Generic Name: Chlorpheniramine/Dextromethorphan/Guaifenesin/Phenylephrine (klor-fen-EER-a-meen/ dex -troe-meth-OR-fan/gwye-FEN-e-sin/ fen-ill-EF-rin)
Brand Name: Examples include Genelan NF and Zotex-DM

Zotex-DM Liquid is used for:

Relieving symptoms of sinus congestion, runny nose, sneezing, cough, and throat and airway irritation due to colds, upper respiratory infections, and allergies. It may also be used for other conditions as determined by your doctor.

Zotex-DM Liquid is an antihistamine, decongestant, cough suppressant, and expectorant combination. It works by constricting blood vessels and reducing swelling in the nasal passages, loosening mucus and lung secretions in the chest, and making coughs more productive. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing while the cough suppressant works in the brain to help decrease the cough reflex to reduce a dry cough.

Do NOT use Zotex-DM Liquid if:

• you are allergic to any ingredient in Zotex-DM Liquid
• you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems
• you are unable to urinate or are having an asthma attack
• you take sodium oxybate (GHB) or if you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zotex-DM Liquid:

Some medical conditions may interact with Zotex-DM Liquid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, plan to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a fast, slow, or irregular heartbeat
• if you have a history of adrenal gland problems (eg, adrenal gland tumor), heart problems, high blood pressure, diabetes, heart blood vessel problems, stroke, glaucoma, a blockage of your bladder, stomach, or intestines, ulcers, trouble urinating, an enlarged prostate, seizures, or an overactive thyroid
• if you have a history of asthma, chronic cough, lung problems (eg, chronic bronchitis, emphysema), or chronic obstructive pulmonary disease (COPD), or if cough occurs with large amounts of mucus

Some MEDICINES MAY INTERACT with Zotex-DM Liquid. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Beta-blockers (eg, propranolol), COMT inhibitors (eg, tolcapone), furazolidone, indomethacin, MAO inhibitors (eg, phenelzine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because side effects of Zotex-DM Liquid may be increased
• Digoxin or droxidopa because risk of irregular heartbeat or heart attack may be increased
• Bromocriptine or hydantoins (eg, phenytoin) because side effects may be increased by Zotex-DM Liquid
• Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because effectiveness may be decreased by Zotex-DM Liquid

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zotex-DM Liquid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zotex-DM Liquid:

Use Zotex-DM Liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Zotex-DM Liquid may be taken with or without food.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• If you miss a dose of Zotex-DM Liquid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zotex-DM Liquid.

Important safety information:

• Zotex-DM Liquid may cause dizziness, drowsiness, or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Zotex-DM Liquid. Using Zotex-DM Liquid alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• Do not take diet or appetite control medicines while you are taking Zotex-DM Liquid without checking with your doctor.
• Zotex-DM Liquid contains phenylephrine. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains phenylephrine. If it does or if you are uncertain, contact your doctor or pharmacist.
• Do NOT exceed the recommended dose or take Zotex-DM Liquid for longer than prescribed without checking with your doctor.
• If your symptoms do not improve within 5 to 7 days or if they become worse, check with your doctor.
• Zotex-DM Liquid may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Zotex-DM Liquid. Use a sunscreen or protective clothing if you must be outside for a prolonged period.
• If you are scheduled for allergy skin testing, do not take Zotex-DM Liquid for several days before the test because it may decrease your response to the skin tests.
• Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Zotex-DM Liquid.
• Use Zotex-DM Liquid with caution in the ELDERLY because they may be more sensitive to its effects.
• Caution is advised when using Zotex-DM Liquid in CHILDREN because they may be more sensitive to its effects.
• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Zotex-DM Liquid, discuss with your doctor the benefits and risks of using Zotex-DM Liquid during pregnancy. It is unknown if Zotex-DM Liquid is excreted in breast milk. Do not breast-feed while taking Zotex-DM Liquid.

Possible side effects of Zotex-DM Liquid:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor; trouble sleeping; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Zotex-DM Liquid:

Store Zotex-DM Liquid at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zotex-DM Liquid out of the reach of children and away from pets.

General information:

• If you have any questions about Zotex-DM Liquid, please talk with your doctor, pharmacist, or other health care provider.
• Zotex-DM Liquid is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zotex-DM Liquid. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Guaifenesin/Phenylephrine (gwye-FEN-e-sin/fen-il-EF-rin)
Brand Name: Zotex-GP

Zotex-GP is used for:

Relieving symptoms of congestion, cough, and throat and airway irritation due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Zotex-GP is a decongestant and expectorant combination. It works by constricting blood vessels and shrinking swollen and congested nasal tissues (mucous membranes) and by thinning and loosening mucus in the airway. This allows you to breathe more easily and makes coughs more productive.

Do NOT use Zotex-GP if:

• you are allergic to any ingredient in Zotex-GP
• you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems
• you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zotex-GP:

Some medical conditions may interact with Zotex-GP. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a fast, slow, or irregular heartbeat
• if you have a history of adrenal gland problems (eg, tumor), heart problems, high blood pressure, diabetes, heart blood vessel problems, stroke, glaucoma, an enlarged prostate, seizures, or an overactive thyroid
• if you have chronic cough

Some MEDICINES MAY INTERACT with Zotex-GP. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, MAOIs (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Zotex-GP’s side effects
• Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased
• Bromocriptine because the risk of their side effects may be increased by Zotex-GP
• Guanethidine, guanadrel, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Zotex-GP

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zotex-GP may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zotex-GP:

Use Zotex-GP as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Zotex-GP by mouth with or without food.
• Take Zotex-GP with a full glass of water (8 oz/240 mL) unless your doctor directs otherwise.
• Swallow Zotex-GP whole. Do not crush or chew before swallowing. Some brands of Zotex-GP may be broken in half before they are taken. If you have difficulty swallowing the whole tablet, ask your pharmacist if your brand may be broken in half.
• If you miss a dose of Zotex-GP, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zotex-GP.

Important safety information:

• Zotex-GP may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Zotex-GP with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do not take diet or appetite control medicines while you are taking Zotex-GP without checking with you doctor.
• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
• If your symptoms do not get better within 5 to 7 days or if they get worse, check with your doctor.
• Zotex-GP may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Zotex-GP.
• Tell your doctor or dentist that you take Zotex-GP before you receive any medical or dental care, emergency care, or surgery.
• Use Zotex-GP with caution in the ELDERLY; they may be more sensitive to its effects.
• Caution is advised when using Zotex-GP in CHILDREN; they may be more sensitive to its effects.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zotex-GP while you are pregnant. It is not known if Zotex-GP is found in breast milk. Do not breast-feed while taking Zotex-GP.

Possible side effects of Zotex-GP:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; excitability; headache; nausea; nervousness or anxiety; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Zotex-GP:

Store Zotex-GP at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zotex-GP out of the reach of children and away from pets.

General information:

• If you have any questions about Zotex-GP, please talk with your doctor, pharmacist, or other health care provider.
• Zotex-GP is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zotex-GP. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Codeine/Phenylephrine/Pyrilamine (KOE-deen/fen-ill-EF-rin/peer-IL-a-meen)
Brand Name: Examples include Pro-Red AC and Zotex-C

Zotex-C Syrup is used for:

Treating symptoms of the common cold, flu, or hay fever, and other upper respiratory allergies such as cough, congestion, runny nose, sneezing, itching of the nose and throat, and itchy, watery eyes. Zotex-C Syrup may also be used for other conditions as determined by your doctor.

Zotex-C Syrup is a narcotic antitussive (cough suppressant), antihistamine, and decongestant combination. The antitussive works by suppressing the cough center in the brain. The antihistamine works by blocking the action of histamine, which reduces the symptoms of an allergic reaction such as itch, watery eyes and runny nose. The decongestant shrinks swollen nasal passages, which relieves nasal congestion.

Do NOT use Zotex-C Syrup if:

• you are allergic to any ingredient in Zotex-C Syrup or any other codeine-related medicine (eg, dihydrocodeine)
• you have diarrhea associated with poisoning, antibiotic use, or a bacterial infection (from eating or drinking contaminated food or water)
• you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems
• you are taking sodium oxybate (GHB) or if you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zotex-C Syrup:

Some medical conditions may interact with Zotex-C Syrup. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of alcohol or drug abuse, dependence on narcotics, or suicidal thoughts or behaviors
• if you have increased pressure in the head, an unusual growth in the brain (eg, tumor), a recent head injury, Parkinson disease, Reye syndrome, the blood disease porphyria, or a blockage of your stomach, bowel, or bladder
• if you have a history of epilepsy or seizures, asthma or other breathing problems (eg, sleep apnea), stomach or intestinal problems, chronic constipation, liver problems, glaucoma, an enlarged prostate gland or other prostate problems, difficulty urinating, heart problems, diabetes, high blood pressure, blood vessel problems, adrenal gland problems, overactive thyroid, seizures, or stroke
• if you have recently had abdominal surgery

Some MEDICINES MAY INTERACT with Zotex-C Syrup. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Barbiturate anesthetics (eg, thiopental), beta-blockers (eg, propranolol), cimetidine, catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, ketorolac, MAO inhibitors (eg, phenelzine), naltrexone, sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because side effects of Zotex-C Syrup may be increased, including dangerous sleepiness and a decrease in the ability to breathe
• Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased
• Rifampin or risperidone because the effectiveness of Zotex-C Syrup may be decreased
• Bromocriptine or hydantoins (eg, phenytoin) because the actions and side effects may be increased by Zotex-C Syrup
• Guanadrel, guanethidine, mecamylamine, methyldopa, mexiletine, or reserpine because the effectiveness may be decreased by Zotex-C Syrup
• Naltrexone because the effectiveness of Zotex-C Syrup will be decreased and withdrawal symptoms may occur in patients who have become physically dependent on opioids. You must not take naltrexone until you have stopped taking Zotex-C Syrup for 7 to 10 days and after a naloxone challenge test is negative.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zotex-C Syrup may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zotex-C Syrup:

Use Zotex-C Syrup as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Zotex-C Syrup may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• If you miss a dose of Zotex-C Syrup and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zotex-C Syrup.

Important safety information:

• Zotex-C Syrup may cause dizziness or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Zotex-C Syrup. Using Zotex-C Syrup alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
• Do not drink alcohol while you are using Zotex-C Syrup. Avoid taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Zotex-C Syrup. Zotex-C Syrup will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
• If your symptoms do not improve within 7 days or if you develop a high fever or persistent headache, check with your doctor.
• Use Zotex-C Syrup with caution in the ELDERLY because they may be more sensitive to its effects, especially possible breathing problems and drowsiness.
• Use Zotex-C Syrup with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
• PREGNANCY and BREAST-FEEDING: It is unknown if Zotex-C Syrup can cause harm to the fetus. If you become pregnant while taking Zotex-C Syrup, discuss with your doctor the benefits and risks of using Zotex-C Syrup during pregnancy. Zotex-C Syrup is excreted in breast milk. If you are or will be breast-feeding while you are using Zotex-C Syrup, check with your doctor or pharmacist to discuss the risks to your baby.

Use of Zotex-C Syrup can lead to TOLERANCE. When using for an extended period, Zotex-C Syrup may not work as well and may require different dosing. Talk with your doctor if Zotex-C Syrup stops working well.

Long-term use of Zotex-C Syrup can lead to physical DEPENDENCE. The early sign of addiction is medicine ineffectiveness. Dependence is not an issue in terminal illness, when pain relief is more important. If using Zotex-C Syrup for an extended period of time, do not suddenly stop taking Zotex-C Syrup without your doctor’s approval. WITHDRAWAL symptoms have occurred when Zotex-C Syrup is suddenly stopped and may include anxiety; diarrhea; fever; runny nose or sneezing; goose bumps and abnormal skin sensations; nausea and vomiting; pain; rigid muscles; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; trouble sleeping. Contact your doctor if you notice any of these symptoms after stopping use of Zotex-C Syrup.

Possible side effects of Zotex-C Syrup:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; dry mouth, throat, or nose; excitement; nausea; stomach upset; thickening or mucus in nose or throat.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating; fast or irregular heartbeat; flushing or redness of face.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include agitation; coma; confusion; deep sleep or loss of consciousness; difficulty breathing; diminished mental alertness; hallucinations; hot or cold skin; large and unchanging pupils; sedation; seizures; shaking; sleeplessness; slowed breathing; slow heartbeat.

Proper storage of Zotex-C Syrup:

Store Zotex-C Syrup at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zotex-C Syrup out of the reach of children and away from pets.

General information:

• If you have any questions about Zotex-C Syrup, please talk with your doctor, pharmacist, or other health care provider.
• Zotex-C Syrup is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zotex-C Syrup. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Pseudoephedrine/Pyrilamine/Carbetapentane (SOO-doe-e-FED-rin/pir-IL-a-meen/kar-bay-ta-PEN-tane)
Brand Name: Zotex-D

Zotex-D Liquid is used for:

Relieving symptoms of sinus congestion; runny nose, sneezing, and cough caused by colds; upper respiratory infections; and allergies. It may also be used for other conditions as determined by your doctor.

Zotex-D Liquid is a decongestant, antihistamine, and cough suppressant combination. It works by constricting blood vessels and reducing swelling in the nasal passages. The antihistamine works by blocking the action of histamine, which helps reduce symptoms, such as watery eyes and sneezing. The cough suppressant works in the brain to help decrease the cough reflex to reduce a dry cough.

Do NOT use Zotex-D Liquid if:

• you are allergic to any ingredient in Zotex-D Liquid
• you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, severe heart problems, stomach ulcer, or narrow-angle glaucoma
• you are unable to urinate or are having an asthma attack
• you take sodium oxybate (GHB) or you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zotex-D Liquid:

Some medical conditions may interact with Zotex-D Liquid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a fast, slow, or irregular heartbeat
• if you have a history of adrenal gland problems (eg, adrenal gland tumor); heart problems (eg, ischemic heart disease); high blood pressure; diabetes; heart blood vessel problems; stroke; glaucoma; a blockage of your stomach, bladder, or intestines; ulcers; trouble urinating; an enlarged prostate or other prostate problems; seizures; mental or mood problems (eg, depression); sleep apnea; or an overactive thyroid
• if you have a history of asthma, chronic cough, lung problems (eg, chronic bronchitis, emphysema), or chronic obstructive pulmonary disease (COPD), or if your cough occurs with large amounts of mucus
• if you are in poor health or are very overweight

Some MEDICINES MAY INTERACT with Zotex-D Liquid. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased
• Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, MAOIs (eg, phenelzine), sodium oxybate (GHB), tricyclic antidepressants (eg, amitriptyline), or urinary alkalinizers (eg, potassium citrate) because they may increase the risk of Zotex-D Liquid’s side effects
• Bromocriptine or hydantoins (eg, phenytoin) because the risk of their side effects may be increased by Zotex-D Liquid
• Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Zotex-D Liquid

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zotex-D Liquid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zotex-D Liquid:

Use Zotex-D Liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Zotex-D Liquid by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
• Take Zotex-D Liquid with a full glass of water (8 oz/240 mL).
• Drink plenty of water while taking Zotex-D Liquid.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• If you miss a dose of Zotex-D Liquid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zotex-D Liquid.

Important safety information:

• Zotex-D Liquid may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Zotex-D Liquid with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Zotex-D Liquid; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
• Do not take diet or appetite control medicines while you take Zotex-D Liquid without checking with your doctor.
• Zotex-D Liquid has pseudoephedrine, pyrilamine, and carbetapentane in it. Before you start any new medicine, check the label to see if it has pseudoephedrine, pyrilamine, or carbetapentane in it too. If it does or if you are not sure, check with your doctor or pharmacist.
• Do not use Zotex-D Liquid for a cough with a lot of mucus. Do not use it for a long-term cough (eg, caused by asthma, emphysema, smoking). However, you may use it for these conditions if your doctor tells you to.
• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
• If cough persists for more than 1 week or is accompanied by a fever, contact your health care provider. A persistent cough could be a sign of a serious condition.
• Zotex-D Liquid may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Zotex-D Liquid. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
• Zotex-D Liquid may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking Zotex-D Liquid for a few days before the tests.
• Tell your doctor or dentist that you take Zotex-D Liquid before you receive any medical or dental care, emergency care, or surgery.
• Use Zotex-D Liquid with caution in the ELDERLY; they may be more sensitive to its effects.
• Zotex-D Liquid should be used with extreme caution in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.
• Caution is advised when using Zotex-D Liquid in CHILDREN; they may be more sensitive to its effects, especially excitability.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zotex-D Liquid while you are pregnant. It is not known if Zotex-D Liquid is found in breast milk. If you are or will be breast-feeding while you use Zotex-D Liquid, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Zotex-D Liquid:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; drowsiness; dry mouth, nose, or throat; excitability; headache; indigestion; loss of appetite; nausea; nervousness; trouble sleeping; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain or tightness; difficult or painful urination, inability to urinate, or changes in the amount of urine; fast or irregular heartbeat; fever, chills, or persistent sore throat; hallucinations; increased trouble sleeping; mental or mood changes; seizures; severe dryness of mouth, nose, and throat; severe or persistent dizziness, drowsiness, lightheadedness, or headache; shortness of breath; tremor; vision changes (eg, blurred or double vision)

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include blurred vision; confusion; decreased coordination or loss of balance; flushing or redness of the face; hallucinations; muscle spasms; seizures; severe dizziness, drowsiness, lightheadedness, or headache; severe or persistent stomach cramping with nausea or vomiting; unusually fast, slow, or irregular heartbeat.

Proper storage of Zotex-D Liquid:

Store Zotex-D Liquid at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zotex-D Liquid out of the reach of children and away from pets.

General information:

• If you have any questions about Zotex-D Liquid, please talk with your doctor, pharmacist, or other health care provider.
• Zotex-D Liquid is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zotex-D Liquid. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Phenylephrine/Dextromethorphan/Guaifenesin (FEN-il-EF-rin/DEX-troe-meth-OR-fan/gwye-FEN-e-sin)
Brand Name: Examples include Despec NR Drops and Zotex Pediatric Drops

Zotex Pediatric Drops is used for:

Relieving congestion, cough, and throat and airway irritation due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Zotex Pediatric Drops is a decongestant, cough suppressant, and expectorant combination. It works by constricting blood vessels, reducing swelling in the nasal passages, and loosening mucus and lung secretions in the chest, making coughs more productive. The cough suppressant works in the brain to help decrease the cough reflex.

Do NOT use Zotex Pediatric Drops if:

• you are allergic to any ingredient in Zotex Pediatric Drops
• you have severe high blood pressure, rapid heartbeat, or other severe heart problems (eg, heart blood vessel disease)
• you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zotex Pediatric Drops:

Some medical conditions may interact with Zotex Pediatric Drops. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of glaucoma, enlarged prostate gland or other prostate problems, heart problems, diabetes, high blood pressure, blood vessel problems, adrenal gland problems, mental or mood problems (eg, depression), an overactive thyroid, seizures, or stroke
• if you have a chronic cough, chronic obstructive pulmonary disease (COPD), or other lung problems (eg, asthma, chronic bronchitis, emphysema), or if your cough produces large amounts of mucus
• if you are in poor health or are very overweight

Some MEDICINES MAY INTERACT with Zotex Pediatric Drops. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased
• Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, MAOIs (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Zotex Pediatric Drops’s side effects
• Bromocriptine because the risk of its side effects may be increased by Zotex Pediatric Drops
• Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Zotex Pediatric Drops

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zotex Pediatric Drops may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zotex Pediatric Drops:

Use Zotex Pediatric Drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Zotex Pediatric Drops by mouth with or without food.
• Use the dropper that comes with Zotex Pediatric Drops to measure your dose. Ask your pharmacist for help if you are unsure of how to measure your dose.
• Take Zotex Pediatric Drops with a full glass of water (8 oz/240 mL).
• Drink plenty of water while taking Zotex Pediatric Drops.
• If you miss a dose of Zotex Pediatric Drops, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zotex Pediatric Drops.

Important safety information:

• Zotex Pediatric Drops may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Zotex Pediatric Drops with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Zotex Pediatric Drops has phenylephrine and dextromethorphan in it. Before you start any new medicine, check the label to see if it has phenylephrine or dextromethorphan in it too. If it does or if you are not sure, check with your doctor or pharmacist.
• Do NOT exceed the recommended dose or take Zotex Pediatric Drops for longer than prescribed without checking with your doctor.
• If your symptoms do not get better within 5 to 7 days or if they get worse, check with your doctor or pharmacist.
• Do not use Zotex Pediatric Drops for a cough with a lot of mucus. Do not use it for a long-term cough (eg, caused by asthma, emphysema, smoking). However, you may use it for these conditions if your doctor tells you to.
• Zotex Pediatric Drops may interfere with certain lab tests. Be sure that your doctor and lab personnel know you are taking Zotex Pediatric Drops.
• Tell your doctor or dentist that you take Zotex Pediatric Drops before you receive any medical or dental care, emergency care, or surgery.
• Use Zotex Pediatric Drops with caution in the ELDERLY; they may be more sensitive to its effects.
• PREGNANCY and BREAST-FEEDING: It is not known if Zotex Pediatric Drops can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zotex Pediatric Drops while you are pregnant. It is not known if Zotex Pediatric Drops is found in breast milk. Do not breast-feed while taking Zotex Pediatric Drops.

Possible side effects of Zotex Pediatric Drops:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; drowsiness; excitability; headache; irritability; nausea; stomach upset; trouble sleeping.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating; fast, slow, or irregular heartbeat; fever; hallucinations; mental or mood changes (eg, anxiety, nervousness); paleness; seizures; severe or persistent dizziness, lightheadedness, or headache; tremor.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include blurred vision; confusion; difficulty urinating; fast or shallow breathing; hallucinations; paleness; restlessness; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Zotex Pediatric Drops:

Store Zotex Pediatric Drops at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zotex Pediatric Drops out of the reach of children and away from pets.

General information:

• If you have any questions about Zotex Pediatric Drops, please talk with your doctor, pharmacist, or other health care provider.
• Zotex Pediatric Drops is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zotex Pediatric Drops. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Dexchlorpheniramine/Hydrocodone/Phenylephrine (dex-klor-fen-EER-a-meen/hye-droe-KOE-done/fen-ill-EF-rin)
Brand Name: Examples include Hydex PD and Zotex HC

Zotex HC Liquid is used for:

Relieving symptoms of sinus congestion, runny nose, sneezing, and cough due to colds, upper respiratory infections, and allergies. It may also be used for other conditions as determined by your doctor.

Zotex HC Liquid is a decongestant, antihistamine, and cough suppressant combination. The decongestant works by constricting blood vessels and reducing swelling in the nasal passages. The antihistamine works by blocking the action of histamine, which helps reduce symptoms, such as watery eyes and sneezing. The cough suppressant works in the brain to help decrease the cough reflex, which reduces a dry cough.

Do NOT use Zotex HC Liquid if:

• you are allergic to any ingredient in Zotex HC Liquid or any other codeine- or morphine-related medicine (eg, codeine)
• you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems
• you are unable to urinate or are having an asthma attack
• you are taking sodium oxybate (GHB) or if you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zotex HC Liquid:

Some medical conditions may interact with Zotex HC Liquid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a fast, slow, or irregular heartbeat, blood vessel problems, or other heart problems
• if you have a history of adrenal gland problems (eg, adrenal gland tumor); high blood pressure; diabetes; stroke; glaucoma; a blockage of your bladder, stomach, or intestines; ulcers; trouble urinating; an enlarged prostate or other prostate problems; or an overactive thyroid
• if you have a history of asthma, chronic cough, lung problems (eg, chronic bronchitis, emphysema), or chronic obstructive pulmonary disease (COPD), or if your cough occurs with large amounts of mucus
• if you have or recently have had any head or brain injury, brain tumor, increased pressure in the brain, infection of the brain or nervous system, epilepsy, or seizures
• if you have a history of stomach problems (eg, ulcers), bowel problems (eg, chronic inflammation or ulceration of the bowel), or gallbladder problems (eg, gallstones), or if you have had recent abdominal surgery
• if you have a history of alcohol or substance abuse or suicidal thoughts or behavior

Some MEDICINES MAY INTERACT with Zotex HC Liquid. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, MAOIs (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Zotex HC Liquid’s side effects
• Cimetidine, digoxin, droxidopa, or sodium oxybate (GHB) because the risk of severe drowsiness, breathing problems, seizures, irregular heartbeat, or heart attack may be increased
• Naltrexone because it may decrease Zotex HC Liquid’s effectiveness
• Bromocriptine or hydantoins (eg, phenytoin) because the risk of their side effects may be increased by Zotex HC Liquid
• Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Zotex HC Liquid

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zotex HC Liquid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zotex HC Liquid:

Use Zotex HC Liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Zotex HC Liquid by mouth with or without food.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• If you miss a dose of Zotex HC Liquid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zotex HC Liquid.

Important safety information:

• Zotex HC Liquid may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Zotex HC Liquid with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do not take diet or appetite control medicines while you take Zotex HC Liquid without checking with your doctor.
• Zotex HC Liquid has dexchlorpheniramine and phenylephrine in it. Before you start any new medicine, check the label to see if it has dexchlorpheniramine or phenylephrine in it too. If it does or if you are not sure, check with your doctor or pharmacist.
• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
• If your symptoms do not get better within 5 to 7 days or if they get worse, check with your doctor.
• Zotex HC Liquid may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Zotex HC Liquid. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
• Zotex HC Liquid may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking Zotex HC Liquid for a few days before the tests.
• Tell your doctor or dentist that you take Zotex HC Liquid before you receive any medical or dental care, emergency care, or surgery.
• Use Zotex HC Liquid with caution in the ELDERLY; they may be more sensitive to its effects.
• Caution is advised when using Zotex HC Liquid in CHILDREN; they may be more sensitive to its effects.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zotex HC Liquid while you are pregnant. It is not known if Zotex HC Liquid is found in breast milk. Do not breast-feed while taking Zotex HC Liquid.

When used for long periods of time or at high doses, Zotex HC Liquid may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Zotex HC Liquid stops working well. Do not take more than prescribed.

When used for longer than a few weeks or at high doses, some people develop a need to continue taking Zotex HC Liquid. This is known as DEPENDENCE or addiction.

If you suddenly stop taking Zotex HC Liquid, you may experience WITHDRAWAL symptoms including anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; seeing, hearing or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping.

Possible side effects of Zotex HC Liquid:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; tremor; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Zotex HC Liquid:

Store Zotex HC Liquid at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zotex HC Liquid out of the reach of children and away from pets.

General information:

• If you have any questions about Zotex HC Liquid, please talk with your doctor, pharmacist, or other health care provider.
• Zotex HC Liquid is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zotex HC Liquid. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Brompheniramine/Phenylephrine (BROME-fen-IR-a-meen/FEN-il-EF-rin)
Brand Name: Examples include Seradex LA and Zotex PE

Zotex PE Sustained-Release Tablets are used for:

Relieving symptoms of sinus congestion, pressure, runny nose, and sneezing due to colds, upper respiratory infections, and allergies. It may also be used for other conditions as determined by your doctor.

Zotex PE Sustained-Release Tablets are an antihistamine and decongestant combination. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing. The decongestant promotes sinus and nasal drainage, which relieves congestion and pressure.

Do NOT use Zotex PE Sustained-Release Tablets if:

• you are allergic to any ingredient in Zotex PE Sustained-Release Tablets
• you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems
• you are taking sodium oxybate (GHB) or you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zotex PE Sustained-Release Tablets:

Some medical conditions may interact with Zotex PE Sustained-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a fast, slow, or irregular heartbeat
• if you have a history of asthma; lung problems (eg, emphysema); sleep apnea; adrenal gland problems (eg, adrenal gland tumor); heart problems; high blood pressure; diabetes; heart blood vessel problems; stroke; glaucoma or increased pressure in the eye; a blockage of your bladder, stomach, or intestines; ulcers; trouble sleeping; trouble urinating; an enlarged prostate or other prostate problems; seizures; or thyroid problems

Some MEDICINES MAY INTERACT with Zotex PE Sustained-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased
• Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, MAOIs (eg, phenelzine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Zotex PE Sustained-Release Tablets’s side effects
• Bromocriptine or hydantoins (eg, phenytoin) because the risk of their side effects may be increased by Zotex PE Sustained-Release Tablets
• Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Zotex PE Sustained-Release Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zotex PE Sustained-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zotex PE Sustained-Release Tablets:

Use Zotex PE Sustained-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Zotex PE Sustained-Release Tablets by mouth with or without food.
• Swallow Zotex PE Sustained-Release Tablets whole. Do not break, crush, or chew before swallowing.
• If you miss a dose of Zotex PE Sustained-Release Tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zotex PE Sustained-Release Tablets.

Important safety information:

• Zotex PE Sustained-Release Tablets may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Zotex PE Sustained-Release Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Zotex PE Sustained-Release Tablets; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
• Do not take diet or appetite control medicines while you are taking Zotex PE Sustained-Release Tablets without checking with your doctor.
• Zotex PE Sustained-Release Tablets has brompheniramine and phenylephrine in it. Before you start any new medicine, check the label to see if it has brompheniramine or phenylephrine in it too. If it does or if you are not sure, check with your doctor or pharmacist.
• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
• If your symptoms do not get better within 5 to 7 days or if they get worse, check with your doctor.
• Zotex PE Sustained-Release Tablets may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Zotex PE Sustained-Release Tablets. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
• Zotex PE Sustained-Release Tablets may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking Zotex PE Sustained-Release Tablets for a few days before the tests.
• Tell your doctor or dentist that you take Zotex PE Sustained-Release Tablets before you receive any medical or dental care, emergency care, or surgery.
• Use Zotex PE Sustained-Release Tablets with caution in the ELDERLY; they may be more sensitive to its effects, especially confusion, dizziness, drowsiness, dry mouth, excitability, low blood pressure, and trouble urinating.
• Caution is advised when using Zotex PE Sustained-Release Tablets in CHILDREN; they may be more sensitive to its effects, especially excitability.
• Zotex PE Sustained-Release Tablets should not be used in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zotex PE Sustained-Release Tablets while you are pregnant. Do not take Zotex PE Sustained-Release Tablets in the third trimester of pregnancy. Zotex PE Sustained-Release Tablets are found in breast milk. Do not breast-feed while taking Zotex PE Sustained-Release Tablets.

Possible side effects of Zotex PE Sustained-Release Tablets:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; dry mouth; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; mood or mental changes; persistent trouble sleeping; restlessness; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; tremor.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; ringing in the ears; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular breathing; unusually fast, slow, or irregular heartbeat.

Proper storage of Zotex PE Sustained-Release Tablets:

Store Zotex PE Sustained-Release Tablets at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zotex PE Sustained-Release Tablets out of the reach of children and away from pets.

General information:

• If you have any questions about Zotex PE Sustained-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.
• Zotex PE Sustained-Release Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zotex PE Sustained-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Dextromethorphan/Guaifenesin/Phenylephrine (dex-troe-meth-OR-fan/gwye-FEN-eh-sin/fen-ill-EF-rin)
Brand Name: Examples include Tussidex and Zotex

Zotex Liquid is used for:

Relieving congestion, cough, and throat and airway irritation due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Zotex Liquid is a decongestant, cough suppressant, and expectorant combination. It works by constricting blood vessels and reducing swelling in the nasal passages, loosening mucus and lung secretions in the chest, and making coughs more productive. It also works in the brain to help decrease the cough reflex to reduce a dry cough.

Do NOT use Zotex Liquid if:

• you are allergic to any ingredient in Zotex Liquid
• you have severe high blood pressure, rapid heartbeat, or other severe heart problems (eg, heart blood vessel disease)
• you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zotex Liquid:

Some medical conditions may interact with Zotex Liquid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of glaucoma, an enlarged prostate gland or other prostate problems, heart problems, diabetes, high blood pressure, blood vessel problems, adrenal gland problems, an overactive thyroid, seizures, or stroke
• if you have a chronic cough, lung problems (eg, asthma, chronic bronchitis, emphysema), or chronic obstructive pulmonary disease (COPD), or if your cough occurs with large amounts of mucus

Some MEDICINES MAY INTERACT with Zotex Liquid. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Beta-blockers (eg, propranolol), COMT inhibitors (eg, tolcapone), furazolidone, indomethacin, MAO inhibitors (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because the risk of side effects from Zotex Liquid may be increased
• Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased
• Bromocriptine because the risk of side effects may be increased by Zotex Liquid
• Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Zotex Liquid

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zotex Liquid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zotex Liquid:

Use Zotex Liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Zotex Liquid may be taken with or without food.
• Drink plenty of water while taking Zotex Liquid.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• If you miss a dose of Zotex Liquid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zotex Liquid.

Important safety information:

• Zotex Liquid may cause dizziness or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Zotex Liquid. Using Zotex Liquid alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• Do not take appetite suppressants while you are taking Zotex Liquid without checking with your doctor.
• Zotex Liquid contains phenylephrine. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains phenylephrine. If it does or if you are uncertain, contact your doctor or pharmacist.
• Do NOT exceed the recommended dose or take Zotex Liquid for longer than prescribed without checking with your doctor.
• If your symptoms do not improve within 5 to 7 days or if they become worse, check with your doctor.
• Zotex Liquid may interfere with certain lab test results. Make sure that all of your doctors and lab personnel know that you are taking Zotex Liquid.
• Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Zotex Liquid.
• Use Zotex Liquid with caution in the ELDERLY because they may be more sensitive to its effects.
• Caution is advised when using Zotex Liquid in CHILDREN because they may be more sensitive to its effects.
• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Zotex Liquid, discuss with your doctor the benefits and risks of using Zotex Liquid during pregnancy. It is unknown if Zotex Liquid is excreted in breast milk. Do not breast-feed while taking Zotex Liquid.

Possible side effects of Zotex Liquid:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; excitability; headache; nausea; nervousness or anxiety; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Zotex Liquid:

Store Zotex Liquid at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zotex Liquid out of the reach of children and away from pets.

General information:

• If you have any questions about Zotex Liquid, please talk with your doctor, pharmacist, or other health care provider.
• Zotex Liquid is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zotex Liquid. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Capsaicin (kap-SAY-sin)
Brand Name: Examples include Capzasin-P and Zostrix

Zostrix Cream is used for:

Temporary relief of muscle and joint pain associated with arthritis, simple backaches, sprains, strains, and bruises. It may also be used for other conditions as determined by your doctor.

Zostrix Cream is a topical analgesic. Exactly how it works is unknown, but it is thought to decrease the amount of a certain substance (substance P) that transmits pain in the body.

Do NOT use Zostrix Cream if:

• you are allergic to any ingredient in Zostrix Cream

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zostrix Cream:

Some medical conditions may interact with Zostrix Cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have an open wound or damaged, broken, or irritated skin

Some MEDICINES MAY INTERACT with Zostrix Cream. Because little, if any, of Zostrix Cream is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Zostrix Cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zostrix Cream:

Use Zostrix Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Zostrix Cream. Talk to your pharmacist if you have questions about this information.
• Apply just enough medicine to cover the affected area. Gently massage the medicine into skin until it disappears.
• Wash your hands with soap and water immediately after using Zostrix Cream unless your hands are part of the treated area.
• If you are using Zostrix Cream on your hands, allow 30 minutes for the medicine to absorb before washing. During this time, avoid touching damaged or irritated skin, contact lenses, or your eyes, nose, mouth, or other mucous membranes. Wash hands after 30 minutes.
• Do not apply to wounds or damaged, broken (open), or irritated skin.
• Do not bandage or wrap the affected area.
• Do not use Zostrix Cream with a heating pad.
• Do not expose the treated area to heat or direct sunlight. Warm or hot water or sunlight may increase the likelihood of burning or itching. Do not use Zostrix Cream immediately after bathing, swimming, using a hot tub, sunbathing, or exposure to heat.
• If you miss a dose of Zostrix Cream, use it as soon as you remember. Continue to use it as directed by your doctor or on the package label.

Ask your health care provider any questions you may have about how to use Zostrix Cream.

Important safety information:

• For external use only. Avoid contact with the eyes, nose, and mouth. If Zostrix Cream gets into your eyes, rinse immediately with cool water.
• Do not use more than the recommended dose, use for longer than prescribed, or use large amounts of Zostrix Cream without checking with your doctor.
• Do not inhale any residue from Zostrix Cream after it has dried. Coughing, sneezing, or throat or respiratory irritation may occur.
• Zostrix Cream may be harmful if swallowed. If you may have taken Zostrix Cream by mouth, contact your local poison control center or emergency room immediately.
• If condition worsens, or if symptoms persists for more than 7 days or clear up and occur again within a few days, stop use of this product and contact your health care provider.
• If redness is present or if irritation develops, check with your doctor before using any more of Zostrix Cream.
• If severe burning or itching occurs, remove product by thoroughly washing the area with soap and cold water.
• Zostrix Cream should not be used in CHILDREN younger than 18 years old without checking with the child’s doctor; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zostrix Cream while you are pregnant. It is not known if Zostrix Cream is found in breast milk. If you are or will be breast-feeding while you use Zostrix Cream, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Zostrix Cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Temporary burning or stinging at the application site that usually disappears in a few days.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty breathing or swallowing; irritation, redness, blistering, or severe or persistent burning at the application site.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Zostrix Cream may be harmful if swallowed.

Proper storage of Zostrix Cream:

Store Zostrix Cream at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Close cap tightly after use. Do not store in the bathroom. Keep Zostrix Cream out of the reach of children and away from pets.

General information:

• If you have any questions about Zostrix Cream, please talk with your doctor, pharmacist, or other health care provider.
• Zostrix Cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Zostrix Cream. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Aspirin (AS-pir-in)
Brand Name: Examples include Bayer Low Adult Strength and ZORprin

ZORprin Controlled-Release Tablets are used for:

Relieving arthritis symptoms. It may also be used for other conditions as determined by your doctor.

ZORprin Controlled-Release Tablets are a salicylate. It works by inhibiting several different chemical processes within the body that cause pain, inflammation, and fever. It also reduces the tendency for blood to clot.

Do NOT use ZORprin Controlled-Release Tablets if:

• you are allergic to any ingredient in ZORprin Controlled-Release Tablets
• you are a child or teenager with influenza (flu) or chicken pox
• you have bleeding problems such as hemophilia, von Willebrand disease, or low blood platelets
• you have had a severe allergic reaction (eg, severe rash, hives, breathing difficulties, dizziness), to aspirin, tartrazine, or an NSAID (eg, ibuprofen, naproxen, celecoxib)
• you are taking anticoagulants (eg, heparin, warfarin) or methotrexate

Contact your doctor or health care provider right away if any of these apply to you.

Before using ZORprin Controlled-Release Tablets:

Some medical conditions may interact with ZORprin Controlled-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, plan to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines or other substances
• if you have alcoholism or if you consume 3 or more alcohol-containing drinks every day
• if you have asthma, bleeding or clotting problems, growths in the nose (nasal polyps), kidney or liver problems, stomach or peptic ulcers (bleeding ulcers), heartburn, upset stomach, stomach pain, influenza (flu) or chicken pox, or vitamin K deficiency
• if you are a child with a stroke, a weakened blood vessel (cerebral aneurysm) or bleeding in the brain, or Kawasaki syndrome (a rare inflammation causing heart problems in children)

Some MEDICINES MAY INTERACT with ZORprin Controlled-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Carbonic anhydrase inhibitors (eg, acetazolamide) because they may decrease ZORprin Controlled-Release Tablets’s effectiveness
• Anticoagulants (eg, heparin, warfarin) or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, celecoxib) because the risk of their side effects, including risk of bleeding, may be increased by ZORprin Controlled-Release Tablets
• Insulin and oral antidiabetics (eg, glyburide, nateglinide) because the risk of their side effects, including low blood sugar (eg, hunger, shakiness or weakness, dizziness, headache, sweating), may be increased by ZORprin Controlled-Release Tablets
• Methotrexate or valproic acid because the risk of their actions and side effects may be increased by ZORprin Controlled-Release Tablets
• Angiotensin-converting enzyme inhibitors (eg, enalapril), probenecid, or sulfinpyrazone because their effectiveness may be decreased by ZORprin Controlled-Release Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if ZORprin Controlled-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use ZORprin Controlled-Release Tablets:

Use ZORprin Controlled-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take ZORprin Controlled-Release Tablets by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
• Swallow ZORprin Controlled-Release Tablets whole. Do not break, crush, or chew before swallowing unless directed by your health care provider.
• Take ZORprin Controlled-Release Tablets with a full glass of water (8 oz/240 mL).
• Use ZORprin Controlled-Release Tablets exactly as directed on the package, unless instructed differently by your doctor. If you are taking ZORprin Controlled-Release Tablets without a prescription, follow any warnings and precautions on the label.
• If you miss a dose of ZORprin Controlled-Release Tablets and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use ZORprin Controlled-Release Tablets.

Important safety information:

• ZORprin Controlled-Release Tablets has aspirin in it. Before you start any new medicine, check the label to see if it has aspirin in it too. If it does or if you are not sure, check with your doctor or pharmacist.
• Talk to your doctor before you take ZORprin Controlled-Release Tablets or other pain relievers/fever reducers if you drink more than 3 drinks with alcohol per day. Serious stomach ulcers or bleeding can occur with the use of ZORprin Controlled-Release Tablets. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking ZORprin Controlled-Release Tablets with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.
• ZORprin Controlled-Release Tablets may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
• Aspirin has been linked to a serious illness called Reye syndrome. Do not give ZORprin Controlled-Release Tablets to a child or teenager who has the flu, chickenpox, or a viral infection. Contact your doctor with any questions or concerns.
• If ZORprin Controlled-Release Tablets has a strong vinegar-like smell upon opening, do not use. It means the medicine is breaking down. Throw the bottle away safely and out of the reach of children; contact your pharmacist and replace.
• Tell your doctor or dentist that you take ZORprin Controlled-Release Tablets before you receive any medical or dental care, emergency care, or surgery.
• Do not take ZORprin Controlled-Release Tablets for at least 7 days after any surgery unless directed by your health care provider.
• Do not take ZORprin Controlled-Release Tablets for more than 10 days for pain or for more than 3 days for fever unless directed to do so by your health care provider.
• Diabetes patients-ZORprin Controlled-Release Tablets may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
• Use ZORprin Controlled-Release Tablets with caution in the ELDERLY; they may be more sensitive to its effects, especially those with a blood coagulation disorder.
• Different brands of ZORprin Controlled-Release Tablets may have different dosing instructions for CHILDREN. Follow the dosing instructions on the package labeling. If your doctor has given you instructions, follow those. If you are unsure of the dose to give a child, check with your doctor or pharmacist.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using ZORprin Controlled-Release Tablets while you are pregnant. ZORprin Controlled-Release Tablets are not recommended during the last 3 months (third trimester) of pregnancy because it may cause harm to the fetus. ZORprin Controlled-Release Tablets are found in breast milk. If you are or will be breast-feeding while you use ZORprin Controlled-Release Tablets, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of ZORprin Controlled-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Heartburn; nausea; upset stomach.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or bloody stools; confusion; diarrhea; dizziness; drowsiness; hearing loss; ringing in the ears; severe stomach pain; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include agitation; fever; hearing loss; lethargy; lightheadedness, especially upon standing; nausea; rapid breathing; rapid or irregular heartbeat; ringing in the ears; seizures; shortness of breath; stomach pain; vomiting.

Proper storage of ZORprin Controlled-Release Tablets:

Store ZORprin Controlled-Release Tablets at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep ZORprin Controlled-Release Tablets out of the reach of children and away from pets.

General information:

• If you have any questions about ZORprin Controlled-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.
• ZORprin Controlled-Release Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about ZORprin Controlled-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.