Generic Name: bioflavonoids (BYE oh FLAV oh noids)
Brand Names: Amino-Opti-C, Limbrel, P-1000, Pan C 500, Peridin-C, Rutin, Span C

What are P-1000 (bioflavonoids)?

Bioflavonoids are found in the rind of green citrus fruits and in rose hips and black currants.

Bioflavonoids have been used in alternative medicine as an aid to enhance the action of vitamin C, to support blood circulation, as an antioxidant, and to treat allergies, viruses, or arthritis and other inflammatory conditions.

Not all uses for bioflavonoids have been approved by the FDA. Bioflavonoids should not be used in place of medication prescribed for you by your doctor.

Bioflavonoids is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Bioflavonoids may also be used for other purposes not listed in this product guide.

What is the most important information I should know about P-1000 (bioflavonoids)?

Not all uses for bioflavonoids have been approved by the FDA. Bioflavonoids should not be used in place of medication prescribed for you by your doctor.

Bioflavonoids is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Use bioflavonoids as directed on the label, or as your healthcare provider has prescribed. Do not use this product in larger amounts or for longer than recommended.

What should I discuss with my healthcare provider before taking P-1000 (bioflavonoids)?

Do not use this product if you are allergic to bioflavonoids or if you have:

Before using bioflavonoids, talk to your doctor, pharmacist, herbalist, or other healthcare provider. You may not be able to use bioflavonoids if you have certain medical conditions.

Do not take bioflavonoids without first talking to your doctor if you are pregnant or planning a pregnancy. It is not known whether bioflavonoids will be harmful to an unborn baby. Do not take bioflavonoids without first talking to your doctor if you are breast-feeding a baby. It is not known whether bioflavonoids will be harmful to a nursing infant. Do not give any herbal/health supplement to a child without the advice of a doctor.

How should I take P-1000 (bioflavonoids)?

When considering the use of herbal supplements, seek the advice of your doctor. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements.

If you choose to take bioflavonoids, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. Do not use more of this product than is recommended on the label.

Take this medicine with a full glass of water.

Do not use different formulations of bioflavonoids at the same time without first talking to your doctor. Using different formulations together increases the risk of an bioflavonoids overdose.

If your condition does not improve, or if it appears to get worse, contact your doctor.

Store bioflavonoids at room temperature away from moisture and heat.

What happens if I miss a dose?

Consult your doctor, pharmacist, herbalist, or other healthcare provider for instructions if you miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking P-1000 (bioflavonoids)?

There are no known restrictions on food, beverages, or activities while you are taking bioflavonoids unless otherwise directed by your health care provider.

P-1000 (bioflavonoids) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects are more likely to occur, and you may have none at all.

Tell your doctor, pharmacist, herbalist, or other healthcare provider about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect P-1000 (bioflavonoids)?

There may be other drugs that can interact with bioflavonoids. Tell your healthcare provider about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your healthcare provider.

Where can I get more information?

• Consult with a licensed healthcare professional before using any herbal/health supplement. Whether you are treated by a medical doctor or a practitioner trained in the use of natural medicines/supplements, make sure all your healthcare providers know about all of your medical conditions and treatments.

• Consultation with a licensed health care professional is advisable before using any herbal/health supplement. Additionally, consultation with a practitioner trained in the uses of herbal/health supplements may be beneficial and coordination of treatment among all health care providers involved may be advantageous. Remember, keep this and all other prescription drug products, over-the-counter drug products, and herbal/health supplements out of the reach of children.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 4.01. Revision Date: 02/26/2010 10:13:30 AM.

Generic Name: Aspirin/Caffeine (AS-pir-in/cah-FEEN)
Brand Name: Examples include Anacin and P-A-C

P-A-C is used for:

Treating pain including, headache, muscle aches, sprains, tooth extraction and toothache, menstrual cramps, arthritis and rheumatism, and pain and fever of the common cold. It may also be used for other conditions as determined by your doctor.

P-A-C is a combination salicylate and stimulant. It works by blocking several different chemical processes within the body that cause pain, inflammation, and fever. It also reduces the tendency for blood to clot.

Do NOT use P-A-C if:

• you are allergic to any ingredient in P-A-C
• you are a child or teenager with influenza (flu) or chickenpox
• you have bleeding problems such as hemophilia, von Willebrand disease, or low blood platelets, or you have active severe bleeding
• you have had a severe allergic reaction (eg, severe rash, hives, breathing difficulties, dizziness) to aspirin, tartrazine, or a nonsteroidal anti-inflammatory drug (NSAID) (eg, ibuprofen, naproxen, celecoxib)
• you are taking anticoagulants (eg, heparin, warfarin) or methotrexate

Contact your doctor or health care provider right away if any of these apply to you.

Before using P-A-C:

Some medical conditions may interact with P-A-C. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have alcoholism or if you consume 3 or more alcohol-containing drinks every day
• if you have asthma, bleeding or clotting problems, growths in the nose (nasal polyps), kidney or liver problems, stomach or intestinal problems (eg, ulcer, inflammation), heart problems, heartburn, upset stomach, stomach pain, hives, influenza (flu) or chickenpox, or vitamin K deficiency
• if you have anxiety, trouble sleeping, or heart problems
• if you are a child with a stroke, a weakened blood vessel (cerebral aneurysm) or bleeding in the brain, rheumatic disease (eg, rheumatoid arthritis), or Kawasaki syndrome (a rare inflammation causing heart problems in children)

Some MEDICINES MAY INTERACT with P-A-C. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Carbonic anhydrase inhibitors (eg, acetazolamide) because they may decrease P-A-C’s effectiveness
• Anticoagulants (eg, heparin, warfarin), clopidogrel, or NSAIDs (eg, ibuprofen, celecoxib) because the risk of their side effects, including risk of bleeding, may be increased by P-A-C
• Quinolones (eg, ciprofloxacin) because side effects, such as problems sleeping, nervousness, jitteriness, or anxiety, may occur
• Insulin or oral antidiabetics (eg, glyburide, nateglinide) because the risk of their side effects, including low blood sugar (eg, hunger, shakiness or weakness, dizziness, headache, sweating), may be increased by P-A-C
• Methotrexate, theophylline, or valproic acid because the risk of their actions and side effects may be increased by P-A-C
• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), probenecid, or sulfinpyrazone because their effectiveness may be decreased by P-A-C

This may not be a complete list of all interactions that may occur. Ask your health care provider if P-A-C may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use P-A-C:

Use P-A-C as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take P-A-C by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. Taking it with food may not decrease the risk of stomach or bowel problems (eg, bleeding, ulcers) that may occur while taking P-A-C.
• Take P-A-C with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking P-A-C.
• Use P-A-C exactly as directed on the package, unless instructed differently by your doctor. If you are taking P-A-C without a prescription, follow any warnings and precautions on the label.
• If you miss a dose of P-A-C and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use P-A-C.

Important safety information:

• P-A-C may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use P-A-C with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Avoid large amounts of food or drink that have caffeine (eg, coffee, tea, cocoa, cola, chocolate). This includes any medicines that contain caffeine.
• P-A-C has aspirin in it. Before you start any new medicine, check the label to see if it has aspirin in it too. If it does or if you are not sure, check with your doctor or pharmacist.
• Talk to your doctor before you take P-A-C or other pain relievers/fever reducers if you drink more than 3 drinks with alcohol per day. Serious stomach ulcers or bleeding can occur with the use of P-A-C. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking P-A-C with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.
• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor. Taking more than the recommended dose or taking P-A-C regularly may be habit-forming.
• P-A-C may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.
• Aspirin has been linked to a serious illness called Reye syndrome. Do not give P-A-C to a child or teenager who has the flu, chickenpox, or a viral infection. Contact your doctor with any questions or concerns.
• Diabetes patients – P-A-C may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
• If P-A-C has a strong vinegar-like smell upon opening, do not use. It means the medicine is breaking down. Throw the bottle away safely and out of the reach of children; contact your pharmacist and replace.
• Tell your doctor or dentist that you take P-A-C before you receive any medical or dental care, emergency care, or surgery.
• Do not take P-A-C for at least 7 days after any surgery unless directed by your health care provider.
• Do not take P-A-C for more than 10 days for pain or for more than 3 days for fever unless directed to do so by your health care provider.
• Different brands of P-A-C may have different dosing instructions for CHILDREN. Follow the dosing instructions on the package labeling. If your doctor has given you instructions, follow those. If you are unsure of the dose to give a child, check with your doctor or pharmacist.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using P-A-C while you are pregnant. P-A-C is not recommended during the last 3 months (third trimester) of pregnancy because it may cause harm to the fetus. P-A-C is found in breast milk. If you are or will be breast-feeding while you use P-A-C, check with your doctor. Discuss any possible risks to your baby.

Some people who use P-A-C for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction.

If you stop taking P-A-C suddenly, you may have WITHDRAWAL symptoms including dizziness, headache, unusual tiredness, irritability, muscle tension, and nausea.

Possible side effects of P-A-C:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; heartburn; irritability; nausea; nervousness; upset stomach.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or bloody stools; confusion; diarrhea; drowsiness; hearing loss; ringing in the ears; severe or persistent dizziness; severe or persistent stomach pain or heartburn; shakiness; trouble sleeping; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include agitation; anxiety; confusion; fever; hearing loss; lethargy; lightheadedness, especially upon standing; muscle twitching; nausea; rapid breathing; rapid or irregular heartbeat; ringing in the ears; seizures; shortness of breath; stomach pain; trouble sleeping; vomiting.

Proper storage of P-A-C:

Store P-A-C at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep P-A-C out of the reach of children and away from pets.

General information:

• If you have any questions about P-A-C, please talk with your doctor, pharmacist, or other health care provider.
• P-A-C is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about P-A-C. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.