Generic Name: Travoprost (TRAV-oh-prost)
Brand Name: Examples include Travatan and Travatan Z

Travatan Z Drops are used for:

Treating increased pressure in the eye (ocular hypertension) and open-angle glaucoma in patients who cannot use or do not respond to other medicines.

Travatan Z Drops are a prostaglandin analog. It works to lower pressure in the eye by increasing fluid drainage from the eye.

Do NOT use Travatan Z Drops if:

• you are allergic to any ingredient in Travatan Z Drops
• you have inflammation in the eye (eg, iritis, uveitis)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Travatan Z Drops:

Some medical conditions may interact with Travatan Z Drops. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have swelling, infection, or injury of the eye, or you have a history of inflammation in the eye (eg, iritis, uveitis)
• if you do not have a lens in your eye or have had the lens in your eye replaced
• if you have other types of glaucoma (eg, narrow-angle, neovascular)
• if you will be having eye surgery

Some MEDICINES MAY INTERACT with Travatan Z Drops. However, no specific interactions with Travatan Z Drops are known at this time.

Ask your health care provider if Travatan Z Drops may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Travatan Z Drops:

Use Travatan Z Drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Use Travatan Z Drops in the evening unless your doctor tells you otherwise.
• Some brands of Travatan Z Drops contain a chemical (benzalkonium chloride) that can be absorbed by contact lenses. Check with your pharmacist to see if your brand contains this chemical. If so, you will need to remove your contact lenses before you use Travatan Z Drops; lenses may be placed back in the eyes 15 minutes after use of Travatan Z Drops.
• Wash your hands before and after using Travatan Z Drops.
• Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eyelid for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.
• To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.
• Use Travatan Z Drops at least 5 minutes apart from any other medicine that you put in your eye.
• Continue to use Travatan Z Drops even if you feel well. Do not miss any doses.
• If you miss a dose of Travatan Z Drops, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Travatan Z Drops.

Important safety information:

• Travatan Z Drops are for use in the eye only. Do not get it in your nose or mouth.
• Travatan Z Drops may cause blurred vision or make your eyes more sensitive to light. Use Travatan Z Drops with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. If your eyes become sensitive to light, wearing sunglasses may help.
• Travatan Z Drops may cause the colored part of your eye (iris) to turn brown. This change may be permanent. It may not be noticeable for several months to years. If it occurs, you will need to have regular eye examinations. Discuss any questions or concerns with your doctor.
• Travatan Z Drops may cause your eyelids to darken. It may also cause changes in the way that your eyelashes grow (eg, length, thickness, number of lashes). This change may be permanent. Discuss any questions or concerns with your doctor.
• Do NOT use more than the recommended dose without checking with your doctor.
• If you will be having eye surgery, tell your doctor that you use Travatan Z Drops.
• Lab tests, including eye pressure, may be performed while you use Travatan Z Drops. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Travatan Z Drops should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Travatan Z Drops while you are pregnant. It is not known if Travatan Z Drops are found in breast milk. If you are or will be breast-feeding while you use Travatan Z Drops, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Travatan Z Drops:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bloodshot eyes; blurred vision; changes in eyelash growth; eye dryness, itching, or discomfort; feeling of having something in your eye; headache; increased tear production.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; darkening of the eyelid or eye color; eye or eyelid crusting, discharge, inflammation, irritation, pain, or swelling; severe headache or dizziness; slow heartbeat; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org ), or emergency room immediately.

Proper storage of Travatan Z Drops:

Store Travatan Z Drops between 36 and 77 degrees F (2 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Travatan Z Drops out of the reach of children and away from pets.

General information:

• If you have any questions about Travatan Z Drops, please talk with your doctor, pharmacist, or other health care provider.
• Travatan Z Drops are to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is summary only. It does not contain all information about Travatan Z Drops. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Meclizine (MEK-li-zeen)
Brand Name: Travel-Ease

Travel-Ease Chewable Tablets are used for:

Preventing and treating nausea, vomiting, and dizziness associated with motion sickness. It may also be used for other conditions as determined by your doctor.

Travel-Ease Chewable Tablets are an anticholinergic. It works by blocking a chemical messenger that is activating the vomiting center and thus prevents or reduces nausea and vomiting due to motion.

Do NOT use Travel-Ease Chewable Tablets if:

• you are allergic to any ingredient in Travel-Ease Chewable Tablets
• you are taking sodium oxybate (GHB) or you drink alcohol

Contact your doctor or health care provider right away if any of these apply to you.

Before using Travel-Ease Chewable Tablets:

Some medical conditions may interact with Travel-Ease Chewable Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have asthma; chronic obstructive pulmonary disease (COPD); chronic bronchitis, or emphysema; blockage of the stomach, intestine, or urinary tract;enlargement of the prostate; or glaucoma

Some MEDICINES MAY INTERACT with Travel-Ease Chewable Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Ethanol or sodium oxybate (GHB) because an increase in sleep duration and a decrease in the ability to breathe are likely to occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if Travel-Ease Chewable Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Travel-Ease Chewable Tablets:

Use Travel-Ease Chewable Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Travel-Ease Chewable Tablets by mouth with or without food.
• Travel-Ease Chewable Tablets may be chewed or swallowed whole.
• For prevention of motion sickness, take Travel-Ease Chewable Tablets at least 1 hour before activity or travel.
• If you miss a dose of Travel-Ease Chewable Tablets and you are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Travel-Ease Chewable Tablets.

Important safety information:

• Travel-Ease Chewable Tablets may cause drowsiness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Travel-Ease Chewable Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Travel-Ease Chewable Tablets; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
• This product may contain tartrazine dye (FD&C Yellow No. 5). This may cause an allergic reaction in some patients. If you have ever had an allergic reaction to tartrazine, ask your pharmacist if your product has tartrazine in it.
• Travel-Ease Chewable Tablets should not be used in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Travel-Ease Chewable Tablets while you are pregnant. It is unknown if Travel-Ease Chewable Tablets are found in breast milk. If you are or will be breast-feeding while you use Travel-Ease Chewable Tablets, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Travel-Ease Chewable Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Drowsiness; dry mouth.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include drowsiness; hallucinations; seizures; unusual excitability; very slow or shallow breathing.

Proper storage of Travel-Ease Chewable Tablets:

Store at room temperature, below 86 degrees F (30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Travel-Ease Chewable Tablets out of the reach of children and away from pets.

General information:

• If you have any questions about Travel-Ease Chewable Tablets, please talk with your doctor, pharmacist, or other health care provider.
• Travel-Ease Chewable Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Travel-Ease Chewable Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Travoprost (TRAV-oh-prost)
Brand Name: Travatan

Travatan Drops are used for:

Treating increased pressure in the eye (ocular hypertension) and open-angle glaucoma in patients who cannot use or do not respond to other medicines.

Travatan Drops are a prostaglandin analog. It works to lower pressure in the eye by increasing fluid drainage from the eye.

Do NOT use Travatan Drops if:

• you are allergic to any ingredient in Travatan Drops
• you have inflammation in the eye (eg, iritis, uveitis)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Travatan Drops:

Some medical conditions may interact with Travatan Drops. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have swelling, infection, or injury of the eye, or you have a history of inflammation in the eye (eg, iritis, uveitis)
• if you do not have a lens in your eye or have had the lens in your eye replaced
• if you have other types of glaucoma (eg, narrow-angle, neovascular)
• if you will be having eye surgery

Some MEDICINES MAY INTERACT with Travatan Drops. However, no specific interactions with Travatan Drops are known at this time.

Ask your health care provider if Travatan Drops may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Travatan Drops:

Use Travatan Drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Use Travatan Drops in the evening unless your doctor tells you otherwise.
• Soft contact lenses may absorb a chemical in Travatan Drops. Remove contact lenses before you use Travatan Drops; lenses may be placed back in the eyes 15 minutes after use of Travatan Drops.
• Wash your hands before and after using Travatan Drops.
• Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eyelid for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.
• To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.
• Use Travatan Drops at least 5 minutes apart from any other medicine that you put in your eye.
• Continue to use Travatan Drops even if you feel well. Do not miss any doses.
• If you miss a dose of Travatan Drops, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Travatan Drops.

Important safety information:

• Travatan Drops are for use in the eye only. Do not get it in your nose or mouth.
• Travatan Drops may cause blurred vision or make your eyes more sensitive to light. Use Travatan Drops with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. If your eyes become sensitive to light, wearing sunglasses may help.
• Travatan Drops may cause the colored part of your eye (iris) to turn brown. This change may be permanent. It may not be noticeable for several months to years. If it occurs, you will need to have regular eye examinations. Discuss any questions or concerns with your doctor.
• Travatan Drops may cause your eyelids to darken. It may also cause changes in the way that your eyelashes grow (eg, length, thickness, number of lashes). This change may be permanent. Discuss any questions or concerns with your doctor.
• Do NOT use more than the recommended dose without checking with your doctor.
• If you will be having eye surgery, tell your doctor that you use Travatan Drops.
• Lab tests, including eye pressure, may be performed while you use Travatan Drops. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Travatan Drops should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Travatan Drops while you are pregnant. It is not known if Travatan Drops are found in breast milk. If you are or will be breast-feeding while you use Travatan Drops, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Travatan Drops:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bloodshot eyes; blurred vision; changes in eyelash growth; eye dryness, itching, or discomfort; feeling of having something in your eye; headache; increased tear production.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; darkening of the eyelid or eye color; eye or eyelid crusting, discharge, inflammation, irritation, pain, or swelling; severe headache or dizziness; slow heartbeat; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Travatan Drops:

Store Travatan Drops between 36 and 77 degrees F (2 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Travatan Drops out of the reach of children and away from pets.

General information:

• If you have any questions about Travatan Drops, please talk with your doctor, pharmacist, or other health care provider.
• Travatan Drops are to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is summary only. It does not contain all information about Travatan Drops. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Homeopathic Analgesic (hoh-mee-o-PATH-ik AN-al-JE-zik)
Brand Name: Traumeel

Traumeel Ointment is used for:

Temporary relief of minor muscle and joint aches and pains caused by strains, sprains, and bruising. Traumeel Ointment is a topical homeopathic analgesic. It works by reducing inflammation to temporarily relieve pain.

Do NOT use Traumeel Ointment if:

• you are allergic to any ingredient in Traumeel Ointment

Contact your doctor or health care provider right away if any of these apply to you.

Before using Traumeel Ointment:

Some medical conditions may interact with Traumeel Ointment. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a burn or open wound at the affected area or if your skin is damaged, broken, or irritated in any way

Some MEDICINES MAY INTERACT with Traumeel Ointment. Because little, if any, of Traumeel Ointment is absorbed into the blood, the risk of it interacting with another medicine is low.

Do not start, stop, or change the dose of any medicine without approval from your doctor or health care provider.

How to use Traumeel Ointment:

Use Traumeel Ointment as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Apply generously to the affected area. Gently massage the medicine into the skin until it disappears.
• Wash your hands immediately after using Traumeel Ointment.
• Do not apply to burns, open wounds, or damaged, broken, or irritated skin.
• A bandage or wrap may be applied over Traumeel Ointment.
• If you miss a dose of Traumeel Ointment, use it as soon as you remember. Continue to use it as directed by your doctor or on the package label.

Ask your health care provider any questions you may have about how to use Traumeel Ointment.

Important safety information:

• Traumeel Ointment is for external use only. Do not get it in your eyes, nose, or mouth. If you get it any of these areas, rinse right away with cool tap water.
• Do NOT use more than the recommended dose or use more often than directed without checking with your doctor.
• Do not use Traumeel Ointment over large areas of the body without checking with your doctor.
• If your symptoms do not get better, if they get worse, or if you develop a rash, check with your doctor.
• Traumeel Ointment may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Traumeel Ointment while you are pregnant. It is not known if Traumeel Ointment is found in breast milk after topical use. If you are or will be breast-feeding while you use Traumeel Ointment, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Traumeel Ointment:

All medicines may cause side effects, but many people have no, or minor, side effects. No COMMON side effects have been reported with Traumeel Ointment. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Traumeel Ointment:

Store Traumeel Ointment at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Traumeel Ointment out of the reach of children and away from pets.

General information:

• If you have any questions about Traumeel Ointment, please talk with your doctor, pharmacist, or other health care provider.
• Traumeel Ointment is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Traumeel Ointment. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Aprotinin (a-proe-TYE-nin)
Brand Name: Trasylol

Trasylol is used for:

Reducing blood loss and the need for blood transfusions in patients undergoing certain types of heart surgery.

Trasylol is a protease inhibitor. It works by reducing the inflammatory response associated with cardiopulmonary bypass surgery.

Do NOT use Trasylol if:

• you are allergic to any ingredient in Trasylol
• you have received Trasylol within the past 12 months

Contact your doctor or health care provider right away if any of these apply to you.

Before using Trasylol:

Some medical conditions may interact with Trasylol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have kidney problems
• if you have previously had heart surgery

Some MEDICINES MAY INTERACT with Trasylol. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Aminoglycosides (eg, gentamicin) or medicines that alter kidney function because the risk of kidney damage may be increased
• Angiotensin-converting enzyme (ACE) inhibitors (eg, captopril) or fibrinolytics (eg, streptokinase) because the effectiveness of these medicines may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Trasylol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Trasylol:

Use Trasylol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Trasylol. Talk to your pharmacist if you have questions about this information.
• Trasylol is administered as an intravenous (IV; into a vein) injection only in a medical setting.
• If you miss a dose of Trasylol, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Trasylol.

Important safety information:

• Lab tests, including kidney function and blood clotting tests, may be performed while you use Trasylol. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Trasylol should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Trasylol while you are pregnant. It is not known if Trasylol is found in breast milk. If you are or will be breast-feeding while you use Trasylol, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Trasylol:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; difficulty urinating; infection (eg, fever, chills, sore throat); lightheadedness; sleeplessness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); asthma; chest pain; confusion; decreased urination; fast or irregular heartbeat; lung disorder; nausea; numbness of an arm or leg; one-sided weakness; severe stomach pain; sudden severe headache, dizziness, fainting, or vomiting; sudden weight gain; swelling of the hands, legs, or feet; vision or speech changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800 -222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Trasylol:

Trasylol is usually handled and stored by a health care provider. Keep Trasylol out of the reach of children and away from pets.

General information:

• If you have any questions about Trasylol, please talk with your doctor, pharmacist, or other health care provider.
• Trasylol is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Trasylol. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Clorazepate (klor-AZE-eh-pate)
Brand Name: Tranxene-SD

Tranxene-SD Sustained-Release Tablets are used for:

Treating nervousness or anxiety, seizures, and alcohol withdrawal. It may also be used for other conditions as determined by your doctor.

Tranxene-SD Sustained-Release Tablets are a benzodiazepine. It works by slowing down the movement of chemicals in the brain. This results in a reduction in nervous tension (anxiety) and causes little drowsiness.

Do NOT use Tranxene-SD Sustained-Release Tablets if:

• you are allergic to any ingredient in Tranxene-SD Sustained-Release Tablets
• you are taking sodium oxybate (GHB)
• you have narrow-angle glaucoma or severe liver disease

Contact your doctor or health care provider right away if any of these apply to you.

Before using Tranxene-SD Sustained-Release Tablets:

Some medical conditions may interact with Tranxene-SD Sustained-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicines, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have glaucoma, liver problems, seizures, muscle problems, a blood disorder, lung problems, depression, thoughts of suicide, or psychosis
• if you have a history of alcohol or substance abuse or dependence

Some MEDICINES MAY INTERACT with Tranxene-SD Sustained-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Hydantoins (eg, phenytoin) or rifampin because they may decrease Tranxene-SD Sustained-Release Tablets’s effectiveness
• Disulfiram, HIV protease inhibitors (eg, ritonavir), nefazodone, omeprazole, sodium oxybate (GHB), or valproic acid because side effects, such as confusion and increased drowsiness, may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if Tranxene-SD Sustained-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Tranxene-SD Sustained-Release Tablets:

Use Tranxene-SD Sustained-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Tranxene-SD Sustained-Release Tablets by mouth with or without food.
• If you also take clozapine, do not take it within 2 hours before or after taking Tranxene-SD Sustained-Release Tablets. These doses must be separated. Check with your doctor if you have questions.
• Do not suddenly stop taking Tranxene-SD Sustained-Release Tablets. You may have an increased risk of serious side effects.
• If you miss a dose of Tranxene-SD Sustained-Release Tablets and are using it regularly, take it as soon as possible. If you do not remember until later, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Tranxene-SD Sustained-Release Tablets.

Important safety information:

• Tranxene-SD Sustained-Release Tablets may cause blurred vision, dizziness, drowsiness, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Tranxene-SD Sustained-Release Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do not drink alcohol while you are using Tranxene-SD Sustained-Release Tablets.
• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Tranxene-SD Sustained-Release Tablets; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
• The risk of Tranxene-SD Sustained-Release Tablets becoming habit-forming may be greater if you take Tranxene-SD Sustained-Release Tablets in high doses or for a long time. Do NOT take more than the recommended dose or take for longer than prescribed without checking with your doctor.
• Lab tests, including liver and kidney tests, may be performed while you use Tranxene-SD Sustained-Release Tablets. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Tranxene-SD Sustained-Release Tablets with caution in the ELDERLY; they may be more sensitive to its effects.
• Tranxene-SD Sustained-Release Tablets should be used with extreme caution in CHILDREN younger than 9 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: Tranxene-SD Sustained-Release Tablets has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Tranxene-SD Sustained-Release Tablets while you are pregnant. Tranxene-SD Sustained-Release Tablets are found in breast milk. Do not breast-feed while taking Tranxene-SD Sustained-Release Tablets.

When used for long periods of time or at high doses, Tranxene-SD Sustained-Release Tablets may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Tranxene-SD Sustained-Release Tablets stops working well. Do not take more than prescribed. Some people who use Tranxene-SD Sustained-Release Tablets for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction. Talk with your doctor if Tranxene-SD Sustained-Release Tablets stops working well. Do not take more than prescribed. If you suddenly stop taking Tranxene-SD Sustained-Release Tablets, you may experience WITHDRAWAL symptoms.

Possible side effects of Tranxene-SD Sustained-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; clumsiness; confusion; dizziness; drowsiness; dry mouth; headache; lightheadedness; nervousness; stomach upset; unsteadiness; unusual weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include clumsiness; confusion; deep sleep; drowsiness; impaired coordination; loss of consciousness; slow reflexes.

Proper storage of Tranxene-SD Sustained-Release Tablets:

Store Tranxene-SD Sustained-Release Tablets between 59 and 77 degrees F (15 and 25 degrees C). Store in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Tranxene-SD Sustained-Release Tablets out of the reach of children and away from pets.

General information:

• If you have any questions about Tranxene-SD Sustained-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.
• Tranxene-SD Sustained-Release Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is summary only. It does not contain all information about Tranxene-SD Sustained-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Scopolamine (skoe-POL-a-meen)
Brand Name: Transderm Scop

Transderm Scop Patch is used for:

Preventing nausea and vomiting associated with motion sickness and recovery from anesthesia and surgery. It may also be used for other conditions as determined by your doctor.

Transderm Scop Patch is an anticholinergic agent. It works by blocking transmission of impulses at nerve sites in the gastrointestinal tract and the vomiting center.

Do NOT use Transderm Scop Patch if:

• you are allergic to any ingredient in Transderm Scop Patch
• you have narrow-angle glaucoma, difficulty swallowing, stomach or bowel problems (eg, blockage, muscle weakness, ulcerative colitis), bleeding, acid reflux disease, myasthenia gravis, or a blockage of the urinary tract

Contact your doctor or health care provider right away if any of these apply to you.

Before using Transderm Scop Patch:

Some medical conditions may interact with Transderm Scop Patch. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have nerve problems, prostate problems, difficulty urinating, irregular heartbeat, heart failure, hernia, glaucoma, or a predisposition to glaucoma
• if you will be having a magnetic resonance imaging (MRI) scan

Some MEDICINES MAY INTERACT with Transderm Scop Patch. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Beta-adrenergic blockers (eg, propranolol) or digoxin because the risk of their side effects may be increased by Transderm Scop Patch
• Phenothiazines (eg, chlorpromazine) because their effectiveness may be decreased by Transderm Scop Patch

This may not be a complete list of all interactions that may occur. Ask your health care provider if Transderm Scop Patch may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Transderm Scop Patch:

Use Transderm Scop Patch as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Wear only 1 patch at a time. Apply the patch to a hairless area of skin behind 1 ear. Do not apply the patch to irritated skin. Wash your hands thoroughly after applying the patch.
• If the patch becomes loose, remove it and apply and new patch behind the other ear.
• Remove the patch after 3 days. After removing the used patch, fold it in half with the sticky sides together. Discard the patch out of the reach of children and away from pets.
• If you miss a dose of Transderm Scop Patch, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Transderm Scop Patch.

Important safety information:

• Transderm Scop Patch may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Transderm Scop Patch with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Limit alcohol intake while you are taking Transderm Scop Patch. Talk with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Transderm Scop Patch; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
• Do not become overheated in hot weather or while you are being active; heatstroke may occur.
• Transderm Scop Patch may make your eyes more sensitive to sunlight. It may help to wear sunglasses.
• Do not get Transderm Scop Patch in your eyes or mouth.
• Skin burns may occur if this patch is worn during a magnetic resonance imaging (MRI) scan. If you will be having an MRI, tell your doctor that you use Transderm Scop Patch. You will need to remove the patch before having the MRI.
• Transderm Scop Patch should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Transderm Scop Patch while you are pregnant. It is not known if Transderm Scop Patch is found in breast milk. Do not breast-feed while taking Transderm Scop Patch.

Possible side effects of Transderm Scop Patch:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; dizziness; drowsiness; dry mouth.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating; pain and reddening of the eyes, accompanied by dilated pupils; skin irritation.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include confusion; disorientation; dizziness; hallucinations; memory disturbances; restlessness.

Proper storage of Transderm Scop Patch:

Store Transderm Scop Patch at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Transderm Scop Patch out of the reach of children and away from pets.

General information:

• If you have any questions about Transderm Scop Patch, please talk with your doctor, pharmacist, or other health care provider.
• Transderm Scop Patch is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Transderm Scop Patch. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Trandolapril/

Verapamil

Generic Name: Trandolapril/Verapamil (tran-DOLE-a-pril/ver-AP-a-mil)
Brand Name: Tarka

Trandolapril/Verapamil is used for:

Treating high blood pressure. It may also be used for certain conditions as determined by your doctor.

Trandolapril/Verapamil is an angiotensin-converting enzyme (ACE) inhibitor and calcium channel blocker combination. It works by helping to relax blood vessels, which helps to lower blood pressure.

Do NOT use Trandolapril/Verapamil if:

• you are allergic to any ingredient in Trandolapril/Verapamil or to another ACE inhibitor (eg, lisinopril)
• you have a history of angioedema (swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or unusual hoarseness), including angioedema caused by treatment with an ACE inhibitor
• you have certain heart problems (eg, left ventricular dysfunction, sick sinus syndrome, second- or third-degree heart block and do not have a pacemaker), very low blood pressure, or moderate to severe congestive heart failure (CHF)
• you have atrial fibrillation or flutter and a pre-excitation syndrome (extra conduction pathway in the heart), such as Wolff-Parkinson-White (WPW) syndrome or Lown-Ganong-Levine (LGL) syndrome
• you have shock caused by serious heart problems
• you are in your second or third trimester of pregnancy
• you are taking dofetilide, erythromycin, everolimus, or disopyramide

Contact your doctor or health care provider right away if any of these apply to you.

Before using Trandolapril/Verapamil:

Some medical conditions may interact with Trandolapril/Verapamil. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you are able to become pregnant
• if you have a history of heart problems (eg, aortic stenosis, heart failure), blood vessel problems, blood flow problems, bone marrow problems, kidney or liver problems, nervous system problems, diabetes, muscular dystrophy, a neuromuscular disease, or fluid in the lungs
• if you have a history of stroke, a recent heart attack, or a kidney transplant
• if you have an autoimmune disease (eg, lupus, rheumatoid arthritis, scleroderma)
• if you are dehydrated or have low blood volume or low blood pressure
• if you have high potassium levels, low blood sodium levels, or are on a low-salt (sodium) diet
• if you are receiving treatments to reduce sensitivity to bee or wasp stings
• if you are having dialysis or apheresis, or are scheduled to have major surgery
• if you are taking another blood pressure medicine or you are being treated for cancer

Some MEDICINES MAY INTERACT with Trandolapril/Verapamil. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Diuretics (eg, furosemide, hydrochlorothiazide) or quinazolines (eg, prazosin) because the risk of low blood pressure may be increased
• Aldosterone blockers (eg, eplerenone), potassium-sparing diuretics (eg, spironolactone), or potassium supplements because the risk of high blood potassium levels may be increased
• Angiotensin receptor blockers (eg, losartan) or trimethoprim because the risk of kidney problems may be increased
• Insulin, sulfonylureas (eg, glipizide), or other oral diabetes medicines (eg, metformin) because the risk of low blood sugar may be increased
• Certain gold-containing medicines (eg, sodium aurothiomalate) because flushing, low blood pressure, nausea, and vomiting may occur
• Cephalosporin antibiotics (eg, cephalexin), clindamycin, clonidine, ketolide antibiotics (eg, telithromycin), lincomycin, macrolide antibiotics (eg, clarithromycin, erythromycin), or ritonavir because they may increase the risk of Trandolapril/Verapamil’s side effects
• Barbiturates (eg, phenobarbital), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin), rifampin, salicylates (eg, aspirin), or St. John’s wort because they may decrease Trandolapril/Verapamil’s effectiveness
• Aspirin, beta-blockers (eg, propranolol), carbamazepine, colchicine, cyclosporine, digoxin, disopyramide, dofetilide, doxorubicin, dronedarone, eletriptan, erythromycin, everolimus, flecainide, HMG-CoA reductase inhibitors (eg, simvastatin), indomethacin, lithium, narcotic pain medicines (eg, fentanyl), paclitaxel, quinidine, ranolazine, theophyllines (eg, aminophylline), thiopurines (eg, azathioprine), or tolvaptan because the risk of their side effects may be increased by Trandolapril/Verapamil

This may not be a complete list of all interactions that may occur. Ask your health care provider if Trandolapril/Verapamil may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Trandolapril/Verapamil:

Use Trandolapril/Verapamil as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Trandolapril/Verapamil by mouth with food.
• Eating grapefruit or drinking grapefruit juice may affect the amount of Trandolapril/Verapamil in your blood. Talk with your doctor before including grapefruit or grapefruit juice in your diet.
• Take Trandolapril/Verapamil on a regular schedule to get the most benefit from it. Taking Trandolapril/Verapamil at the same time each day will help you remember to take it.
• Continue to use Trandolapril/Verapamil even if you feel well. Do not miss any doses.
• If you miss a dose of Trandolapril/Verapamil, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Trandolapril/Verapamil.

Important safety information:

• Trandolapril/Verapamil may cause dizziness, lightheadedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Trandolapril/Verapamil with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Trandolapril/Verapamil; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
• Trandolapril/Verapamil may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. If lightheadedness occurs, especially during the first few days of treatment, contact your health care provider.
• Trandolapril/Verapamil may cause a serious side effect called angioedema. Contact your doctor at once if you develop swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or unusual hoarseness.
• Trandolapril/Verapamil may not work as well in black patients. They may also be at greater risk of side effects. Contact your doctor if your symptoms do not improve or if they become worse.
• Dehydration, excessive sweating, vomiting, or diarrhea may increase the risk of low blood pressure. Contact your health care provider at once if any of these occur.
• Rarely, Trandolapril/Verapamil may lower the ability of your body to fight infection. This risk may be greater if you have certain other health problems (eg, kidney problems, collagen vascular disease). Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
• Check with your doctor before you use a salt substitute or a product that has potassium in it.
• Proper dental care is important while you are taking Trandolapril/Verapamil. Brush and floss your teeth carefully to reduce swelling and tenderness of your gums while you are using Trandolapril/Verapamil, and visit the dentist regularly.
• Tell your doctor or dentist that you take Trandolapril/Verapamil before you receive any medical or dental care, emergency care, or surgery.
• Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel “normal.” Tell your doctor if you develop any new symptoms.
• If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.
• Diabetes patients – Trandolapril/Verapamil may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
• Lab tests, including liver function, kidney function, complete blood cell counts, and blood pressure, may be performed while you use Trandolapril/Verapamil. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Trandolapril/Verapamil should not be used in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: Trandolapril/Verapamil may cause birth defects or fetal death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. Trandolapril/Verapamil is found in breast milk. Do not breast-feed while taking Trandolapril/Verapamil.

Possible side effects of Trandolapril/Verapamil:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; lightheadedness when sitting up or standing; nausea; persistent, dry cough; tiredness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); chest pain; decreased urination; difficulty swallowing; fainting; muscle pain or cramping; numbness of an arm or leg; one-sided weakness; shortness of breath; slurred speech; stomach pain (with or without nausea or vomiting); swelling of the hands or feet; symptoms of infection (eg, fever, chills, persistent sore throat); symptoms of liver problems (eg, yellowing of the skin or eyes, dark urine, pale stools, severe or persistent stomach pain, fever, general feeling of being unwell); symptoms of low blood pressure (eg, fainting, severe dizziness or lightheadedness); tender, bleeding, or swollen gums; unusually fast, slow, or irregular heartbeat.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include fainting; severe dizziness or lightheadedness; unusually fast, slow, or irregular heartbeat; weakness.

Proper storage of Trandolapril/Verapamil:

Store Trandolapril/Verapamil at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Trandolapril/Verapamil out of the reach of children and away from pets.

General information:

• If you have any questions about Trandolapril/Verapamil, please talk with your doctor, pharmacist, or other health care provider.
• Trandolapril/Verapamil is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Trandolapril/Verapamil. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Tramadol/

Acetaminophen

Generic Name: Tramadol/Acetaminophen (TRAM-a-dol/a-SEET-a-MIN-oh-fen)
Brand Name: Ultracet

Tramadol/Acetaminophen is used for:

Short-term treatment (5 days or less) of pain.

Tramadol/Acetaminophen is an analgesic combination. It works in certain areas of the brain and nervous system to decrease pain. The combination may provide better pain relief than either medicine alone.

Do NOT use Tramadol/Acetaminophen if:

• you are allergic to any ingredient in Tramadol/Acetaminophen or to any other codeine-or morphine-related medicine (eg, codeine, oxycodone, hydrocodone, dihydrocodeine, hydromorphone)
• you have severe diarrhea due to taking an antibiotic
• you are intoxicated with alcohol, other opioids or narcotics (eg, morphine, codeine), sedatives or sleeping medicines (eg, temazepam, zolpidem), or other medicines
• you are taking nefazodone or carbamazepine
• you have liver problems
• you are taking any other medicine containing tramadol or acetaminophen

Contact your doctor or health care provider right away if any of these apply to you.

Before using Tramadol/Acetaminophen:

Some medical conditions may interact with Tramadol/Acetaminophen. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription (especially depression medicines) or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of alcoholism or substance abuse, or if you consume more than 3 alcoholic drinks per day
• if you have considered or attempted suicide
• if you have or recently have had any head injury, brain injury or tumor, increased pressure in the brain, infection of the brain or nervous system, epilepsy, or seizures
• if you have asthma or other lung or breathing problems
• if you have or have a history of stomach or intestinal problems, chronic inflammation or ulceration of the bowel, or if you have had recent abdominal surgery
• if you have heart problems, liver problems (eg, hepatitis), kidney problems, thyroid problems, enlargement of the prostate gland, or urinary problems

Some MEDICINES MAY INTERACT with Tramadol/Acetaminophen. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Carbamazepine because it may decrease Tramadol/Acetaminophen’s effectiveness and the risk of seizures may be increased
• Certain medicines for mental or mood disorders (eg, olanzapine, haloperidol), cyclobenzaprine, isoniazid, other opioid pain medicines (eg, codeine, hydrocodone), phenothiazines (eg, promethazine), sleeping medicines (eg, zolpidem), tricyclic antidepressants (amitriptyline), or weight loss medicines (eg, phentermine) because side effects, including excessive drowsiness, trouble breathing, liver problems, or seizures may be increased
• Linezolid, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), nefazodone, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), or selegiline because they may cause serious and sometimes fatal reactions including restlessness, fever, excessive sweating, confusion, twitching, and seizures
• Oral anticoagulants (eg, warfarin) because the risk of their side effects, including bleeding, may be increased by Tramadol/Acetaminophen
• Digoxin because the risk of its side effects, including nausea, vomiting, or slow heartbeat, may be increased by Tramadol/Acetaminophen

This may not be a complete list of all interactions that may occur. Ask your health care provider if Tramadol/Acetaminophen may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Tramadol/Acetaminophen:

Use Tramadol/Acetaminophen as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Tramadol/Acetaminophen by mouth with or without food.
• Do not use Tramadol/Acetaminophen for more than 5 days unless advised to do so by your doctor.
• Do not take more than 8 tablets per day. Do not take more than 4 tablets per day if you have kidney problems.
• If you miss a dose of Tramadol/Acetaminophen and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Tramadol/Acetaminophen.

Important safety information:

• Tramadol/Acetaminophen may cause drowsiness and dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Tramadol/Acetaminophen with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Tramadol/Acetaminophen; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
• Tramadol/Acetaminophen may cause dizziness; alcohol, hot weather, exercise, or fever may increase this effect. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of this effect.
• Tell your doctor or dentist that you take Tramadol/Acetaminophen before you receive any medical or dental care, emergency care, or surgery.
• Tramadol/Acetaminophen has acetaminophen in it. Before you start any new medicine, check the label to see if it has acetaminophen in it too. If it does or if you are not sure, check with your doctor or pharmacist.
• Talk to your doctor before you take Tramadol/Acetaminophen if you drink more than 3 drinks with alcohol per day. Tramadol/Acetaminophen may cause stomach bleeding. Your risk may be greater if you drink alcohol while you are using Tramadol/Acetaminophen.
• Use Tramadol/Acetaminophen with caution in the ELDERLY; they may be more sensitive to its effects.
• Tramadol/Acetaminophen should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: Tramadol/Acetaminophen has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Tramadol/Acetaminophen while you are pregnant. Tramadol/Acetaminophen is found in breast milk. Do not breast-feed while taking Tramadol/Acetaminophen.

When used for long periods of time or at high doses, Tramadol/Acetaminophen may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Tramadol/Acetaminophen stops working well. Do not take more than prescribed.

Some people who use Tramadol/Acetaminophen for a long time without a break may develop a physical need to continue taking it. This is known as physical DEPENDENCE. If you suddenly stop taking Tramadol/Acetaminophen, you may experience WITHDRAWAL symptoms including anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea and vomiting; pain; rigid muscles; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping.

Possible side effects of Tramadol/Acetaminophen:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; increased sweating; loss of appetite; nausea.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe seizures (convulsions).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( http://www.aapcc.org), or emergency room immediately. Symptoms may include bluish skin; cold clammy skin; difficult or slow breathing; drowsiness leading to unresponsiveness or coma; excessive sweating; loss of function in the heart and lungs; nausea and vomiting; pinpoint pupils; seizure (convulsions); stomach or intestinal pain.

Proper storage of Tramadol/Acetaminophen:

Store Tramadol/Acetaminophen at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Tramadol/Acetaminophen out of the reach of children and away from pets.

General information:

• If you have any questions about Tramadol/Acetaminophen, please talk with your doctor, pharmacist, or other health care provider.
• Tramadol/Acetaminophen is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Tramadol/Acetaminophen. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: Tramadol (TRAM-a-dol)
Brand Name: Ultram

Tramadol is used for:

Treating moderate to moderately severe pain.

Tramadol is an analgesic. It works in certain areas of the brain and nervous system to decrease pain.

Do NOT use Tramadol if:

• you are allergic to any ingredient in Tramadol
• you have had a severe allergic reaction (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue) to codeine or other opioids (eg, morphine)
• you are intoxicated with alcohol, other opioids or narcotics (eg, codeine, morphine), sedatives or sleeping medicines (eg, temazepam, zolpidem), or other medicines
• you have severe liver or kidney problems
• you are taking carbamazepine, nefazodone, sodium oxybate (GHB), a thioxanthene (eg, thiothixene), or another product that contains tramadol

Contact your doctor or health care provider right away if any of these apply to you.

Before using Tramadol:

Some medical conditions may interact with Tramadol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription (especially depression medicines) or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have liver, kidney, or thyroid problems; a blockage in the bladder; diabetes; heart problems; high blood pressure; prostate problems; or metabolism problems
• if you have or recently have had any head injury, brain injury or tumor, increased pressure in the brain, or infection of the brain or nervous system
• if you have a history of diarrhea caused by antibiotic use, recent stomach or bowel surgery, or any other stomach or bowel problems (eg, pain, inflammation, ulcers)
• if you have a history of lung or breathing problems (eg, asthma, chronic obstructive pulmonary disease [COPD]) or a seizure disorder (eg, epilepsy)
• if you are going through withdrawal from alcohol or other substances or if you have a history of alcohol or other substance abuse, mood or mental problems (eg, depression), or suicidal thoughts or actions

Some MEDICINES MAY INTERACT with Tramadol. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Azole antifungals (eg, ketoconazole), linezolid, lithium, macrolide antibiotics (eg, erythromycin), nefazodone, quinidine, selective serotonin and norepinephrine reuptake inhibitors (SNRIs) (eg, duloxetine), selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine, paroxetine), St. John’s wort, tricyclic antidepressants (eg, amitriptyline), or triptans (eg, sumatriptan) because serotonin syndrome may occur
• Anorexiants (eg, phentermine), buytrophenones (eg, haloperidol), certain medicines for mental or mood disorders (eg, olanzapine), cyclobenzaprine, furazolidone, loxapine, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine, selegiline), molindone, other opioid pain medicine (eg, codeine, hydrocodone), phenothiazines (eg, promethazine), sodium oxybate (GHB), thioxanthenes (eg, thiothixene), or tiagabine, because the risk of side effects, including excessive drowsiness, trouble breathing, liver problems, or seizures, may be increased
• Other products containing tramadol because they may increase the risk of Tramadol’s side effects
• Rifampin because it may decrease Tramadol’s effectiveness
• Carbamazepine because it may decrease Tramadol’s effectiveness; the risk of seizures may also be increased
• Anticoagulants (eg, warfarin) or digoxin because the risk of their side effects may be increased by Tramadol

This may not be a complete list of all interactions that may occur. Ask your health care provider if Tramadol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Tramadol:

Use Tramadol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Tramadol by mouth with or without food.
• If you miss a dose of Tramadol and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Tramadol.

Important safety information:

• Tramadol may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Tramadol with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Tramadol; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
• Tramadol may cause dizziness; alcohol, hot weather, exercise, or fever may increase this effect. To prevent it, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of this effect.
• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
• Tell your doctor or dentist that you take Tramadol before you receive any medical or dental care, emergency care, or surgery.
• Serotonin syndrome is a possibly fatal syndrome that can be caused by Tramadol. Your risk may be greater if you take Tramadol with certain other medicines (eg, “triptans,” MAOIs). Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms.
• Use Tramadol with caution in the ELDERLY; they may be more sensitive to its effects, especially constipation, weakness or tiredness, severe lightheadedness, and indigestion.
• Tramadol should not be used in CHILDREN younger than 16 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: Tramadol has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Tramadol while you are pregnant. Tramadol is found in breast milk. Do not breast-feed while taking Tramadol.

When used for long periods of time or at high doses, Tramadol may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Tramadol stops working well. Do not take more than prescribed.

Some people who use Tramadol for a long time without a break may develop a physical need to continue taking it. This is known as physical DEPENDENCE. If you suddenly stop taking Tramadol, you may experience WITHDRAWAL symptoms, including anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; seeing, hearing or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping.

Possible side effects of Tramadol:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; nausea; trouble sleeping; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; chest pain; difficult or painful urination; disorientation; fainting; hallucinations; irregular heartbeat; loss of coordination; mood or mental changes (eg, depression); red, blistered, swollen, or peeling skin; seizures; severe dizziness or lightheadedness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include bluish skin; cold clammy skin; difficult or slow breathing; drowsiness leading to unresponsiveness or coma; excessive sweating; limp muscles; pinpoint pupils; seizures; slow or irregular heartbeat.

Proper storage of Tramadol:

Store Tramadol at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Tramadol out of the reach of children and away from pets.

General information:

• If you have any questions about Tramadol, please talk with your doctor, pharmacist, or other health care provider.
• Tramadol is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Tramadol. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.