Generic Name: Gatifloxacin (ga-ti-FLOKS-a-sin)
Brand Name: Zymar

Zymar Drops are used for:

Treating eye infections caused by certain bacteria.

Zymar Drops are a fluoroquinolone antibiotic. It works by stopping the production of proteins that bacteria need to survive.

Do NOT use Zymar Drops if:

• you are allergic to any ingredient in Zymar Drops or similar medicines (eg, ciprofloxacin)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zymar Drops:

Some medical conditions may interact with Zymar Drops. Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines or other substances
• if you wear contact lenses
• if you have heart problems, including a slow heartbeat, a history of lack of blood supply to your heart, or hardening of the arteries
• if you have a history of low blood potassium levels, diabetes, or kidney or liver problems
• if you have Alzheimer disease, tendonitis, a history of seizures or other central nervous system problems, or increased pressure in the head

Some MEDICINES MAY INTERACT with Zymar Drops. Because little, if any, of Zymar Drops are absorbed into the blood, the risk of it interacting with another medicine is low. Tell your health care provider if you are taking any other medicines.

Ask your health care provider if Zymar Drops may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zymar Drops:

Use Zymar Drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Zymar Drops are only for the eye. Do not get it in your nose or mouth.
• To use Zymar Drops in the eye, first, wash your hands. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eyelid for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.
• To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.
• Remove excess medicine around your eye with a clean tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.
• If you are using other kinds of eye drops, wait at least 5 minutes before applying the other medicines.
• Do not wear contact lenses while you are using Zymar Drops. Take care of your contact lenses as directed by the manufacturer. Check with your doctor before you use them.
• Zymar Drops works best if it is used at the same time each day.
• To clear up your infection completely, use Zymar Drops for the full course of treatment. Keep using it even if you feel better in a few days.
• Discard the medicine if it changes color, turns cloudy, or if it contains particles.
• If you miss a dose of Zymar Drops, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Zymar Drops.

Important safety information:

• If your symptoms do not get better within 7 days or if they get worse, check with your doctor.
• Zymar Drops may cause temporary blurred vision. Use Zymar Drops with caution. Do not drive or perform other possibly unsafe tasks if you cannot see clearly.
• Long-term or repeated use of Zymar Drops may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
• Be sure to use Zymar Drops for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
• Zymar Drops may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.
• Zymar Drops should not be used in CHILDREN younger than 1 year old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zymar Drops while you are pregnant. It is not known if Zymar Drops are found in breast milk. If you are or will be breast-feeding while you use Zymar Drops, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Zymar Drops:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bad taste in the mouth; blurred vision; eye discharge; headache; irritation, pain, dryness, or redness of the eyes; itchy eyes; tearing; watery eyes.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); persistent eye redness; swelling of the eye or eyelid.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Zymar Drops:

Store Zymar Drops between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not freeze. Do not store in the bathroom. Keep Zymar Drops out of the reach of children and away from pets.

General information:

• If you have any questions about Zymar Drops, please talk with your doctor, pharmacist, or other health care provider.
• Zymar Drops are to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zymar Drops. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Loteprednol/Tobramycin (loe-te-PRED-nol/toe-bra-MYE-sin)
Brand Name: Zylet

Zylet Drops are used for:

Treating certain types of eye inflammation in which an infection or risk of infection is present.

Zylet Drops are a combination of a corticosteroid and antibiotic. It reduces inflammation and treats or protects against infection due to certain bacteria.

Do NOT use Zylet Drops if:

• you are allergic to any ingredient in Zylet Drops or to similar medicines, including corticosteroids or aminoglycoside antibiotics.
• you have a viral disease in the eye, including herpes simplex keratitis (dendritic keratitis), vaccinia, or varicella
• you have a mycobacterial or fungal infection of the eye

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zylet Drops:

Some medical conditions may interact with Zylet Drops. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have glaucoma, thinning of certain parts of the eye (the cornea or the sclera), or a history of herpes simplex infection, or have recently had cataract surgery
• if you have diabetes or wear contact lenses

Some MEDICINES MAY INTERACT with Zylet Drops. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Certain diuretic medicines (eg, furosemide), cyclosporine, nonsteroidal anti-inflammatory medicines (NSAIDs), or other medicines containing aminoglycoside antibiotics (eg, tobramycin, gentamicin) because the risk of their side effects may be increased by Zylet Drops

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zylet Drops may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zylet Drops:

Use Zylet Drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Zylet Drops are to be used as eye drops. It is not to be injected into the eye.
• Shake well before each use.
• To use Zylet Drops in the eye, first, wash your hands. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eyelid for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.
• To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.
• To clear up your infection completely, take/use Zylet Drops for the full course of treatment. Keep taking/using it even if you feel better in a few days.
• Zylet Drops are usually used for a maximum of 2 weeks. If it is used for longer than 10 days, eye exams may be required.
• If you miss a dose of Zylet Drops, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Zylet Drops.

Important safety information:

• Zylet Drops may cause blurred vision. Use Zylet Drops with caution. Do not drive or perform other possibly unsafe tasks if you cannot see clearly.
• If your symptoms do not get better after 2 days or if they get worse, contact your health care provider.
• Soft contact lenses may absorb a chemical in Zylet Drops. Do not wear contact lenses while you are using Zylet Drops.
• Tell your doctor or dentist that you take Zylet Drops before you receive any medical or dental care, emergency care, or surgery.
• Zylet Drops only works against bacteria; it does not treat viral infections (eg, the common cold).
• Be sure to use Zylet Drops for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
• Long-term or repeated use of Zylet Drops may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
• Lab tests, including eye examinations, may be performed while you use Zylet Drops. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Zylet Drops should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zylet Drops while you are pregnant. It is not known if Zylet Drops are found in breast milk. If you are or will be breast-feeding while you use Zylet Drops, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Zylet Drops:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Burning or stinging upon using Zylet Drops; mild itching, discomfort, or redness of the eye.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; sensitivity to light; severe or worsening pain, redness, swelling, or discharge from the eye or eyelid; unusual tearing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Zylet Drops:

Store upright, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Do not freeze. Keep Zylet Drops out of the reach of children and away from pets.

General information:

• If you have any questions about Zylet Drops, please talk with your doctor, pharmacist, or other health care provider.
• Zylet Drops are to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zylet Drops. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Zileuton (zye-LOO-ton)
Brand Name: Zyflo CR

Zyflo CR Extended-Release Tablets are used for:

Preventing and treating asthma in patients 12 years old and older. It may also be used for other conditions as determined by your doctor.

Zyflo CR Extended-Release Tablets are a leukotriene synthesis inhibitor. It works by blocking the formation of a substance called leukotriene, which helps to decrease certain asthma and allergy symptoms.

Do NOT use Zyflo CR Extended-Release Tablets if:

• you are allergic to any ingredient in Zyflo CR Extended-Release Tablets
• you have liver disease or abnormal liver function tests
• if you are taking an H₁ antagonist (eg, astemizole, terfenadine) or pimozide

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zyflo CR Extended-Release Tablets:

Some medical conditions may interact with Zyflo CR Extended-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of liver problems (eg, hepatitis) or symptoms of liver problems (eg, yellowing of the skin or eyes, dark urine)
• if you have a history of mental or mood problems (eg, depression) or suicidal thoughts or actions
• if you drink alcohol
• if you have trouble swallowing tablets

Some MEDICINES MAY INTERACT with Zyflo CR Extended-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin) because the risk of bleeding may be increased
• Azole antifungals (eg, ketoconazole) because they may increase the risk of Zyflo CR Extended-Release Tablets’s side effects
• Beta-blockers (eg, propranolol), calcium channel blockers (eg, amlodipine), cisapride, cyclosporine, H₁ antagonists (eg, astemizole, terfenadine), pimozide, or theophylline because the risk of their side effects may be increased by Zyflo CR Extended-Release Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zyflo CR Extended-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zyflo CR Extended-Release Tablets:

Use Zyflo CR Extended-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Zyflo CR Extended-Release Tablets. Talk to your pharmacist if you have questions about this information.
• Take Zyflo CR Extended-Release Tablets by mouth within 1 hour after the morning and evening meal.
• Swallow Zyflo CR Extended-Release Tablets whole. Do not break, crush, or chew before swallowing.
• Take Zyflo CR Extended-Release Tablets on a regular schedule to get the most benefit from it. Taking Zyflo CR Extended-Release Tablets at the same times each day will help you remember to take it.
• Continue to take Zyflo CR Extended-Release Tablets even if you feel well. Do not miss any doses.
• If you miss a dose of Zyflo CR Extended-Release Tablets, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zyflo CR Extended-Release Tablets.

Important safety information:

• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
• It may take a few weeks before you get the full benefit of Zyflo CR Extended-Release Tablets. Do not stop using Zyflo CR Extended-Release Tablets without checking with your doctor.
• Zyflo CR Extended-Release Tablets will not stop an asthma attack once it has already started. Be sure to carry a short-acting bronchodilator with you at all times to treat any breathing problems that may occur between doses of Zyflo CR Extended-Release Tablets (eg, severe or sudden onset of wheezing or shortness of breath). If you have any questions about which medicines stop asthma attacks, check with your doctor or pharmacist.
• Tell your doctor at once if you notice that your short-acting bronchodilator inhaler does not work as well, if you need to use it more often, or if you have a decrease in your peak flow meter results.
• Contact your doctor or seek medical care right away if you have breathing problems that worsen quickly, or if you use your short-acting bronchodilator and do not get relief.
• Talk with your doctor or pharmacist about all your asthma medicines and how to use them. Do not start, stop, or change the dose of any asthma medicine unless your doctor tells you to.
• Contact your doctor at once if you develop upper stomach pain, severe or persistent nausea, unusual tiredness or fatigue, yellowing of the eyes or skin, dark urine, pale stools, fever, or flu-like symptoms. These may be signs of liver problems.
• Some patients taking Zyflo CR Extended-Release Tablets have developed mental or mood changes, including suicidal thoughts or actions. Contact your doctor immediately if you experience symptoms such as agitation, aggression, hostility, anxiety, depression, strange dreams, trouble sleeping, sleepwalking, tremor, hallucinations, restlessness, irritability, or any unusual change in mood or behavior. Contact your doctor immediately if any signs of suicidal thoughts or actions occur.
• Lab tests, including liver function, may be performed while you use Zyflo CR Extended-Release Tablets. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Zyflo CR Extended-Release Tablets with caution in the ELDERLY; they may be more sensitive to its effects, especially liver toxicity.
• Zyflo CR Extended-Release Tablets should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY AND BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zyflo CR Extended-Release Tablets while you are pregnant. It is not known if Zyflo CR Extended-Release Tablets are found in breast milk. Do not breast-feed while taking Zyflo CR Extended-Release Tablets.

Possible side effects of Zyflo CR Extended-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; headache; muscle aches; nausea; nose irritation; sinus inflammation; throat pain or irritation.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; dark urine; fever, chills, or persistent sore throat; flu-like symptoms; mental or mood changes (eg, agitation, aggression, hostility, anxiety, depression, strange dreams, sleepwalking, tremor, hallucinations, restlessness, irritability); pale stools; right upper stomach pain; severe or persistent nausea or stomach pain; suicidal thoughts or actions; trouble sleeping; unusual changes in behavior; unusual tiredness or weakness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Zyflo CR Extended-Release Tablets:

Store at controlled room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zyflo CR Extended-Release Tablets out of the reach of children and away from pets.

General information:

• If you have any questions about Zyflo CR Extended-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.
• Zyflo CR Extended-Release Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zyflo CR Extended-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Bupropion (bue-PROE-pee-on)
Brand Name: Zyban

Zyban Sustained-Release Tablets are used for:

Helping certain patients to stop smoking. It may also be used for other conditions as determined by your doctor.

Zyban Sustained-Release Tablets are an antidepressant that has been found to aid in the stopping of smoking.

Do NOT use Zyban Sustained-Release Tablets if:

• you are allergic to any ingredient in Zyban Sustained-Release Tablets
• you are taking any other medicine that contains bupropion
• you have a history of an eating disorder (eg, anorexia, bulimia) or seizures (eg, epilepsy)
• you are suddenly stopping the use of alcohol or sedatives (eg, benzodiazepines) after long-term use
• you are taking or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zyban Sustained-Release Tablets:

Some medical conditions may interact with Zyban Sustained-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you or a family member has a history of bipolar disorder (manic depression), other mental or mood problems (eg, depression), suicidal thoughts or attempts, or alcohol or substance abuse
• if you have diabetes, kidney problems, liver problems (eg, cirrhosis), high blood pressure, heart problems (eg, congestive heart failure), or a recent heart attack
• if you have a history of seizures, head injury, or tumor in the brain or spinal cord

Some MEDICINES MAY INTERACT with Zyban Sustained-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Amantadine, antipsychotics (eg, haloperidol, risperidone), corticosteroids (eg, prednisone), cyclophosphamide, efavirenz, HIV protease inhibitors (eg, nelfinavir, ritonavir), insulin, levodopa, MAOIs (eg, phenelzine), nicotine patches, oral hypoglycemics (eg, glipizide), orphenadrine, other antidepressants (eg, amitriptyline, fluoxetine), sympathomimetics (eg, pseudoephedrine), theophylline, thiotepa, or tiagabine because they may increase the risk of Zyban Sustained-Release Tablets’s side effects
• Carbamazepine, phenobarbital, phenytoin, or rifampin because they may decrease Zyban Sustained-Release Tablets’s effectiveness
• Antiarrhythmics (eg, flecainide, propafenone), beta-blockers (eg, metoprolol), phenothiazines (eg, thioridazine), selective serotonin reuptake inhibitor (SSRI) antidepressants (eg, fluoxetine), or tricyclic antidepressants (eg, nortriptyline) because the risk of their side effects may be increased by Zyban Sustained-Release Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zyban Sustained-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zyban Sustained-Release Tablets:

Use Zyban Sustained-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Zyban Sustained-Release Tablets comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Zyban Sustained-Release Tablets refilled.
• Take Zyban Sustained-Release Tablets by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
• Swallow Zyban Sustained-Release Tablets whole. Do not break, crush, or chew before swallowing.
• Several weeks may pass before your symptoms improve. Do not stop taking Zyban Sustained-Release Tablets without checking with your doctor.
• Take your doses at the same times each day, at least 8 hours apart unless directed otherwise by your doctor. This may help to decrease the risk of seizures with Zyban Sustained-Release Tablets.
• It takes about 1 week for Zyban Sustained-Release Tablets to work. You should begin taking Zyban Sustained-Release Tablets while you are still smoking. However, you and your doctor should decide on a date that you will stop smoking during the 2nd week of taking Zyban Sustained-Release Tablets.
• If you have not made progress towards stopping smoking by the 12th week, contact your doctor.
• If you are not able to stop smoking while using Zyban Sustained-Release Tablets, talk to your doctor to determine why you were not successful. After the reasons have been reduced or eliminated, you should try to stop smoking again.
• Continue to take Zyban Sustained-Release Tablets even if you feel well. Do not miss any doses.
• If you miss a dose of Zyban Sustained-Release Tablets, skip the missed dose and go back to your regular dosing schedule. Do not take more than 1 dose within 8 hours. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zyban Sustained-Release Tablets.

Important safety information:

• Zyban Sustained-Release Tablets may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Zyban Sustained-Release Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are taking Zyban Sustained-Release Tablets; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
• Zyban Sustained-Release Tablets may increase your risk of seizures. Your risk may be greater if you also have certain medical conditions, use certain medicines, or if you use a lot of alcohol. Talk to your doctor to see if you may have a greater risk of seizures while taking Zyban Sustained-Release Tablets.
• If you already drink alcohol or use sedatives, do not suddenly stop them without first checking with your doctor. Suddenly stopping them may increase your seizure risk.
• Do not take decongestants (eg, pseudoephedrine), stimulants, or diet pills while you are taking Zyban Sustained-Release Tablets without first checking with your doctor. They may increase your risk of seizures.
• The risk of seizures may be greater if you take Zyban Sustained-Release Tablets in high doses or for a long time. Do NOT take more than the recommended dose, change your dose, or use Zyban Sustained-Release Tablets for longer than prescribed without checking with your doctor.
• Children, teenagers, and young adults who take Zyban Sustained-Release Tablets may be at increased risk for suicidal thoughts or actions. Watch all patients who take Zyban Sustained-Release Tablets closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.
• If you have trouble sleeping, you may be taking your dose too close to bedtime. Talk with your doctor about changing your dosing schedule.
• It is important to follow the program that your doctor has prescribed, including behavioral changes, counseling, or support services, in order to stop smoking.
• Zyban Sustained-Release Tablets can be used together with the nicotine skin patches only under the supervision of your doctor. Using these medicines together may raise your blood pressure. If you are already using a nicotine skin patch, your blood pressure should be checked regularly.
• Do not smoke if you are using Zyban Sustained-Release Tablets along with the nicotine skin patch or any nicotine product.
• Stopping smoking may change the amount of certain medicines (eg, theophylline, warfarin) in your blood. Be sure your doctor knows all the medicines that you are taking.
• Zyban Sustained-Release Tablets contains the same ingredients as the antidepressants Aplenzin and Wellbutrin. Do not take Zyban Sustained-Release Tablets if you are also taking Aplenzin, Wellbutrin, or other brands of bupropion. Discuss any questions or concerns with your doctor.
• Use Zyban Sustained-Release Tablets with caution in the ELDERLY; they may be more sensitive to its effects.
• Zyban Sustained-Release Tablets should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zyban Sustained-Release Tablets while you are pregnant. Zyban Sustained-Release Tablets are found in breast milk. Do not breast-feed while taking Zyban Sustained-Release Tablets.

Possible side effects of Zyban Sustained-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; changes in appetite; constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; increased sweating; nausea; nervousness; stomach pain; stuffy nose; trouble sleeping; vomiting; weight changes.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); blurred vision or other vision changes; chest pain; changes in sexual desire or ability; confusion; dark urine; delusions; fainting; fast or irregular heartbeat; fever or chills; hallucinations; hearing problems or ringing in the ears; joint or muscle pain; menstrual changes; new or worsening mental or mood changes (eg, concentration problems, depression, panic attacks, aggressiveness, agitation, anxiety, impulsiveness, irritability, hostility, exaggerated feeling of well-being, inability to sit still); red, swollen, blistered, or peeling skin; seizures; severe headache or dizziness; severe or persistent nausea, vomiting, or stomach pain; severe or persistent restlessness or trouble sleeping; shortness of breath; suicidal thoughts or attempts; tremor; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include chest pain; fast, slow, or irregular heartbeat; fever; hallucinations; loss of consciousness; rigid or painful muscles; seizures; severe dizziness; slow or difficult breathing.

Proper storage of Zyban Sustained-Release Tablets:

Store Zyban Sustained-Release Tablets at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tight, light-resistant container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zyban Sustained-Release Tablets out of the reach of children and away from pets.

General information:

• If you have any questions about Zyban Sustained-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.
• Zyban Sustained-Release Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zyban Sustained-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Guaifenesin/Hydrocodone (gwye-FEN-e-sin/hye-droe-KOE-done)
Brand Name: Examples include EndaCof-Tab and Ztuss ZT

Ztuss ZT is used for:

Relieving cough and throat and airway irritation due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Ztuss ZT is a cough suppressant and expectorant combination. It works by loosening mucus and lung secretions in the chest, and making coughs more productive. The cough suppressant works in the brain to help decrease the cough reflex to reduce a dry cough.

Do NOT use Ztuss ZT if:

• you are allergic to any ingredient in Ztuss ZT or any other codeine or morphine-related medicine (eg, oxycodone)
• you are taking sodium oxybate (GHB)
• you have increased pressure in the brain, trouble breathing, or diarrhea due to antibiotic use

Contact your doctor or health care provider right away if any of these apply to you.

Before using Ztuss ZT:

Some medical conditions may interact with Ztuss ZT. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of glaucoma, an enlarged prostate gland or other prostate problems, heart problems, diabetes, high blood pressure, blood vessel problems, stroke, adrenal gland problems, or an underactive thyroid
• if you have a history of stomach problems, bowel problems (eg, chronic inflammation or ulceration of the bowel), or gallbladder problems (eg, gallstones), or if you have had recent abdominal surgery
• if you have breathing or lung problems (eg, asthma, chronic bronchitis, emphysema), or chronic obstructive pulmonary disease (COPD), or if cough occurs with large amounts of mucus
• if you have recently had any head injury, brain injury or tumor, infection of the brain or nervous system, epilepsy, or seizures
• if you have a history of alcohol abuse, drug abuse, or suicidal thoughts or behavior

Some MEDICINES MAY INTERACT with Ztuss ZT. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Cimetidine because it may increase the risk of Ztuss ZT’s side effects
• Barbiturates (eg, phenobarbital) or sodium oxybate (GHB) because the risk of severe drowsiness or breathing problems may be increased
• Naltrexone because it may decrease Ztuss ZT’s effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ztuss ZT may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Ztuss ZT:

Use Ztuss ZT as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Ztuss ZT by mouth with or without food.
• Drink plenty of water while taking Ztuss ZT.
• If you miss a dose of Ztuss ZT, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Ztuss ZT.

Important safety information:

• Ztuss ZT may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Ztuss ZT with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
• If your symptoms do not get better within 5 to 7 days or if they get worse, check with your doctor.
• Ztuss ZT may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Ztuss ZT.
• Tell your doctor or dentist that you take Ztuss ZT before you receive any medical or dental care, emergency care, or surgery.
• Use Ztuss ZT with caution in the ELDERLY; they may be more sensitive to its effects.
• Ztuss ZT should be used with extreme caution in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ztuss ZT while you are pregnant. It is not known if Ztuss ZT is found in breast milk. Do not breast-feed while taking Ztuss ZT.

Possible side effects of Ztuss ZT:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; excitability; headache; nausea; nervousness or anxiety; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); anxiety; change in amount of urine; difficulty urinating; hearing change or loss; mental or mood changes; severe drowsiness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Ztuss ZT:

Store Ztuss ZT at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Ztuss ZT out of the reach of children and away from pets.

General information:

• If you have any questions about Ztuss ZT, please talk with your doctor, pharmacist, or other health care provider.
• Ztuss ZT is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Ztuss ZT. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Acyclovir (ay-SYE-kloe-vir)
Brand Name: Zovirax

Zovirax Capsules is used for:

Treating chickenpox (varicella) or shingles (herpes zoster) and treating or suppressing genital herpes infections. It may also be used for other conditions as determined by your doctor.

Zovirax Capsules is an antiviral. It works by stopping viral replication. However, Zovirax Capsules does not eliminate the virus, is not a cure, and does not prevent transmission to others.

Do NOT use Zovirax Capsules if:

• you are allergic to any ingredient in Zovirax Capsules or to valacyclovir

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zovirax Capsules:

Some medical conditions may interact with Zovirax Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have kidney problems or a weakened immune system

Some MEDICINES MAY INTERACT with Zovirax Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Medicines that may harm the kidney (eg, aminoglycoside antibiotics [eg, gentamicin], amphotericin B, cyclosporine, nonsteroidal anti-inflammatory drugs [NSAIDs] [eg, ibuprofen], tacrolimus, vancomycin) because the risk of kidney side effects may be increased. Ask your doctor if you are unsure if any of your medicines might harm the kidney

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zovirax Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zovirax Capsules:

Use Zovirax Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Zovirax Capsules by mouth with or without food.
• Drinking extra fluids while you are taking Zovirax Capsules is recommended. Check with your doctor for instructions.
• Start therapy with Zovirax Capsules at the earliest sign or symptom of shingles or genital herpes (pain, burning, blisters).
• If treating an acute outbreak, continue using Zovirax Capsules for the full course of treatment even if you feel better in a few days.
• For suppressive therapy, Zovirax Capsules works best if it is taken at the same times each day.
• If you miss a dose of Zovirax Capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zovirax Capsules.

Important safety information:

• Zovirax Capsules may cause drowsiness, dizziness, vision changes, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Zovirax Capsules with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Zovirax Capsules may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
• Zovirax Capsules may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Zovirax Capsules. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
• Zovirax Capsules is not a cure for genital herpes and will not prevent the virus from spreading. Avoid sexual intercourse when sores are present to prevent infecting your partner. You can also be contagious and spread the herpes virus but not have any signs or symptoms at all. This is called asymptomatic viral shedding.
• Lab tests, including kidney function and serum urea nitrogen (BUN), may be performed while you use Zovirax Capsules. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Zovirax Capsules with caution in the ELDERLY; they may be more sensitive to its effects, especially confusion, drowsiness, or hallucinations.
• Zovirax Capsules is not recommended for use in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zovirax Capsules while you are pregnant. Zovirax Capsules is found in breast milk. If you are or will be breast-feeding while you use Zovirax Capsules, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Zovirax Capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; general body discomfort; headache; nausea/vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); aggressive behavior; blood in the urine; confusion; decreased consciousness; decreased urination; hallucinations; lower back pain; mental or mood changes; red, swollen, blistered, or peeling skin; seizures; unusual bruising or bleeding.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include agitation; coma; seizures (convulsions); sleepiness; sluggishness.

Proper storage of Zovirax Capsules:

Store Zovirax Capsules at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zovirax Capsules out of the reach of children and away from pets.

General information:

• If you have any questions about Zovirax Capsules, please talk with your doctor, pharmacist, or other health care provider.
• Zovirax Capsules is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is summary only. It does not contain all information about Zovirax Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Acyclovir (ay-SYE-kloe-veer)
Brand Name: Zovirax

Zovirax Cream is used for:

Treating cold sores on the face or lips that are caused by the herpes virus. It may also be used for other conditions as determined by your doctor.

Zovirax Cream is an antiviral. It works by stopping viral replication. However, Zovirax Cream does not eliminate the herpes virus, it is not a cure, and it does not prevent transmission to others.

Do NOT use Zovirax Cream if:

• you are allergic to any ingredient in Zovirax Cream or valacyclovir

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zovirax Cream:

Some medical conditions may interact with Zovirax Cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Zovirax Cream. Because little, if any, of Zovirax Cream is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Zovirax Cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zovirax Cream:

Use Zovirax Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Wash and completely dry your hands and the affected area. Apply the medicine only to the affected area and not to the surrounding skin. Gently rub the medicine in until it disappears. Wash your hands after using Zovirax Cream.
• Do not bandage or wrap the area unless directed to do so by your doctor.
• Do not bathe, shower, or swim right after using Zovirax Cream.
• To clear up your infection completely, use Zovirax Cream for the full course of treatment. Keep using it even if you feel better in a few days.
• For best results, use Zovirax Cream at the first sign of a cold sore (tingling, redness, itching, or bump).
• If you miss a dose of Zovirax Cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Zovirax Cream.

Important safety information:

• Do not use Zovirax Cream for genital herpes.
• Do not use other skin products such as cosmetics, sunscreen, or lip balm on the cold sore area while you are using Zovirax Cream unless otherwise instructed by your doctor.
• Do not get Zovirax Cream in your eyes or on the inside of your nose or mouth. If Zovirax Cream gets in your eyes, flush them with cool tap water.
• Zovirax Cream may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.
• Zovirax Cream should not be used in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zovirax Cream while you are pregnant. It is not known if Zovirax Cream is found in breast milk. If you are or will be breast-feeding while you use Zovirax Cream, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Zovirax Cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Burning or stinging; dry or cracked lips; flakiness or dryness of the skin; itching.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; excessive itching; dizziness).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Zovirax Cream:

Store Zovirax Cream at room temperature, between 59 to 86 degrees F (15 to 30 degrees C) in a tightly capped container. Store away from heat, moisture, and light. Do not leave in a car in cold or hot weather. Keep Zovirax Cream out of the reach of children and away from pets.

General information:

• If you have any questions about Zovirax Cream, please talk with your doctor, pharmacist, or other health care provider.
• Zovirax Cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is summary only. It does not contain all information about Zovirax Cream. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Acyclovir (ay-SYE-kloe-veer)
Brand Name: Zovirax

Zovirax Ointment is used for:

Treating the symptoms of the first episode of genital herpes and limited non-life-threatening herpes simplex viral infections of the skin, lips, and genitals in patients with weakened immune systems.

Zovirax Ointment is a purine nucleoside analogue. It works by stopping the virus from multiplying.

Do NOT use Zovirax Ointment if:

• you are allergic to any ingredient in Zovirax Ointment
• you are allergic to valacyclovir

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zovirax Ointment:

Some medical conditions may interact with Zovirax Ointment. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Zovirax Ointment. Because little, if any, of Zovirax Ointment is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Zovirax Ointment may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zovirax Ointment:

Use Zovirax Ointment as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Wash and completely dry the affected area.
• Apply enough medicine to thoroughly cover all lesions. A one-half inch ribbon of ointment will cover about 4 square inches.
• Use a finger cot or rubber glove when applying the ointment to avoid spreading infection.
• Gently rub the medicine in until it is evenly distributed.
• Wash your hands immediately after using Zovirax Ointment.
• Start therapy as soon as possible after the onset of signs and symptoms of herpes.
• To clear up your infection completely, take/use Zovirax Ointment for the full course of treatment. Keep using it even if you feel better in a few days.
• If a dose is missed, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Zovirax Ointment.

Important safety information:

• Zovirax Ointment is not a cure for herpes simplex infections. Avoid sexual intercourse when symptoms or lesions are present to prevent infecting your partner. Zovirax Ointment will not prevent you from transmitting herpes to others.
• Zovirax Ointment is for external use only. Do not use Zovirax Ointment in or near the eyes or on the inside of the nose or mouth. If Zovirax Ointment gets in your eyes, flush them with cool tap water.
• Do not use Zovirax Ointment to prevent future infections.
• Zovirax Ointment may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.
• Use Zovirax Ointment with extreme caution in CHILDREN; safety and effectiveness have not been established.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zovirax Ointment while you are pregnant. It is not known if Zovirax Ointment is found in breast milk. If you are or will be breast-feeding while you use Zovirax Ointment, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Zovirax Ointment:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Swelling, pain, burning, stinging, or itching at the application site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; itching; dizziness).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Zovirax Ointment:

Store Zovirax Ointment at room temperature, between 59 and 77 degrees F (15 and 25 degrees C), in a tightly capped container. Store away from heat, moisture, and light. Do not leave it in a car in cold or hot weather. Do not store in the bathroom. Keep Zovirax Ointment out of the reach of children and away from pets.

General information:

• If you have any questions about Zovirax Ointment, please talk with your doctor, pharmacist, or other health care provider.
• Zovirax Ointment is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is summary only. It does not contain all information about Zovirax Ointment. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Acyclovir (ay-SYE-kloe-vir)
Brand Name: Zovirax

Zovirax Suspension is used for:

Treating shingles or chickenpox, or treating or suppressing genital herpes. It may also be used for other conditions as determined by your doctor.

Zovirax Suspension is an antiviral. It works by preventing the herpes virus from reproducing. Acyclovir does not eliminate the virus and is not a cure. It does not prevent transmission of the virus to others.

Do NOT use Zovirax Suspension if:

• you are allergic to any ingredient in Zovirax Suspension or to valacyclovir

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zovirax Suspension:

Some medical conditions may interact with Zovirax Suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have kidney problems or a weakened immune system
• if you are receiving hemodialysis

Some MEDICINES MAY INTERACT with Zovirax Suspension. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Medicines that may harm the kidney (eg, aminoglycoside antibiotics [eg, gentamicin], amphotericin B, cyclosporine, nonsteroidal anti-inflammatory drugs [NSAIDs] [eg, ibuprofen], tacrolimus, vancomycin) because the risk of kidney side effects may be increased. Ask your doctor if you are unsure if any of your medicines might harm the kidney

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zovirax Suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zovirax Suspension:

Use Zovirax Suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Zovirax Suspension by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
• Shake well before each use.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• Drinking extra fluids while you are taking Zovirax Suspension is recommended. Check with your doctor for instructions.
• Start therapy with Zovirax Suspension at the earliest sign or symptom of chickenpox, shingles, or genital herpes (pain, burning, blisters).
• If treating an acute outbreak, continue using Zovirax Suspension for the full course of treatment even if you feel better in a few days.
• If you miss a dose of Zovirax Suspension, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zovirax Suspension.

Important safety information:

• Zovirax Suspension may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Zovirax Suspension with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Zovirax Suspension may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Zovirax Suspension. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
• Zovirax Suspension is not a cure for genital herpes and will not prevent the virus from spreading. Avoid sexual intercourse when sores are present to prevent infecting your partner. You can also be contagious and spread the herpes virus but not have any signs or symptoms at all. This is called asymptomatic viral shedding.
• Lab tests, including kidney function, may be performed while you use Zovirax Suspension. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Zovirax Suspension with caution in the ELDERLY; they may be more sensitive to its effects, especially confusion, drowsiness, or hallucinations.
• Zovirax Suspension should be used with extreme caution in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zovirax Suspension while you are pregnant. Zovirax Suspension is found in breast milk. If you are or will be breast-feeding while you use Zovirax Suspension, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Zovirax Suspension:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; drowsiness; general body discomfort; headache; muscle weakness; nausea; stomach upset; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); aggressive behavior; blood in the urine; confusion; decreased consciousness; decreased urination; easy bruising or bleeding; fever; hallucinations; hoarseness; lower back pain; mania; mental or mood changes; red, swollen, or blistered skin; seizures; swelling of the hands or feet; vision changes; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include agitation; loss of consciousness; seizures; tiredness.

Proper storage of Zovirax Suspension:

Store Zovirax Suspension at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zovirax Suspension out of the reach of children and away from pets.

General information:

• If you have any questions about Zovirax Suspension, please talk with your doctor, pharmacist, or other health care provider.
• Zovirax Suspension is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zovirax Suspension. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Ethynodiol/Ethinyl Estradiol (e-thye-noe-DYE-ole/ETH-in-il ess-trah-DYE-ole)
Brand Name: Examples include Demulen and Zovia

Zovia is used for:

Preventing pregnancy. It may also be used for other conditions as determined by your doctor.

Zovia is an estrogen/progestin combination. It works by preventing the release of eggs from the ovaries and thereby preventing pregnancy.

Do NOT use Zovia if:

• you are allergic to any ingredient in Zovia
• you are pregnant or think you may be pregnant
• you have blood clots in the legs, lungs, or eyes; or a history of heart attack, chest pain, or stroke
• you have known or suspected breast cancer or cancer of the lining of the uterus, cervix, or vagina, or have had vaginal bleeding of unknown causes
• you have a liver tumor or active liver disease, or a history of yellowing of the eyes or skin during pregnancy or previous birth control use
• you have headaches with neurological symptoms or will be on bed rest for a long period following surgery

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zovia:

Some medical conditions may interact with Zovia. Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

• if you are planning to become pregnant or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have high blood pressure; high cholesterol, triglycerides, or calcium levels; have pancreatitis or gallbladder problems; or are obese
• if you have breast nodules, fibrocystic disease of the breast, an abnormal breast x-ray or mammogram, endometriosis or endometrial carcinomas, uterine fibroids, or irregular or scanty menstrual periods
• if you have diabetes, headaches, migraine headaches, epilepsy, or a history of mental depression
• if you are having surgery
• if you are a heavy smoker (15 or more cigarettes per day), especially if you are older than 35 years of age

Some MEDICINES MAY INTERACT with Zovia. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Azole antifungals (eg, itraconazole), aprepitant, bosentan, barbiturates (eg, phenobarbital), carbamazepine, felbamate, griseofulvin, HIV protease inhibitors (eg, ritonavir), hydantoins (eg, phenytoin), modafinil, nevirapine, penicillins (eg, amoxicillin), rifampin, St. John’s wort, tetracyclines (eg, doxycycline), topiramate, and troglitazone because they may decrease Zovia’s effectiveness. Alternative forms of birth control are strongly recommended when taking any of these medicines along with this birth control medicine.
• Beta-blockers (eg, atenolol), selegiline, theophyllines (eg, aminophylline), and troleandomycin because the risk of their side effects may be increased by Zovia
• Lamotrigine because its effectiveness may be decreased by Zovia

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zovia may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zovia:

Use Zovia as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Zovia. Talk to your pharmacist if you have questions about this information.
• Take Zovia by mouth with or without food.
• To achieve maximum effectiveness of Zovia, it must be taken every day (every 24 hours) and at the same time each day.
• Remember to take all of the pills in the pack. Do not skip any doses.
• Be sure to have an extra full pack of this medication available at all times.
• If you miss 1 dose of Zovia, take it as soon as you remember. Take your next dose at the regular time. This means you may take 2 doses on the same day. You do not need to use a backup method of birth control if you only miss 1 pill. If you miss more than 1 active dose of Zovia, read the extra patient leaflet that comes with your medicine or contact your doctor for instructions. You must use a backup method of birth control if you miss more than 1 active dose of Zovia. If you are not sure about how to handle missed doses, use an extra form of birth control (eg, condoms) and talk with your doctor.

Ask your health care provider any questions you may have about how to use Zovia.

Important safety information:

• Zovia may cause dizziness or changes in vision. These effects may be worse if you take it with alcohol or certain medicines. Use Zovia with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• If you miss your period during the week of inactive pills, call your doctor immediately. A missed period may indicate that you are pregnant.
• Zovia may cause dark skin patches on your face. Exposure to the sun may make these patches darker. If patches develop, use a sunscreen or protective clothing when exposed to the sun, sunlamps, or tanning booths.
• If you wear contact lenses and you develop problems with them or with your vision, contact your doctor as soon as possible.
• Follow your doctor’s instructions for examining your own breasts, and report any lumps immediately.
• Zovia may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Zovia.
• If you will be having surgery or will be confined to a chair or bed for a long period of time (such as a long plane flight), notify your doctor 3 to 4 weeks beforehand. Special precautions may need to be taken in these circumstances while you are taking Zovia.
• Bleeding or spotting may occur while taking Zovia. Do not stop taking Zovia if this occurs. If bleeding or spotting continues for more than 7 days or is heavy, contact your doctor.
• Smoking cigarettes while using Zovia may increase your risk of stroke, heart attack, blood clots, high blood pressure, or other diseases of the heart and blood vessels.
• Taking certain antibiotics or anticonvulsants while you are using Zovia, or vomiting or diarrhea may decrease the effectiveness of Zovia. To prevent pregnancy, use an additional form of birth control (such as condoms, spermicide, diaphragm) until your next period. If you have any questions, contact your doctor or pharmacist.
• Use of Zovia will not prevent the spread of sexually transmitted diseases (STDs).
• You should usually not start taking Zovia within 4 weeks after giving birth. Discuss any questions or concerns you have with your doctor.
• Lab tests will be required while you are taking Zovia. You will need to have follow-up exams at least once per year. Be sure to keep all doctor and lab appointments.
• Zovia should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: Do not take Zovia if you are pregnant. If you think you may be pregnant, contact your doctor right away. Zovia is found in breast milk. Do not breast-feed while taking Zovia.

Possible side effects of Zovia:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Breast tenderness or enlargement; changes in appetite; changes in weight; dizziness; headache; loss of scalp hair; nausea; nervousness; stomach cramps or bloating; vaginal spotting or breakthrough bleeding; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloating; breast lumps; breast tenderness; calf/leg pain or swelling; changes in vision; chest pain or heaviness in the chest; coughing up blood; dark urine or light-colored bowel movements; dizziness or fainting; fever; missed menstrual period; mood/mental changes; numbness of an arm or leg; persistent or recurrent abnormal vaginal bleeding; severe pain or tenderness in the stomach area; shortness of breath; sleeplessness; slurred speech; sudden severe headache (migraine); sudden shortness of breath; swelling of fingers or ankles; unusual vaginal itching, discharge, or odor; vomiting; weakness or fatigue; weakness or numbness in the arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include nausea or vomiting; vaginal bleeding.

Proper storage of Zovia:

Store Zovia at room temperature, below 86 degrees F (30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zovia out of the reach of children and away from pets.

General information:

• If you have any questions about Zovia, please talk with your doctor, pharmacist, or other health care provider.
• Zovia is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zovia. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.