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Pyrethrins/

Piperonyl Gel

Generic Name: Pyrethrins/Piperonyl (pye-REE-thrins/pye-PEER-i-nil)
Brand Name: Examples include RID and Lice Treatment

Pyrethrins/Piperonyl Gel is used for:

Treating head, pubic (crab), or body lice.

Pyrethrins/Piperonyl Gel is a pediculicide combination. It works by interfering with the nerves of the lice, which causes death of the lice.

Do NOT use Pyrethrins/Piperonyl Gel if:

you are allergic to any ingredient in Pyrethrins/Piperonyl Gel

Contact your doctor or health care provider right away if any of these apply to you.

Before using Pyrethrins/Piperonyl Gel:

Some medical conditions may interact with Pyrethrins/Piperonyl Gel. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances, including ragweed
if you have skin irritation

Some MEDICINES MAY INTERACT with Pyrethrins/Piperonyl Gel. Because little, if any, of Pyrethrins/Piperonyl Gel is absorbed into the blood, the risk of it interacting with another medicine is low.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Pyrethrins/Piperonyl Gel may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Pyrethrins/Piperonyl Gel:

Use Pyrethrins/Piperonyl Gel as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Pyrethrins/Piperonyl Gel is for external use only. Pyrethrins/Piperonyl Gel is not to be used for lice in the eyebrows or eyelashes. Contact a doctor if lice are present in these areas.
Use Pyrethrins/Piperonyl Gel on dry hair.
Apply to the affected area until all hair is completely wet. Allow Pyrethrins/Piperonyl Gel to remain on the affected area for no more than 10 minutes. Add sufficient warm water to form a lather and shampoo as usual. Rinse completely. Close eyes tightly and protect them with a washcloth or towel when rinsing Pyrethrins/Piperonyl Gel out of the hair.
Use a fine-toothed comb to remove dead lice or eggs (nits) from hair.
Check daily for any lice or eggs that you missed.
Repeat this treatment in 7 to 10 days to kill any newly hatched lice.
If infestation continues, contact a doctor for other treatments.
If you miss a dose of Pyrethrins/Piperonyl Gel, use it as soon as you remember. Continue to use it as directed by your doctor.

Ask your health care provider any questions you may have about how to use Pyrethrins/Piperonyl Gel.

Important safety information:

Do not get Pyrethrins/Piperonyl Gel in your eyes, vagina, nose, or mouth. If you get Pyrethrins/Piperonyl Gel in your eyes, flush them with cool tap water.
Do not inhale Pyrethrins/Piperonyl Gel. Use Pyrethrins/Piperonyl Gel in a well-ventilated area.
All hats, scarves, coats, clothes, underwear, and bed linens should be dry cleaned or washed in hot water and dried on the hot cycle of the dryer for at least 20 minutes. Hair combs and brushes should also be cleaned in hot water.
All members of the household should be examined for the presence of lice and treated if lice are found.
PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Pyrethrins/Piperonyl Gel during pregnancy. It is unknown if Pyrethrins/Piperonyl Gel is excreted in breast milk. If you are or will be breast-feeding while you are using Pyrethrins/Piperonyl Gel, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Pyrethrins/Piperonyl Gel:

All medicines may cause side effects, but many people have no, or minor, side effects. No COMMON side effects have been reported with the proper use of Pyrethrins/Piperonyl Gel. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); eye irritation; infection; persistent skin or scalp irritation; skin tenderness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include coughing; diarrhea; difficulty breathing; headache; nausea; unusual dizziness or drowsiness; vomiting.

Proper storage of Pyrethrins/Piperonyl Gel:

Store Pyrethrins/Piperonyl Gel at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Pyrethrins/Piperonyl Gel out of the reach of children and away from pets.

General information:

If you have any questions about Pyrethrins/Piperonyl Gel, please talk with your doctor, pharmacist, or other health care provider.
Pyrethrins/Piperonyl Gel is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Pyrethrins/Piperonyl Gel. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: May 5, 2010

Database Edition 10.2.1.002

Med-facts,P

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30/06/10

Pyrethrins/

Piperonyl Shampoo

Generic Name: Pyrethrins/Piperonyl (pye-REE-thrins/pye-PEER-i-nil)
Brand Name: Examples include Licide and Tisit

Pyrethrins/Piperonyl Shampoo is used for:

Treating head, pubic (crab), or body lice.

Pyrethrins/Piperonyl Shampoo is a pediculicide combination. It works by interfering with the nerves of the lice, which causes death of the lice.

Do NOT use Pyrethrins/Piperonyl Shampoo if:

you are allergic to any ingredient in Pyrethrins/Piperonyl Shampoo

Contact your doctor or health care provider right away if any of these apply to you.

Before using Pyrethrins/Piperonyl Shampoo:

Some medical conditions may interact with Pyrethrins/Piperonyl Shampoo. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances, including ragweed
if you have skin irritation

Some MEDICINES MAY INTERACT with Pyrethrins/Piperonyl Shampoo. Because little, if any, of Pyrethrins/Piperonyl Shampoo is absorbed into the blood, the risk of it interacting with another medicine is low.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Pyrethrins/Piperonyl Shampoo may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Pyrethrins/Piperonyl Shampoo:

Use Pyrethrins/Piperonyl Shampoo as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Pyrethrins/Piperonyl Shampoo is for external use only. Pyrethrins/Piperonyl Shampoo is not to be used for lice in the eyebrows or eyelashes. Contact a doctor if lice are present in these areas.
Shake well before use.
Use Pyrethrins/Piperonyl Shampoo on dry hair.
Apply to the affected area until all hair is completely wet. Allow Pyrethrins/Piperonyl Shampoo to remain on the affected area for no more than 10 minutes. Add sufficient warm water to form a lather and shampoo as usual. Rinse completely. Close eyes tightly and protect them with a washcloth or towel when rinsing Pyrethrins/Piperonyl Shampoo out of the hair.
Use a fine-toothed comb to remove dead lice or eggs (nits) from hair.
Check daily for any lice or eggs that you missed.
Repeat this treatment in 7 to 10 days to kill any newly hatched lice.
If infestation continues, contact a doctor for other treatments.
If you miss a dose of Pyrethrins/Piperonyl Shampoo, use it as soon as you remember. Continue to use it as directed by your doctor.

Ask your health care provider any questions you may have about how to use Pyrethrins/Piperonyl Shampoo.

Important safety information:

Do not get Pyrethrins/Piperonyl Shampoo in your eyes, vagina, nose, or mouth. If you get Pyrethrins/Piperonyl Shampoo in your eyes, flush them with cool tap water.
Do not inhale Pyrethrins/Piperonyl Shampoo. Use Pyrethrins/Piperonyl Shampoo in a well-ventilated area.
All hats, scarves, coats, clothes, underwear, and bed linens should be dry cleaned or washed in hot water and dried on the hot cycle of the dryer for at least 20 minutes. Hair combs and brushes should also be cleaned in hot water.
All members of the household should be examined for the presence of lice and treated if lice are found.
PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Pyrethrins/Piperonyl Shampoo during pregnancy. It is unknown if Pyrethrins/Piperonyl Shampoo is excreted in breast milk. If you are or will be breast-feeding while you are using Pyrethrins/Piperonyl Shampoo, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Pyrethrins/Piperonyl Shampoo:

All medicines may cause side effects, but many people have no, or minor, side effects. No COMMON side effects have been reported with the proper use of Pyrethrins/Piperonyl Shampoo. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); eye irritation; infection; persistent skin or scalp irritation; skin tenderness.

If OVERDOSE is suspected:

Proper storage of Pyrethrins/Piperonyl Shampoo:

Store Pyrethrins/Piperonyl Shampoo at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Do not store at temperatures above 110 degrees F (43 degrees C). Keep Pyrethrins/Piperonyl Shampoo out of the reach of children and away from pets.

General information:

If you have any questions about Pyrethrins/Piperonyl Shampoo, please talk with your doctor, pharmacist, or other health care provider.
Pyrethrins/Piperonyl Shampoo is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Pyrethrins/Piperonyl Shampoo. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: May 5, 2010

Database Edition 10.2.1.002

Med-facts,P

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pyrethrum extract and piperonyl butoxide (Topical route)

30/06/10

pye-REE-thrum EX-trackt, PIP-er-oh-nil byoo-TOX-ide

Commonly used brand name(s):

In the U.S.

A200 Maximum Strength
A200 Time-Tested Formula
Lice-X
Licide
Medi-Lice Maximum Strength
Pronto Maximum Strength
Pyrinex
Pyrinyl
Rid
Tisit

Available Dosage Forms:

Gel/Jelly
Liquid
Shampoo
Kit
Foam

Therapeutic Class: Pediculicide

Chemical Class: Pyrethrums

Uses For pyrethrum extract and piperonyl butoxide

Medicine containing pyrethrins is used to treat head, body, and pubic lice infections. pyrethrum extract and piperonyl butoxide is absorbed by the lice and destroys them by acting on their nervous systems. It does not affect humans in this way. The piperonyl butoxide is included to make the pyrethrins more effective in killing the lice. This combination medicine is known as a pediculicide.

pyrethrum extract and piperonyl butoxide is available without a prescription.

Before Using pyrethrum extract and piperonyl butoxide

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For pyrethrum extract and piperonyl butoxide, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to pyrethrum extract and piperonyl butoxide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no specific information comparing use of pyrethrins and piperonyl butoxide combination in children with use in other age groups, pyrethrum extract and piperonyl butoxide is not expected to cause different side effects or problems in children than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of pyrethrins and piperonyl butoxide combination medicine in the elderly with use in other age groups, pyrethrum extract and piperonyl butoxide is not expected to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of pyrethrum extract and piperonyl butoxide

Pyrethrins and piperonyl butoxide combination medicine usually comes with patient directions. Read them carefully before using pyrethrum extract and piperonyl butoxide.

Use pyrethrum extract and piperonyl butoxide only as directed. Do not use more of it and do not use it more often than recommended on the label. To do so may increase the chance of absorption through the skin and the chance of side effects.

Keep pyrethrins and piperonyl butoxide combination medicine away from the mouth and do not inhale it. pyrethrum extract and piperonyl butoxide is harmful if swallowed or inhaled.

To lessen the chance of inhaling pyrethrum extract and piperonyl butoxide, apply it in a well-ventilated room (for example, one with free flowing air or with a fan turned on).

Keep pyrethrum extract and piperonyl butoxide away from the eyes and other mucous membranes, such as the inside of the nose, mouth, or vagina, because it may cause irritation. If you accidentally get some in your eyes, flush them thoroughly with water at once.

Do not apply pyrethrum extract and piperonyl butoxide to the eyelashes or eyebrows . If they become infected with lice, check with your doctor.

To use the gel or solution form of pyrethrum extract and piperonyl butoxide:

Apply enough medicine to thoroughly wet the dry hair and scalp or skin. Allow the medicine to remain on the affected areas for exactly 10 minutes.
Then, thoroughly wash the affected areas with warm water and soap or regular shampoo. Rinse thoroughly and dry with a clean towel.

To use the shampoo form of pyrethrum extract and piperonyl butoxide:

Apply enough medicine to thoroughly wet the dry hair and scalp or skin. Allow the medicine to remain on the affected areas for exactly 10 minutes.
Then use a small amount of water and work shampoo into the hair and scalp or skin until a lather forms. Rinse thoroughly and dry with a clean towel.

After rinsing and drying, use a nit removal comb (special fine-toothed comb, usually included with pyrethrum extract and piperonyl butoxide) to remove the dead lice and eggs (nits) from hair.

Immediately after using pyrethrum extract and piperonyl butoxide, wash your hands to remove any medicine that may be on them.

pyrethrum extract and piperonyl butoxide should be used again in 7 to 10 days after the first treatment in order to kill any newly hatched lice.

Lice can easily move from one person to another by close body contact. This can happen also by direct contact with such things as clothing, hats, scarves, bedding, towels, washcloths, hairbrushes and combs, or the hair of infected persons. Therefore, all members of your household should be examined for lice and receive treatment if they are found to be infected.

To use pyrethrum extract and piperonyl butoxide for pubic (crab) lice:

Your sexual partner may also need to be treated, since the infection may spread to persons in close contact. If your partner is not being treated or if you have any questions about this, check with your doctor.

Dosing

The dose of pyrethrum extract and piperonyl butoxide will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of pyrethrum extract and piperonyl butoxide. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For topical dosage forms (gel, solution shampoo, and topical solution):
- For head, body, or pubic lice:
  - Adults and children—Use one time, then repeat one time in seven to ten days.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using pyrethrum extract and piperonyl butoxide

To prevent reinfection or spreading of the infection to other people, good health habits are also required. These include the following:

For head lice
- Machine wash all clothing (including hats, scarves, and coats), bedding, towels, and washcloths in very hot water and dry them by using the hot cycle of a dryer for at least 20 minutes. Clothing or bedding that cannot be washed should be dry-cleaned or sealed in a plastic bag for 2 weeks.
- Shampoo all wigs and hairpieces.
- Wash all hairbrushes and combs in very hot soapy water (above 130 °F) for 5 to 10 minutes and do not share them with other people.
- Clean the house or room by thoroughly vacuuming upholstered furniture, rugs, and floors.
For body lice
- Machine wash all clothing, bedding, towels, and washcloths in very hot water and dry them by using the hot cycle of a dryer for at least 20 minutes. Clothing or bedding that cannot be washed should be dry-cleaned or sealed in a plastic bag for 2 weeks.
- Clean the house or room by thoroughly vacuuming upholstered furniture, rugs, and floors.
For pubic lice
- Machine wash all clothing (especially underwear), bedding, towels, and washcloths in very hot water and dry them by using the hot cycle of a dryer for at least 20 minutes. Clothing or bedding that cannot be washed should be dry-cleaned or sealed in a plastic bag for 2 weeks.
- Scrub toilet seats frequently.

pyrethrum extract and piperonyl butoxide Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common or rare

Skin irritation not present before use of pyrethrum extract and piperonyl butoxide
skin rash or infection
sneezing (sudden attacks of)
stuffy or runny nose
wheezing or difficulty in breathing

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided “AS IS” and “as available” for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

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Pyri-500

30/06/10

Generic Name: pyridoxine (Oral route, Injection route)

pir-i-DOX-een

Commonly used brand name(s):

In the U.S.

Aminoxin
Pyri-500
Rodex
Vitabee 6

Available Dosage Forms:

Injectable
Solution
Tablet
Capsule
Tablet, Extended Release
Tablet, Enteric Coated

Therapeutic Class: Nutritive Agent

Pharmacologic Class: Vitamin B

Uses For Pyri-500

Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Pyridoxine (vitamin B 6) is necessary for normal breakdown of proteins, carbohydrates, and fats.

Some conditions may increase your need for pyridoxine. These include:

Alcoholism
Burns
Diarrhea
Dialysis
Heart disease
Intestinal problems
Liver disease
Overactive thyroid
Stress, long-term illness, or serious injury
Surgical removal of stomach

In addition, infants receiving unfortified formulas such as evaporated milk may need additional pyridoxine.

Increased need for pyridoxine should be determined by your health care professional.

Lack of pyridoxine may lead to anemia (weak blood), nerve damage, seizures, skin problems, and sores in the mouth. Your doctor may treat these problems by prescribing pyridoxine for you.

Claims that pyridoxine is effective for treatment of acne and other skin problems, alcohol intoxication, asthma, hemorrhoids, kidney stones, mental problems, migraine headaches, morning sickness, and menstrual problems, or to stimulate appetite or milk production have not been proven.

Injectable pyridoxine is given by or under the supervision of a health care professional. Other forms of pyridoxine are available without a prescription.

Importance of Diet

For good health, it is important that you eat a balanced and varied diet. Follow carefully any diet program your health care professional may recommend. For your specific dietary vitamin and/or mineral needs, ask your health care professional for a list of appropriate foods. If you think that you are not getting enough vitamins and/or minerals in your diet, you may choose to take a dietary supplement.

Pyridoxine is found in various foods, including meats, bananas, lima beans, egg yolks, peanuts, and whole-grain cereals. Pyridoxine is not lost from food during ordinary cooking, although some other forms of vitamin B 6 are.

Vitamins alone will not take the place of a good diet and will not provide energy. Your body also needs other substances found in food such as protein, minerals, carbohydrates, and fat. Vitamins themselves often cannot work without the presence of other foods.

The daily amount of pyridoxine needed is defined in several different ways.

For U.S.—
Recommended Dietary Allowances (RDAs) are the amount of vitamins and minerals needed to provide for adequate nutrition in most healthy persons. RDAs for a given nutrient may vary depending on a person’s age, sex, and physical condition (e.g., pregnancy).
Daily Values (DVs) are used on food and dietary supplement labels to indicate the percent of the recommended daily amount of each nutrient that a serving provides. DV replaces the previous designation of United States Recommended Daily Allowances (USRDAs).

For Canada—
Recommended Nutrient Intakes (RNIs) are used to determine the amounts of vitamins, minerals, and protein needed to provide adequate nutrition and lessen the risk of chronic disease.

Normal daily recommended intakes for pyridoxine are generally defined as follows:

Infants and children—
- Birth to 3 years of age: 0.3 to 1 milligram (mg).
- 4 to 6 years of age: 1.1 mg.
- 7 to 10 years of age: 1.4 mg.
Adolescent and adult males—1.7 to 2 mg.
Adolescent and adult females—1.4 to 1.6 mg.
Pregnant females—2.2 mg.
Breast-feeding females—2.1 mg.

Before Using Pyri-500

If you are taking this dietary supplement without a prescription, carefully read and follow any precautions on the label. For this supplement, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Problems in children have not been reported with intake of normal daily recommended amounts.

Geriatric

Problems in older adults have not been reported with intake of normal daily recommended amounts.

Breast Feeding

Interactions with Medicines

Using this dietary supplement with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Altretamine

Interactions with Food/Tobacco/Alcohol

Proper Use of pyridoxine

This section provides information on the proper use of a number of products that contain pyridoxine. It may not be specific to Pyri-500. Please read with care.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

For oral dosage forms (capsules, tablets, oral solution):
- To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes:
  - Adult and teenage males—1.7 to 2 milligrams (mg) per day.
  - Adult and teenage females—1.4 to 1.6 mg per day.
  - Pregnant females—2.2 mg per day.
  - Breast-feeding females—2.1 mg per day.
  - Children 7 to 10 years of age—1.4 mg per day.
  - Children 4 to 6 years of age—1.1 mg per day.
  - Children birth to 3 years of age—0.3 to 1 mg per day.
- To treat deficiency:
  - Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on the severity of deficiency.

To use the extended-release capsule form of this dietary supplement:

Swallow the capsule whole.
Do not crush, break, or chew before swallowing.
If the capsule is too large to swallow, you may mix the contents of the capsule with jam or jelly and swallow without chewing.

To use the extended-release tablet form of this dietary supplement:

Swallow the tablet whole.
Do not crush, break, or chew before swallowing.

Missed Dose

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Pyri-500 Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

With large doses

Clumsiness
numbness of hands or feet

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Pyridiate

30/06/10

Generic Name: phenazopyridine (fen AY zoe PIR i deen)
Brand Names: Azo-Gesic, Azo-Standard, Baridium, Phenazo, Prodium, Pyridiate, Pyridium, Re-Azo, Uricalm, Uristat

What is Pyridiate (phenazopyridine)?

Phenazopyridine is a pain reliever that affects the lower part of your urinary tract (bladder and urethra).

Phenazopyridine is used to treat pain, burning, increased urination, and increased urge to urinate. These symptoms are usually caused by infection, injury, surgery, catheter, or other conditions that irritate the lower urinary tract.

Phenazopyridine will treat the symptoms of a urinary tract infection, but this medication does not treat the actual infection. Take any antibiotic that your doctor prescribes to treat your infection.

Phenazopyridine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Pyridiate (phenazopyridine)?

Do not take this medication if you are allergic to phenazopyridine, or if you have kidney disease. Phenazopyridine will treat the symptoms of a urinary tract infection, but this medication does not treat the actual infection. Take any antibiotic that your doctor prescribes to treat your infection. To avoid stomach upset, take phenazopyridine with food.

Phenazopyridine will most likely darken the color of your urine to an orange or red color. This is a normal effect and is not cause for alarm unless you have other symptoms such as pale or yellowed skin, fever, stomach pain, nausea, and vomiting. Darkened urine may also cause stains to your underwear, which may or may not be removed by laundering.

Phenazopyridine can also permanently stain soft contact lenses, and you should not wear them while taking this medicine.

Do not use phenazopyridine for longer than 2 days unless your doctor has told you to.

Stop taking this medication and call your doctor at once if you have pale skin, fever, confusion, yellowing of your skin or eyes, increased thirst, swelling, or if you urinate less than usual or not at all.

What should I discuss with my health care provider before taking Pyridiate (phenazopyridine)?

Do not take this medication if you are allergic to phenazopyridine, or if you have kidney disease.

Before using phenazopyridine, tell your doctor if you are allergic to any drugs, or if you have:

liver disease;
diabetes; or
a condition called G6PD (glucose-6-phosphate dehydrogenase) deficiency.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take phenazopyridine.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether phenazopyridine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Pyridiate (phenazopyridine)?

Take phenazopyridine exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take this medicine with a full glass of water. To avoid stomach upset, take phenazopyridine with food.

Phenazopyridine can also permanently stain soft contact lenses, and you should not wear them while taking this medicine.

Do not use phenazopyridine for longer than 2 days unless your doctor has told you to.

This medication can cause you to have false results with glucose or ketone urine tests. Tell any doctor who treats you that you are using phenazopyridine.

Store this medication at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include yellowed skin, fever, confusion, weakness, urinating less than usual, nausea, vomiting, swelling, numbness, or blue-colored skin.

What should I avoid while taking Pyridiate (phenazopyridine)?

Avoid wearing soft contact lenses while you are taking phenazopyridine. The medication can cause permanent staining of soft contact lenses.

Pyridiate (phenazopyridine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using phenazopyridine and call your doctor at once if you have any of these serious side effects:

pale skin, fever, confusion or weakness;
jaundice (yellowing of your skin or eyes);
urinating less than usual or not at all;
drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting;
swelling, weight gain, feeling short of breath; or
blue or purple coloring in your skin.

Less serious side effects may include:

headache;
dizziness;
stomach pain, upset stomach; or
skin itching.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Pyridiate (phenazopyridine)?

There may be other drugs that can interact with phenazopyridine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about phenazopyridine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Pyrantel Pamoate

30/06/10

Generic Name: Pyrantel Pamoate (pi-RAN-tel)
Brand Name: Reese’s Pinworm Medicine

Pyrantel Pamoate is used for:

Treating certain worm infections (eg, pinworm, roundworm).

Pyrantel Pamoate is an anthelmintic agent. It works by paralyzing the nervous system of intestinal parasites (worms). The parasite is then passed in the stool.

Do NOT use Pyrantel Pamoate if:

you are allergic to any ingredient in Pyrantel Pamoate
you have liver problems

Contact your doctor or health care provider right away if any of these apply to you.

Before using Pyrantel Pamoate:

Some medical conditions may interact with Pyrantel Pamoate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have worms other than pinworms
if others in your home also have pinworms

Some MEDICINES MAY INTERACT with Pyrantel Pamoate. Tell your health care provider if you are taking any other medicines, especially any of the following:

Piperazine because the effectiveness of Pyrantel Pamoate may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Pyrantel Pamoate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Pyrantel Pamoate:

Use Pyrantel Pamoate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Pyrantel Pamoate may be taken on an empty stomach or with food, milk, or juice.
Wear tight underwear both day and night while taking Pyrantel Pamoate.
Pyrantel Pamoate is usually prescribed as a single dose.
Only one dose of Pyrantel Pamoate is required. If you forget to take Pyrantel Pamoate, take it as soon as you remember.

Ask your health care provider any questions you may have about how to use Pyrantel Pamoate.

Important safety information:

Pyrantel Pamoate may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Pyrantel Pamoate. Using Pyrantel Pamoate alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
This infection spreads easily to family members and close contacts. To prevent reinfection: Disinfect toilet and change and wash underwear, bed linens, towels, clothes, and pajamas daily. Wash hands with soap often during the day, especially before eating and after using the toilet. Do not scratch the infected area or place your fingers in your mouth.
The entire household should be treated with Pyrantel Pamoate if one individual in the household has pinworms.
After treatment with Pyrantel Pamoate, clean the bedroom floor by vacuuming or damp mopping.
If any worms other than pinworms are visible after treatment with Pyrantel Pamoate, contact your doctor.
Use Pyrantel Pamoate with extreme caution in CHILDREN younger than 2 years of age. Safety and effectiveness in this age group have not been confirmed.
PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Pyrantel Pamoate, discuss with your doctor the benefits and risks of using Pyrantel Pamoate during pregnancy. It is unknown if Pyrantel Pamoate is excreted in breast milk. If you are or will be breast-feeding while you are using Pyrantel Pamoate, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Pyrantel Pamoate:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; drowsiness; headache; loss of appetite; nausea; stomach cramps; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Pyrantel Pamoate:

Store Pyrantel Pamoate at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Pyrantel Pamoate out of the reach of children and away from pets.

General information:

If you have any questions about Pyrantel Pamoate, please talk with your doctor, pharmacist, or other health care provider.
Pyrantel Pamoate is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Pyrantel Pamoate. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: May 5, 2010

Database Edition 10.2.1.002

Med-facts,P

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Pyrantel Pamoate Suspension

30/06/10

Generic Name: Pyrantel Pamoate (pi-RAN-tel)
Brand Name: Examples include Pin-X and Reese’s Pinworm Medicine

Pyrantel Pamoate Suspension is used for:

Treating certain worm infections (eg, pinworm, roundworm).

Pyrantel Pamoate Suspension is an anthelmintic agent. It works by paralyzing the nervous system of intestinal parasites (worms). The parasite is then passed in the stool.

Do NOT use Pyrantel Pamoate Suspension if:

you are allergic to any ingredient in Pyrantel Pamoate Suspension
you have liver problems

Contact your doctor or health care provider right away if any of these apply to you.

Before using Pyrantel Pamoate Suspension:

Some medical conditions may interact with Pyrantel Pamoate Suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have worms other than pinworms
if others in your home also have pinworms

Some MEDICINES MAY INTERACT with Pyrantel Pamoate Suspension. Tell your health care provider if you are taking any other medicines, especially any of the following:

Piperazine because the effectiveness of Pyrantel Pamoate Suspension may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Pyrantel Pamoate Suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Pyrantel Pamoate Suspension:

Use Pyrantel Pamoate Suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Pyrantel Pamoate Suspension may be taken on an empty stomach or with food, milk, or juice.
Shake well before using a dose of Pyrantel Pamoate Suspension.
Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
Wear tight underwear both day and night while taking Pyrantel Pamoate Suspension.
Pyrantel Pamoate Suspension is usually prescribed as a single dose.
Only one dose of Pyrantel Pamoate Suspension is required. If you forget to take Pyrantel Pamoate Suspension, take it as soon as you remember.

Ask your health care provider any questions you may have about how to use Pyrantel Pamoate Suspension.

Important safety information:

Pyrantel Pamoate Suspension may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Pyrantel Pamoate Suspension. Using Pyrantel Pamoate Suspension alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
This infection spreads easily to family members and close contacts. To prevent reinfection: Disinfect toilet and change and wash underwear, bed linens, towels, clothes, and pajamas daily. Wash hands with soap often during the day, especially before eating and after using the toilet. Do not scratch the infected area or place your fingers in your mouth.
The entire household should be treated with Pyrantel Pamoate Suspension if one individual in the household has pinworms.
After treatment with Pyrantel Pamoate Suspension, clean the bedroom floor by vacuuming or damp mopping.
If any worms other than pinworms are visible after treatment with Pyrantel Pamoate Suspension, contact your doctor.
Use Pyrantel Pamoate Suspension with extreme caution in CHILDREN younger than 2 years of age. Safety and effectiveness in this age group have not been confirmed.
PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Pyrantel Pamoate Suspension, discuss with your doctor the benefits and risks of using Pyrantel Pamoate Suspension during pregnancy. It is unknown if Pyrantel Pamoate Suspension is excreted in breast milk. If you are or will be breast-feeding while you are using Pyrantel Pamoate Suspension, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Pyrantel Pamoate Suspension:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; drowsiness; headache; loss of appetite; nausea; stomach cramps; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Pyrantel Pamoate Suspension:

Store Pyrantel Pamoate Suspension at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Pyrantel Pamoate Suspension out of the reach of children and away from pets.

General information:

If you have any questions about Pyrantel Pamoate Suspension, please talk with your doctor, pharmacist, or other health care provider.
Pyrantel Pamoate Suspension is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Pyrantel Pamoate Suspension. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: May 5, 2010

Database Edition 10.2.1.002

Med-facts,P

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pyrazinamide

30/06/10

Generic Name: pyrazinamide (peer a ZIN a mide)
Brand Names:

What is pyrazinamide?

Pyrazinamide is an antibiotic. The exact way that pyrazinamide works is unknown.

Pyrazinamide is used to treat tuberculosis (TB).

Pyrazinamide may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about pyrazinamide?

Take all of the pyrazinamide that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated.

Call your doctor immediately if you experience a fever, loss of appetite, nausea and vomiting, painful or swollen joints, yellowing of your skin or eyes, or darkening of your urine.

Who should not take pyrazinamide?

Before taking pyrazinamide, tell your doctor if you have

ever had an allergic reaction to pyrazinamide,
liver disease,
gout,
kidney disease, or
diabetes mellitus.

You may not be able to take pyrazinamide, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Pyrazinamide is in the FDA pregnancy category C. This means that it is not known whether it will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. Pyrazinamide passes into breast milk and may affect a nursing baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take pyrazinamide?

Take pyrazinamide exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass (8 ounces) of water. Take all of the pyrazinamide that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated.

Pyrazinamide is usually combined with one or more other tuberculosis medicines.

Store this medication at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of an pyrazinamide overdose are not well known. Liver damage has been detected.

What should I avoid while taking pyrazinamide?

There are no restrictions on foods, beverages, or activities during treatment with pyrazinamide unless your doctor directs otherwise.

Pyrazinamide side effects

If you experience any of the following serious side effects, stop taking pyrazinamide and seek emergency medical attention or contact your doctor immediately:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
a fever;
unusual weakness or fatigue;
nausea, vomiting, or loss of appetite;
yellow skin or eyes;
dark urine;
difficult or painful urination;
painful or swollen joints;
worsening gout; or
a rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pyrazinamide Dosing Information

Usual Adult Dose for Tuberculosis — Active:

15 to 30 mg/kg (up to 2 g) orally once a day in combination with three other antituberculous drugs for the initial 2 months of a 6-month or 9-month treatment regimen, until drug susceptibility tests are known. An alternate dosing regimen of 50 to 75 mg/kg (up to 3 g) orally twice a week may be used after 2 weeks of daily therapy to increase patient compliance.

Alternatively, the CDC, The American Thoracic Society, and the Infectious Diseases Society of America suggest the following dosing based on estimated lean body weight:

Daily dosing:
40 to 45 kg: 1000 mg
56 to 75 kg: 1500 mg
76 to 90 kg: 2000 mg

Twice weekly dosing:
40 to 55 kg: 2000 mg
56 to 75 kg: 3000 mg
76 to 90 kg: 4000 mg

Thrice weekly dosing:
40 to 55 kg: 1500 mg
56 to 75 kg: 2500 mg
76 to 90 kg: 3000 mg

Usual Adult Dose for Tuberculosis — Latent:

A public health expert should be consulted prior to the use of the combination regimen with rifampin.

15 to 20 mg/kg, based on actual body weight (lean), orally once daily (maximum 2 g) for 2 months. Alternatively, a dosage of 50 mg/kg may be administered orally twice-weekly (maximum 4 g).

Usual Pediatric Dose for Tuberculosis — Active:

Child: 15 to 30 mg/kg (up to 2 g) orally once a day. An alternate dosing regimen of 50 mg/kg (up to 3 g) orally twice a week may be used after 2 weeks of daily therapy to increase patient compliance.

What other drugs will affect pyrazinamide?

Pyrazinamide may decrease the effects of allopurinol (Zyloprim). A dosage adjustment may be necessary if you take pyrazinamide during treatment with allopurinol.

Pyrazinamide may affect the Acetest and Ketostix urine tests for ketones. This reaction can cause a pink-brown color to appear.

Drugs other than those listed here may also interact with pyrazinamide. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

Your pharmacist can provide more information about pyrazinamide.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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pyrazinamide (Oral route)

30/06/10

pir-a-ZIN-a-mide

Available Dosage Forms:

Tablet

Therapeutic Class: Antitubercular

Uses For pyrazinamide

Pyrazinamide belongs to the family of medicines called anti-infectives. It is used, along with other medicines, to treat tuberculosis (TB).

To help clear up your tuberculosis (TB) infection completely, you must keep taking pyrazinamide for the full time of treatment, even if you begin to feel better. This is very important. It is also important that you do not miss any doses.

Pyrazinamide is available only with your doctor’s prescription.

Before Using pyrazinamide

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For pyrazinamide, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to pyrazinamide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Pyrazinamide has been used in children and, in effective doses, has not been reported to cause different side effects or problems in children than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing pyrazinamide in the elderly with use in other age groups, pyrazinamide is not expected to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Interactions with Medicines

Using pyrazinamide with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Cyclosporine
Ethionamide
Rifampin
Zidovudine

Interactions with Food/Tobacco/Alcohol

Proper Use of pyrazinamide

To help clear up your TB completely, it is important that you keep taking pyrazinamide for the full time of treatment, even if you begin to feel better after a few weeks. It is important that you do not miss any doses.

Dosing

The dose of pyrazinamide will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of pyrazinamide. If your dose is different, do not change it unless your doctor tells you to do so.

For oral dosage form (tablets):
- For tuberculosis (TB):
  - Adults and children—Dose is based on body weight. The usual dose is 15 to 30 milligrams (mg) of pyrazinamide per kilogram (kg) (6.8 to 13.6 mg per pound) of body weight once a day; or 50 to 70 mg per kg (22.7 to 31.8 mg per pound) two times a week or three times a week, depending on the schedule your doctor chooses for you. pyrazinamide must be taken along with other medicines used to treat TB.

Missed Dose

If you miss a dose of pyrazinamide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using pyrazinamide

It is very important that your doctor check your progress at regular visits.

If your symptoms do not improve within 2 to 3 weeks, or if they become worse, check with your doctor.

For diabetic patients:

pyrazinamide may cause false test results with urine ketone tests. Check with your doctor before changing your diet or the dosage of your diabetes medicine.

pyrazinamide Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Pain in large and small joints

Rare

Loss of appetite
pain and swelling of joints, especially big toe, ankle, and knee
tense, hot skin over affected joints
unusual tiredness or weakness
yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

Itching
skin rash

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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pyrantel

30/06/10

Generic Name: pyrantel (pie RAN tell)
Brand Names: Antiminth, Ascarel, Pin-X, Pinworm Caplets, Pinworm Medicine

What is pyrantel?

Pyrantel is an “antihelmintic,” or anti-worm, medication. It prevents worms from growing or multiplying in your body.

Pyrantel is used to treat infections caused by worms such as pinworm and roundworm.

Pyrantel may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about pyrantel?

Take the whole dose of pyrantel. It can be taken with food or on an empty stomach at any time during the day.

Follow your doctor’s instructions or the instructions that accompany the package about treatment; about washing of clothes, linens, and towels; and about household disinfecting. Pinworm infections are easily spread from one person to another.

Who should not take pyrantel?

Before taking pyrantel, talk to your doctor about any other medical conditions that you have. Pyrantel should not be used if you have liver disease or if you have had an allergic reaction to this medicine in the past.

Do not take pyrantel without first talking to your doctor if you are pregnant. Do not take pyrantel without first talking to your doctor if you are breast-feeding a baby. Children younger than 2 years of age should not use pyrantel unless otherwise directed by your doctor.

How should I take pyrantel?

Take pyrantel exactly as directed by your doctor or as directed in the package labeling. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Pyrantel may be taken with or without food at any time of the day.

Shake the suspension well before measuring a dose.

Use a dose-measuring spoon, cup, or dropper (not a regular tablespoon) to ensure that you measure the correct dose of medication. Ask your pharmacist where you can get a dose-measuring device if you do not have one.

Fasting, laxatives, and purging will not help cure this infection.

Treatment of family members and other close contacts may be necessary. Pinworm is spread very easily to others in close contact with the infected person.

Toilets must be disinfected daily and clothing, linens, towels, and pajamas must be changed and washed daily.

Store pyrantel at room temperature away from moisture and heat.

See also: Pyrantel dosage in more detail

What happens if I miss a dose?

Since pyrantel is usually taken in one dose, you are not likely to miss a dose.

What happens if I overdose?

Seek emergency medical attention.

What should I avoid while taking pyrantel?

Treatment of family members and other close contacts may be necessary. Pinworm is spread very easily to others in close contact with the infected person.

To prevent reinfection, toilets must be disinfected daily, and clothing, linens, towels, and pajamas must be changed and washed daily.

Use caution when driving, operating machinery, or performing other hazardous activities. Pyrantel may cause dizziness. If you experience dizziness, avoid these activities.

Pyrantel side effects

Seek emergency medical attention if you experience an allergic reaction (swelling of your lips, tongue, or face; shortness of breath; closing of your throat; or hives).

Other, less serious side effects may be more likely to occur. Continue to take pyrantel and talk to your doctor if you experience

nausea, vomiting, abdominal cramps, diarrhea, or a decreased appetite;
headache;
drowsiness or dizziness;
insomnia; or
a rash.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Pyrantel Dosing Information

Usual Adult Dose for Enterobiasis:

11 mg/kg base (maximum 1 g) orally once. Repeat dose in 2 weeks.

Usual Adult Dose for Pinworm Infection (Enterobius vermicularis):

11 mg/kg base (maximum 1 g) orally once. Repeat dose in 2 weeks.

Usual Adult Dose for Hookworm Infection (Necator or Ancylostoma):

11 mg/kg base (maximum 1 g) orally daily for 3 days.

Usual Adult Dose for Ascariasis:

11 mg/kg base (maximum 1 g) orally once.

Usual Adult Dose for Trichostrongylosis:

11 mg/kg base (maximum 1 g) orally once.

Usual Adult Dose for Moniliformis Infection:

11 mg/kg base (maximum 1 g) orally once. Repeat dose twice at 2 weeks intervals.

Usual Pediatric Dose for Enterobiasis:

>=2 years: 11 mg/kg base (maximum 1 g) once. Repeat dose in 2 weeks.

Usual Pediatric Dose for Pinworm Infection (Enterobius vermicularis):

>=2 years: 11 mg/kg base (maximum 1 g) once. Repeat dose in 2 weeks.

Usual Pediatric Dose for Hookworm Infection (Necator or Ancylostoma):

>=2 years: 11 mg/kg base (maximum 1 g) orally daily for 3 days.

Usual Pediatric Dose for Ascariasis:

>=2 years: 11 mg/kg base (maximum 1 g) orally once.

Usual Pediatric Dose for Trichostrongylosis:

>=2 years: 11 mg/kg base (maximum 1 g) orally once.

Usual Pediatric Dose for Moniliformis Infection:

>=2 years: 11 mg/kg base (maximum 1 g) orally once. Repeat dose twice at 2 weeks intervals.

What other drugs will affect pyrantel?

Do not take other anti-worm medicines at the same time as pyrantel unless otherwise directed by your doctor. Other drugs used to treat infections caused by worms may decrease the effectiveness of pyrantel.

Theophylline (Theo-Dur, Theolair, Theochron, Theo-Bid, Elixophylline, others) may have dangerous side effects when taken during therapy with pyrantel. Your doctor may want to monitor your theophylline blood levels.

Drugs other than those listed here may also interact with pyrantel. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

Your pharmacist has more information about pyrantel written for health professionals that you may read.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Concise,P

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