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oxytetracycline and polymyxin B ophthalmic

30/06/10

Generic Name: oxytetracycline and polymyxin B ophthalmic (ox ee te tra SYE kleen and paw lee MIX in)
Brand Names: Terak, Terramycin with Polymyxin B Sulfate

What is oxytetracycline and polymyxin B ophthalmic?

Oxytetracycline and polymyxin B are antibiotics. They are used to treat bacterial infections.

The ophthalmic form of oxytetracycline and polymyxin B is used to treat bacterial infections of the eyes.

Oxytetracycline and polymyxin B ophthalmic may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about oxytetracycline and polymyxin B ophthalmic?

Contact your doctor if your symptoms begin to get worse or if you do not see any improvement in your condition after a few days.

Do not touch the tube opening to any surface, including your eyes or hands. The tube opening is sterile. If it becomes contaminated, it could cause an infection in your eye.

Who should not use oxytetracycline and polymyxin B ophthalmic?

Do not use oxytetracycline and polymyxin B ophthalmic if you have a viral or fungal infection in your eye. It is used to treat infections caused by bacteria only. It is not known whether oxytetracycline and polymyxin B ophthalmic will harm an unborn baby. Do not use this medication without first talking to your doctor if you are pregnant. It is not known whether oxytetracycline and polymyxin B ophthalmic passes into breast milk. Do not use this medication without first talking to your doctor if you are breast-feeding a baby.

How should I use oxytetracycline and polymyxin B ophthalmic?

Use oxytetracycline and polymyxin B ophthalmic ointment exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Wash your hands before and after using your eye ointment.

To apply the ointment:

Hold the tube in your hand for a few minutes to warm it up so that the ointment comes out easily. Tilt your head back slightly and pull down gently on your lower eyelid. Apply a thin film of the ointment into your lower eyelid. Close your eye and roll your eyeball around in all directions for 1 to 2 minutes. If you are applying another eye medication, allow at least 10 minutes before your next application.

Do not touch the tube opening to any surface, including your eyes or hands. The tube opening is sterile. If it becomes contaminated, it could cause an infection in your eye. Store oxytetracycline and polymyxin B ophthalmic at room temperature away from moisture and heat. Keep the tube properly capped.

What happens if I miss a dose?

Apply the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and apply the next one as directed. Do not use a double dose of this medication.

What happens if I overdose?

An overdose of this medication is unlikely to occur. If you do suspect an overdose, wash the eye with water and call an emergency room or poison control center near you. If the ointment has been ingested, drink plenty of fluid and call an emergency center for advice.

What should I avoid while using oxytetracycline and polymyxin B ophthalmic?

Do not touch the tube opening to any surface, including your eyes or hands. The tube opening is sterile. If it becomes contaminated, it could cause an infection in your eye. Use caution when driving, operating machinery, or performing other hazardous activities. Oxytetracycline and polymyxin B ophthalmic may cause blurred vision. If you experience blurred vision, avoid these activities.

Use caution with contact lenses. Wear them only if your doctor approves. After applying this medication, wait at least 15 minutes before inserting contact lenses.

Avoid other eye medications unless your doctor approves.

Oxytetracycline and polymyxin B ophthalmic side effects

Serious side effects are not expected with this medication.

Commonly, some burning, stinging, irritation, itching, redness, blurred vision, eyelid itching, eyelid swelling or crusting, tearing, or sensitivity to light may occur. Continue to use oxytetracycline and polymyxin B ophthalmic and talk to your doctor about any side effects you experience.

What other drugs will affect oxytetracycline and polymyxin B ophthalmic?

Avoid other eye medications unless they are approved by your doctor.

Drugs other than those listed here may also interact with oxytetracycline and polymyxin B ophthalmic. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

Your pharmacist has additional information about oxytetracycline and polymyxin B ophthalmic written for health professionals that you may read.

What does my medication look like?

Oxytetracycline and polymyxin B ophthalmic is available with a prescription under the brand names Terak Ointment and Terramycin with Polymyxin B Ointment. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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30/06/10

Oxytetracycline/

Polymyxin B Sulfate Ointment

Generic Name: Oxytetracycline/Polymyxin B Sulfate (OX-i-TET-ra-SYE-kleen/POL-ee-MIX-in)
Brand Name: Terak and Terramycin with Polymyxin B

Oxytetracycline/Polymyxin B Sulfate Ointment is used for:

Treating eye infections caused by certain bacteria. It may be used alone or with other medicines.

Oxytetracycline/Polymyxin B Sulfate Ointment is an antibiotic combination. It works by interfering with the bacteria’s cell wall and the production of the bacteria’s proteins, which kills the bacteria.

Do NOT use Oxytetracycline/Polymyxin B Sulfate Ointment if:

you are allergic to any ingredient in Oxytetracycline/Polymyxin B Sulfate Ointment or to other tetracyclines (eg, doxycycline)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Oxytetracycline/Polymyxin B Sulfate Ointment:

Some medical conditions may interact with Oxytetracycline/Polymyxin B Sulfate Ointment. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Oxytetracycline/Polymyxin B Sulfate Ointment. Because little, if any, of Oxytetracycline/Polymyxin B Sulfate Ointment is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Oxytetracycline/Polymyxin B Sulfate Ointment may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Oxytetracycline/Polymyxin B Sulfate Ointment:

Use Oxytetracycline/Polymyxin B Sulfate Ointment as directed by your doctor. Check the label on the medicine for exact dosing instructions.

To use Oxytetracycline/Polymyxin B Sulfate Ointment in the eye, first, wash your hands. Using your index finger, pull the lower eyelid away from your eye to form a pouch. Squeeze a thin strip of ointment into the pouch. After using Oxytetracycline/Polymyxin B Sulfate Ointment, gently close your eyes for 1 to 2 minutes. Wash your hands to remove any medicine that may be on them. Wipe the applicator tip with a clean, dry tissue.
To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.
If you miss a dose of Oxytetracycline/Polymyxin B Sulfate Ointment, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Oxytetracycline/Polymyxin B Sulfate Ointment.

Important safety information:

Be sure to use Oxytetracycline/Polymyxin B Sulfate Ointment for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
Long-term or repeated use of Oxytetracycline/Polymyxin B Sulfate Ointment may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
Oxytetracycline/Polymyxin B Sulfate Ointment only works against bacteria; it does not treat viral infections (eg, the common cold).
PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Oxytetracycline/Polymyxin B Sulfate Ointment while you are pregnant. It is not known if Oxytetracycline/Polymyxin B Sulfate Ointment is found in breast milk. If you are or will be breast-feeding while you use Oxytetracycline/Polymyxin B Sulfate Ointment, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Oxytetracycline/Polymyxin B Sulfate Ointment:

All medicines may cause side effects, but many people have no, or minor, side effects. When used in small doses, no COMMON side effects have been reported with this product. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); eye swelling or redness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Oxytetracycline/Polymyxin B Sulfate Ointment:

Store Oxytetracycline/Polymyxin B Sulfate Ointment at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Oxytetracycline/Polymyxin B Sulfate Ointment out of the reach of children and away from pets.

General information:

If you have any questions about Oxytetracycline/Polymyxin B Sulfate Ointment, please talk with your doctor, pharmacist, or other health care provider.
Oxytetracycline/Polymyxin B Sulfate Ointment is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Oxytetracycline/Polymyxin B Sulfate Ointment. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: May 5, 2010

Database Edition 10.2.1.002

Med-facts,O

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Oxymorphone Suppositories

30/06/10

Generic Name: Oxymorphone (ox-ee-MOR-fone)
Brand Name: Numorphan

Oxymorphone Suppositories are used for:

Treating moderate to severe pain. It may be used before surgery to cause sedation and reduce anxiety. It may also be used for other conditions as determined by your doctor.

Oxymorphone Suppositories are a narcotic pain reliever. It works by dulling the pain perception center in the brain. It may also affect other body systems (eg, respiratory and circulatory systems) at higher doses.

Do NOT use Oxymorphone Suppositories if:

you are allergic to any ingredient in Oxymorphone Suppositories or any other oxymorphone- or morphine-related medicine (eg, codeine)
you are taking sodium oxybate (GHB)
you have severe bowel motility problems (eg, paralytic ileus) or severe diarrhea associated with antibiotic use (pseudomembranous colitis)
you have severely slow or difficult breathing, fluid in the lungs due to chemical irritation, or severe asthma, or you are having an asthma attack

Contact your doctor or health care provider right away if any of these apply to you.

Before using Oxymorphone Suppositories:

Some medical conditions may interact with Oxymorphone Suppositories. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, plan to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines or other substances
if you have a history of asthma, chronic obstructive pulmonary disease (COPD), trouble breathing while asleep (eg, sleep apnea), or other lung or breathing problems
if you have a history of recent head injury, increased pressure in the brain, growths in the brain (eg, tumors), or seizures
if you have a history of heart problems, low blood pressure, liver or kidney problems, underactive thyroid, adrenal gland problems (eg, Addison disease), increased pressure in the eye, glaucoma, stomach or bowel problems, gallbladder problems, inflammation of the pancreas, a blockage of the bladder or bowel, an enlarged prostate, or the blood disease porphyria
if you have a history of drug or alcohol abuse, mood or mental problems, or suicidal thoughts or behavior

Some MEDICINES MAY INTERACT with Oxymorphone Suppositories. Tell your health care provider if you are taking any other medicines, especially any of the following:

Cimetidine, furazolidone, monoamine oxidase (MAO) inhibitors (eg, phenelzine), phenothiazines (eg, chlorpromazine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because the risk of side effects such as severe drowsiness, slow or difficult breathing, confusion, and seizures may be increased
Buprenorphine, butorphanol, nalbuphine, naltrexone, or pentazocine because the effectiveness of Oxymorphone Suppositories may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Oxymorphone Suppositories may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Oxymorphone Suppositories:

Use Oxymorphone Suppositories as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Oxymorphone Suppositories are a rectal suppository. If the suppository is too soft to use, put it in the refrigerator for about 15 minutes or run cold water over it. Then remove the wrapper and moisten the suppository with cool water. Lie down on your side. Insert the pointed end of the suppository into the rectum, then use your finger to push it in completely. Wash your hands thoroughly after using Oxymorphone Suppositories.
If you miss a dose of Oxymorphone Suppositories and you are using it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Oxymorphone Suppositories.

Important safety information:

Oxymorphone Suppositories may cause dizziness or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Oxymorphone Suppositories. Using Oxymorphone Suppositories alone, with other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Oxymorphone Suppositories. Oxymorphone Suppositories will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
Oxymorphone Suppositories may cause dizziness, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.
Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Oxymorphone Suppositories.
Use Oxymorphone Suppositories with caution in the ELDERLY because they may be more sensitive to its effects.
Use Oxymorphone Suppositories with extreme caution in CHILDREN younger than 18 years of age. Safety and effectiveness in this age group have not been confirmed.
PREGNANCY AND BREAST-FEEDING: If you become pregnant while taking Oxymorphone Suppositories, discuss with your doctor the benefits and risks of using Oxymorphone Suppositories during pregnancy. It is unknown if Oxymorphone Suppositories are excreted in breast milk. If you are or will be breast-feeding while you are using Oxymorphone Suppositories, check with your doctor or pharmacist to discuss the risks to your baby.

When used for long periods of time or at high doses, Oxymorphone Suppositories may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Oxymorphone Suppositories stops working well. Do not take more than prescribed.

When used for long periods of time or at high doses, some people develop a need to continue taking Oxymorphone Suppositories. This is known as DEPENDENCE or addiction.

If you suddenly stop taking Oxymorphone Suppositories, you may experience WITHDRAWAL symptoms including anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; hallucinations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; shivering or tremors; sweating; and trouble sleeping.

Possible side effects of Oxymorphone Suppositories:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; headache; nausea; sleeplessness; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; difficulty urinating; fast or slow heartbeat; seizures; severe dizziness, lightheadedness, or fainting; slowed or difficult breathing; stomach pain; tremor; vision changes.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include cold and clammy skin; confusion; loss of consciousness; seizures; severe drowsiness, dizziness, or lightheadedness; slow breathing; slow heartbeat.

Proper storage of Oxymorphone Suppositories:

Store Oxymorphone Suppositories in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Do not store in the bathroom. Keep Oxymorphone Suppositories out of the reach of children and away from pets.

General information:

If you have any questions about Oxymorphone Suppositories, please talk with your doctor, pharmacist, or other health care provider.
Oxymorphone Suppositories are to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Oxymorphone Suppositories. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: May 5, 2010

Database Edition 10.2.1.002

Med-facts,O

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Oxymorphone Extended-Release Tablets

30/06/10

Generic Name: Oxymorphone (OX-i-MOR-fone)
Brand Name: Opana ER

Oxymorphone Extended-Release Tablets are used to treat constant (around-the-clock), moderate to severe pain that is expected to last for an extended amount of time. Oxymorphone Extended-Release Tablets are not for patients who only need occasional or “as-needed” pain relief.

Oxymorphone Extended-Release Tablets must be swallowed whole. Do NOT break, crush, dissolve, or chew Oxymorphone Extended-Release Tablets before swallowing it. Do not drink alcohol or take medicines that contain alcohol while you are using Oxymorphone Extended-Release Tablets. Doing any of these things may cause Oxymorphone Extended-Release Tablets to be absorbed into the body too quickly. This could result in very serious side effects, including severe trouble breathing and death from overdose. If you are unsure if any of your medicines contain alcohol, check with your doctor or pharmacist.

Oxymorphone Extended-Release Tablets are used for:

Treating pain in adults with constant (around-the-clock), moderate to severe pain that is expected to last for an extended period of time. Oxymorphone Extended-Release Tablets are not for use right after surgery if you have not already been using narcotic pain relievers, or if the pain is mild or not expected to last for an extended period of time.

Oxymorphone Extended-Release Tablets are an opioid (narcotic) analgesic. It works by binding to certain receptors in the brain and nervous system to reduce pain.

Do NOT use Oxymorphone Extended-Release Tablets if:

you are allergic to any ingredient in Oxymorphone Extended-Release Tablets or any other codeine- or morphine-related medicine (eg, morphine, codeine, oxycodone)
you have difficult or slowed breathing, high levels of carbon dioxide in the blood, or severe asthma, or you are having an asthma attack
you are in labor
you have moderate to severe liver problems
you have severe diarrhea, bowel problems caused by antibiotics or food poisoning, or certain other severe bowel problems (eg, paralytic ileus)
you are taking sodium oxybate (GHB) or an agonist/antagonist analgesic (eg, pentazocine)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Oxymorphone Extended-Release Tablets:

Some medical conditions may interact with Oxymorphone Extended-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have a history of lung or breathing problems (eg, asthma, emphysema, bronchitis, chronic obstructive pulmonary disease [COPD]), sleep apnea (you stop breathing when you sleep), curvature of the spine (eg, kyphoscoliosis), heart problems (eg, cor pulmonale), low blood pressure, dehydration, or low blood volume
if you have severe drowsiness, a recent head injury, growths in the brain, increased pressure in the brain, or a history of seizures (eg, epilepsy)
if you have liver or kidney problems, gallbladder or pancreas problems, adrenal gland problems (eg, Addison disease), an underactive thyroid, an enlarged prostate, a urinary blockage, or stomach or bowel problems (eg, inflammation), or if you have had recent stomach or bowel surgery.
if you drink alcohol regularly, have symptoms of alcohol withdrawal, or have a history of suicidal thoughts or attempts
if you have a personal or family history of mental or mood problems, alcohol abuse, or other substance abuse or dependence
if you are in poor health or shock, are very overweight, or will be having surgery

Some MEDICINES MAY INTERACT with Oxymorphone Extended-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

Phenothiazines (eg, chlorpromazine) because the risk of low blood pressure may be increased
Barbiturate anesthetics (eg, thiopental), cimetidine, or sodium oxybate (GHB) because the risk of severe drowsiness, coma, confusion, or slowed or difficult breathing may be increased
Anticholinergics (eg, scopolamine, benztropine) because the risk of severe constipation or trouble urinating may be increased
Monoamine oxidase inhibitors (MAOIs) (eg, phenelzine) because the risk of a severe reaction including fever, seizures, and coma may be increased
Agonist/antagonist analgesics (eg, pentazocine) or naltrexone because they may decrease Oxymorphone Extended-Release Tablets’s effectiveness and withdrawal may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if Oxymorphone Extended-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Oxymorphone Extended-Release Tablets:

Use Oxymorphone Extended-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Oxymorphone Extended-Release Tablets on an empty stomach at least 1 hour before or 2 hours after eating.
Oxymorphone Extended-Release Tablets must only be taken by mouth.
Swallow Oxymorphone Extended-Release Tablets whole. Do not break, crush, dissolve, or chew the tablet.
If you are taking Oxymorphone Extended-Release Tablets for persistent pain, take it on a regular schedule to help control the pain more effectively.
Do not change your dose or suddenly stop taking Oxymorphone Extended-Release Tablets without checking with your doctor.
If Oxymorphone Extended-Release Tablets are no longer needed, dispose of it as soon as possible. Ask your doctor or pharmacist how to dispose of Oxymorphone Extended-Release Tablets properly.
If you miss a dose of Oxymorphone Extended-Release Tablets and you are taking it regularly, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Oxymorphone Extended-Release Tablets.

Important safety information:

Oxymorphone Extended-Release Tablets may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol, other opiate pain medicines, or certain other medicines. Use Oxymorphone Extended-Release Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Do not drink alcohol, take medicines that contain alcohol, or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you take Oxymorphone Extended-Release Tablets; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
Oxymorphone Extended-Release Tablets may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
Oxymorphone Extended-Release Tablets may be habit forming. Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor. Misuse or abuse of Oxymorphone Extended-Release Tablets may cause severe side effects, including severe breathing problems, seizures, coma, and possibly death.
Constipation is a common side effect of Oxymorphone Extended-Release Tablets. Talk to your doctor about using laxatives or stool softeners to prevent or treat constipation while you use Oxymorphone Extended-Release Tablets.
If your pain continues or becomes worse or if you have side effects that concern you, contact your doctor.
Tell your doctor or dentist that you take Oxymorphone Extended-Release Tablets before you receive any medical or dental care, emergency care, or surgery.
Use Oxymorphone Extended-Release Tablets with caution in the ELDERLY; they may be more sensitive to its effects, especially drowsiness, dizziness, confusion, and nausea.
Oxymorphone Extended-Release Tablets should be used with extreme caution in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
PREGNANCY and BREAST-FEEDING: Oxymorphone Extended-Release Tablets may cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Oxymorphone Extended-Release Tablets while you are pregnant. It is unknown if Oxymorphone Extended-Release Tablets are found in breast milk. Do not breast-feed while taking Oxymorphone Extended-Release Tablets.

When used for long periods of time or at high doses, Oxymorphone Extended-Release Tablets may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Oxymorphone Extended-Release Tablets stops working well. Do not take more than prescribed.

Some people who use Oxymorphone Extended-Release Tablets for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction. Dependence is unlikely to be an issue in terminally ill patients where comfort is more important. If you are taking Oxymorphone Extended-Release Tablets regularly, do not suddenly stop taking it without checking with your doctor. WITHDRAWAL symptoms have occurred when Oxymorphone Extended-Release Tablets are suddenly stopped and may include anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea and vomiting; pain; rigid muscles; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping. Contact your doctor if you notice any of these symptoms after stopping Oxymorphone Extended-Release Tablets.

Possible side effects of Oxymorphone Extended-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; constipation; decreased appetite; dizziness; drowsiness; dry mouth; gas; headache; lightheadedness; nausea; sweating; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; fainting; fast, slow, or irregular heartbeat; fever; hallucinations; mental or mood changes; seizure; severe or persistent dizziness or drowsiness; severe or persistent headache or vomiting; shallow, slowed, or difficult breathing; trouble urinating; unusual swelling; vision changes.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include bluish skin; chest pain; cold and clammy skin; coma; difficult or slow breathing; limp muscles; numbness of an arm or leg; pinpoint pupils; severe drowsiness or dizziness; slow or irregular heartbeat.

Proper storage of Oxymorphone Extended-Release Tablets:

Store Oxymorphone Extended-Release Tablets at 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Do not store Oxymorphone Extended-Release Tablets in the bathroom. Keep Oxymorphone Extended-Release Tablets out of the reach of children and away from pets.

General information:

If you have any questions about Oxymorphone Extended-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.
Oxymorphone Extended-Release Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Oxymorphone Extended-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: May 5, 2010

Database Edition 10.2.1.002

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Oxymorphone hydrochloride

30/06/10

Brand names: Opana ER

Why is Oxymorphone hydrochloride prescribed?

Opana ER is used to treat moderate-to-severe pain in people needing around-the-clock opioid treatment for a long period of time. It should not be used 12 to 24 hours after surgery.

Most important fact about Oxymorphone hydrochloride

Do not break, chew, dissolve, or crush Opana ER tablets. Taking tablets in this way could cause a deadly dose of oxymorphone to be released into the body. Also, while on Opana ER therapy, you should not consume any alcohol, including prescription or nonprescription drugs that contain alcohol. Having alcohol with Opana ER may cause an overdose of oxymorphone.

How should you take Oxymorphone hydrochloride?

Opana ER should be taken on an empty stomach, at least one hour prior to or two hours after eating. Opana ER tablets should be swallowed whole and should not to be broken, chewed, dissolved, or crushed.

If you miss a dose…
If you miss a dose, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take two doses at once unless your doctor tells you to. If you are not sure about your dosing schedule, call your doctor.

Storage instructions…
Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Oxymorphone hydrochloride.

Side effects may include:
Constipation, dizziness (vertigo), feeling of tiredness, headache, itchiness, nausea, sleeplessness, sweating, vomiting

Why should Oxymorphone hydrochloride not be prescribed?

Do not take Opana ER if you have breathing problems, such as severe asthma, or if you are allergic to any of its ingredients. Also, you should not take Oxymorphone hydrochloride if you do not need pain treatment for a prolonged period of time.

Special warnings about Oxymorphone hydrochloride

Avoid taking broken, dissolved, or crushed Opana ER tablets. Taking anything other than whole tablets can lead to a fatal overdose of oxymorphone.

While using Opana ER, do not eat or drink anything that contains alcohol (e.g., alcoholic beverages or certain medications). Alcohol may cause an overdose of oxymorphone.

Opana ER can make you sleepy. Do not drive, operate heavy machinery, or participate in any other possibly dangerous activities until you know how this medicine affects you.

Tell the doctor about your complete medical history, especially if you have a history of the following: breathing problems, liver or kidney problems, brain injury, Addison’s disease, seizures, problems urinating, prostate trouble, or a history of drug or alcohol dependency.

Possible food and drug interactions when taking Oxymorphone hydrochloride

If Opana ER is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Opana ER with the following:

Alcohol
General anesthetics
Hypnotics
Opioids
Phenothiazines
Sedatives
Tranquilizers

Special information if you are pregnant or breastfeeding

The effects of Opana ER during pregnancy and breastfeeding are unknown. Talk with your doctor before taking Oxymorphone hydrochloride if you are pregnant, plan to become pregnant, or are breastfeeding.

Recommended dosage for Oxymorphone hydrochloride

ADULTS

Initial Therapy
If you have never used an opioid drug before, the recommended initial dose of Opana ER is 5 milligrams every 12 hours. Depending on how you respond, the doctor may increase the dose slowly at increments of 5-10 milligrams every 12 hours.

Switching from Opana to Opana ER
If you are currently taking regular Opana, the doctor will decide which dosage of Opana ER is right for you.

Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

Symptoms of Opana ER overdose include:
Cold and clammy skin, coma, constricted (small) pupils, death, heart problems, low blood pressure, problems breathing, severe sleepiness

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oxymorphone (Oral route)

30/06/10

ox-i-MOR-fone

Oral routeTablet, Extended Release

Opana(R) ER contains oxymorphone, which is a morphine-like opioid agonist and a Schedule II controlled substance, with an abuse liability similar to other opioid analgesics.

Oxymorphone can be abused in a manner similar to other opioid agonists, legal or illicit. This should be considered when prescribing or dispensing Opana(R) ER in situations where the physician or pharmacist is concerned about an increased risk of misuse, abuse, or diversion.

Opana(R) ER is an extended-release oral formulation of oxymorphone indicated for the management of moderate to severe pain when a continuous, around-the-clock opioid analgesic is needed for an extended period of time.

Opana(R) ER is NOT intended for use as a prn analgesic.

Opana(R) ER tablets are to be swallowed whole and are not to be broken, chewed, dissolved, or crushed. Taking broken, chewed, dissolved, or crushed Opana(R) ER tablets leads to rapid release and absorption of a potentially fatal dose of oxymorphone.

Patients must not consume alcoholic beverages, or prescription or nonprescription medications containing alcohol, while on Opana(R) ER therapy. The co-ingestion of alcohol with Opana(R) ER may result in increased plasma levels and a potentially fatal overdose of oxymorphone .

OPANA(R) ER contains oxymorphone, a Schedule II controlled substance with an abuse liability similar to other opioid analgesics. OPANA(R) ER is an extended-release oral formulation of oxymorphone indicated for the management of moderate to severe pain when a continuous, around-the-clock opioid analgesic is needed for an extended period of time. Extended release tablets should be swallowed whole; not broken, chewed, dissolved, or crushed. Avoid alcohol and alcohol-containing medications as consumption of alcohol may result in increased plasma levels and a potentially fatal overdose of oxymorphone .

Commonly used brand name(s):

In the U.S.

Opana
Opana ER

Available Dosage Forms:

Tablet, Extended Release
Tablet

Therapeutic Class: Analgesic

Chemical Class: Opioid

Uses For oxymorphone

Oxymorphone is a narcotic analgesic. It acts in the central nervous system (CNS) to relieve pain. Many of its side effects are also caused by actions in the CNS .

When oxymorphone is used for a long time, it may become habit-forming (causing mental or physical dependence). However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by reducing the dose gradually over a period of time before treatment is stopped completely. Your doctor will take this into consideration when deciding on the amount of oxymorphone you should receive .

oxymorphone is available only with your doctor’s prescription .

Before Using oxymorphone

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For oxymorphone, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to oxymorphone or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of oxymorphone in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of oxymorphone in the elderly. However, elderly patients are more likely to have age-related liver, kidney or heart problems, which may require an adjustment of dosage in patients receiving oxymorphone .

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using oxymorphone with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Naltrexone

Using oxymorphone with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Adinazolam
Alfentanil
Alprazolam
Amobarbital
Anileridine
Aprobarbital
Bromazepam
Brotizolam
Buprenorphine
Butabarbital
Butalbital
Butorphanol
Carisoprodol
Chloral Hydrate
Chlordiazepoxide
Chlorzoxazone
Clobazam
Clonazepam
Clorazepate
Codeine
Dantrolene
Dezocine
Diazepam
Estazolam
Ethchlorvynol
Fentanyl
Flunitrazepam
Flurazepam
Fospropofol
Halazepam
Hydrocodone
Hydromorphone
Ketazolam
Levorphanol
Lorazepam
Lormetazepam
Medazepam
Meperidine
Mephenesin
Mephobarbital
Meprobamate
Metaxalone
Methocarbamol
Methohexital
Midazolam
Morphine
Morphine Sulfate Liposome
Nalbuphine
Nitrazepam
Nordazepam
Opium
Oxazepam
Oxycodone
Oxymorphone
Pentazocine
Pentobarbital
Phenobarbital
Prazepam
Propoxyphene
Quazepam
Remifentanil
Secobarbital
Sodium Oxybate
Sufentanil
Tapentadol
Temazepam
Thiopental
Triazolam

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Using oxymorphone with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use oxymorphone, or give you special instructions about the use of food, alcohol, or tobacco.

Ethanol

Proper Use of oxymorphone

It is best to take oxymorphone on an empty stomach, at least one hour before or two hours after a meal .

Swallow the extended-release tablet whole. Do not crush, dissolve, break, or chew it .

Do not interrupt or stop taking oxymorphone without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are taking before stopping it completely. Withdrawal side effects may occur when the medicine is stopped suddenly because your body has become used to oxymorphone .

Dosing

The dose of oxymorphone will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of oxymorphone. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For pain:
- For oral dosage form (tablets):
  - Adults—At first, 5 milligrams (mg) every four to six hours. Your doctor may adjust your dose if needed.
  - Children—Use and dose must be determined by your doctor .
- For oral dosage form (extended-release tablets):
  - Adults—At first, 5 milligrams (mg) every 12 hours. Your doctor may adjust your dose if needed.
  - Children—Use and dose must be determined by your doctor .

Missed Dose

If you miss a dose of oxymorphone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using oxymorphone

If you will be taking oxymorphone for a long time, it is very important that your doctor check you at regular visits for any problems or unwanted effects that may be caused by oxymorphone.

Oxymorphone may increase your risk of having serious breathing problems. Check with your doctor right away if you are having difficult or troubled breathing; irregular, fast, slow, or shallow breathing; pale or blue lips, fingernails, or skin; or shortness of breath .

oxymorphone will add to the effects of alcohol and other CNS depressants (medicines that can make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; other prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the other medicines listed above while you are using oxymorphone .

Oxymorphone may cause some people to become drowsy, dizzy, or lightheaded, or to feel a false sense of well-being. Make sure you know how you react to oxymorphone before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert and clearheaded.

Dizziness, lightheadedness, or even fainting may occur when you get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem. Also, lying down for a while may relieve dizziness or lightheadedness .

Using oxymorphone for a long time can cause severe constipation. To prevent this, your doctor may direct you to take laxatives, drink a lot of fluids, or increase the amount of fiber in your diet. Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems .

Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are using oxymorphone. Serious side effects can occur if your medical doctor or dentist gives you certain other medicines without knowing that you are using oxymorphone .

oxymorphone Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Blurred vision
confusion
decreased urination
difficult or labored breathing
dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
dry mouth
fast, pounding, racing, or irregular heartbeat or pulse
headache
nervousness
pounding in the ears
rapid breathing
shortness of breath
sunken eyes
sweating
swelling of hands, ankles, or feet
thirst
tightness in chest
unusual tiredness or weakness
wheezing
wrinkled skin

Rare

Abdominal pain
chest pain or discomfort
chills
cold sweats
cough
decrease in urine volume
decrease in consciousness
difficulty in passing urine [dribbling]
difficulty sleeping
difficulty swallowing
disorientation
drowsiness to profound coma
fear
fever
hallucination
hyperventilation
hives
hoarseness
irregular, slow, or shallow breathing
irritability
irritation
itching
joint pain, stiffness or swelling
lethargy
mood or other mental changes
painful urination
pale or blue lips, fingernails, or skin
puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
redness of skin
restlessness
severe constipation
severe vomiting
shaking
shortness of breath
skin rash
swelling of eyelids, face, or lips
trouble in holding or releasing urine
trouble sleeping
troubled breathing or swallowing

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Cold and clammy skin
constricted, pinpoint, or small pupils [black part of eye]
decreased awareness or responsiveness
muscle weakness
no blood pressure or pulse
not breathing
severe sleepiness or unusual drowsiness
stopping of heart

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Difficulty having a bowel movement (stool)
feeling of constant movement of self or surroundings
increased sweating
nausea or vomiting
relaxed and calm
sensation of spinning
sleepiness

Less common

Acid or sour stomach
belching
decreased appetite
decreased weight
diarrhea
discouragement
excess air or gas in stomach or intestines
feeling of warmth
feeling sad or empty
full or bloated feeling
heartburn
indigestion
lack of appetite
loss of interest or pleasure
passing gas
pressure in the stomach
redness of the face, neck, arms and occasionally, upper chest
sleeplessness
stomach discomfort or upset
swelling of abdominal or stomach area
tiredness
trouble concentrating
unable to sleep

Rare

Blistering, crusting, irritation, itching, or reddening of skin
cracked, dry, scaly skin
difficulty in thinking or concentrating
disturbed color perception
double vision
false or unusual sense of well-being
feeling jittery
halos around lights
loss of vision
mental depression
night blindness
nightmares or unusually vivid dreams
overbright appearance of lights
sudden sweating
tunnel vision
welts

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided “AS IS” and “as available” for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

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oxymorphone (Injection route)

30/06/10

ox-i-MOR-fone

Oral routeTablet, Extended Release

Opana(R) ER contains oxymorphone, which is a morphine-like opioid agonist and a Schedule II controlled substance, with an abuse liability similar to other opioid analgesics.

Opana(R) ER is NOT intended for use as a prn analgesic.

Commonly used brand name(s):

In the U.S.

Numorphan

Available Dosage Forms:

Solution

Therapeutic Class: Analgesic

Chemical Class: Opioid

Uses For oxymorphone

Oxymorphone injection is used to treat moderate to severe pain, including labor pain. It may also be given before surgery or with a general anesthetic (medicine that puts you to sleep), and may be used to relieve anxiety for patients with breathing problems from pulmonary edema caused by heart disease.

Oxymorphone injection belongs to the group of medicines called narcotic analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain.

When oxymorphone injection is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely.

oxymorphone is available only with your doctor’s prescription.

Before Using oxymorphone

Allergies

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of oxymorphone injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of oxymorphone injection in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart disease, which may require caution and an adjustment in the dose for patients receiving oxymorphone injection.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Interactions with Medicines

Using oxymorphone with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Naltrexone

Adinazolam
Alfentanil
Alprazolam
Amobarbital
Anileridine
Aprobarbital
Bromazepam
Brotizolam
Buprenorphine
Butabarbital
Butalbital
Butorphanol
Carisoprodol
Chloral Hydrate
Chlordiazepoxide
Chlorzoxazone
Clobazam
Clonazepam
Clorazepate
Codeine
Dantrolene
Dezocine
Diazepam
Estazolam
Ethchlorvynol
Fentanyl
Flunitrazepam
Flurazepam
Fospropofol
Halazepam
Hydrocodone
Hydromorphone
Ketazolam
Levorphanol
Lorazepam
Lormetazepam
Medazepam
Meperidine
Mephenesin
Mephobarbital
Meprobamate
Metaxalone
Methocarbamol
Methohexital
Midazolam
Morphine
Morphine Sulfate Liposome
Nalbuphine
Nitrazepam
Nordazepam
Opium
Oxazepam
Oxycodone
Oxymorphone
Pentazocine
Pentobarbital
Phenobarbital
Prazepam
Propoxyphene
Quazepam
Remifentanil
Secobarbital
Sodium Oxybate
Sufentanil
Tapentadol
Temazepam
Thiopental
Triazolam

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Ethanol

Proper Use of oxymorphone

A nurse or other trained health professional will give you oxymorphone in a hospital. oxymorphone may be given as a shot under the skin, as a shot into one of your muscles, or through a needle placed in one of your veins.

Your doctor will give you a few doses of oxymorphone until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Precautions While Using oxymorphone

It is very important that your doctor check your progress while you are receiving oxymorphone. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

oxymorphone will add to the effects of alcohol and other CNS depressants (medicines that can make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds; sedatives, tranquilizers, or sleeping medicine; other prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the medicines listed above while you are using oxymorphone.

oxymorphone may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.

Dizziness, lightheadedness, or fainting may occur when you get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem. Also, lying down for a while may relieve the dizziness or lightheadedness.

oxymorphone may make you dizzy, drowsy, confused, or disoriented. Make sure you know how you react to oxymorphone before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

Using narcotics for a long time can cause severe constipation. To prevent this, your doctor may direct you to take laxatives, drink a lot of fluids, or increase the amount of fiber in your diet. Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems.

If you have been using oxymorphone regularly for several weeks or longer, do not suddenly stop using it without checking with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent worsening of your condition and reduce the possibility of withdrawal symptoms, such as abdominal or stomach cramps, anxiety, fever, nausea, runny nose, sweating, tremors, or trouble with sleeping.

Do not take other medicines unless thy have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

oxymorphone Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Incidence not known

Blurred vision
chest pain or discomfort
confusion
constricted, pinpoint, or small pupils (black part of eye)
difficult or painful urination
difficult or troubled breathing
difficulty sleeping
disorientation
double vision
drowsiness or sleepiness
fast, pounding, or irregular heartbeat or pulse
frequent urge to urinate
hallucinations
irregular, fast or slow, or shallow breathing
noisy breathing
pale or blue lips, fingernails, or skin
slow or irregular heartbeat
seeing double
seeing, hearing, or feeling things that are not there
shortness of breath
tightness in chest
trouble breathing
unconsciousness
unusual tiredness or weakness
very slow breathing
wheezing

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Bigger, dilated, or enlarged pupils (black part of eye)
cold, clammy skin
increased sensitivity of eyes to light
low blood pressure or pulse
no muscle tone or movement
unconsciousness
very slow heartbeat

Incidence not known

Abdominal or stomach cramps or pain
bloating
chills
cold sweats
constipation
cough
decrease in frequency of urination
decrease in urine volume
diarrhea
difficulty in passing urine (dribbling)
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
dry mouth
flushing
headache
lethargy
lightheadedness
loss of appetite
mood or other mental changes
nausea
restlessness
sleepiness or unusual drowsiness
skin rash, hives, itching, or redness
sweating
swelling or puffiness of face
unusual tiredness
vomiting
weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Oxymorphone

30/06/10

Generic Name: Oxymorphone (ox-ee-MOR-fone)
Brand Name: Numorphan

Oxymorphone is used for:

Treating moderate to severe pain. It may be used before surgery to cause sedation and reduce anxiety. It may also be used for other conditions as determined by your doctor.

Oxymorphone is a narcotic pain reliever. It works by dulling the pain perception center in the brain. It may also affect other body systems (eg, respiratory and circulatory systems) at higher doses.

Do NOT use Oxymorphone if:

you are allergic to any ingredient in Oxymorphone or any other oxymorphone- or morphine-related medicine (eg, codeine)
you are taking sodium oxybate (GHB)
you have severe bowel motility problems (eg, paralytic ileus) or severe diarrhea associated with antibiotic use (pseudomembranous colitis)
you have severely slow or difficult breathing, fluid in the lungs due to chemical irritation, or severe asthma, or you are having an asthma attack

Contact your doctor or health care provider right away if any of these apply to you.

Before using Oxymorphone:

Some medical conditions may interact with Oxymorphone. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, plan to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines or other substances
if you have a history of asthma, chronic obstructive pulmonary disease (COPD), trouble breathing while asleep (eg, sleep apnea), or other lung or breathing problems
if you have a history of recent head injury, increased pressure in the brain, growths in the brain (eg, tumors), or seizures
if you have a history of heart problems, low blood pressure, liver or kidney problems, underactive thyroid, adrenal gland problems (eg, Addison disease), increased pressure in the eye, glaucoma, stomach or bowel problems, gallbladder problems, inflammation of the pancreas, a blockage of the bladder or bowel, an enlarged prostate, or the blood disease porphyria
if you have a history of drug or alcohol abuse, mood or mental problems, or suicidal thoughts or behavior

Some MEDICINES MAY INTERACT with Oxymorphone. Tell your health care provider if you are taking any other medicines, especially any of the following:

Cimetidine, furazolidone, monoamine oxidase (MAO) inhibitors (eg, phenelzine), phenothiazines (eg, chlorpromazine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because the risk of side effects such as severe drowsiness, slow or difficult breathing, confusion, and seizures may be increased
Buprenorphine, butorphanol, nalbuphine, naltrexone, or pentazocine because the effectiveness of Oxymorphone may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Oxymorphone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Oxymorphone:

Use Oxymorphone as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Oxymorphone is usually administered as an injection at your doctor’s office, hospital, or clinic. If you are using Oxymorphone at home, carefully follow the injection procedures taught to you by your health care provider.
If Oxymorphone contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
If you miss a dose of Oxymorphone and you are using it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Oxymorphone.

Important safety information:

Oxymorphone may cause dizziness or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Oxymorphone. Using Oxymorphone alone, with other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Oxymorphone. Oxymorphone will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
Oxymorphone may cause dizziness, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.
Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Oxymorphone.
Use Oxymorphone with caution in the ELDERLY because they may be more sensitive to its effects.
Use Oxymorphone with extreme caution in CHILDREN younger than 18 years of age. Safety and effectiveness in this age group have not been confirmed.
PREGNANCY AND BREAST-FEEDING: If you become pregnant while taking Oxymorphone, discuss with your doctor the benefits and risks of using Oxymorphone during pregnancy. It is unknown if Oxymorphone is excreted in breast milk. If you are or will be breast-feeding while you are using Oxymorphone, check with your doctor or pharmacist to discuss the risks to your baby.

When used for long periods of time or at high doses, Oxymorphone may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Oxymorphone stops working well. Do not take more than prescribed.

When used for long periods of time or at high doses, some people develop a need to continue taking Oxymorphone. This is known as DEPENDENCE or addiction.

If you suddenly stop taking Oxymorphone, you may experience WITHDRAWAL symptoms including anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; hallucinations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; shivering or tremors; sweating; and trouble sleeping.

Possible side effects of Oxymorphone:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; headache; nausea; sleeplessness; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; difficulty urinating; fast or slow heartbeat; seizures; severe dizziness, lightheadedness, or fainting; slowed or difficult breathing; stomach pain; tremor; vision changes.

If OVERDOSE is suspected:

Proper storage of Oxymorphone:

Store Oxymorphone at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Do not store in the bathroom. Keep Oxymorphone out of the reach of children and away from pets.

General information:

If you have any questions about Oxymorphone, please talk with your doctor, pharmacist, or other health care provider.
Oxymorphone is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Oxymorphone. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: May 5, 2010

Database Edition 10.2.1.002

Med-facts,O

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oxymetazoline nasal

30/06/10

Generic Name: oxymetazoline nasal (ox ee me TAZ oh leen)
Brand names: Afrin, Afrin Nasal Sinus, Allerest 12 Hour Nasal Spray, Duramist Plus, Duration, Four-Way Nasal Spray, Genasal, Neo-Synephrine 12 Hour, Nostrilla, NRS Nasal, NTZ Long Acting Nasal, Oxyfrin, Oxymeta-12, Sinarest Nasal, Sinex Long-Acting, Twice-A-Day, …show all 35 brand names.

What is oxymetazoline nasal?

Oxymetazoline is a decongestant. It works by constricting (shrinking) blood vessels (veins and arteries) in your body. The nasal formulation acts directly on the blood vessels in your nasal tissues. Constriction of the blood vessels in your nose and sinuses leads to drainage of these areas and a decrease in congestion.

Oxymetazoline nasal is used to treat congestion associated with allergies, hay fever, sinus irritation, and the common cold.

Oxymetazoline nasal may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about oxymetazoline nasal?

Do not use oxymetazoline nasal for longer than 3 to 5 days. Longer use could cause damage to your nasal tissue and lead to chronic congestion. If your symptoms do not improve, see your doctor.

Do not use more of this medication than is recommended on the package or by your doctor.

Who should not use oxymetazoline nasal?

Do not use oxymetazoline nasal if you have taken a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. This could cause a very dangerous drug interaction with serious side effects.

Before taking this medication, tell your doctor if you have

high blood pressure;
any type of heart disease, hardening of the arteries, or irregular heart beats;
thyroid problems;
diabetes;
glaucoma or increased pressure in the eye;
an enlarged prostate or difficulty urinating; or
liver or kidney disease.

You may not be able to use oxymetazoline nasal, or you may require a lower dose or special monitoring during your therapy if you have any of the conditions listed above.

It is not known whether oxymetazoline nasal will harm an unborn baby. Do not use oxymetazoline nasal without first talking to your doctor if you are pregnant. Infants are especially sensitive to the effects of oxymetazoline nasal. Do not use this medication without first talking to your doctor if you are breast-feeding a baby. If you over 60 years of age, you may be more likely to experience side effects from oxymetazoline nasal. You may require a lower dose of this medication.

How should I use oxymetazoline nasal?

Use oxymetazoline nasal exactly as directed by your doctor, or follow the instructions that accompany the package. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

To apply the nasal spray, keep your head upright, spray, then sniff hard for a few minutes after administering a dose.

To apply the nasal drops, lie on a bed on your back with your head hanging over the edge. Insert the drops and remain in this position for several minutes. Gently turn your head from side to side.

Do not allow the tip of the container to touch the inside of your nose or any other surface. This spreads the infection.

Also, to prevent the spread of infection, do not share this medication with anyone else.

Discard this medication bottle after use. Do not save it for reuse.

Never use this medication in larger doses or more often than is recommended. Too much oxymetazoline nasal could be very harmful. Oxymetazoline nasal should not be used more often than twice a day (every 12 hours).

Do not use oxymetazoline nasal for longer than 3 to 5 days. Longer use could cause damage to your nasal tissue and lead to chronic congestion. If your symptoms do not improve, see your doctor.

Store oxymetazoline nasal at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and use the next one as directed. Do not use a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of an oxymetazoline nasal overdose include extreme tiredness, sweating, dizziness, a slow heartbeat, and coma.

What should I avoid while taking oxymetazoline nasal?

Never use this medication in larger doses or more often than is recommended. Too much oxymetazoline nasal could be very harmful.

Oxymetazoline nasal side effects

If you experience any of the following serious side effects, stop using oxymetazoline nasal and seek emergency medical attention:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
seizures;
unusual behavior or hallucinations; or
an irregular or fast heartbeat.

More commonly, you may experience some sneezing or burning, stinging, dryness, or irritation of the nose. These side effects are usually mild and temporary.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Oxymetazoline nasal Dosing Information

Usual Adult Dose for Nasal Congestion:

0.025% solution: 4 to 6 drops to each nostril twice daily as needed.

0.05% solution: 2 to 3 drops to each nostril twice daily as needed.

Usual Pediatric Dose for Nasal Congestion:

0.025% solution:
>= 2 years to 5 years: 2 to 3 drops to each nostril twice daily as needed.
6 years to 18 years: 4 to 6 drops to each nostril twice daily as needed.

0.05% solution:
>= 6 years to 18 years: 2 to 3 drops to each nostril twice daily as needed.

0.05% spray:
>= 6 years to 18 years: 1 to 2 sprays to each nostril twice daily as needed.

What other drugs will affect oxymetazoline nasal?

Do not use oxymetazoline nasal if you have taken a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days.

Although drug interactions between topical nasal decongestants and drugs taken by mouth are not expected, they can occur. Rarely, oxymetazoline nasal may interact with the following medicines:

furazolidone (Furoxone);
guanethidine (Ismelin);
indomethacin (Indocin);
methyldopa (Aldomet);
bromocriptine (Parlodel);
caffeine in cola, tea, coffee, chocolate and other products;
theophylline (Theo-Dur, Theochron, Theolair, others);
tricyclic antidepressants such as amitriptyline (Elavil, Endep), doxepin (Sinequan), and nortriptyline (Pamelor);
other commonly used tricyclic antidepressants, including amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Tofranil), protriptyline (Vivactil), and trimipramine (Surmontil);
phenothiazines such as chlorpromazine (Thorazine), thioridazine (Mellaril), and prochlorperazine (Compazine); and
other commonly used phenothiazines, including fluphenazine (Prolixin), perphenazine (Trilafon), mesoridazine (Serentil), and trifluoperazine (Stelazine).

Drugs other than those listed here may also interact with oxymetazoline nasal. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

Your pharmacist has additional information about oxymetazoline nasal written for health professionals that you may read.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Concise,O

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oxymetazoline ophthalmic

30/06/10

Generic Name: oxymetazoline ophthalmic (OX i me TAZ oh leen off THAL mik)
Brand Names: Ocuclear, Visine L.R., Visine Long Lasting

What is oxymetazoline ophthalmic?

Oxymetazoline ophthalmic is a vasoconstrictor. It works by narrowing blood vessels in the eyes.

Oxymetazoline ophthalmic is used to relieve redness, burning, irritation, and dryness of the eye caused by wind, sun, and other minor irritants.

Oxymetazoline ophthalmic may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about oxymetazoline ophthalmic?

You should not use this medication if you are allergic to it. Do not use oxymetazoline ophthalmic without your doctor’s advice if you have glaucoma.

Ask a doctor or pharmacist if it is safe for you to take this medication if you have heart disease, high blood pressure, asthma, diabetes, or a thyroid disorder.

Do not use oxymetazoline ophthalmic for longer than 3 days in a row without a doctor’s advice. Call your doctor if your eye symptoms do not improve or if they get worse while using this oxymetazoline ophthalmic.. Do not use this medication while you are wearing contact lenses. Oxymetazoline ophthalmic may contain a preservative that can be absorbed by soft contact lenses. Wait at least 15 minutes after using oxymetazoline ophthalmic before putting your contact lenses in.

Do not allow the dropper tip to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

Do not use the eye drops if the liquid has changed colors or has particles in it. Call your doctor for a new prescription.

What should I discuss with my healthcare provider before using oxymetazoline ophthalmic?

You should not use this medication if you are allergic to it. Do not use oxymetazoline ophthalmic without your doctor’s advice if you have glaucoma.

Ask a doctor or pharmacist if it is safe for you to take this medication if you have:

heart disease or high blood pressure;
asthma;
diabetes; or
a thyroid disorder.

FDA pregnancy category C. It is not known whether oxymetazoline ophthalmic is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether oxymetazoline ophthalmic passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use oxymetazoline ophthalmic?

Use this medication exactly as directed on the label, or as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended.

Do not use oxymetazoline ophthalmic for longer than 3 days in a row without a doctor’s advice. Overuse of this medication may damage blood vessels in your eyes. Call your doctor if your eye symptoms do not improve or if they get worse while using this oxymetazoline ophthalmic.. Wash your hands before using the eye drops. Do not use this medication while you are wearing contact lenses. Oxymetazoline ophthalmic may contain a preservative that can be absorbed by soft contact lenses. Wait at least 15 minutes after using oxymetazoline ophthalmic before putting your contact lenses in.

To apply the eye drops:

Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the dropper tip down. Look up and away from the dropper as you squeeze out a drop, then close your eye.
Use only the number of drops your doctor has prescribed.
Gently press your finger to the inside corner of the eye (near your nose) for about 1 minute to keep the liquid from draining into your tear duct. If you use more than one drop in the same eye, wait about 5 minutes before putting in the next drop.
Do not allow the dropper tip to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

Do not use the eye drops if the liquid has changed colors or has particles in it. Call your doctor for a new prescription.

Store the drops at room temperature away from heat and moisture. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Use the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

An overdose of oxymetazoline ophthalmic is not likely to cause life-threatening symptoms.

What should I avoid while using oxymetazoline ophthalmic?

Avoid using other medications in your eyes during treatment with oxymetazoline ophthalmic unless your doctor has told you to.

Oxymetazoline ophthalmic side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using oxymetazoline ophthalmic and call your doctor at once if you have a serious side effect such as:

severe burning, stinging, pain, or eye irritation;
fast or uneven heart rate; or
dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Less serious side effects may include:

mild burning or stinging of the eye;
eye redness or tearing, blurred vision;
headache;
nausea;
sweating;
feeling nervous or shaky;
dizziness; or
drowsiness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect oxymetazoline ophthalmic?

Tell your doctor about all other medications you use, especially:

a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil); or
a beta-blocker such as propranolol (Inderal), metoprolol (Lopressor, Toprol XL), or labetalol (Normodyne, Trandate).

This list is not complete and there may be other drugs that can interact with oxymetazoline ophthalmic. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about oxymetazoline ophthalmic.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Concise,O

Comments (0)

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30/06/10

What is oxytetracycline and polymyxin B ophthalmic?

What is the most important information I should know about oxytetracycline and polymyxin B ophthalmic?

Who should not use oxytetracycline and polymyxin B ophthalmic?

How should I use oxytetracycline and polymyxin B ophthalmic?

What happens if I miss a dose?

What happens if I overdose?

What should I avoid while using oxytetracycline and polymyxin B ophthalmic?

Oxytetracycline and polymyxin B ophthalmic side effects

What other drugs will affect oxytetracycline and polymyxin B ophthalmic?

Where can I get more information?

What does my medication look like?

30/06/10

Oxytetracycline/ Polymyxin B Sulfate Ointment

Oxytetracycline/Polymyxin B Sulfate Ointment is used for:

Do NOT use Oxytetracycline/Polymyxin B Sulfate Ointment if:

Before using Oxytetracycline/Polymyxin B Sulfate Ointment:

How to use Oxytetracycline/Polymyxin B Sulfate Ointment:

Important safety information:

Possible side effects of Oxytetracycline/Polymyxin B Sulfate Ointment:

If OVERDOSE is suspected:

General information:

30/06/10

Oxymorphone Suppositories are used for:

Do NOT use Oxymorphone Suppositories if:

Before using Oxymorphone Suppositories:

How to use Oxymorphone Suppositories:

Important safety information:

Possible side effects of Oxymorphone Suppositories:

If OVERDOSE is suspected:

General information:

30/06/10

Oxymorphone Extended-Release Tablets are used for:

Do NOT use Oxymorphone Extended-Release Tablets if:

Before using Oxymorphone Extended-Release Tablets:

How to use Oxymorphone Extended-Release Tablets:

Important safety information:

Possible side effects of Oxymorphone Extended-Release Tablets:

If OVERDOSE is suspected:

General information:

30/06/10

Why is Oxymorphone hydrochloride prescribed?

Most important fact about Oxymorphone hydrochloride

How should you take Oxymorphone hydrochloride?

What side effects may occur?

Why should Oxymorphone hydrochloride not be prescribed?

Special warnings about Oxymorphone hydrochloride

Possible food and drug interactions when taking Oxymorphone hydrochloride

Special information if you are pregnant or breastfeeding

Recommended dosage for Oxymorphone hydrochloride

Overdosage

30/06/10

Uses For oxymorphone

Before Using oxymorphone

Allergies

Pediatric

Geriatric

Pregnancy

Breast Feeding

Interactions with Medicines

Interactions with Food/Tobacco/Alcohol

Other Medical Problems

Proper Use of oxymorphone

Dosing

Missed Dose

Storage

Precautions While Using oxymorphone

oxymorphone Side Effects

30/06/10

Uses For oxymorphone

Before Using oxymorphone

Allergies

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Oxytetracycline/

Polymyxin B Sulfate Ointment