Generic Name: Linezolid (lin-AYZ-oh-lid)
Brand Name: Zyvox

Zyvox Suspension is used for:

Treating adults with certain serious bacterial infections that are often resistant to other antibiotics.

Zyvox Suspension is an oxazolidinone antibiotic. It works by interfering with the production of proteins needed by bacteria to grow.

Do NOT use Zyvox Suspension if:

• you are allergic to any ingredient in Zyvox Suspension
• you are taking an amphetamine (eg, dextroamphetamine), certain anorexiants (eg, phentermine), buspirone, a catechol-O-methyltransferase (COMT) inhibitor (eg, entacapone), levodopa, meperidine, a sympathomimetic (eg, albuterol, dopamine, epinephrine, pseudoephedrine), tetrabenazine, or a triptan (eg, sumatriptan)
• you are taking or have taken certain anorexiants (eg, sibutramine), apraclonidine, bupropion, cyclobenzaprine, a monoamine oxidase inhibitor (MAOI) (eg, phenelzine), a norepinephrine reuptake inhibitor (eg, atomoxetine), a serotonin-norepinephrine reuptake inhibitor (SNRI) (eg, duloxetine), a serotonin reuptake inhibitor (eg, paroxetine), a tetracyclic antidepressant (eg, maprotiline), or a tricyclic antidepressant (eg, amitriptyline) within the past 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zyvox Suspension:

Some medical conditions may interact with Zyvox Suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of high blood pressure, kidney problems, eye or vision problems, bone marrow problems, low blood cell or platelet levels, an adrenal gland tumor (pheochromocytoma), carcinoid syndrome, severe liver problems, seizures, an overactive thyroid, or phenylketonuria
• if you have a prolonged infection that has been previously treated with another antibiotic medicine
• if you are taking any medicine for depression

Some MEDICINES MAY INTERACT with Zyvox Suspension. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Amphetamines (eg, dextroamphetamine), certain anorexiants (eg, phentermine, sibutramine), apraclonidine, ginseng, meperidine, sympathomimetics (eg, albuterol, dopamine, epinephrine, pseudoephedrine), or tryptophan because the risk of serious side effects, including severe headache, fever, or high blood pressure, may be increased
• Bupropion, busporine, catechol-O-methyltransfirase (COMT) inhibitors (eg, entacapone), levodopa, MAOIs (eg, phenelzine), norepinephrine reuptake inhibitors (eg, atomoxetine), propoxyphene, SNRIs (eg, duloxetine ), tetrabenazine, tetracyclic antidepressants (eg, maprotiline), tricyclic antidepressants (eg, amitriptyline), or triptans (eg, sumatriptan) because the risk of serious side effects, including severe fever, mental or mood changes, or muscle problems, may be increased
• Carbamazepine, barbiturates (eg, phenobarbital), hydantoins (eg, phenytoin), or rifamycins (eg, rifampin) because they may decrease Zyvox Suspension’s effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zyvox Suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zyvox Suspension:

Use Zyvox Suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Zyvox Suspension by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
• Gently mix before each dose by turning the bottle upside-down 3 to 5 times. Do not shake Zyvox Suspension.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• To clear up your infection completely, take Zyvox Suspension for the full course of treatment. Keep taking it even if you feel better in a few days.
• If you miss a dose of Zyvox Suspension, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zyvox Suspension.

Important safety information:

• Zyvox Suspension may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Zyvox Suspension with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Be sure to use Zyvox Suspension for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
• Long-term or repeated use of Zyvox Suspension may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
• Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
• Eating foods high in tyramine (eg, aged cheeses, red wines, beer, certain meats and sausages, liver, sour cream, soy sauce, raisins, bananas, avocados) while you use an MAOI may cause severe high blood pressure. This could occur for up to 2 weeks after you stop taking an MAOI. Do not eat foods high in tyramine while you take Zyvox Suspension. Ask your health care provider for a complete list of foods you should avoid. Seek medical attention at once if symptoms of severe high blood pressure occur. These may include severe headache, fast or irregular heartbeat, sore or stiff neck, nausea, vomiting, sweating, enlarged pupils, or sensitivity to light.
• Zyvox Suspension may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
• Zyvox Suspension only works against bacteria; it does not treat viral infections (eg, the common cold).
• Lactic acidosis has occurred with the use of Zyvox Suspension. Contact your doctor if you have severe, persistent nausea, vomiting, stomach pain, or unusual tiredness or weakness.
• Serious eye problems (eg, peripheral and optic neuropathy) have occurred with the use of Zyvox Suspension. Contact your doctor if you experience vision changes (eg, decreased or blurred vision, changes in color vision, loss of vision).
• Phenylketonuria patients – Zyvox Suspension contains phenylalanine. If you must have a diet that is low in phenylalanine, talk with your doctor or pharmacist.
• Lab tests, including complete blood cell counts and eye exams, may be performed while you use Zyvox Suspension. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Zyvox Suspension should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zyvox Suspension while you are pregnant. It is not known if Zyvox Suspension is found in breast milk. If you are or will be breast-feeding while you use Zyvox Suspension, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Zyvox Suspension:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bad taste in mouth; constipation; diarrhea; dizziness; headache; nausea; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); agitation; bloody stools; bloody vomit; chills, fever, or sore throat; confusion; exaggerated reflexes; excitation; fast heartbeat; loss of coordination; mental or mood changes; muscle spasms; prolonged or repeated nausea or vomiting; red, swollen, peeling, or blistered skin; seizures; severe or continuing diarrhea; stomach pain/cramps; sweating; swelling of the hands or feet; tingling or numbness of the hands or feet; unusual bleeding or bruising; unusual tiredness or weakness; vaginal irritation or unusual discharge; vision changes; white patches in the mouth.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Zyvox Suspension:

Store Zyvox Suspension at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep the bottle tightly closed. Discard any unused medicine 21 days after mixing. Keep Zyvox Suspension out of the reach of children and away from pets.

General information:

• If you have any questions about Zyvox Suspension, please talk with your doctor, pharmacist, or other health care provider.
• Zyvox Suspension is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zyvox Suspension. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Cetirizine/Pseudoephedrine (seh-TIH-rih-zeen/SUE-doe-eh-FED-rin)
Brand Name: Zyrtec-D 12 Hour

Zyrtec-D 12 Hour is used for:

Relieving nasal and non-nasal symptoms associated with seasonal and perennial allergies such as watery or itchy eyes, runny nose, sneezing, and stuffy nose.

Zyrtec-D 12 Hour is a decongestant (pseudoephedrine) and antihistamine (cetirizine) combination. It works by blocking a chemical in the body, histamine, which causes allergy symptoms. It also shrinks swollen nasal passages, which relieves nasal congestion.

Do NOT use Zyrtec-D 12 Hour if:

• you are allergic to any ingredient in Zyrtec-D 12 Hour
• you have narrow-angle glaucoma, severe difficulty urinating, very high blood pressure, or severe heart or blood vessel disease
• you are currently taking or have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zyrtec-D 12 Hour:

Some medical conditions may interact with Zyrtec-D 12 Hour. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have diabetes, difficulty urinating due to an enlarged prostate, heart or kidney problems, an overactive thyroid, glaucoma, or high blood pressure

Some MEDICINES MAY INTERACT with Zyrtec-D 12 Hour. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Furazolidone or MAO inhibitors (eg, phenelzine) because they can cause serious, sometimes fatal, reactions. Do not take MAO inhibitors within 2 weeks of taking Zyrtec-D 12 Hour.
• Certain stimulants (albuterol, amphetamine), digitalis (eg, digoxin), or droxidopa because toxic effects on the heart may occur
• Urinary alkalinizers (eg, sodium bicarbonate) because it may increase the actions and side effects of Zyrtec-D 12 Hour
• Bromocriptine or certain antihypertensives (guanethidine, methyldopa, mecamylamine, reserpine) because their effectiveness may be decreased by Zyrtec-D 12 Hour

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zyrtec-D 12 Hour may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zyrtec-D 12 Hour:

Use Zyrtec-D 12 Hour as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Zyrtec-D 12 Hour may be taken with or without food.
• Swallow whole. Do not crush, break, or chew before swallowing.
• If you miss a dose of Zyrtec-D 12 Hour, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zyrtec-D 12 Hour.

Important safety information:

• Zyrtec-D 12 Hour may cause dizziness or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Zyrtec-D 12 Hour. Using Zyrtec-D 12 Hour alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
• Avoid drinking alcohol or taking other medicines that cause drowsiness (eg, sedatives, tranquilizers) while taking Zyrtec-D 12 Hour. Zyrtec-D 12 Hour will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
• If you have trouble sleeping, ask your doctor or pharmacist about the best time to take Zyrtec-D 12 Hour.
• Zyrtec-D 12 Hour may interfere with allergy test results. Check with your doctor for more information.
• Diabetes patients – Zyrtec-D 12 Hour may affect your blood sugar level. Your doctor may need to change the amount of diabetes medicine you are taking.
• Use Zyrtec-D 12 Hour with caution in the ELDERLY because they may be more sensitive to its effects, especially drowsiness.
• Zyrtec-D 12 Hour is not recommended for use in children younger than 12 years of age. Safety and effectiveness in the age group have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Zyrtec-D 12 Hour during pregnancy. Zyrtec-D 12 Hour is excreted in breast milk. Do not breast-feed while taking Zyrtec-D 12 Hour.

Possible side effects of Zyrtec-D 12 Hour:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; dry mouth; fatigue; headache; nausea; nervousness; sore throat; trouble sleeping.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine; difficulty urinating; mental or mood changes; persistent tiredness; seizures; sleeplessness; uncontrolled shaking or tremor; unusually fast/irregular heart rhythm; weakness; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include confusion; difficulty breathing; hallucinations; irregular or fast heartbeat; loss of consciousness; seizures; severe drowsiness; sleeplessness; tremors.

Proper storage of Zyrtec-D 12 Hour:

Store Zyrtec-D 12 Hour at room temperature, 68 to 77 degrees F (20 to 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zyrtec-D 12 Hour out of the reach of children and away from pets.

General information:

• If you have any questions about Zyrtec-D 12 Hour, please talk with your doctor, pharmacist, or other health care provider.
• Zyrtec-D 12 Hour is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zyrtec-D 12 Hour. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Cetirizine (se-TIR-i-zeen)
Brand Name: Zyrtec

Zyrtec Syrup is used for:

Preventing or treating symptoms of hay fever and other upper respiratory allergies such as stuffy nose, runny nose, sneezing, itching of the nose and throat, and itchy, watery eyes. It is also used for preventing or treating chronic hives. It may also be used for other conditions as determined by your doctor.

Zyrtec Syrup is an antihistamine. It works by blocking the action of histamine, which reduces the symptoms of an allergic reaction.

Do NOT use Zyrtec Syrup if:

• you are allergic to any ingredient in Zyrtec Syrup or to hydroxyzine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zyrtec Syrup:

Some medical conditions may interact with Zyrtec Syrup. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have kidney or liver problems, or you are receiving dialysis

Some MEDICINES MAY INTERACT with Zyrtec Syrup. Tell your health care provider if you are taking any other medicines, especially any of the following:

Theophylline because it may increase the risk of Zyrtec Syrup’s side effects

How to use Zyrtec Syrup:

Use Zyrtec Syrup as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Zyrtec Syrup by mouth with or without food.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• If you miss a dose of Zyrtec Syrup, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zyrtec Syrup.

Important safety information:

• Zyrtec Syrup may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Zyrtec Syrup with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Zyrtec Syrup; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
• Zyrtec Syrup may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Zyrtec Syrup. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
• Zyrtec Syrup may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking Zyrtec Syrup for a few days before the tests.
• Use Zyrtec Syrup with caution in the ELDERLY; they may be more sensitive to its effects.
• Caution is advised when using Zyrtec Syrup in CHILDREN; they may be more sensitive to its effects, especially stomach pain and trouble sleeping.
• Zyrtec Syrup should be used with extreme caution in CHILDREN younger than 6 months old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: It is not known if Zyrtec Syrup can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zyrtec Syrup while you are pregnant. Zyrtec Syrup is found in breast milk. Do not breast-feed while taking Zyrtec Syrup.

Possible side effects of Zyrtec Syrup:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Drowsiness; dry mouth; stomach pain (in children); tiredness; trouble sleeping (in children).

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); dark urine; fainting; fast or irregular heartbeat; mental or mood changes; persistent fatigue; seizures; severe dizziness; unusual bruising or bleeding; yellowing of eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include irritability; restlessness; severe drowsiness.

Proper storage of Zyrtec Syrup:

Store Zyrtec Syrup at 77 degrees F ( 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Zyrtec Syrup may be refrigerated at 36 to 46 degrees F (2 to 8 degrees C). Do not store in the bathroom. Keep Zyrtec Syrup out of the reach of children and away from pets.

General information:

• If you have any questions about Zyrtec Syrup, please talk with your doctor, pharmacist, or other health care provider.
• Zyrtec Syrup is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zyrtec Syrup. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Cetirizine (se-TIR-i-zeen)
Brand Name: Zyrtec

Zyrtec Chewable Tablets are used for:

Preventing or treating symptoms of hay fever and other upper respiratory allergies such as stuffy nose, runny nose, sneezing, itching of the nose and throat, and itchy, watery eyes. It is also used for preventing or treating chronic hives. It may also be used for other conditions as determined by your doctor.

Zyrtec Chewable Tablets are an antihistamine. It works by blocking the action of histamine, which reduces the symptoms of an allergic reaction.

Do NOT use Zyrtec Chewable Tablets if:

• you are allergic to any ingredient in Zyrtec Chewable Tablets or to hydroxyzine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zyrtec Chewable Tablets:

Some medical conditions may interact with Zyrtec Chewable Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have kidney or liver problems, or you are receiving dialysis

Some MEDICINES MAY INTERACT with Zyrtec Chewable Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

Theophylline because it may increase the risk of Zyrtec Chewable Tablets’s side effects

How to use Zyrtec Chewable Tablets:

Use Zyrtec Chewable Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Zyrtec Chewable Tablets by mouth with or without food.
• Chew thoroughly before swallowing.
• If you miss a dose of Zyrtec Chewable Tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zyrtec Chewable Tablets.

Important safety information:

• Zyrtec Chewable Tablets may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Zyrtec Chewable Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Zyrtec Chewable Tablets; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
• Zyrtec Chewable Tablets may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Zyrtec Chewable Tablets. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
• Zyrtec Chewable Tablets may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking Zyrtec Chewable Tablets for a few days before the tests.
• Use Zyrtec Chewable Tablets with caution in the ELDERLY; they may be more sensitive to its effects.
• Caution is advised when using Zyrtec Chewable Tablets in CHILDREN; they may be more sensitive to its effects, especially stomach pain and trouble sleeping.
• Zyrtec Chewable Tablets should be used with extreme caution in CHILDREN younger than 6 months old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: It is not known if Zyrtec Chewable Tablets can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zyrtec Chewable Tablets while you are pregnant. Zyrtec Chewable Tablets are found in breast milk. Do not breast-feed while taking Zyrtec Chewable Tablets.

Possible side effects of Zyrtec Chewable Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Drowsiness; dry mouth; stomach pain (in children); tiredness; trouble sleeping (in children).

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); dark urine; fainting; fast or irregular heartbeat; mental or mood changes; persistent fatigue; seizures; severe dizziness; unusual bruising or bleeding; yellowing of eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include irritability; restlessness; severe drowsiness.

Proper storage of Zyrtec Chewable Tablets:

Store Zyrtec Chewable Tablets between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zyrtec Chewable Tablets out of the reach of children and away from pets.

General information:

• If you have any questions about Zyrtec Chewable Tablets, please talk with your doctor, pharmacist, or other health care provider.
• Zyrtec Chewable Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zyrtec Chewable Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Olanzapine (oh-LAN-za-peen)
Brand Name: Zyprexa Zydis

Zyprexa Zydis Orally Disintegrating Tablets are used for:

Treating schizophrenia or bipolar disorder. It is also used along with another medicine (fluoxetine) to treat certain types of depression. It may also be used for other conditions as determined by your doctor.

Zyprexa Zydis Orally Disintegrating Tablets are an atypical antipsychotic. Exactly how it works is not known. It is thought to affect certain substances in the brain.

Do NOT use Zyprexa Zydis Orally Disintegrating Tablets if:

• you are allergic to any ingredient in Zyprexa Zydis Orally Disintegrating Tablets

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zyprexa Zydis Orally Disintegrating Tablets:

Some medical conditions may interact with Zyprexa Zydis Orally Disintegrating Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of seizures, heart problems (eg, heart failure; fast, slow, or irregular heartbeat), abnormal electrocardiogram (ECG), heart attack, stroke or mini-stroke, blood vessel problems, high blood cholesterol levels, high or low blood pressure, or low white blood cell levels
• if you have a history of liver problems, stomach or bowel problems (eg, decreased muscle movement), enlarged prostate, narrow-angle glaucoma, neuroleptic malignant syndrome (NMS), aspiration pneumonia, or suicidal thoughts or attempts
• if you have Alzheimer disease, bowel blockage, dementia, phenylketonuria, or trouble swallowing
• if you have diabetes or are very overweight, or if a family member has had diabetes
• if you have had high blood prolactin levels or a history of certain types of cancer (eg, breast, pancreas, pituitary), or if you are at risk for breast cancer
• if you are dehydrated, drink alcohol, smoke, or you will be exposed to high temperatures

Some MEDICINES MAY INTERACT with Zyprexa Zydis Orally Disintegrating Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Alpha blockers (eg, doxazosin), diazepam, or medicine for high blood pressure because the risk of low blood pressure and fainting may be increased
• Anticholinergics (eg, scopolamine), benzodiazepines (eg, lorazepam), or fluvoxamine because they may increase the risk of Zyprexa Zydis Orally Disintegrating Tablets’s side effects
• Carbamazepine, HIV protease inhibitors (eg, ritonavir), omeprazole, or rifampin because they may decrease Zyprexa Zydis Orally Disintegrating Tablets’s effectiveness
• Dopamine receptor agonists (eg, pramipexole) or levodopa because their effectiveness may be decreased by Zyprexa Zydis Orally Disintegrating Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zyprexa Zydis Orally Disintegrating Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zyprexa Zydis Orally Disintegrating Tablets:

Use Zyprexa Zydis Orally Disintegrating Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Zyprexa Zydis Orally Disintegrating Tablets comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Zyprexa Zydis Orally Disintegrating Tablets refilled.
• Take Zyprexa Zydis Orally Disintegrating Tablets by mouth with or without food.
• Do not remove the blister from the outer pouch until you are ready to take Zyprexa Zydis Orally Disintegrating Tablets. Make sure that your hands are dry when you open the blister pack.
• Do not push the tablet through the foil. Peel back the foil on the blister pack and place the tablet on your tongue. The tablet dissolves quickly and can be swallowed with saliva. Zyprexa Zydis Orally Disintegrating Tablets may be taken with or without water.
• Take the tablet immediately after opening the blister pack. Do not store the removed tablet for future use.
• Drinking extra fluids while you are taking Zyprexa Zydis Orally Disintegrating Tablets are recommended. Check with your doctor for instructions.
• Continue to take Zyprexa Zydis Orally Disintegrating Tablets even if you feel well. Do not miss any doses.
• If you miss a dose of Zyprexa Zydis Orally Disintegrating Tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zyprexa Zydis Orally Disintegrating Tablets.

Important safety information:

• Zyprexa Zydis Orally Disintegrating Tablets may cause dizziness, drowsiness, or decreased vision. These effects may be worse if you take it with alcohol or certain medicines. Use Zyprexa Zydis Orally Disintegrating Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do not drink alcohol while you are taking Zyprexa Zydis Orally Disintegrating Tablets.
• Talk with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are taking Zyprexa Zydis Orally Disintegrating Tablets; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
• Zyprexa Zydis Orally Disintegrating Tablets may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
• Do not suddenly stop taking Zyprexa Zydis Orally Disintegrating Tablets without checking with your doctor.
• Do not become overheated in hot weather or while you are being active; heatstroke may occur.
• This product contains phenylalanine. If you must have a diet that is low in phenylalanine, ask your pharmacist if it is in your product.
• Zyprexa Zydis Orally Disintegrating Tablets may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
• Zyprexa Zydis Orally Disintegrating Tablets may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
• NMS is a possibly fatal syndrome that can be caused by Zyprexa Zydis Orally Disintegrating Tablets. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.
• Some patients who take Zyprexa Zydis Orally Disintegrating Tablets may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take Zyprexa Zydis Orally Disintegrating Tablets in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements) while taking Zyprexa Zydis Orally Disintegrating Tablets.
• Lab tests, including fasting blood glucose, cholesterol, complete blood cell counts, and liver function, may be performed while you take Zyprexa Zydis Orally Disintegrating Tablets. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Zyprexa Zydis Orally Disintegrating Tablets with caution in the ELDERLY; they may be more sensitive to its effects, especially uncontrolled muscle movements.
• Caution is advised when using Zyprexa Zydis Orally Disintegrating Tablets in CHILDREN; they may be more sensitive to its effects, especially drowsiness, increased cholesterol and lipid levels, increased levels of prolactin (a hormone), and weight gain. Children may need regular weight checks while they take Zyprexa Zydis Orally Disintegrating Tablets.
• Zyprexa Zydis Orally Disintegrating Tablets should be used with extreme caution in CHILDREN younger than 13 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Zyprexa Zydis Orally Disintegrating Tablets while you are pregnant. Zyprexa Zydis Orally Disintegrating Tablets are found in breast milk. Do not breast-feed while taking Zyprexa Zydis Orally Disintegrating Tablets.

Possible side effects of Zyprexa Zydis Orally Disintegrating Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back or joint pain; constipation; cough; dizziness; drowsiness; dry mouth; increased appetite; indigestion; lightheadedness; numbness or tingling of the skin; restlessness; sore throat; weakness; weight gain.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); abnormal thoughts; chest pain; confusion; decreased urination; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; increased saliva production or drooling; increased sweating; memory loss; menstrual changes; muscle pain, weakness, or stiffness; new or worsening mental or mood changes (eg, depression, hallucinations); seizures; severe or prolonged dizziness or headache; shortness of breath; suicidal thoughts or actions; swelling of the hands, legs, or feet; symptoms of high blood sugar (eg, increased thirst, hunger, urination; unusual weakness); symptoms of high prolactin levels (eg, enlarged breast size, decreased sexual ability, missed menstrual period, nipple discharge); tremor; trouble concentrating, speaking, or swallowing; trouble sitting still; trouble walking or standing; uncontrolled muscle movements (eg, arm or leg movements, jerking or twisting, twitching of the face or tongue); unusual bruising; vision changes; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include aggression; agitation; chest pain; coma; difficult or slurred speech; fast or irregular heartbeat; seizure; severe drowsiness; slow or shallow breathing; uncontrolled muscle movements.

Proper storage of Zyprexa Zydis Orally Disintegrating Tablets:

Store Zyprexa Zydis Orally Disintegrating Tablets at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Keep Zyprexa Zydis Orally Disintegrating Tablets out of the reach of children and away from pets.

General information:

• If you have any questions about Zyprexa Zydis Orally Disintegrating Tablets, please talk with your doctor, pharmacist, or other health care provider.
• Zyprexa Zydis Orally Disintegrating Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zyprexa Zydis Orally Disintegrating Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Hydrocortisone Acetate/Pramoxine (HYE-droe-KOR-ti-sone AS-e-tate/pram-OX-een )
Brand Name: Zypram

Zypram Cream with Cleansing Wipes is used for:

Treating inflammation and itching of the anal area due to certain skin conditions.

Zypram Cream with Cleansing Wipes is a combination topical corticosteroid and local anesthetic. It works by reducing skin inflammation (redness, swelling, itching, and irritation) in a way that is not exactly understood. It also decreases pain in the affected area.

Do NOT use Zypram Cream with Cleansing Wipes if:

• you are allergic to any ingredient in Zypram Cream with Cleansing Wipes
• you have a rectal obstruction, abscess, or perforation

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zypram Cream with Cleansing Wipes:

Some medical conditions may interact with Zypram Cream with Cleansing Wipes. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have any kind of skin infection, cuts, scrapes, or lessened blood flow to your skin in the affected area
• if you have a parasitic, bacterial, fungal, or viral infection; diabetes; diarrhea; swelling of the esophagus; stomach or intestinal problems (eg, blockage, colostomy, fistula, inflammation, perforation, ulcer); inflammation of the lining of the abdomen; measles; tuberculosis (TB); a positive TB skin test; chickenpox; shingles; herpes infection of the eye; or kidney problems; or if you have received a recent vaccination
• if you have a history of congestive heart failure or heart attack
• if you have had a recent intestinal surgery or procedure

Some MEDICINES MAY INTERACT with Zypram Cream with Cleansing Wipes. Because little, if any, of Zypram Cream with Cleansing Wipes is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Zypram Cream with Cleansing Wipes may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zypram Cream with Cleansing Wipes:

Use Zypram Cream with Cleansing Wipes as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Zypram Cream with Cleansing Wipes is for use around the rectal area only.
• Wash your hands immediately before and after using Zypram Cream with Cleansing Wipes.
• Gently clean the affected area with the cleansing wipe provided.
• Fill the applicator with Zypram Cream with Cleansing Wipes as directed. Gently insert the tip of the filled applicator about ½ inch into the anal area and apply Zypram Cream with Cleansing Wipes as directed. Do not insert the applicator too far into the anus or rectum.
• If you miss a dose of Zypram Cream with Cleansing Wipes, apply it as soon as possible. If you do not remember until the next day, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once. Ask your health care provider any questions you may have about how to use Zypram Cream with Cleansing Wipes.

Important safety information:

• Avoid getting Zypram Cream with Cleansing Wipes in your eyes. If you get Zypram Cream with Cleansing Wipes in your eyes, immediately flush them with cool tap water.
• If your symptoms do not get better within 2 to 3 weeks or if they get worse, check with your doctor.
• Do not use more than the recommended dose or use for longer than prescribed without checking with your doctor.
• Do not use Zypram Cream with Cleansing Wipes for other rectal conditions at a later time.
• Check with your doctor before having vaccinations while you are using Zypram Cream with Cleansing Wipes.
• Corticosteroids may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they use Zypram Cream with Cleansing Wipes.
• Caution is advised when using Zypram Cream with Cleansing Wipes in CHILDREN; they may be more sensitive to its effects.
• Serious side effects may occur if too much of Zypram Cream with Cleansing Wipes is absorbed through the skin. This may be more likely to occur if you use Zypram Cream with Cleansing Wipes over a large area of the body. It may also be more likely if you wrap or bandage the area after you apply Zypram Cream with Cleansing Wipes. The risk is greater in children. Do not use more than the prescribed dose. Contact your doctor right away if you develop unusual weight gain (especially in the face), muscle weakness, increased thirst or urination, confusion, unusual drowsiness, severe or persistent headache, or vision changes. Discuss any questions or concerns with your doctor.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zypram Cream with Cleansing Wipes while you are pregnant. It is not known if Zypram Cream with Cleansing Wipes is found in breast milk after topical use. If you are or will be breast-feeding while you use Zypram Cream with Cleansing Wipes, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Zypram Cream with Cleansing Wipes:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild burning, dryness, itching, or irritation at the application site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); acne-like rash; excessive hair growth; fever or other signs of infection; inflamed hair follicles; muscle weakness; rectal pain, burning, cracking, itching, bleeding, peeling, or irritation not present before using Zypram Cream with Cleansing Wipes; thinning, softening, or discoloration of the skin; unusual weight gain, especially in the face.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include increased thirst or urination; muscle weakness; unusual weight gain, especially in the face.

Proper storage of Zypram Cream with Cleansing Wipes:

Store Zypram Cream with Cleansing Wipes between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zypram Cream with Cleansing Wipes out of the reach of children and away from pets.

General information:

• If you have any questions about Zypram Cream with Cleansing Wipes, please talk with your doctor, pharmacist, or other health care provider.
• Zypram Cream with Cleansing Wipes is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zypram Cream with Cleansing Wipes. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Pseudoephedrine/Triprolidine (soo-doe-e-FED-rin/try-PRO-li-deen)
Brand Name: Examples include Allerfrim and Zymine-D

Zymine-D Liquid is used for:

Temporarily relieving symptoms of hay fever, allergies, or the common cold, including nasal congestion, runny nose, sneezing, itching of the nose and throat, and itchy/watery eyes. It may also be used for other conditions as determined by your doctor.

Zymine-D Liquid is an antihistamine and decongestant combination. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing. The decongestant promotes sinus and nasal drainage, relieving congestion and pressure.

Do NOT use Zymine-D Liquid if:

• you are allergic to any ingredient in Zymine-D Liquid
• you are taking droxidopa or sodium oxybate (GHB), or you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the past 14 days
• you have severe high blood pressure or severe heart disease (eg, coronary artery disease, ischemic heart disease)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zymine-D Liquid:

Some medical conditions may interact with Zymine-D Liquid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have glaucoma or increased pressure in the eyes; high blood pressure; diabetes; heart or blood vessel disease; overactive thyroid; seizures; blockage of the stomach, bowel, or bladder; trouble breathing when you sleep; trouble sleeping; a breathing problem (eg, asthma, emphysema, chronic bronchitis); the blood disease porphyria; or an enlarged prostate or prostate disease; or if you have difficulty urinating

Some MEDICINES MAY INTERACT with Zymine-D Liquid. Tell your health care provider if you are taking any other medicines, especially if any of the following apply to you:

• Furazolidone or MAO inhibitors (eg, phenelzine) because side effects such as severe headache, high blood pressure, or high fever may occur
• Bromocriptine or sodium oxybate (GHB) because the risk of side effects or toxic effects may be increased by Zymine-D Liquid
• Guanethidine, guanadrel, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Zymine-D Liquid.
• Droxidopa because side effects such as irregular heartbeat or heart attack may occur
• Urinary alkalinizers (eg, sodium bicarbonate) because the side effects of Zymine-D Liquid may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zymine-D Liquid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zymine-D Liquid:

Use Zymine-D Liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Zymine-D Liquid may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• If you miss a dose of Zymine-D Liquid and are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zymine-D Liquid.

Important safety information:

• Zymine-D Liquid may cause dizziness or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Zymine-D Liquid. Using Zymine-D Liquid alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Zymine-D Liquid. Zymine-D Liquid will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
• Contact your health care provider if symptoms last for more than 7 days or are accompanied by a fever.
• Diabetes patients – Zymine-D Liquid may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.
• Zymine-D Liquid contains pseudoephedrine. Before you begin taking any new prescription or nonprescription medicine, including medicine used on the skin, read the ingredients to see if it also contains pseudoephedrine. If it does, or if you are uncertain if it does, contact your doctor or pharmacist.
• Do not take diet or appetite control medicines while you are taking Zymine-D Liquid without checking with your doctor.
• Do not exceed the recommended dose or take Zymine-D Liquid for longer than prescribed without checking with your doctor.
• If you have trouble sleeping, ask your pharmacist or doctor about the best time of day to take Zymine-D Liquid.
• Use Zymine-D Liquid with caution in the ELDERLY because they may be more sensitive to its effects.
• Zymine-D Liquid is not recommended for use in CHILDREN younger than 6 years of age without first checking with your doctor.
• Caution is advised when using Zymine-D Liquid in CHILDREN because they may be more sensitive to its effects, especially excitability.
• PREGNANCY AND BREAST-FEEDING: If you become pregnant while taking Zymine-D Liquid, discuss with your doctor the benefits and risks of using Zymine-D Liquid during pregnancy. If you are or will be breast-feeding while you are using Zymine-D Liquid, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Zymine-D Liquid:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; dry mouth, nose, or throat; excitability (especially in children); headache; loss of appetite; nausea; nervousness; restlessness; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; chest pain; decreased coordination; difficulty urinating; fast or irregular heartbeat; fever; hallucinations; seizure; severe dizziness and drowsiness; severe nervousness, anxiety, or restlessness; tremors; unusual weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include bluish-colored skin; difficulty breathing; dilated pupils; fast or irregular heartbeat; fever; flushing; hallucinations; mental or mood changes; seizures; severe drowsiness or dizziness; severe excitability; severe nausea or vomiting; sweating; tremors.

Proper storage of Zymine-D Liquid:

Store Zymine-D Liquid at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zymine-D Liquid out of the reach of children and away from pets.

General information:

• If you have any questions about Zymine-D Liquid, please talk with your doctor, pharmacist, or other health care provider.
• Zymine-D Liquid is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zymine-D Liquid. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Hydrocortisone Acetate/Pramoxine (hye-droe-KOR-ti-sone ASS-eh-tate/pra-MOX-een)
Brand Name: Examples include Analpram-HC and Zypram

Zypram Cream is used for:

Treating inflammation and itching of the anal area due to certain skin conditions.

Zypram Cream is a combination topical corticosteroid and local anesthetic. It works by reducing skin inflammation (redness, swelling, itching, and irritation) in a way that is not exactly understood. It also decreases pain in the affected area.

Do NOT use Zypram Cream if:

• you are allergic to any ingredient in Zypram Cream
• you have a rectal obstruction, abscess, or perforation

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zypram Cream:

Some medical conditions may interact with Zypram Cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have any kind of skin infection, cuts, scrapes, or lessened blood flow to your skin in the affected area
• if you have a parasitic, bacterial, fungal, or viral infection; diabetes; diarrhea; swelling of the esophagus; stomach or intestinal problems (eg, inflammation, blockage, ulcer, perforation, fistula, colostomy); inflammation of the lining of the abdomen; measles; tuberculosis (TB); a positive TB skin test; chickenpox; shingles; herpes infection of the eye; kidney problems; or you have received a recent vaccination
• if you have a history of congestive heart failure or heart attack
• if you have had recent intestinal surgery or procedure

Some MEDICINES MAY INTERACT with Zypram Cream. Because little, if any, of Zypram Cream is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Zypram Cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zypram Cream:

Use Zypram Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Zypram Cream is for use around the rectal area only.
• Wash your hands immediately before and after using Zypram Cream.
• For use around the anus, apply a small amount of medicine to the affected area and rub in gently.
• If you miss a dose of Zypram Cream, apply it as soon as possible. If you do not remember until the next day, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Zypram Cream.

Important safety information:

• Avoid getting Zypram Cream in your eyes. If you get Zypram Cream in your eyes, immediately flush them with cool tap water.
• If your symptoms do not get better within 2 to 3 weeks or if they get worse, check with your doctor.
• Do not use Zypram Cream for other rectal conditions at a later time.
• Check with your doctor before having vaccinations while you are using Zypram Cream.
• Corticosteroids may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they use Zypram Cream.
• Caution is advised when using Zypram Cream in CHILDREN; they may be more sensitive to its effects.
• Serious side effects may occur if too much of Zypram Cream is absorbed through the skin. This may be more likely to occur if you use Zypram Cream over a large area of the body. It may also be more likely if you wrap or bandage the area after you apply Zypram Cream. The risk is greater in children. Do not use more than the prescribed dose. Contact your doctor right away if you develop unusual weight gain (especially in the face), muscle weakness, increased thirst or urination, confusion, unusual drowsiness, severe or persistent headache, or vision changes. Discuss any questions or concerns with your doctor.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zypram Cream while you are pregnant. It is not known if Zypram Cream is found in breast milk after topical use. If you are or will be breast-feeding while you use Zypram Cream, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Zypram Cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dry skin; itching.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); acne-like rash; excessive hair growth; inflamed hair follicles; inflammation around the mouth; muscle weakness; rectal pain, burning, cracking, itching, bleeding, peeling, or irritation not present before using Zypram Cream; thinning, softening, or discoloration of the skin; unusual weight gain, especially in the face.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include increased thirst or urination; muscle weakness; unusual weight gain, especially in the face. Zypram Cream may be harmful if swallowed.

Proper storage of Zypram Cream:

Store Zypram Cream at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zypram Cream out of the reach of children and away from pets.

General information:

• If you have any questions about Zypram Cream, please talk with your doctor, pharmacist, or other health care provider.
• Zypram Cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zypram Cream. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Triprolidine (trye-PROE-li-deen)
Brand Name: Zymine

Zymine Syrup is used for:

Preventing or treating symptoms of hay fever and other upper respiratory allergies or the common cold, such as runny nose, sneezing, itching of the nose and throat, and itchy, watery eyes, and relieving cough. It may also be used for other conditions as determined by your doctor.

Zymine Syrup is an antihistamine. It works by blocking the action of histamine, reducing the symptoms of an allergic reaction.

Do NOT use Zymine Syrup if:

• you are allergic to any ingredient in Zymine Syrup or other similar medicines
• you are taking sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zymine Syrup:

Some medical conditions may interact with Zymine Syrup. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a fast, slow, or irregular heartbeat
• if you have a history of asthma; chronic obstructive pulmonary disease (COPD); chronic bronchitis; lung problems (eg, emphysema); shortness of breath; sleep apnea; heart blood vessel problems; stroke; seizures; a blockage of your stomach, intestine, or bladder; difficulty urinating; diabetes; ulcers; an enlarged prostate or other prostate problems; glaucoma; heart problems; high blood pressure; porphyria; phenylketonuria; or an overactive thyroid

Some MEDICINES MAY INTERACT with Zymine Syrup. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Sodium oxybate (GHB) because an increase in sleep duration and a decrease in the ability to breathe are likely to occur
• Monoamine oxidase (MAO) inhibitors (eg, phenelzine) because they may increase side effects of Zymine Syrup

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zymine Syrup may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zymine Syrup:

Use Zymine Syrup as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Zymine Syrup may be taken with or without food.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• Use Zymine Syrup exactly as directed on the package, unless instructed differently by your doctor. If you are taking Zymine Syrup without a prescription, follow any warnings and precautions on the label.
• If you miss a dose of Zymine Syrup and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zymine Syrup.

Important safety information:

• Zymine Syrup may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Zymine Syrup. Using Zymine Syrup alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Zymine Syrup. Zymine Syrup will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
• Zymine Syrup may cause dizziness. Alcohol, hot weather, exercise, and fever can increase this effect. To prevent it, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness.
• Do not become overheated in hot weather or during exercise or other activities since heatstroke may occur.
• If you are scheduled for allergy skin testing, do not take Zymine Syrup for several days before the test because it may decrease your response to the skin tests.
• Phenylketonuria patients – Zymine Syrup contains phenylalanine.
• If you are using Zymine Syrup for cough, cold, or allergy symptoms, stop use and contact your doctor if your symptoms do not improve within 7 days or are accompanied by fever.
• Use Zymine Syrup with caution in the ELDERLY because they may be more sensitive to its effects, especially dizziness, sedation, and lightheadedness upon standing.
• Safe use and instructions for use in CHILDREN differs according to the brand used. Talk to your doctor or pharmacist if you have any questions about the brand you are using.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Zymine Syrup during pregnancy. Zymine Syrup is excreted in breast milk. If you are or will be breast-feeding while you are using Zymine Syrup, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Zymine Syrup:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; dry mouth, throat, and nose; excitability; thickening of mucus in nose or throat.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); convulsions; fast heartbeat or pounding in the chest; decreased alertness; hallucinations; tremor; wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include coma; excitement; hallucinations; loss of consciousness; muscle twitching; seizures; tremor; weakness.

Proper storage of Zymine Syrup:

Store Zymine Syrup at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zymine Syrup out of the reach of children and away from pets.

General information:

• If you have any questions about Zymine Syrup, please talk with your doctor, pharmacist, or other health care provider.
• Zymine Syrup is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zymine Syrup. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Triprolidine (trye-PROE-li-deen)
Brand Name: Zymine XR

Zymine XR Suspension is used for:

Preventing or treating symptoms of hay fever or other allergies, such as runny nose, sneezing, itching of the nose and throat, and itchy, watery eyes. It may also be used for other conditions as determined by your doctor.

Zymine XR Suspension is an antihistamine. It works by blocking the action of histamine, reducing the symptoms of an allergic reaction.

Do NOT use Zymine XR Suspension if:

• you are allergic to any ingredient in Zymine XR Suspension or other similar medicines
• you are taking sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zymine XR Suspension:

Some medical conditions may interact with Zymine XR Suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a fast, slow, or irregular heartbeat
• if you have a history of asthma; chronic obstructive pulmonary disease (COPD); chronic bronchitis; lung problems (eg, emphysema); shortness of breath; sleep apnea; heart blood vessel problems; stroke; seizures; a blockage of your stomach, intestine, or bladder; difficulty urinating; diabetes; ulcers; an enlarged prostate or other prostate problems; glaucoma; heart problems; high blood pressure; porphyria; phenylketonuria; or an overactive thyroid

Some MEDICINES MAY INTERACT with Zymine XR Suspension. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Sodium oxybate (GHB) because an increase in sleep duration and a decrease in the ability to breathe are likely to occur
• Monoamine oxidase inhibitors (MAOIs) (eg, phenelzine) or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Zymine XR Suspension’s side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zymine XR Suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zymine XR Suspension:

Use Zymine XR Suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Zymine XR Suspension by mouth with or without food.
• Shake well before each use.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• If you miss a dose of Zymine XR Suspension and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zymine XR Suspension.

Important safety information:

• Zymine XR Suspension may cause drowsiness, dizziness, or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Zymine XR Suspension. Using Zymine XR Suspension alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Zymine XR Suspension. Zymine XR Suspension will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
• Zymine XR Suspension may cause dizziness. Alcohol, hot weather, exercise, and fever can increase this effect. To prevent it, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness.
• Do not become overheated in hot weather or during exercise or other activities since heatstroke may occur.
• If you are scheduled for allergy skin testing, check with your doctor. You may need to stop taking Zymine XR Suspension for several days before the test because it may decrease your response to the skin tests.
• Phenylketonuria patients – Zymine XR Suspension contains phenylalanine. If you must have a diet that is low in phenylalanine, ask your pharmacist if it is in your product.
• If your symptoms do not get better, or if they get worse, or if they occur with a fever, contact your doctor.
• Use Zymine XR Suspension with caution in the ELDERLY; they may be more sensitive to its effects, especially dizziness, sedation, and lightheadedness upon standing.
• Zymine XR Suspension should be used with extreme caution in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zymine XR Suspension while you are pregnant. Zymine XR Suspension is found in breast milk. Do not breast-feed while you are taking Zymine XR Suspension.

Possible side effects of Zymine XR Suspension:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; dry mouth, throat, and nose; excitability; loss of appetite; thickening of mucus in nose or throat.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); convulsions; decreased alertness; fast heartbeat or pounding in the chest; hallucinations; tremor; trouble urinating; wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include coma; excitement; hallucinations; loss of consciousness; muscle twitching; seizures; tremor; weakness.

Proper storage of Zymine XR Suspension:

Store Zymine XR Suspension at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zymine XR Suspension out of the reach of children and away from pets.

General information:

• If you have any questions about Zymine XR Suspension, please talk with your doctor, pharmacist, or other health care provider.
• Zymine XR Suspension is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zymine XR Suspension. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.