).

Before using ambenonium, tell your doctor if you are allergic to any drugs, or if you have:

• asthma;

• Parkinson’s disease; or

• a bladder or bowel obstruction.

If you have any of these conditions, you may need a dose adjustment or special tests during treatment.

This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether ambenonium passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Mytelase Chloride (ambenonium)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

This medication is usually given every 3 or 4 hours during the day. Follow your doctor’s instructions.

Your doctor may occasionally change your dose to make sure you get the best results from this medication. You may be asked to keep a daily record of when you took each dose and how long the effects lasted. This will help your doctor determine if your dose needs to be adjusted.

Store ambenonium at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include severe diarrhea, muscle twitching, anxiety, sweating, and cough or breathing problems.

What should I avoid while taking Mytelase Chloride (ambenonium)?

There are no restrictions on food, beverages, or activity while using ambenonium unless your doctor has told you otherwise.

Mytelase Chloride (ambenonium) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• severe diarrhea;

• muscle twitching; or

• cough with sputum (mucus).

Less serious side effects may include:

• sweating or urinating more than usual;

• drooling, watery eyes;

• warmth or tingly feeling;

• nausea, vomiting, stomach pain;

• blurred vision;

• anxiety;

• dizziness, spinning feeling; or

• muscle cramps.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Mytelase Chloride (ambenonium)?

Before taking ambenonium, tell your doctor if you are taking any form of belladonna. You may not be able to use ambenonium, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can interact with ambenonium. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about ambenonium.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 1.03. Revision Date: 4/12/2009 4:39:55 PM.

Generic Name: nystatin and triamcinolone (topical) (nye STAT in and TRYE am SIN o lone)
Brand Names: Mycogen II, Mytrex

What is nystatin and triamcinolone?

Nystatin is an antibiotic medication that prevents fungus from growing on your skin.

Triamcinolone is a steroid. It reduces the actions of chemicals in the body that cause inflammation, redness, and swelling.

The combination of nystatin and triamcinolone topical (for the skin) is used to treat skin infections caused by fungus or yeast.

Nystatin and triamcinolone may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about nystatin and triamcinolone?

You should not use this medication if you are allergic to nystatin or triamcinolone.

Before using nystatin and triamcinolone, tell your doctor if you have any type of skin infection (especially tuberculosis infection of the skin), or if you have chicken pox or herpes infection (including cold sores).

Also tell your doctor if you have diabetes. Topical steroid medicines absorbed through the skin may increase the glucose (sugar) levels in your blood or urine.

Use this medication exactly as it has been prescribed by your doctor. Do not use the medication in larger amounts or for longer than recommended. Topical steroid medicine can be absorbed through the skin, which may cause steroid side effects throughout the body.

What should I discuss with my health care provider before using nystatin and triamcinolone?

You should not use this medication if you are allergic to nystatin or triamcinolone.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:

• any type of skin infection, especially tuberculosis infection of the skin; or

• chicken pox or herpes infection (including cold sores).

Also tell your doctor if you have diabetes. Topical steroid medicines absorbed through the skin may increase the glucose (sugar) levels in your blood or urine.

FDA pregnancy category C. It is not known whether nystatin and triamcinolone topical is harmful to an unborn baby. Before using this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether nystatin and triamcinolone topical passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use nystatin and triamcinolone?

Use this medication exactly as it has been prescribed by your doctor. Do not use the medication in larger amounts or for longer than recommended. Topical steroid medicine can be absorbed through the skin, which may cause steroid side effects throughout the body.

Apply a thin layer of nystatin and triamcinolone to your skin and rub in gently.

Do not cover treated skin areas with a bandage or other covering unless your doctor has told you to. Covering the skin that is treated with nystatin and triamcinolone can increase the amount of the drug your skin absorbs, which may lead to unwanted side effects. Follow your doctor’s instructions.

Avoid tight-fitting clothes over treated skin areas. If you are treating the diaper area of a baby, do not use plastic pants or tight-fitting diapers.

Call your doctor if your symptoms do not improve, or if they get worse after using this medication.

Do not use nystatin and triamcinolone for any other skin conditions your doctor has not prescribed the medication to treat.

Store this medicine at room temperature away from moisture and heat. Keep the tube or bottle tightly closed when not in use.

What happens if I miss a dose?

Apply the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may result if you absorb this medicine through your skin by applying too much of it.

An overdose of nystatin and triamcinolone is not expected to produce life-threatening symptoms. However, long-term use of high steroid doses can lead to symptoms such as thinning skin, easy bruising, changes in the shape or location of body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.

What should I avoid while using nystatin and triamcinolone?

Avoid getting this medication in your eyes, mouth, and nose, or on your lips. If it does get into any of these areas, wash with water. Do not use nystatin and triamcinolone on sunburned, windburned, irritated, or broken skin. Also avoid using this medication in open wounds.

Nystatin and triamcinolone side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these signs that you may be absorbing triamcinolone through your skin:

• blurred vision, or seeing halos around lights;

• uneven heartbeats;

• mood changes;

• sleep problems (insomnia);

• weight gain, puffiness in your face; or

• feeling tired.

Less serious side effects may include:

• stinging, burning, itching, or skin irritation;

• acne;

• dry skin; or

• changes in skin color.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect nystatin and triamcinolone?

It is not likely that other drugs you take orally or inject will have an effect on topically applied nystatin and triamcinolone. But many drugs can interact with each other. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about nystatin and triamcinolone topical.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 1.05. Revision Date: 10/16/2009 1:06:23 PM.

Generic Name: simethicone (sye METH i cone)
Brand Names: Alka-Seltzer Anti-Gas, Equalize Gas Relief Drops, Gas Aide, Gas-X, Gas-X Extra Strength, Gas-X Infant Drops, Gas-X Maximum Strength, Gas-X Thin Strips Cinnamon, Gas-X Thin Strips Peppermint, Gas-X Tongue Twisters Thin Strips Children’s, Genasyme, Infantaire Gas Relief, Little Tummys, Maalox Anti-Gas, Maalox Anti-Gas Extra Strength, Mi-Acid Gas Relief, Mylanta Gas, Mylanta Gas Maximum Strength, Mylicon, Mytab Gas, Phazyme, Phazyme Maximum Strength, Phazyme Ultra, Phazyme-125, Phazyme-95

What is Mytab Gas (simethicone)?

Simethicone allows gas bubbles in the stomach and intestines to come together more easily, which allows for easier passage of gas.

Simethicone is used to relieve painful pressure caused by excess gas in the stomach and intestines. Simethicone is for use in babies, children, and adults.

Simethicone may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Mytab Gas (simethicone)?

Simethicone works best if you take it after meals and at bedtime.

Do not take more of this medication than is directed.

Simethicone may be only part of a complete program of treatment that also includes a special diet or increased exercise. It is very important to follow the diet and exercise plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you must avoid to help control your condition.

There may be other drugs that can interact with simethicone. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

What should I discuss with my healthcare provider before taking Mytab Gas (simethicone)?

You should not use this medication if you are allergic to simethicone.

Before taking simethicone, tell your doctor if you are allergic to any drugs.

Also tell your doctor if you have any type of serious illness, especially one that involves your stomach or intestines.

FDA pregnancy category C. It is not known whether this medication is harmful to an unborn baby. Before taking simethicone, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether simethicone passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Mytab Gas (simethicone)?

Use this medication exactly as directed on the label, or as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended.

Do not take more of this medication than is directed.

Simethicone works best if you take it after meals and at bedtime.

The chewable tablet must be chewed before swallowing.

Measure the oral drops with the medicine dropper provided, or use a special dose-measuring spoon. Do not use a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Clean the medicine dropper after each use. Allow it to air dry.

Some liquid forms of simethicone must be shaken before each use. Follow the directions on the medicine label.

Simethicone liquid drops can be mixed with water, baby formula, or other liquids to make swallowing easier for an infant or child.

Children should never be given more than the recommended dose of simethicone. Call your doctor if the child’s gas symptoms do not improve after treatment with simethicone.

Simethicone may be only part of a complete program of treatment that also includes a special diet or increased exercise. It is very important to follow the diet and exercise plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you must avoid to help control your condition.

Store simethicone at room temperature away from moisture, light, and heat. Do not allow the liquid medicine to freeze. Keep all liquid medicine in a tightly closed container.

What happens if I miss a dose?

Since simethicone is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

An overdose of simethicone is not likely to cause life-threatening symptoms.

What should I avoid while taking Mytab Gas (simethicone)?

Follow your doctor’s instructions about any restrictions on food, beverages, or activity while you are using simethicone.

Mytab Gas (simethicone) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Mytab Gas (simethicone)?

There may be other drugs that can interact with simethicone. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about simethicone.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed
• The information in this leaflet is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 4.02. Revision Date: 4/12/2009 4:39:00 PM.

Generic Name: brompheniramine and phenylpropanolamine (brome feh NEER a meen/fen ill proe pa NO la meen)
Brand Names: Altatapp, Dibrom, Dibromm, Dimaphen, Dimetapp, Myphetapp

What is Myphetapp (brompheniramine and phenylpropanolamine)?

Brompheniramine is an antihistamine. It works against the naturally occurring chemical histamine in your body. Brompheniramine prevents sneezing; itchy, watery eyes and nose; and other symptoms of allergies and hay fever.

Phenylpropanolamine is a decongestant. It constricts (shrinks) blood vessels (veins and arteries). This reduces the blood flow to certain areas and allows nasal passages to open up.

Brompheniramine and phenylpropanolamine is used to treat nasal congestion and sinusitis (inflammation of the sinuses) associated with allergies, hay fever, and the common cold.

Phenylpropanolamine, an ingredient in this product, has been associated with an increased risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food and Drug Administration (FDA) recommends that consumers not use any products that contain phenylpropanolamine.

Brompheniramine and phenylpropanolamine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Myphetapp (brompheniramine and phenylpropanolamine)?

Phenylpropanolamine, an ingredient in this product, has been associated with an increased risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food and Drug Administration (FDA) recommends that consumers not use any products that contain phenylpropanolamine.

Use caution when driving, operating machinery, or performing other hazardous activities. Brompheniramine and phenylpropanolamine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking brompheniramine and phenylpropanolamine.

Do not take more of this medication than is recommended. If your symptoms do not improve, or if they worsen, talk to your doctor.

What should I discuss with my healthcare provider before taking Myphetapp (brompheniramine and phenylpropanolamine)?

Do not take brompheniramine and phenylpropanolamine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Before taking this medication, tell your doctor if you have

• kidney disease,
• liver disease,

• diabetes,

• glaucoma,

• any type of heart disease or high blood pressure,

• thyroid disease,

• emphysema or chronic bronchitis, or

• difficulty urinating or an enlarged prostate.

You may not be able to take brompheniramine and phenylpropanolamine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Brompheniramine and phenylpropanolamine is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. This medication passes into breast milk and may harm a nursing baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby. If you are over 60 years of age, you may be more likely to experience side effects from brompheniramine and phenylpropanolamine. You may require a lower dose of this medication. Read the package label for directions or consult your doctor or pharmacist before treating a child with this medication. Children are more susceptible than adults to the effects of medicines and may have unusual reactions.

How should I take Myphetapp (brompheniramine and phenylpropanolamine)?

Take brompheniramine and phenylpropanolamine exactly as directed. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Do not crush, chew, or break the long-acting or sustained-release forms of this medication. Swallow them whole. If you are unsure about the formulation of the medicine, ask your pharmacist for help.

If you cannot swallow the tablets or capsules, look for a liquid form of the medication.

To ensure that you get a correct dose, measure the liquid form of brompheniramine and phenylpropanolamine with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Do not take more of this medication than is recommended. An overdose of this medication can cause serious harm.

Do not take brompheniramine and phenylpropanolamine for longer than 7 days in a row. If your symptoms do not improve, if they get worse, or if you have a fever, talk to your doctor.

Store brompheniramine and phenylpropanolamine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a brompheniramine and phenylpropanolamine overdose include a dry mouth, large pupils, flushing, nausea, and vomiting.

What should I avoid while taking Myphetapp (brompheniramine and phenylpropanolamine)?

Use caution when driving, operating machinery, or performing other hazardous activities. Brompheniramine and phenylpropanolamine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking brompheniramine and phenylpropanolamine.

Brompheniramine and phenylpropanolamine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if brompheniramine and phenylpropanolamine is taken with any of these medications.

Myphetapp (brompheniramine and phenylpropanolamine) side effects

Serious side effects are unlikely to occur. Stop taking brompheniramine and phenylpropanolamine and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Other, less serious side effects may be more likely to occur. Continue to take brompheniramine and phenylpropanolamine and talk to your doctor or try another similar medication if you experience

• dryness of the eyes, nose, and mouth;

• drowsiness or dizziness;

• blurred vision;

• difficulty urinating; or

• excitation in children.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Myphetapp (brompheniramine and phenylpropanolamine)?

Do not take brompheniramine and phenylpropanolamine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Do not take other over-the-counter cough, cold, allergy, diet, or sleep aids while taking brompheniramine and phenylpropanolamine without first talking to your doctor or pharmacist. Other medications may also contain brompheniramine, phenylpropanolamine, or other similar drugs. You may accidentally take too much of these medicines.

Brompheniramine and phenylpropanolamine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if brompheniramine and phenylpropanolamine is taken with any of these medications.

Drugs other than those listed here may also interact with brompheniramine and phenylpropanolamine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

• Your pharmacist has additional information about brompheniramine and phenylpropanolamine written for health professionals that you may read.

What does my medication look like?

Many formulations of brompheniramine and phenylpropanolamine are available both over-the-counter and with a prescription. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 6.02. Revision Date: 2/13/04 4:04:05 PM.

Generic Name: Minocycline (MIN-oh-SYE-kleen)
Brand Name: Examples include Dynacin and Myrac

Myrac is used for:

Treating infections caused by certain bacteria. It is also used with other medicines to treat severe acne. It may also be used for other conditions as determined by your doctor.

Myrac is a tetracycline antibiotic. It works by slowing the growth of certain bacteria and allowing the body’s immune system to destroy them.

Do NOT use Myrac if:

• you are allergic to any ingredient in Myrac
• you are taking acitretin, isotretinoin, methoxyflurane, or a penicillin

Contact your doctor or health care provider right away if any of these apply to you.

Before using Myrac:

Some medical conditions may interact with Myrac. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have kidney problems
• if you have an autoimmune disorder (eg, lupus)

Some MEDICINES MAY INTERACT with Myrac. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Aluminum salts (eg, carbonate) or cimetidine because they may decrease Myrac’s effectiveness
• Acitretin, anticoagulants (eg, warfarin), digoxin, ergot alkaloids and derivatives (eg, ergotamine), insulin, isotretinoin, methotrexate, methoxyflurane, or theophyllines because the risk of their side effects may be increased by Myrac
• Live oral typhoid vaccine, oral contraceptives (birth control pills), or penicillins because their effectiveness may be decreased by Myrac

This may not be a complete list of all interactions that may occur. Ask your health care provider if Myrac may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Myrac:

Use Myrac as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Myrac by mouth. Do not take Myrac with food or milk unless otherwise directed. Myrac is sometimes taken with food or milk to reduce stomach upset. However, certain foods and milk may bind with Myrac, preventing its full absorption. To avoid this problem, take Myrac 2 to 3 hours before or after milk or any food containing magnesium, aluminum, or calcium.
• If you also take bismuth salts (eg, bismuth subsalicylate), calcium salts (eg, calcium carbonate), colestipol, iron salts (eg, iron sulfate), magnesium, urinary alkalinizers (eg, daily antacids), sucralfate, vitamins/minerals, quinapril, didanosine, or zinc salts (eg, zinc sulfate), do not take them within 2 to 3 hours before or after taking Myrac. Check with your doctor if you have questions.
• Take Myrac with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Myrac.
• To clear up your infection completely, take Myrac for the full course of treatment. Keep taking it even if you feel better in a few days.
• Myrac works best if it is taken at the same time each day.
• If you miss a dose of Myrac, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Myrac.

Important safety information:

• Myrac may cause dizziness, lightheadedness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Myrac with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Long-term or repeated use of Myrac may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
• Myrac may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Myrac. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
• Myrac only works against bacteria; it does not treat viral infections (eg, the common cold).
• Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
• Tell your doctor or dentist that you take Myrac before you receive any medical or dental care, emergency care, or surgery.
• Be sure to use Myrac for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
• Hormonal birth control (eg, birth control pills) may not work as well while you are using Myrac. To prevent pregnancy, use an extra form of birth control (eg, condoms).
• Use Myrac with caution in the ELDERLY; they may be more sensitive to its effects.
• Use Myrac with extreme caution in CHILDREN younger than 10 years old who have diarrhea or an infection of the stomach or bowel.
• Myrac should not be used in CHILDREN younger than 8 years old; safety and effectiveness in these children have not been confirmed. Using Myrac in CHILDREN younger than 8 years old or in women during the last half of pregnancy may cause a permanent change in the tooth coloring of the child.
• PREGNANCY and BREAST-FEEDING: Myrac has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Myrac while you are pregnant. Myrac is found in breast milk. Do not breast-feed while taking Myrac.

Possible side effects of Myrac:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Changes in skin color; diarrhea; difficulty swallowing; dizziness; feeling of a whirling motion; lightheadedness; loss of appetite; nausea; sensitivity to sunlight; unsteadiness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bleeding or discharge from the gums; bloody stools; blurred vision; decreased hearing; fever; headache; inflammation of the pancreas (stomach tenderness, nausea, vomiting, increased pulse rate); joint pain; muscle pain or weakness; pain, redness, or swelling in the mouth; painful sores in the mouth; redness or swelling of gums; red, swollen, blistered, or peeling skin; ringing in the ears; severe diarrhea; severe skin reaction to the sun; stomach cramps/pain; unusual tiredness or weakness; vaginal irritation or discharge.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( http://www.aapcc.org), or emergency room immediately.

Proper storage of Myrac:

Store Myrac at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Myrac out of the reach of children and away from pets.

General information:

• If you have any questions about Myrac, please talk with your doctor, pharmacist, or other health care provider.
• Myrac is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Myrac. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: primidone (PRIM i done)
Brand Names: Mysoline

What is Mysoline (primidone)?

Primidone is an anti-epileptic drug, also called an anticonvulsant.

Primidone is used to control seizures.

Primidone may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Mysoline (primidone)?

You should not use this medication if you are allergic to primidone or phenobarbital (Luminal, Solfoton), or if you have porphyria.

Before taking this medication, tell your doctor if you are allergic to any drugs, or if you are pregnant or breast-feeding.

You may have thoughts about suicide while taking this medication. Your doctor will need to check you at regular visits. Do not miss any scheduled appointments.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself. If you are taking primidone to prevent seizures, keep taking the medication even if you feel fine. You may have an increase in seizures if you stop taking primidone. Follow your doctor’s instructions.

To be sure this medication is helping your condition, your blood may need to be tested on a regular basis. Do not miss any scheduled appointments.

Do not change your dose of primidone without your doctor’s advice. Tell your doctor if the medication does not seem to work as well in treating your condition.

Carry an ID card or wear a medical alert bracelet stating that you are taking primidone, in case of emergency. Any doctor, dentist, or emergency medical care provider who treats you should know that you are taking a seizure medication.

What should I discuss with my healthcare provider before taking Mysoline (primidone)?

You should not use this medication if you are allergic to primidone or phenobarbital (Luminal, Solfoton), or if you have porphyria.

You may have thoughts about suicide while taking this medication. Tell your doctor if you have new or worsening depression or suicidal thoughts during the first several months of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits. Do not miss any scheduled appointments.

Before taking this medication, tell your doctor if you are allergic to any drugs, or if you are pregnant or breast-feeding.

Primidone may cause harm to an unborn baby, but having a seizure during pregnancy could harm both the mother and the baby. Do not start taking primidone during pregnancy without your doctor’s advice.

If you become pregnant while taking primidone, do not stop taking it without telling your doctor. Seizure control is very important during pregnancy and the benefits of preventing seizures may outweigh any risks posed by taking primidone.

If you have taken primidone during pregnancy, be sure to tell the doctor who delivers your baby about your primidone use. Both you and the baby may need to receive medications to prevent excessive bleeding during delivery and just after birth.

Primidone can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Mysoline (primidone)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Primidone is usually taken 2 to 4 times daily. If you are switching to primidone from another seizure medication, you may need to start taking primidone only at bedtime. Follow your doctor’s instructions.

If you are taking primidone to treat seizures, keep taking the medication even if you feel fine. You may have an increase in seizures if you stop taking primidone. Follow your doctor’s instructions.

To be sure this medication is helping your condition, your blood may need to be tested on a regular basis. Do not miss any scheduled appointments.

Do not change your dose of primidone without your doctor’s advice. Tell your doctor if the medication does not seem to work as well in treating your condition.

Carry an ID card or wear a medical alert bracelet stating that you are taking primidone, in case of emergency. Any doctor, dentist, or emergency medical care provider who treats you should know that you are taking a seizure medication. Store primidone at room temperature away from moisture, light, and heat.

See also: Mysoline dosage in more detail

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a primidone overdose are not known.

What should I avoid while taking Mysoline (primidone)?

Follow your doctor’s instructions about any restrictions on food, beverages, or activity while you are using primidone.

Mysoline (primidone) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

• slurred speech;

• loss of balance or coordination;

• easy bruising or bleeding; or

• unusual weakness.

Less serious side effects may include:

• dizziness, drowsiness, spinning sensation;

• nausea, vomiting, loss of appetite;

• feeling irritable;

• blurred vision;

• mild skin rash; or

• impotence, loss of interest in sex.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Mysoline (primidone)?

There may be other drugs that can interact with primidone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about primidone.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 3.02. Revision Date: 4/12/2009 4:37:09 PM.