Generic Name: brompheniramine and phenylephrine (BROM fen IR a meen and FEN il EFF rin)
Brand Names: Alacol, Alenaze-D, Alenaze-D NR, BPM PE, Brom Tann PE, Bromfed, Bromfed-PD Capsules, BroveX ADT, Children’s Cold & Allergy, Dimaphen Elixir, Dimetapp Cold & Allergy, J-Tan D, J-Tan D SR, Phenyl 15/12mg, Phenyl 7.5/6mg, RespaHist II, Rhinabid, Rhinabid PD, Seradex-LA, Tanabid SR, VazoBid, VaZol-D, Vazotab, Zotex-PE

What is RespaHist II (brompheniramine and phenylephrine)?

Brompheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of brompheniramine and phenylephrine is used to treat nasal congestion, sneezing, itching, watery eyes, and runny nose caused by allergies, hay fever, and the common cold.

Brompheniramine and phenylephrine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about RespaHist II (brompheniramine and phenylephrine)?

Do not give this medication to a child younger than 2 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not use this medication if you are allergic to brompheniramine or phenylephrine, or to other decongestants, diet pills, stimulants, or ADHD medications. Do not use brompheniramine and phenylephrine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cold or allergy medicine before the MAO inhibitor has cleared from your body.

Ask a doctor or pharmacist about taking brompheniramine and phenylephrine if you have heart disease or high blood pressure, diabetes, a thyroid disorder, glaucoma, kidney disease, and enlarged prostate, or problems with urination.

What should I discuss with my healthcare provider before taking RespaHist II (brompheniramine and phenylephrine)?

Do not use this medication if you are allergic to brompheniramine or phenylephrine, or to other decongestants, diet pills, stimulants, or ADHD medications. Do not use brompheniramine and phenylephrine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cold or allergy medicine before the MAO inhibitor has cleared from your body.

Ask a doctor or pharmacist if it is safe for you to take brompheniramine and phenylephrine if you have:

• heart disease or high blood pressure;

• diabetes;

• a thyroid disorder;

• glaucoma;

• kidney disease;

• an enlarged prostate; or

• problems with urination.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Brompheniramine and phenylephrine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take RespaHist II (brompheniramine and phenylephrine)?

Use this medication exactly as directed on the label, or as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Cold medicine is usually taken for only a short time until your symptoms clear up.

Do not give this medication to a child younger than 2 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Take the medicine with a full glass of water. Do not crush, chew, break, or open an extended-release capsule. Swallow the pill whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Call your doctor if your symptoms do not improve, or if they get worse.

Store brompheniramine and phenylephrine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include feeling restless or nervous, nausea, vomiting, stomach pain, dizziness, drowsiness, dry mouth, warmth or tingly feeling, or seizure (convulsions).

What should I avoid while taking RespaHist II (brompheniramine and phenylephrine)?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid becoming overheated or dehydrated during exercise and in hot weather.

Avoid drinking alcohol while you are taking this medication. Alcohol can add to drowsiness caused by an antihistamine.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor’s advice. Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

RespaHist II (brompheniramine and phenylephrine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:

• fast, pounding, or uneven heartbeat;

• severe dizziness, anxiety, restless feeling, or nervousness;

• easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;

• increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);

• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

Less serious side effects may include:

• drowsiness or dizziness;

• blurred vision;

• trouble urinating;

• mild loss of appetite;

• warmth, tingling, or redness under your skin;

• feeling excited or restless;

• sleep problems (insomnia); or

• skin rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect RespaHist II (brompheniramine and phenylephrine)?

Tell your doctor if you regularly use other medicines that make you sleepy (such as pain medication, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by brompheniramine and phenylephrine.

Tell your doctor about all other medications you are using, especially:

• medicines to treat high blood pressure;

• a beta-blocker such as atenolol (Tenormin), carteolol (Cartrol), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), timolol (Blocadren), and others; or

• antidepressants such as amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Janimine, Tofranil), and others.

This list is not complete and there may be other drugs that can interact with brompheniramine and phenylephrine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about brompheniramine and phenylephrine.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 7.09. Revision Date: 11/19/2009 11:58:23 AM.

re-SER-peen, hye-DRAL-a-zeen hye-droe-KLOR-ide, hye-droe-klor-oh-THYE-a-zide

Available Dosage Forms:

• Tablet

Therapeutic Class: Antihypertensive

Pharmacologic Class: Monoamine Depletor

Chemical Class: Rauwolfia

Uses For reserpine, hydralazine, and hydrochlorothiazide

Reserpine, hydralazine, and hydrochlorothiazide combinations are used to treat high blood pressure (hypertension).

High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Reserpine works by controlling nerve impulses along certain nerve pathways. As a result, it acts on the heart and blood vessels to lower blood pressure. Hydralazine works by relaxing blood vessels and increasing the supply of blood to the heart while reducing its work load. Hydrochlorothiazide is a thiazide diuretic (water pill) that helps to reduce the amount of water in the body by increasing the flow of urine. This also helps to lower blood pressure.

reserpine, hydralazine, and hydrochlorothiazide is available only with your doctor’s prescription.

Before Using reserpine, hydralazine, and hydrochlorothiazide

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For reserpine, hydralazine, and hydrochlorothiazide, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to reserpine, hydralazine, and hydrochlorothiazide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no specific information comparing use of reserpine, hydralazine, and hydrochlorothiazide in children with use in other age groups, reserpine, hydralazine, and hydrochlorothiazide is not expected to cause different side effects or problems in children than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of reserpine, hydralazine, and hydrochlorothiazide combination in the elderly with use in other age groups, reserpine, hydralazine, and hydrochlorothiazide is not expected to cause different side effects or problems in older people than it does in younger adults. However, drowsiness, dizziness, or faintness, or symptoms of too much potassium loss may be more likely to occur in the elderly, who are usually more sensitive to the effects of reserpine, hydralazine, and hydrochlorothiazide. Also, reserpine, hydralazine, and hydrochlorothiazide may reduce tolerance to cold temperatures in elderly patients.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Hydralazine

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Hydrochlorothiazide

Studies suggest that this medication may alter milk production or composition. If an alternative to this medication is not prescribed, you should monitor the infant for side effects and adequate milk intake.

Reserpine

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using reserpine, hydralazine, and hydrochlorothiazide with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Brofaromine
• Clorgyline
• Dofetilide
• Furazolidone
• Iproniazid
• Isocarboxazid
• Lazabemide
• Linezolid
• Moclobemide
• Nialamide
• Pargyline
• Phenelzine
• Procarbazine
• Rasagiline
• Selegiline
• Tetrabenazine
• Toloxatone
• Tranylcypromine

Using reserpine, hydralazine, and hydrochlorothiazide with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acetyldigoxin
• Arsenic Trioxide
• Colchicine
• Deslanoside
• Digitalis
• Digitoxin
• Digoxin
• Droperidol
• Flecainide
• Ketanserin
• Levomethadyl
• Lithium
• Metildigoxin
• Ouabain
• Proscillaridin
• Sotalol

Using reserpine, hydralazine, and hydrochlorothiazide with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Aceclofenac
• Acemetacin
• Alacepril
• Alclofenac
• Apazone
• Benazepril
• Benoxaprofen
• Bepridil
• Bromfenac
• Bufexamac
• Calcium Carbonate
• Captopril
• Carbamazepine
• Carprofen
• Celecoxib
• Chlorpropamide
• Cholestyramine
• Cilazapril
• Clometacin
• Clonixin
• Cyclophosphamide
• Delapril
• Dexketoprofen
• Diclofenac
• Diflunisal
• Dipyrone
• Droxicam
• Enalaprilat
• Enalapril Maleate
• Etodolac
• Etofenamate
• Felbinac
• Fenbufen
• Fenoprofen
• Fentiazac
• Floctafenine
• Flufenamic Acid
• Flurbiprofen
• Fosinopril
• Ginkgo
• Glipizide
• Gossypol
• Ibuprofen
• Imidapril
• Indomethacin
• Indoprofen
• Isoxicam
• Ketoprofen
• Ketorolac
• Licorice
• Lisinopril
• Lornoxicam
• Meclofenamate
• Mefenamic Acid
• Meloxicam
• Metoprolol
• Moexipril
• Nabumetone
• Naproxen
• Niflumic Acid
• Nimesulide
• Oxaprozin
• Oxyphenbutazone
• Pentopril
• Perindopril
• Phenylbutazone
• Pirazolac
• Piroxicam
• Pirprofen
• Propyphenazone
• Proquazone
• Quinapril
• Ramipril
• Rofecoxib
• Spirapril
• Sulindac
• Suprofen
• Temocapril
• Tenidap
• Tenoxicam
• Tiaprofenic Acid
• Ticrynafen
• Tolmetin
• Topiramate
• Trandolapril
• Yohimbine
• Zofenopril
• Zomepirac

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Using reserpine, hydralazine, and hydrochlorothiazide with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use reserpine, hydralazine, and hydrochlorothiazide, or give you special instructions about the use of food, alcohol, or tobacco.

• Enteral Nutrition

Other Medical Problems

The presence of other medical problems may affect the use of reserpine, hydralazine, and hydrochlorothiazide. Make sure you tell your doctor if you have any other medical problems, especially:

• Allergies or other breathing problems such as asthma—Reserpine can cause breathing problems

• Type 2 diabetes mellitus—Hydrochlorothiazide may change the amount of diabetes medicine needed

• Epilepsy

• Gallstones or
• Stomach ulcer or
• Ulcerative colitis—Reserpine increases activity of the stomach, which may make the condition worse

• Gout (history of)—Hydrochlorothiazide may increase the amount of uric acid in the blood, which can lead to gout

• Heart disease—Reserpine can cause heart rhythm problems or slow heartbeat. Lowering blood pressure may worsen some conditions

• Kidney disease—Some patients may not do well when blood pressure is lowered by reserpine, hydralazine, and hydrochlorothiazide. Effects of hydralazine may be increased because of slower removal from the body. If kidney disease is severe, hydrochlorothiazide may not work

• Liver disease—If hydrochlorothiazide causes loss of too much water from the body, liver disease can become much worse

• Lupus erythematosus (history of)—Hydrochlorothiazide may worsen the condition

• Mental depression (or history of)—Reserpine causes mental depression

• Pancreatitis (inflammation of pancreas)

• Parkinson’s disease—Reserpine can cause parkinsonism-like effects

• Pheochromocytoma

• Stroke (recent)—Lowering blood pressure may make problems resulting from this condition worse

Proper Use of reserpine, hydralazine, and hydrochlorothiazide

In addition to the use of the medicine your doctor has prescribed, treatment for your high blood pressure may include weight control and care in the types of foods you eat, especially foods high in sodium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that reserpine, hydralazine, and hydrochlorothiazide will not cure your high blood pressure but it does help control it. Therefore, you must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life . If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

reserpine, hydralazine, and hydrochlorothiazide may cause you to have an unusual feeling of tiredness when you begin to take it. You may also notice an increase in the amount of urine or in your frequency of urination. After you have taken the medicine for a while, these effects should lessen. In general, to keep the increase in urine from affecting your sleep:

• If you are to take a single dose a day, take it in the morning after breakfast.
• If you are to take more than one dose a day, take the last dose no later than 6 p.m., unless otherwise directed by your doctor.

However, it is best to plan your dose or doses according to a schedule that will least affect your personal activities and sleep. Ask your health care professional to help you plan the best time to take reserpine, hydralazine, and hydrochlorothiazide.

To help you remember to take your medicine, try to get into the habit of taking it at the same time each day.

If reserpine, hydralazine, and hydrochlorothiazide upsets your stomach, it may be taken with meals or milk. If stomach upset (nausea, vomiting, stomach pain or cramps) continues, check with your doctor.

Dosing

The dose of reserpine, hydralazine, and hydrochlorothiazide will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of reserpine, hydralazine, and hydrochlorothiazide. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  • For high blood pressure:
    • Adults—1 or 2 tablets three times a day.
    • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of reserpine, hydralazine, and hydrochlorothiazide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using reserpine, hydralazine, and hydrochlorothiazide

It is important that your doctor check your progress at regular visits to make sure that reserpine, hydralazine, and hydrochlorothiazide is working properly.

Do not take other medicines unless they have been discussed with your doctor. This especially includes over-the-counter (nonprescription) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may tend to increase your blood pressure.

Before having any kind of surgery (including dental surgery), or emergency treatment, make sure the medical doctor or dentist in charge knows that you are taking reserpine, hydralazine, and hydrochlorothiazide.

reserpine, hydralazine, and hydrochlorothiazide may cause some people to have headaches or to feel dizzy or drowsy. Make sure you know how you react to reserpine, hydralazine, and hydrochlorothiazide before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert.

Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position. This is more likely to occur in the morning. Getting up slowly may help. When you get up from lying down, sit on the edge of the bed with your feet dangling for 1 or 2 minutes. Then stand up slowly. If the problem continues or gets worse, check with your doctor.

The dizziness, lightheadedness, or fainting is also more likely to occur if you drink alcohol, stand for a long time, exercise, or if the weather is hot. While you are taking reserpine, hydralazine, and hydrochlorothiazide, be careful to limit the amount of alcohol you drink. Also, use extra care during exercise or hot weather or if you must stand for a long time.

In some patients, reserpine, hydralazine, and hydrochlorothiazide may cause mental depression. Tell your doctor right away:

• if you or anyone else notices unusual changes in your mood.
• if you start having early-morning sleeplessness or unusually vivid dreams or nightmares.

reserpine, hydralazine, and hydrochlorothiazide will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including dental anesthetics. Check with your doctor before taking any of the above while you are taking reserpine, hydralazine, and hydrochlorothiazide.

reserpine, hydralazine, and hydrochlorothiazide may cause a loss of potassium from your body.

• To help prevent this, your doctor may want you to:
  • eat or drink foods that have a high potassium content (for example, orange or other citrus fruit juices), or
  • take a potassium supplement, or
  • take another medicine to help prevent the loss of the potassium in the first place.
• It is very important to follow these directions. Also, it is important not to change your diet on your own. This is more important if you are already on a special diet (as for diabetes), or if you are taking a potassium supplement or a medicine to reduce potassium loss. Extra potassium may not be necessary and, in some cases, too much potassium could be harmful.

Check with your doctor if you become sick and have severe or continuing nausea, vomiting, or diarrhea. These problems may cause you to lose additional water and potassium.

For diabetic patients:

• reserpine, hydralazine, and hydrochlorothiazide may raise blood sugar levels. While you are using reserpine, hydralazine, and hydrochlorothiazide, be especially careful in testing for sugar in your urine. If you have any questions about this, check with your doctor.

Some people who take reserpine, hydralazine, and hydrochlorothiazide may become more sensitive to sunlight than they are normally. Exposure to sunlight, even for brief periods of time, may cause severe sunburn; skin rash, redness, itching, or discoloration; or vision changes. When you begin taking reserpine, hydralazine, and hydrochlorothiazide:

• Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible.
• Wear protective clothing, including a hat and sunglasses.
• Apply a sun block product that has a skin protection factor (SPF) of at least 15. Some patients may require a product with a higher SPF number, especially if they have a fair complexion. If you have any questions about this, check with your health care professional.
• Do not use a sunlamp or tanning bed or booth.

If you have a severe reaction from the sun, check with your doctor.

reserpine, hydralazine, and hydrochlorothiazide often causes stuffiness in the nose. However, do not use nasal decongestant medicines without first checking with your health care professional.

reserpine, hydralazine, and hydrochlorothiazide may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if dry mouth continues for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

reserpine, hydralazine, and hydrochlorothiazide Side Effects

Suggestions that rauwolfia alkaloids may increase the risk of breast cancer occurring later have not been proven. However, rats and mice given 100 to 300 times the human dose had an increased number of tumors.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• General feeling of discomfort or illness or weakness

Less common

• Drowsiness or faintness
• impotence or decreased sexual interest
• lack of energy or weakness
• mental depression or inability to concentrate
• nervousness or anxiety
• vivid dreams or nightmares or early-morning sleeplessness

Check with your doctor as soon as possible if any of the following side effects occur:

Signs and symptoms of too much potassium loss

• Dryness of mouth
• increased thirst
• irregular heartbeat
• mood or mental changes
• muscle cramps or pain
• weak pulse

Signs and symptoms of too much sodium loss

• Confusion
• convulsions
• decreased mental activity
• irritability
• muscle cramps
• unusual tiredness or weakness

Less common

• Black, tarry stools
• blisters on skin
• bloody vomit
• chest pain
• fever and sore throat
• headache
• irregular heartbeat
• joint pain
• numbness, tingling, pain, or weakness in hands or feet
• shortness of breath
• skin rash or itching
• slow heartbeat
• stomach cramps or pain
• swelling of lymph glands

Rare

• Lower back or side pain
• painful or difficult urination
• stiffness
• stomach pain (severe) with nausea and vomiting
• trembling and shaking of hands and fingers
• unusual bleeding or bruising
• yellow eyes or skin

Signs and symptoms of overdose

• Dizziness or drowsiness (severe)
• dryness of mouth
• flushing of skin
• increased thirst
• muscle cramps or pain
• nausea or vomiting (severe)
• pinpoint pupils of eyes
• slow pulse

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Diarrhea
• dizziness, especially when getting up from a lying or sitting position
• loss of appetite
• nausea or vomiting
• stuffy nose

Less common

• Constipation
• flushing or redness of skin
• increased sensitivity of skin to sunlight
• swelling of feet and lower legs
• watering or irritated eyes

After you stop using reserpine, hydralazine, and hydrochlorothiazide, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

• Drowsiness or faintness
• general feeling of discomfort or illness or weakness
• impotence or decreased sexual interest
• irregular heartbeat
• mental depression or inability to concentrate
• nervousness or anxiety
• vivid dreams or nightmares or early-morning sleeplessness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided “AS IS” and “as available” for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

Generic Name: resorcinol (topical) (re SOR si nol)
Brand Names: R A Acne, Resinol

What is resorcinol?

Resorcinol topical (for the skin) works by breaking down rough, scaly, or hardened skin.

Resorcinol topical is used to treat acne, eczema, psoriasis, seborrhea, corns, callouses, warts, and other skin disorders.

Resorcinol may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about resorcinol?

You should not use this medication if you are allergic to resorcinol. Resorcinol is for use only on the skin. Do not get it in your eyes, nose, or mouth.

Although the risk of serious side effects is low when resorcinol is applied properly to the skin, certain side effects can occur if the medication is absorbed through your skin and into your bloodstream. This includes heart rate or breathing changes, weakness, severe headache, nausea, vomiting, or feeling restless or nervous.

Your body may absorb resorcinol through the skin if you use too much of the medication or if you apply it over large skin areas. Skin that is cut or irritated may also absorb more topical medication.

Call your doctor if your skin condition does not improve or if it gets worse while using resorcinol.

What should I discuss with my health care provider before using resorcinol?

You should not use this medication if you are allergic to resorcinol. It is not known whether this medication could be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether resorcinol passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use resorcinol?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts or for longer than recommended by your doctor.

Apply only enough of the medication to cover the area needing treatment, and rub in gently.

Wash your hands after applying resorcinol unless you are treating a skin condition on the hands. Your body may absorb resorcinol through the skin if you use too much of the medication or if you apply it over large skin areas. Skin that is cut or irritated may also absorb more topical medication.

Call your doctor if your skin condition does not improve or if it gets worse while using resorcinol topical.

Store this medicine at room temperature away from moisture, heat, and direct light. Do not freeze.

What happens if I miss a dose?

Use the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of an overdose of resorcinol absorbed through the skin may include weakness, shortness of breath, slow heart rate, nausea, vomiting, or severe headache.

What should I avoid while using resorcinol?

Avoid getting this medication in your eyes, mouth, or nose. If it does get into any of these areas, rinse with water.

Avoid using other skin products that can cause dryness or irritation such as harsh soaps, abrasive skin cleansers, medicated cosmetics, or skin products with alcohol, spices, astringents, or lime. Applying these products to the same skin you treat with resorcinol may cause severe irritation. Follow your doctor’s instructions about using any other products on skin treated with resorcinol.

Resorcinol side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Although the risk of serious side effects is low when resorcinol is applied properly to the skin, certain side effects can occur if the medication is absorbed through your skin and into your bloodstream. Call your doctor at once if you have any sign that resorcinol has been absorbed through the skin, such as:

• slow heart rate;

• dizziness, drowsiness, or weakness;

• feeling short of breath;

• severe or ongoing headache;

• nausea, vomiting, stomach pain, diarrhea; or

• feeling restless or nervous.

Less serious side effects may include:

• mild skin irritation;

• skin redness; or

• peeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect resorcinol?

Do not use other medicated skin products unless your doctor has told you to, especially:

• benzoyl peroxide (Oxy 10, Fostex, Clearskin, Benzagel, Benzamycin, BenzaClin, ZoDerm, and many others);

• salicylic acid (Dermarest, Sebucare, StriDex, Inova, Oxy Face Scrub, and many others);

• sulfur (Acnotex, NuOx, Sulfoxyl, Sulfo-Lac, Sulforcin, Fostril, and many others; or

• tretinoin (Renova, Retin-A, Altinac, Tretin-X, and others).

This list is not complete and there may be other topical medications that can interact with resorcinol.

It is not likely that other drugs you take orally or inject will have an effect on topically applied resorcinol. But many drugs can interact with each other. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about resorcinol topical.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 1.03. Revision Date: 4/12/2009 4:42:27 PM.

Generic Name: resorcinol (topical) (re SOR si nol)
Brand Names: R A Acne, Resinol

What is resorcinol?

Resorcinol topical (for the skin) works by breaking down rough, scaly, or hardened skin.

Resorcinol topical is used to treat acne, eczema, psoriasis, seborrhea, corns, callouses, warts, and other skin disorders.

Resorcinol may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about resorcinol?

You should not use this medication if you are allergic to resorcinol. Resorcinol is for use only on the skin. Do not get it in your eyes, nose, or mouth.

Although the risk of serious side effects is low when resorcinol is applied properly to the skin, certain side effects can occur if the medication is absorbed through your skin and into your bloodstream. This includes heart rate or breathing changes, weakness, severe headache, nausea, vomiting, or feeling restless or nervous.

Your body may absorb resorcinol through the skin if you use too much of the medication or if you apply it over large skin areas. Skin that is cut or irritated may also absorb more topical medication.

Call your doctor if your skin condition does not improve or if it gets worse while using resorcinol.

What should I discuss with my health care provider before using resorcinol?

You should not use this medication if you are allergic to resorcinol. It is not known whether this medication could be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether resorcinol passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use resorcinol?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts or for longer than recommended by your doctor.

Apply only enough of the medication to cover the area needing treatment, and rub in gently.

Wash your hands after applying resorcinol unless you are treating a skin condition on the hands. Your body may absorb resorcinol through the skin if you use too much of the medication or if you apply it over large skin areas. Skin that is cut or irritated may also absorb more topical medication.

Call your doctor if your skin condition does not improve or if it gets worse while using resorcinol topical.

Store this medicine at room temperature away from moisture, heat, and direct light. Do not freeze.

What happens if I miss a dose?

Use the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of an overdose of resorcinol absorbed through the skin may include weakness, shortness of breath, slow heart rate, nausea, vomiting, or severe headache.

What should I avoid while using resorcinol?

Avoid getting this medication in your eyes, mouth, or nose. If it does get into any of these areas, rinse with water.

Avoid using other skin products that can cause dryness or irritation such as harsh soaps, abrasive skin cleansers, medicated cosmetics, or skin products with alcohol, spices, astringents, or lime. Applying these products to the same skin you treat with resorcinol may cause severe irritation. Follow your doctor’s instructions about using any other products on skin treated with resorcinol.

Resorcinol side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Although the risk of serious side effects is low when resorcinol is applied properly to the skin, certain side effects can occur if the medication is absorbed through your skin and into your bloodstream. Call your doctor at once if you have any sign that resorcinol has been absorbed through the skin, such as:

• slow heart rate;

• dizziness, drowsiness, or weakness;

• feeling short of breath;

• severe or ongoing headache;

• nausea, vomiting, stomach pain, diarrhea; or

• feeling restless or nervous.

Less serious side effects may include:

• mild skin irritation;

• skin redness; or

• peeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Resorcinol Dosing Information

Usual Adult Dose for Dermatological Disorders:

Resorcinol topical 2% ointment:
Apply to affected area not more than 3 to 4 times daily.

Usual Pediatric Dose for Dermatological Disorders:

Resorcinol topical 2% ointment:
2 years or older: Apply to affected area not more than 3 to 4 times daily.

What other drugs will affect resorcinol?

Do not use other medicated skin products unless your doctor has told you to, especially:

• benzoyl peroxide (Oxy 10, Fostex, Clearskin, Benzagel, Benzamycin, BenzaClin, ZoDerm, and many others);

• salicylic acid (Dermarest, Sebucare, StriDex, Inova, Oxy Face Scrub, and many others);

• sulfur (Acnotex, NuOx, Sulfoxyl, Sulfo-Lac, Sulforcin, Fostril, and many others; or

• tretinoin (Renova, Retin-A, Altinac, Tretin-X, and others).

This list is not complete and there may be other topical medications that can interact with resorcinol.

It is not likely that other drugs you take orally or inject will have an effect on topically applied resorcinol. But many drugs can interact with each other. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about resorcinol topical.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 1.03. Revision Date: 4/12/2009 4:42:27 PM.

re-SOR-si-nol

Commonly used brand name(s):

In the U.S.

• DiabetAid Anti-Itch

Available Dosage Forms:

• Cream

Therapeutic Class: Analgesic

Uses For resorcinol

Resorcinol is used to treat acne, seborrheic dermatitis, eczema, psoriasis, and other skin disorders. It is also used to treat corns, calluses, and warts.

Resorcinol works by helping to remove hard, scaly, or roughened skin.

Some of these preparations are available only with your doctor’s prescription.

Before Using resorcinol

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For resorcinol, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to resorcinol or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Resorcinol may be absorbed through the skin and should not be used on large areas of the bodies of infants and children. In addition, resorcinol should not be used on wounds, since doing so may cause a blood disease called methemoglobinemia.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of resorcinol in the elderly with use in other age groups, resorcinol is not expected to cause different side effects or problems in older people than it does in younger adults.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of resorcinol

It is very important that you use resorcinol only as directed. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may increase the chance of absorption through the skin and the chance of resorcinol poisoning.

Apply enough resorcinol to cover the affected areas, and rub in gently.

Immediately after using resorcinol, wash your hands to remove any medicine that may be on them.

Keep resorcinol away from the eyes. If you should accidentally get some in your eyes, flush them thoroughly with water.

Dosing

The dose of resorcinol will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of resorcinol. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For lotion dosage form:
  • For acne, seborrheic dermatitis, eczema, or psoriasis:
    • Adults and children—Use as needed.
• For ointment dosage form:
  • For acne, seborrheic dermatitis, eczema, psoriasis, corns, calluses, or warts:
    • Adults and children—Use and dose must be determined by the doctor.

Missed Dose

If you miss a dose of resorcinol, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using resorcinol

When using resorcinol, do not use any of the following preparations on the same affected area as resorcinol, unless otherwise directed by your doctor:

• Abrasive soaps or cleansers
• Alcohol-containing preparations
• Any other topical acne preparation or preparation containing a peeling agent (for example, benzoyl peroxide, salicylic acid, sulfur, or tretinoin [vitamin A acid])
• Cosmetics or soaps that dry the skin
• Medicated cosmetics
• Other topical medicine for the skin

To use any of the above preparations on the same affected area as resorcinol may cause severe irritation of the skin.

resorcinol may darken light-colored hair.

resorcinol Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common or rare

• Skin irritation not present before use of resorcinol

Symptoms of resorcinol poisoning

• Diarrhea, nausea, stomach pain, or vomiting
• dizziness
• drowsiness
• headache (severe or continuing)
• nervousness or restlessness
• slow heartbeat, shortness of breath, or troubled breathing
• sweating
• unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Redness and peeling of skin (may occur after a few days)

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided “AS IS” and “as available” for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

Generic Name: unoprostone ophthalmic (uh no PROSS tone)
Brand Names: Rescula

What is Rescula (unoprostone ophthalmic)?

Unoprostone ophthalmic reduces pressure in the eye by increasing the amount of fluid that drains from the eye.

Unoprostone ophthalmic is used to treat certain types of glaucoma and other causes of high pressure inside the eye.

Unoprostone ophthalmic may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Rescula (unoprostone ophthalmic)?

Do not use this medication while you are wearing contact lenses. This medication may contain a preservative that can be absorbed by soft contact lenses. Wait at least 15 minutes after using unoprostone before putting your contact lenses in.

Unoprostone ophthalmic may cause a gradual change in the color of your eyes or eyelids and lashes, as well as increased growth or thickness of your eyelashes. These color changes, usually an increase in brown pigment, occur slowly and you may not notice them for months or years. Color changes may be permanent even after your treatment ends, and may occur only in the eye being treated. This could result in a cosmetic difference in eye or eyelash color from one eye to the other.

Do not allow the dropper to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

After using this medication, wait at least 5 minutes before using any other eye drops that your doctor has prescribed.

What should I discuss with my health care provider before using Rescula (unoprostone ophthalmic)?

Do not use this medication if you are allergic to unoprostone.

Before using unoprostone, tell your doctor if you are allergic to any drugs, or if you have swelling or infection of your eye.

Unoprostone ophthalmic may cause a gradual change in the color of your eyes or eyelids and lashes, as well as increased growth or thickness of your eyelashes. These color changes, usually an increase in brown pigment, occur slowly and you may not notice them for months or years. Color changes may be permanent even after your treatment ends, and may occur only in the eye being treated. This could result in a cosmetic difference in eye or eyelash color from one eye to the other.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether unoprostone passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use Rescula (unoprostone ophthalmic)?

Do not use this medication while you are wearing contact lenses. This medication may contain a preservative that can be absorbed by soft contact lenses. Wait at least 15 minutes after using unoprostone before putting your contact lenses in.

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the instructions on your prescription label.

Wash your hands before using the eye drops.

To apply the eye drops:

• Tilt your head back slightly and pull down on the lower eyelid to create a small pocket. Hold the dropper above the eye with the dropper tip down. Look up and away from the dropper. Squeeze out a drop and close your eye. Gently press your finger to the inside corner of the eye (near the nose) for about 1 minute to keep the liquid from draining into your tear duct.

• If you use more than one drop in the same eye, wait about 5 minutes before putting in the next drop. Also wait at least 5 minutes before using any other eye drops that your doctor has prescribed.

Do not allow the dropper to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye. At any time during your use of unoprostone ophthalmic, tell your doctor at once if you have an eye injury, if you develop an eye infection, or if you plan to have eye surgery. Do not use the eye drops if the liquid changes colors or has particles in it. Store the drops at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

If you forget to use the eye drops, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

An overdose of unoprostone ophthalmic used in the eyes is not expected to produce life-threatening symptoms.

What should I avoid while using Rescula (unoprostone ophthalmic)?

Avoid using too much of this medication, which can actually make it less effective in lowering the pressure inside the eye.

Avoid using any eye drop medicine that has not been prescribed by your doctor.

Rescula (unoprostone ophthalmic) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using unoprostone ophthalmic and call your doctor at once if you have any of these serious side effects:

• redness, swelling, itching, or pain in or around your eye;

• oozing or discharge from your eye;

• increased sensitivity to light; or

• vision changes.

Less serious side effects may include:

• cold or flu symptoms such as fever, chills, runny nose, sore throat, cough, diarrhea, and body aches;

• headache, dizziness;

• mild eye discomfort;

• blurred vision;

• feeling like something is in your eye;

• dry or watery eyes; or

• stinging or burning of the eyes after using the drops.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect Rescula (unoprostone ophthalmic)?

There may be other drugs that can affect unoprostone ophthalmic. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about unoprostone ophthalmic.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 3.03. Revision Date: 04/09/2008 1:26:53 PM.

Generic Name: reserpine (re SER peen)
Brand Names:

What is reserpine?

Reserpine lowers blood pressure by decreasing the levels of certain chemicals in your blood. This allows your blood vessels (veins and arteries) to relax (widen) and your heart to beat more slowly and easily.

Reserpine is used to treat hypertension (high blood pressure).

Reserpine is also sometimes used to treat psychotic states such as schizophrenia.

Reserpine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about reserpine?

Use caution when driving, operating machinery, or performing other hazardous activities. Reserpine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Use caution when rising from a sitting or lying position, especially first thing in the morning. You may become dizzy while taking reserpine and you may fall and injure yourself if you get up quickly.

Do not stop taking reserpine suddenly. Even if you feel better, you need this medication to control your condition. Stopping suddenly could cause severe high blood pressure, anxiety, and other dangerous side effects. Avoid alcohol. Alcohol will greatly increase the effects of reserpine, which could be dangerous.

Before having surgery, tell your doctor or dentist that you are taking this medication.

What should I discuss with my healthcare provider before taking reserpine?

Do not take reserpine without first talking to your doctor if you

• have peptic ulcer disease (stomach ulcers);

• have ulcerative colitis;

• are suffering from depression (especially if you have suicidal thoughts);

• are receiving electroconvulsive shock therapy; or

• are taking a monoamine oxidase inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) or have taken one in the last 14 days.

Before taking this medication, tell your doctor if you have

• gallstones,

• kidney disease,

• asthma, or

• any type of heart disease.

You may require a lower dose or special monitoring during therapy with reserpine if you have any of the conditions listed above.

Reserpine is in the FDA pregnancy category C. This means that it is not known whether reserpine will harm an unborn baby. Do not take reserpine without first talking to your doctor if you are pregnant. Reserpine passes into breast milk and may harm a nursing infant. Do not take reserpine without first talking to your doctor if you are breast-feeding a baby. Reserpine has not been approved for use by children.

How should I take reserpine?

Take reserpine exactly as directed. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Take reserpine with food or milk if it upsets your stomach.

Do not stop taking reserpine suddenly. Stopping suddenly could make your condition much worse or cause very serious side effects.

Store this medication at room temperature away from moisture and heat.

See also: Reserpine dosage in more detail

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a reserpine overdose include low blood pressure (fainting, dizziness, weakness); slow pulse; low body temperature; diarrhea; and slow breathing.

What should I avoid while taking reserpine?

Use caution when driving, operating machinery, or performing other hazardous activities. Reserpine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Use caution when rising from a sitting or lying position, especially first thing in the morning. You may become dizzy while taking reserpine and you may fall and injure yourself if you get up quickly.

Avoid becoming overheated in hot weather or during exercise. Also avoid standing for long periods of time and use caution if you have a fever. These situations increase the effects of reserpine in your body, and you may become very dizzy.

Avoid alcohol while taking reserpine. It may increase the drowsiness you experience from reserpine therapy and may also increase dizziness. Use caution even with small amounts of alcohol.

Do not take other drugs such as sleeping pills, prescription pain relievers, antihistamines, or antidepressants without first talking to your doctor. These medicines may increase the drowsiness caused by reserpine. Talk to your doctor or pharmacist about any other prescription or over-the-counter medications you are taking.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Reserpine side effects

If you experience any of the following serious side effects, stop taking reserpine and seek emergency medical attention:

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• a very irregular heartbeat;

• heart failure (shortness of breath, swelling of ankles or legs, sudden weight gain of 5 pounds or more);

• uncontrollable hand, arm, or leg movements; or

• chest pain.

Other, less serious side effects are more likely to occur. Continue to take reserpine and talk to your doctor if you experience

• fatigue or drowsiness;

• dizziness (avoid standing up too quickly and use caution when performing hazardous activities);

• anxiety, depression, or nightmares;

• diarrhea, nausea, or vomiting (take reserpine with food or milk if it upsets your stomach);

• stuffy nose or a dry mouth (sucking on ice chips or sugarless hard candy may relieve a dry mouth);

• blurred vision;

• weight gain; or

• impotence or difficulty ejaculating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Reserpine Dosing Information

Usual Adult Dose for Hypertension:

Initial dose: 0.5 mg orally once a day for 1 to 2 weeks.
Maintenance dose: 0.1 to 0.25 mg orally once a day.

Usual Adult Dose for Schizophrenia:

Initial dose: 0.5 mg orally once a day, but may range from 0.1 to 1 mg.
Maintenance dose: Adjust dose upward or downward according to patient response.

Usual Adult Dose for Hyperthyroidism:

The value of orally administered reserpine during thyrotoxic crisis is not known.

Limited data in which seven patients with thyrotoxic crisis received reserpine 1 to 5 mg intramuscularly, then 0.07 to 0.3 mg per kg in the first 24 hours reveal significant, dose-related improvement in symptoms within four to eight hours of drug administration.

What other drugs will affect reserpine?

Do not take reserpine if you are taking a monoamine oxidase inhibitor (MAOI) or if you have taken one in the last 14 days. MAOIs, used to treat depression, include isocarboxazid (Marplan), phenelzine (Nardil), and tranylcypromine (Parnate).

Before taking reserpine, tell your doctor if you are taking any of the following medicines:

• a tricyclic antidepressant such as amitriptyline (Elavil, Endep), imipramine (Tofranil), doxepin (Sinequan), nortriptyline (Pamelor), and others;

• quinidine (Cardioquin); or

• digoxin (Lanoxin, Lanoxicaps).

You may require special monitoring or a dose adjustment if you are taking any of the medicines listed above.

Reserpine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine unless your doctor approves.

Drugs other than those listed here may also interact with reserpine or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

• Your pharmacist can provide more information about reserpine.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 4.02. Revision Date: 04/02/2009 2:15:59 PM.

Generic Name: Guaifenesin/Phenylephrine (gwye-FEN-e-sin/fen-il-EF-rin)
Brand Name: Examples include Entex and Rescon-GG

Rescon-GG Liquid is used for:

Relieving symptoms of congestion, cough, and throat and airway irritation due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Rescon-GG Liquid is a decongestant and expectorant combination. It works by constricting blood vessels and shrinking swollen and congested nasal tissues (mucous membranes) and by thinning and loosening mucus in the airway. This allows you to breathe more easily and makes coughs more productive.

Do NOT use Rescon-GG Liquid if:

• you are allergic to any ingredient in Rescon-GG Liquid
• you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems
• you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Rescon-GG Liquid:

Some medical conditions may interact with Rescon-GG Liquid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a fast, slow, or irregular heartbeat
• if you have a history of adrenal gland problems (eg, tumor), heart problems, high blood pressure, diabetes, heart blood vessel problems, stroke, glaucoma, an enlarged prostate, seizures, or an overactive thyroid
• if you have chronic cough

Some MEDICINES MAY INTERACT with Rescon-GG Liquid. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, MAOIs (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Rescon-GG Liquid’s side effects
• Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased
• Bromocriptine because its side effects may be increased by Rescon-GG Liquid
• Guanethidine, guanadrel, mecamylamine, methyldopa, or reserpine because its effectiveness may be decreased by Rescon-GG Liquid

This may not be a complete list of all interactions that may occur. Ask your health care provider if Rescon-GG Liquid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Rescon-GG Liquid:

Use Rescon-GG Liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Rescon-GG Liquid by mouth with or without food.
• Take Rescon-GG Liquid with a full glass of water (8 oz/240 mL) unless your doctor directs otherwise.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• If you miss a dose of Rescon-GG Liquid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Rescon-GG Liquid.

Important safety information:

• Rescon-GG Liquid may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Rescon-GG Liquid with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do not take diet or appetite control medicines while you are taking Rescon-GG Liquid without checking with you doctor.
• Do NOT take more than the recommended dose without checking with your doctor.
• If your symptoms do not get better within 5 to 7 days or if they get worse, check with your doctor.
• Rescon-GG Liquid may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Rescon-GG Liquid.
• Tell your doctor or dentist that you take Rescon-GG Liquid before you receive any medical or dental care, emergency care, or surgery.
• Use Rescon-GG Liquid with caution in the ELDERLY; they may be more sensitive to its effects.
• Caution is advised when using Rescon-GG Liquid in CHILDREN; they may be more sensitive to its effects.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Rescon-GG Liquid while you are pregnant. It is not known if Rescon-GG Liquid is found in breast milk. Do not breast-feed while taking Rescon-GG Liquid.

Possible side effects of Rescon-GG Liquid:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; excitability; headache; nausea; nervousness or anxiety; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Rescon-GG Liquid:

Store Rescon-GG Liquid at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Rescon-GG Liquid out of the reach of children and away from pets.

General information:

• If you have any questions about Rescon-GG Liquid, please talk with your doctor, pharmacist, or other health care provider.
• Rescon-GG Liquid is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Rescon-GG Liquid. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Generic Name: chlorpheniramine and phenylephrine (KLOR fen IR a meen and FEN il EFF rin)
Brand Names: Allan Tannate Pediatric, Allerest PE, AlleRx, BP Allergy JR, C Phen, C Phen Drops, Cardec, Cardec Drops, Ceron, Ceron Drops, Chlor-Mes Jr, ChlorTan D, Cold & Allergy Relief, CP Dec, CP Dec Drops, Dallergy Drops, Dallergy-JR, Ed A-Hist, Ed ChlorPed D, Histadec, Nasohist Pediatric, NoHist, Ny-Tannic, PD-Hist D, PD-Hist D Drops, PediaTan D, Phenchlor Tannate Pediatric, R-Tanna, Relera, Rescon-Jr, Rinate Pediatric, Rondec, Rondec Drops, Rondex, Rondex Drops, Ry-Tann, Rynatan, Rynatan Pediatric, Sildec-PE, Sildec-PE Drops, Sinus & Allergy Maximum Strength, Sinus & Allergy PE, Sonahist, Sudafed PE Sinus & Allergy, Tanahist-D, Tannate Pediatric, Triaminic Cold & Allergy

What is Rescon-Jr (chlorpheniramine and phenylephrine)?

Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of chlorpheniramine and phenylephrine is used to treat symptoms of the common cold or seasonal allergies, including sneezing, runny or stuffy nose, and itchy, watery eyes.

Chlorpheniramine and phenylephrine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Rescon-Jr (chlorpheniramine and phenylephrine)?

There are many brands and forms of this medication available and not all brands are listed on this leaflet.

Do not use chlorpheniramine and phenylephrine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Dangerous side effects may occur if you take chlorpheniramine and phenylephrine before the MAO inhibitor has cleared from your body. Do not use this medication if you are allergic to chlorpheniramine or phenylephrine, or if you have severe high blood pressure or coronary artery disease, narrow-angle glaucoma, a stomach ulcer, or if you are unable to urinate.

Do not use this medication during an asthma attack.

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of chlorpheniramine and phenylephrine. Older adults may be more likely to have side effects from this medicine. Do not give this medication to a child younger than 2 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Contact your doctor if your symptoms do not improve or if they get worse after taking this medicine for 7 days.

What should I discuss with my healthcare provider before taking Rescon-Jr (chlorpheniramine and phenylephrine)?

Do not use chlorpheniramine and phenylephrine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Dangerous side effects may occur if you take chlorpheniramine and phenylephrine before the MAO inhibitor has cleared from your body. Do not use this medication if you are allergic to chlorpheniramine or phenylephrine, or if you have:

• severe or uncontrolled high blood pressure;

• severe coronary artery disease;

• narrow angle glaucoma;

• a stomach ulcer; or

• if you are unable to urinate.

Do not use this medication during an asthma attack.

Ask a doctor or pharmacist if it is safe for you to take this medication if you have:

• kidney disease;
• liver disease;

• diabetes;

• glaucoma;

• circulation problems;

• heart disease or high blood pressure;

• overactive thyroid;

• a seizure disorder such as epilepsy;

• asthma, emphysema or chronic bronchitis; or

• urination problems or an enlarged prostate.

FDA pregnancy category C. It is not known whether chlorpheniramine and phenylephrine is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether chlorpheniramine and phenylephrine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have side effects from this medicine.

How should I take Rescon-Jr (chlorpheniramine and phenylephrine)?

Use this medication as directed on the label, or as your doctor has prescribed. Do not use the medication in larger amounts or for longer than recommended.

Do not give this medication to a child younger than 2 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Take this medicine with a full glass of water. Do not crush, chew, break, or open an extended-release tablet or capsule. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time.

The chewable tablet must be chewed before swallowing.

Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Contact your doctor if your symptoms do not improve or if they get worse after taking this medicine for 7 days.

Store chlorpheniramine and phenylephrine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose can cause nausea, vomiting, diarrhea, stomach pain, problems with balance or coordination, headache, urination problems, dizziness, feeling excited or irritable, hallucinations (seeing things), metallic taste in your mouth, tremors, fever, flushed face, and seizure (convulsions).

What should I avoid while taking Rescon-Jr (chlorpheniramine and phenylephrine)?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of chlorpheniramine and phenylephrine.

Avoid using other medicines that may cause restlessness (such as caffeine, stimulants, diet pills, and decongestants contained in over-the-counter cold medicines). They can add to the stimulant effects of phenylephrine.

Rescon-Jr (chlorpheniramine and phenylephrine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using chlorpheniramine and phenylephrine and call your doctor at once if you have any of these serious side effects:

• fast or uneven heart beats;

• feeling light-headed, fainting;

• seizure (convulsions);

• hallucinations (seeing things that are not there); or

• tremors.

Less serious side effects may include:

• heartburn, nausea, vomiting, diarrhea, loss of appetite;

• dry nose or mouth;

• drowsiness, dizziness, weakness, headache;

• dry eyes, blurred vision;

• painful or difficult urination;

• sleep problems (insomnia);

• feeling nervous or excited (especially in children).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Rescon-Jr (chlorpheniramine and phenylephrine)?

Sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by chlorpheniramine. Tell your doctor if you regularly use any of these medicines, or any other cold or allergy medications..

Tell your doctor about all other medications you use, especially:

• mecamylamine (Inversine);

• methyldopa (Aldomet);

• reserpine;

• a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others;

• a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton); or

• an antidepressant such as amitriptyline (Elavil, Vanatrip), doxepin (Sinequan), desipramine (Norpramin), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), and others.

This list is not complete and there may be other drugs that can interact with chlorpheniramine and phenylephrine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about chlorpheniramine and phenylephrine.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 7.03. Revision Date: 11/19/2009 11:50:43 AM.