Generic Name: cyanocobalamin
Dosage Form: FOR ANIMAL USE ONLY
Vitamin B12 1000mcg Injection
Composition
Each mL of sterile aqueous solution contains: Cyanocobalamin (B12)………1000mcg with sodium chloride 0.8% W/V and benzyl alcohol 1.5% V/V (preservative).
Indications and Usage for Vitamin B 12
For use as an aid in the management of vitamin B12 deficiencies in cattle, horses, dogs and cats.
Storage
Store at controlled room temperature 20°-25°C (68°-77°F)Avoid exposure to light
Vitamin B 12 Dosage and Administration
Inject subcutaneously or intramuscularly. Cattle and Horses-1 to 2 mL Dogs and Cats-0.25 to 0.5 mL May be repeated once or twice weekly, as indicated by condition and response..
Observe Directions
Manufactured by
Supplied in 100mL, 250mL and 500mL glass amber vials
Generic Name: Vitamin B Complex/Vitamin C/Biotin/Folic Acid (VYE-ta-min/BYE-oh-tin/FOE-lik AS-id) Brand Name: Examples include: Folbee Plus and Nephrocaps
Vitamin B Complex/Vitamin C/Biotin/Folic Acid is used for:
A dietary supplement for certain patients with high blood levels of homocysteine or kidney failure, or those who are on dialysis or do not receive the proper amount of vitamins from their diet. It may also be used for other conditions as determined by your doctor.
Vitamin B Complex/Vitamin C/Biotin/Folic Acid is a vitamin and folic acid combination. It works by providing vitamins and folic acid to the body to help meet nutritional requirements.
Do NOT use Vitamin B Complex/Vitamin C/Biotin/Folic Acid if:
you are allergic to any ingredient in Vitamin B Complex/Vitamin C/Biotin/Folic Acid
Contact your doctor or health care provider right away if any of these apply to you.
Before using Vitamin B Complex/Vitamin C/Biotin/Folic Acid:
Some medical conditions may interact with Vitamin B Complex/Vitamin C/Biotin/Folic Acid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have anemia (eg, pernicious anemia)
if you are receiving dialysis
Some MEDICINES MAY INTERACT with Vitamin B Complex/Vitamin C/Biotin/Folic Acid. Tell your health care provider if you are taking any other medicines, especially any of the following:
Hydantoins (eg, phenytoin) or levodopa because their effectiveness may be decreased by Vitamin B Complex/Vitamin C/Biotin/Folic Acid
This may not be a complete list of all interactions that may occur. Ask your health care provider if Vitamin B Complex/Vitamin C/Biotin/Folic Acid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Vitamin B Complex/Vitamin C/Biotin/Folic Acid:
Use Vitamin B Complex/Vitamin C/Biotin/Folic Acid as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Vitamin B Complex/Vitamin C/Biotin/Folic Acid may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
If you miss a dose of Vitamin B Complex/Vitamin C/Biotin/Folic Acid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Vitamin B Complex/Vitamin C/Biotin/Folic Acid.
Important safety information:
Vitamin B Complex/Vitamin C/Biotin/Folic Acid may cause drowsiness. This effect may be worse if you take it with alcohol or certain medicines. Use Vitamin B Complex/Vitamin C/Biotin/Folic Acid with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Do not take large doses of vitamins (megadoses or megavitamin therapy) while you use Vitamin B Complex/Vitamin C/Biotin/Folic Acid unless your doctor tells you to.
Vitamin B Complex/Vitamin C/Biotin/Folic Acid contains pyridoxine (vitamin B6) and folic acid. Before you start any new medicine, check the label to see if it has pyridoxine or folic acid in it too. If it does or if you are not sure, check with your doctor or pharmacist.
Vitamin B Complex/Vitamin C/Biotin/Folic Acid may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Vitamin B Complex/Vitamin C/Biotin/Folic Acid.
PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Vitamin B Complex/Vitamin C/Biotin/Folic Acid while you are pregnant. It is not known if Vitamin B Complex/Vitamin C/Biotin/Folic Acid is found in breast milk. If you are or will be breast-feeding while you use Vitamin B Complex/Vitamin C/Biotin/Folic Acid, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Vitamin B Complex/Vitamin C/Biotin/Folic Acid:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Drowsiness; headache; mild diarrhea; nausea.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); feeling of swelling of the entire body; numbness or tingling of the skin.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.
Proper storage of Vitamin B Complex/Vitamin C/Biotin/Folic Acid:
Store Vitamin B Complex/Vitamin C/Biotin/Folic Acid at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Vitamin B Complex/Vitamin C/Biotin/Folic Acid out of the reach of children and away from pets.
General information:
If you have any questions about Vitamin B Complex/Vitamin C/Biotin/Folic Acid, please talk with your doctor, pharmacist, or other health care provider.
Vitamin B Complex/Vitamin C/Biotin/Folic Acid is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.
This information is a summary only. It does not contain all information about Vitamin B Complex/Vitamin C/Biotin/Folic Acid. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Generic Name: Vitamin B Complex/Vitamin C/Biotin/Folic Acid (VYE-ta-min/BYE-oh-tin/FOE-lik AS-id) Brand Name: Examples include: Folbee Plus and Nephrocaps
Vitamin B Complex/Vitamin C/Biotin/Folic Acid is used for:
A dietary supplement for certain patients with high blood levels of homocysteine or kidney failure, or those who are on dialysis or do not receive the proper amount of vitamins from their diet. It may also be used for other conditions as determined by your doctor.
Vitamin B Complex/Vitamin C/Biotin/Folic Acid is a vitamin and folic acid combination. It works by providing vitamins and folic acid to the body to help meet nutritional requirements.
Do NOT use Vitamin B Complex/Vitamin C/Biotin/Folic Acid if:
you are allergic to any ingredient in Vitamin B Complex/Vitamin C/Biotin/Folic Acid
Contact your doctor or health care provider right away if any of these apply to you.
Before using Vitamin B Complex/Vitamin C/Biotin/Folic Acid:
Some medical conditions may interact with Vitamin B Complex/Vitamin C/Biotin/Folic Acid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have anemia (eg, pernicious anemia)
if you are receiving dialysis
Some MEDICINES MAY INTERACT with Vitamin B Complex/Vitamin C/Biotin/Folic Acid. Tell your health care provider if you are taking any other medicines, especially any of the following:
Hydantoins (eg, phenytoin) or levodopa because their effectiveness may be decreased by Vitamin B Complex/Vitamin C/Biotin/Folic Acid
This may not be a complete list of all interactions that may occur. Ask your health care provider if Vitamin B Complex/Vitamin C/Biotin/Folic Acid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Vitamin B Complex/Vitamin C/Biotin/Folic Acid:
Use Vitamin B Complex/Vitamin C/Biotin/Folic Acid as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Vitamin B Complex/Vitamin C/Biotin/Folic Acid may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
If you miss a dose of Vitamin B Complex/Vitamin C/Biotin/Folic Acid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Vitamin B Complex/Vitamin C/Biotin/Folic Acid.
Important safety information:
Vitamin B Complex/Vitamin C/Biotin/Folic Acid may cause drowsiness. This effect may be worse if you take it with alcohol or certain medicines. Use Vitamin B Complex/Vitamin C/Biotin/Folic Acid with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Do not take large doses of vitamins (megadoses or megavitamin therapy) while you use Vitamin B Complex/Vitamin C/Biotin/Folic Acid unless your doctor tells you to.
Vitamin B Complex/Vitamin C/Biotin/Folic Acid contains pyridoxine (vitamin B6) and folic acid. Before you start any new medicine, check the label to see if it has pyridoxine or folic acid in it too. If it does or if you are not sure, check with your doctor or pharmacist.
Vitamin B Complex/Vitamin C/Biotin/Folic Acid may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Vitamin B Complex/Vitamin C/Biotin/Folic Acid.
PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Vitamin B Complex/Vitamin C/Biotin/Folic Acid while you are pregnant. It is not known if Vitamin B Complex/Vitamin C/Biotin/Folic Acid is found in breast milk. If you are or will be breast-feeding while you use Vitamin B Complex/Vitamin C/Biotin/Folic Acid, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Vitamin B Complex/Vitamin C/Biotin/Folic Acid:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Drowsiness; headache; mild diarrhea; nausea.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); feeling of swelling of the entire body; numbness or tingling of the skin.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.
Proper storage of Vitamin B Complex/Vitamin C/Biotin/Folic Acid:
Store Vitamin B Complex/Vitamin C/Biotin/Folic Acid at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Vitamin B Complex/Vitamin C/Biotin/Folic Acid out of the reach of children and away from pets.
General information:
If you have any questions about Vitamin B Complex/Vitamin C/Biotin/Folic Acid, please talk with your doctor, pharmacist, or other health care provider.
Vitamin B Complex/Vitamin C/Biotin/Folic Acid is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.
This information is a summary only. It does not contain all information about Vitamin B Complex/Vitamin C/Biotin/Folic Acid. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Generic Name: Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc (VYE-ta-min B/VYE-ta-min C/BYE-oh-tin/FOE-lik AS-id/zink) Brand Name: Examples include Ivites Rx and Nephplex Rx
Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc is used for:
Treating or preventing a lack of certain vitamins, folic acid, or zinc. It may also be used for other conditions as determined by your doctor.
Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc is a vitamin and folic acid combination. It works by providing vitamins and folic acid to the body to help meet nutritional requirements.
Do NOT use Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc if:
you are allergic to any ingredient in Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc
Contact your doctor or health care provider right away if any of these apply to you.
Before using Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc:
Some medical conditions may interact with Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances (including soy)
if you have anemia (eg, pernicious anemia)
Some MEDICINES MAY INTERACT with Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc. Tell your health care provider if you are taking any other medicines, especially any of the following:
Fluorouracil because the risk of its side effects may be increased by Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc
Hydantoins (eg, phenytoin) because their effectiveness may be decreased by Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc
This may not be a complete list of all interactions that may occur. Ask your health care provider if Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc:
Use Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Take Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
If you are also taking eltrombopag, a quinolone antibiotic (eg, levofloxacin), or a tetracycline antibiotic (eg, doxycycline), ask your doctor how you should take it with Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc.
If you miss a dose of Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc.
Important safety information:
Do not take large doses of vitamins (megadoses or megavitamin therapy) unless directed by your doctor.
Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc contains pyridoxine (vitamin B6) and folic acid. Before you start any medicine, check the label to see if it has pyridoxine or folic acid in it too. If it does or if you are not sure, check with your doctor or pharmacist.
This product may contain tartrazine dye (FD & C Yellow No. 5). This may cause an allergic reaction in some patients. The risk may be higher if you are allergic to aspirin. If you have ever had an allergic reaction to tartrazine, ask your pharmacist if your product has tartrazine in it.
Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc.
PREGNANCY and BREAST-FEEDING: If you plan on becoming pregnant, contact your doctor. You will need to discuss the benefits and risks of using Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc while you are pregnant. It is not known if Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc is found in breast milk. If you are or will be breast-feeding while you are using Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc:
All medicines may cause side effects, but many people have no, or minor, side effects. No COMMON side effects have been reported with Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc. Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); decreased coordination; decreased sensation of touch, temperature, or vibration; numbness or tingling of the skin.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include confusion; decreased coordination; mental or mood changes; numbness or tingling of the hands or feet.
Proper storage of Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc:
Store Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc out of the reach of children and away from pets.
General information:
If you have any questions about Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc, please talk with your doctor, pharmacist, or other health care provider.
Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.
This information is a summary only. It does not contain all information about Vitamin B Complex/Vitamin C/Biotin/Folic Acid/Zinc. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid is used for:
A dietary supplement for certain patients with high blood levels of homocysteine. It may also be used for other conditions as determined by your doctor.
Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid is a vitamin, mineral, and folic acid combination. It works by providing vitamins, minerals, and folic acid to the body to help meet nutritional requirements.
Do NOT use Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid if:
you are allergic to any ingredient in Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid
Contact your doctor or health care provider right away if any of these apply to you.
Before using Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid:
Some medical conditions may interact with Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, plan to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have anemia (eg, pernicious anemia)
Some MEDICINES MAY INTERACT with Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid. Tell your health care provider if you are taking any other medicines, especially any of the following:
Hydantoins (eg, phenytoin), levodopa, or quinolones (eg, ciprofloxacin) because their effectiveness may be decreased by Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid
This may not be a complete list of all interactions that may occur. Ask your health care provider if Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid:
Use Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
Dialysis patients – Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid should be taken after dialysis treatment.
If you are also taking a tetracycline (eg, doxycycline), do not take it within 2 hours before or after taking Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid.
If you miss a dose of Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid.
Important safety information:
Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid may cause drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid. Using Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
Do not take large doses of vitamins (megadoses or megavitamin therapy) unless directed by your doctor.
Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid contains pyridoxine (vitamin B6) and folic acid. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains pyridoxine or folic acid. If it does or if you are uncertain, contact your doctor or pharmacist.
Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid.
PREGNANCY and BREAST-FEEDING: If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid during pregnancy. It is unknown if Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid is excreted in breast milk. If you are or will be breast-feeding while you are using Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid, check with your doctor or pharmacist to discuss the risks to your baby.
Possible side effects of Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Drowsiness; headache; mild diarrhea; nausea.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); feeling of swelling of the entire body; numbness or tingling of the skin.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.
Proper storage of Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid:
Store Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid out of the reach of children and away from pets.
General information:
If you have any questions about Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid, please talk with your doctor, pharmacist, or other health care provider.
Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.
This information is a summary only. It does not contain all information about Vitamin B Complex/Vitamin C/Biotin/Minerals/Folic Acid. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Generic Name: Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid (VYE-ta-min B/VYE-ta-min C/BYE-oh-tin/VYE-ta-min E/FOE-lik AS-id/EYE-urn) Brand Name: Renatabs with Iron
Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid is used for:
A dietary supplement in certain patients with kidney failure. It is also used as a stress vitamin. It may also be used for other conditions as determined by your doctor.
Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid is a vitamin, folic acid, and iron combination. It works by providing vitamins, folic acid, and iron to the body to help meet nutritional requirements.
Do NOT use Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid if:
you are allergic to any ingredient in Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid
you have certain iron metabolism problems (eg, hemochromatosis, hemosiderosis) or you have high levels of iron in your blood
Contact your doctor or health care provider right away if any of these apply to you.
Before using Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid:
Some medical conditions may interact with Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, plan to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have anemia (eg, pernicious anemia) or a history of other blood or bleeding problems
if you have a peptic ulcer or stomach or bowel problems (eg, ulcerative colitis)
if you have a history of seizures
Some MEDICINES MAY INTERACT with Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid. Tell your health care provider if you are taking any other medicines, especially any of the following:
Fluorouracil because the risk of its side effects may be increased by Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid
Bisphosphonates (eg, alendronate), cephalosporins (eg, cefdinir), hydantoins (eg, phenytoin), levodopa, methyldopa, penicillamine, quinolones (eg, ciprofloxacin, levofloxacin), tetracyclines (eg, doxycycline), or thyroid hormones (eg, levothyroxine) because their effectiveness may be decreased by Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid
This may not be a complete list of all interactions that may occur. Ask your health care provider if Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid:
Use Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Take Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
This product contains 2 different tablets; one is a vitamin tablet and the other is an iron tablet. Be sure you understand how to take Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid. Check with your doctor or pharmacist if you have any questions.
Dialysis patients – Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid should be taken after treatment on dialysis days.
If you also take a bisphosphonate (eg, alendronate), a cephalosporin (eg, cefdinir), methyldopa, penicillamine, a quinolone (eg, ciprofloxacin), or a tetracycline (eg, doxycycline) check with your doctor about how to take it with Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid.
If you miss a dose of Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid.
Important safety information:
Do not take large doses of vitamins (megadoses or megavitamin therapy) unless directed by your doctor.
Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid has pyridoxine (vitamin B6), folic acid, and iron in it. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it has pyridoxine, folic acid, or iron in it too. If it does or if you are not sure, check with your doctor or pharmacist.
Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid has iron in it. Iron overdose is a leading cause of fatal poisoning in children younger than 6 years of age. In case of an overdose, call a doctor or poison control center right away.
Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid.
Lab tests, including hematocrit, hemoglobin levels, and blood iron levels, may be performed while you use Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid while you are pregnant. Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid is found in breast milk. If you are or will be breast-feeding while you use Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid:
All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Constipation; dark or green stools; mild diarrhea; nausea; stomach pain; vomiting.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; numbness or tingling of the skin; severe or persistent stomach pain or cramping.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include blue or unusually pale skin; drowsiness or dizziness; fast heartbeat; increased thirst or urination; loss of balance; seizures; severe or persistent nausea, vomiting, or diarrhea; sluggishness; vomiting blood; weakness.
Proper storage of Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid:
Store Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid out of the reach of children and away from pets.
General information:
If you have any questions about Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid, please talk with your doctor, pharmacist, or other health care provider.
Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.
This information is a summary only. It does not contain all information about Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Generic Name: Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc (VYE-ta-min/BYE-oh-tin/FOE-lik AS-id/zink) Brand Name: Examples include Dialyvite 3000 and Dialyvite 5000
Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc is used for:
A dietary supplement for certain patients. It may also be used for other conditions as determined by your doctor.
Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc is a vitamin and folic acid combination. It works by providing vitamins and folic acid to the body to help meet nutritional requirements.
Do NOT use Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc if:
you are allergic to any ingredient in Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc
Contact your doctor or health care provider right away if any of these apply to you.
Before using Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc:
Some medical conditions may interact with Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have anemia (eg, pernicious anemia)
Some MEDICINES MAY INTERACT with Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc. Tell your health care provider if you are taking any other medicines, especially any of the following:
Fluorouracil because the risk of its side effects may be increased by Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc
Hydantoins (eg, phenytoin) or quinolone antibiotics (eg, ciprofloxacin) because their effectiveness may be decreased by Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc
This may not be a complete list of all interactions that may occur. Ask your health care provider if Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc:
Use Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Take Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
If you are also taking a tetracycline antibiotic (eg, doxycycline), do not take it within 2 hours before or after taking Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc. Check with your doctor or pharmacist if you have questions.
If you miss a dose of Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc.
Important safety information:
Do not take large doses of vitamins (megadoses or megavitamin therapy) unless directed by your doctor.
Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc contains pyridoxine (vitamin B6) and folic acid. Before you start any medicine, check the label to see if it has pyridoxine or folic acid in it too. If it does or if you are not sure, check with your doctor or pharmacist.
Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc.
PREGNANCY and BREAST-FEEDING: If you plan on becoming pregnant, contact your doctor. You will need to discuss the benefits and risks of using Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc while you are pregnant. It is not known if Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc is found in breast milk. If you are or will be breast-feeding while you are using Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc:
All medicines may cause side effects, but many people have no, or minor side effects. No COMMON side effects have been reported with Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc. Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); decreased coordination; decreased sensation of touch, temperature, or vibration; numbness or tingling of the skin.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include confusion; decreased coordination; mental or mood changes; numbness or tingling of the hands or feet.
Proper storage of Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc:
Store Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc out of the reach of children and away from pets.
General information:
If you have any questions about Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc, please talk with your doctor, pharmacist, or other health care provider.
Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.
This information is a summary only. It does not contain all information about Vitamin B Complex/Vitamin C/Biotin/Vitamin E/Folic Acid/Zinc. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Vitamin A is needed for night vision and for growth of skin, bones, and male and female reproductive organs. In pregnant women vitamin A is necessary for the growth of a healthy fetus.
Lack of vitamin A may lead to a rare condition called night blindness (problems seeing in the dark), as well as dry eyes, eye infections, skin problems, and slowed growth. Your health care professional may treat these problems by prescribing vitamin A for you.
Some conditions may increase your need for vitamin A. These include:
Diarrhea
Eye diseases
Intestine diseases
Infections (continuing or chronic)
Measles
Pancreas disease
Stomach removal
Stress (continuing)
In addition, infants receiving unfortified formula may need vitamin A supplements.
Vitamin A absorption will be decreased in any condition in which fat is poorly absorbed.
Increased need for vitamin A should be determined by your health care professional.
Claims that vitamin A is effective for treatment of conditions such as acne or lung diseases, or for treatment of eye problems, wounds, or dry or wrinkled skin not caused by lack of vitamin A have not been proven. Although vitamin A is being used to prevent certain types of cancer, some experts feel there is not enough information to show that this is effective, particularly in well-nourished individuals.
Injectable vitamin A is given by or under the supervision of a health care professional. Other forms of vitamin A are available without a prescription.
Importance of Diet
For good health, it is important that you eat a balanced and varied diet. Follow carefully any diet program your health care professional may recommend. For your specific dietary vitamin and/or mineral needs, ask your health care professional for a list of appropriate foods. If you think that you are not getting enough vitamins and/or minerals in your diet, you may choose to take a dietary supplement.
Vitamin A is found in various foods including yellow-orange fruits and vegetables; dark green, leafy vegetables; vitamin A-fortified milk; liver; and margarine. Vitamin A comes in two different forms, retinols and beta-carotene. Retinols are found in foods that come from animals (meat, milk, eggs). The form of vitamin A found in plants is called beta-carotene (which is converted to vitamin A in the body). Food processing may destroy some of the vitamins. For example, freezing may reduce the amount of vitamin A in foods.
Vitamins alone will not take the place of a good diet and will not provide energy. Your body needs other substances found in food, such as protein, minerals, carbohydrates, and fat. Vitamins themselves often cannot work without the presence of other foods. For example, small amounts of fat are needed so that vitamin A can be absorbed into the body.
The daily amount of vitamin A needed is defined in several different ways.
For U.S.—
Recommended Dietary Allowances (RDAs) are the amount of vitamins and minerals needed to provide for adequate nutrition in most healthy persons. RDAs for a given nutrient may vary depending on a person’s age, sex, and physical condition (e.g., pregnancy).
Daily Values (DVs) are used on food and dietary supplement labels to indicate the percent of the recommended daily amount of each nutrient that a serving provides. DV replaces the previous designation of United States Recommended Daily Allowances (USRDAs).
Normal daily recommended intakes in the United States for vitamin A are generally defined according to age or condition and to the form of vitamin A as follows:
Age or Condition
Form of Vitamin A
RE or mcg of Retinol
Amount in Units as Retinol
Amount in Units as a Combination of Retinol and Beta-carotene
Infants and children
Birth to 3 years
375–400
1250–1330
1875–2000
4 to 6 years
500
1665
2500
7 to 10 years
700
2330
3500
Teenage and adult males
1000
3330
5000
Teenage and adult females
800
2665
4000
Pregnant females
800
2665
4000
Breast-feeding females
1200–1300
4000–4330
6000–6500
Note: Based on 1980 U.S. Recommended Dietary Allowances (RDAs) for vitamin A in the diet that is a combination of retinol and beta-carotene.
For Canada—
Recommended Nutrient Intakes (RNIs) are used to determine the amounts of vitamins, minerals, and protein needed to provide adequate nutrition and lessen the risk of chronic disease.
Normal daily recommended intakes in Canada for vitamin A are generally defined according to age or condition and to the form of vitamin A as follows:
Age or Condition
Form of Vitamin A
RE or mcg of Retinol
Amount in Units as Retinol
Amount in Units as a Combination of Retinol and Beta-carotene
Infants and children
Birth to 3 years
400
1330
2000
4 to 6 years
500
1665
2330
7 to 10 years
700–800
2330–2665
3500
Teenage and adult males
1000
3330
5000
Teenage and adult females
800
2665
4000
Pregnant females
900
2665–3000
4000–4500
Breast-feeding females
1200
4000
6000
Note: Based on 1980 U.S. Recommended Dietary Allowances (RDAs) for vitamin A in the diet that is a combination of retinol and beta-carotene.
In the past, the RDA and RNI for vitamin A have been expressed in Units. This term Units has been replaced by retinol equivalents (RE) or micrograms (mcg) of retinol, with 1 RE equal to 1 mcg of retinol. This was done to better describe the two forms of vitamin A, retinol and beta-carotene. One RE of vitamin A is equal to 3.33 Units of retinol and 10 Units of beta-carotene. Some products available have not changed their labels and continue to be labeled in Units.
Before Using vitamin a
If you are taking this dietary supplement without a prescription, carefully read and follow any precautions on the label. For this supplement, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to vitamin a or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Problems in children have not been reported with intake of normal daily recommended amounts. However, side effects from high doses and/or prolonged use of vitamin A are more likely to occur in young children than adults.
Geriatric
Problems in older adults have not been reported with intake of normal daily recommended amounts. However, some studies have shown that the elderly may be at risk of high blood levels of vitamin A with long-term use.
Pregnancy
Pregnancy Category
Explanation
All Trimesters
X
Studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit.
Breast Feeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Using this dietary supplement with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Abciximab
Acenocoumarol
Ancrod
Anisindione
Antithrombin III Human
Argatroban
Bexarotene
Bivalirudin
Clopidogrel
Danaparoid
Defibrotide
Dermatan Sulfate
Desirudin
Dicumarol
Eptifibatide
Fondaparinux
Heparin
Lamifiban
Minocycline
Pentosan Polysulfate Sodium
Phenindione
Phenprocoumon
Sibrafiban
Tirofiban
Warfarin
Xemilofiban
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this dietary supplement. Make sure you tell your doctor if you have any other medical problems, especially:
Alcohol abuse (or history of) or
Liver disease—Vitamin A use may make liver problems worse
Kidney disease—May cause high blood levels of vitamin A, which may increase the chance of side effects
Proper Use of vitamin a
If you miss taking a vitamin for one or more days there is no cause for concern, since it takes some time for your body to become seriously low in vitamins. However, if your health care professional has recommended that you take this vitamin, try to remember to take it as directed every day.
Dosing
The dose of vitamin a will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of vitamin a. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For oral dosage form (capsules, tablets, oral solution):
To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes:
For the U.S.
Adult and teenage males—1000 retinol equivalents (RE) (3330 Units of retinol or 5000 Units as a combination of retinol and beta-carotene) per day.
Adult and teenage females—800 RE (2665 Units of retinol or 4000 Units as a combination of retinol and beta-carotene) per day.
Pregnant females—800 RE (2665 Units of retinol or 4000 Units as a combination of retinol and beta-carotene) per day.
Breast-feeding females—1200 to 1300 RE (4000 to 4330 Units of retinol or 6000 to 6500 Units as a combination of retinol and beta-carotene) per day.
Children 7 to 10 years of age—700 RE (2330 Units of retinol or 3500 Units as a combination of retinol and beta-carotene) per day.
Children 4 to 6 years of age—500 RE (1665 Units of retinol or 2500 Units as a combination of retinol and beta-carotene) per day.
Children birth to 3 years of age—375 to 400 RE (1250 to 1330 Units of retinol or 1875 to 2000 Units as a combination of retinol and beta-carotene) per day.
For Canada
Adult and teenage males—1000 RE (3330 Units of retinol or 5000 Units as a combination of retinol and beta-carotene) per day.
Adult and teenage females—800 RE (2665 Units of retinol or 4000 Units as a combination of retinol and beta-carotene) per day.
Pregnant females—900 RE (2665 to 3000 Units of retinol or 4000 to 4500 Units as a combination of retinol and beta-carotene) per day.
Breast-feeding females—1200 RE (4000 Units of retinol or 6000 Units as a combination of retinol and beta-carotene) per day.
Children 7 to 10 years of age—700 to 800 RE (2330 to 2665 Units of retinol or 3500 Units as a combination of retinol and beta-carotene) per day.
Children 4 to 6 years of age—500 RE (1665 Units of retinol or 2500 Units as a combination of retinol and beta-carotene) per day.
Children birth to 3 years of age—400 RE (1330 Units or 2000 Units as a combination of retinol and beta-carotene) per day.
To treat deficiency:
Adults and teenagers—Treatment dose is determined by prescriber for each individual based on severity of deficiency. The following dose has been determined for xerophthalmia (eye disease): Oral, 7500 to 15,000 RE (25,000 to 50,000 Units) a day.
Children—Treatment dose is determined by prescriber for each individual based of severity of deficiency. The following doses have been determined:
For measles—
Children 6 months to 1 year of age: Oral, 30,000 RE (100,000 Units) as a single dose.
For children 1 year of age and older: Oral, 60,000 RE (200,000 Units) as a single dose.
Xerophthalmia (eye disease)—
Children 6 months to 1 year of age: Oral, 30,000 RE (100,000 Units) as a single dose, the same dose being repeated the next day and again at 4 weeks.
Children 1 year of age and older: Oral, 60,000 RE (200,000 Units) as a single dose, the same dose being repeated the next day and again at 4 weeks.
Note: Vitamin A is used in measles and xerophthalmia only when vitamin A deficiency is a problem as determined by your health care professional. Vitamin A deficiency occurs in malnutrition or in certain disease states.
For individuals taking the oral liquid form of vitamin A:
This preparation is to be taken by mouth even though it comes in a dropper bottle.
This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.
Missed Dose
If you miss a dose of vitamin a, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Precautions While Using vitamin a
Vitamin A is stored in the body; therefore, when you take more than the body needs, it will build up in the body. This may lead to poisoning and even death. Problems are more likely to occur in:
Adults taking 7500 RE (25,000 Units) a day for 8 months in a row, or 450,000 RE (1,500,000 Units) all at once; or
Children taking 5400 RE (18,000 Units) to 15,000 RE (50,000 Units) a day for several months in a row, or 22,500 RE (75,000 Units) to 105,100 RE (350,000 Units) all at once.
Pregnant women taking more than 1800 RE (6000 Units) a day.
Remember that the total amount of vitamin A you get every day includes what you get from foods that you eat and what you take as a supplement.
High doses and/or prolonged use of vitamin A may cause bleeding from the gums; dry or sore mouth; or drying, cracking, or peeling of the lips.
vitamin a Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Bleeding from gums or sore mouth
bulging soft spot on head (in babies)
confusion or unusual excitement
diarrhea
dizziness or drowsiness
double vision
headache (severe)
irritability (severe)
peeling of skin, especially on lips and palms
vomiting (severe)
Check with your doctor as soon as possible if any of the following side effects occur:
Bone or joint pain
convulsions (seizures)
drying or cracking of skin or lips
dry mouth
fever
general feeling of discomfort or illness or weakness
headache
increased sensitivity of skin to sunlight
increase in frequency of urination, especially at night, or in amount of urine
irritability
loss of appetite
loss of hair
stomach pain
unusual tiredness
vomiting
yellow-orange patches on soles of feet, palms of hands, or skin around nose and lips
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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Generic Name: vitamin A, D, and E (topical) (VYE ta min A, D, and E)
Brand Names: A & D, Aloe Grande, Lazer Creme, Vitamin A & D, Topical
What is Vitamin A & D, (vitamin A, D, and E (topical))?
Vitamin A, D, and E topical is a skin protectant. It works by moisturizing and sealing the skin, and aids in skin healing.
This medication is used to treat diaper rash, dry or chafed skin, and minor cuts or burns.
Vitamin A, D, and E may also be used for other purposes not listed in this medication guide.
What is the most important information I should know about Vitamin A & D, (vitamin A, D, and E (topical))?
Call your doctor if your skin condition does not get better after using this medication regularly for 1 week. Contact your doctor at any time if your symptoms get worse.
Call your doctor at once if you have swelling, redness, itching, pus, or other signs of infection. Tell your doctor if you feel any numbness or tingling while using vitamin A, D, and E topical.
Do not apply vitamin A, D, and E topical over large skin areas. Do not use the medicine to treat a deep cut, an animal bite, or a serious burn. Call your doctor for instructions on how to treat these more severe skin injuries.
Avoid applying other creams, lotions, ointments, or other medicated skin products to the same areas you treat with vitamin A, D, and E topical.
What should I discuss with my health care provider before using Vitamin A & D, (vitamin A, D, and E (topical))?
Call your doctor at once if you have swelling, redness, itching, pus, or other signs of infection. Tell your doctor if you feel any numbness or tingling while using vitamin A, D, and E topical.
Before using vitamin A, D, and E topical, tell your doctor if you are allergic to any medicines or skin products, including soaps, oils, lotions, or creams.
How should I use Vitamin A & D, (vitamin A, D, and E (topical))?
Use this medication exactly as directed on the label, or as your doctor has prescribed it for you. Do not use more of the medication or use it for longer than recommended.
Keep the baby’s diaper area as dry as possible. Change wet or soiled diapers immediately to keep wetness and bacteria from irritating the baby’s skin. Always put on a new diaper when the baby first wakes up in the morning, and also just before putting the baby to bed each night.
At each diaper changing, clean the baby’s skin thoroughly with a disposable baby wipe or clean wet washcloth. Gently wipe inside the skin folds between the thighs and genitals. When cleaning the diaper area of a boy, gently clean under the scrotum and beneath the foreskin of the penis. When cleaning the diaper area of a girl, always wipe from front to back across the vagina.
Call your doctor if your skin condition does not get better after using this medication regularly for 1 week. Contact your doctor at any time if your symptoms get worse.
Store this medicine at room temperature away from moisture and heat.
What happens if I miss a dose?
Use the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not use extra medicine to make up the missed dose.
What happens if I overdose?
It is unlikely that this medication would cause serious problems from an overdose. Do not apply vitamin A, D, and E topical over large skin areas. Call your doctor if you think you have used too much of the medicine.
Call a poison control center if anyone accidentally swallows this medicine.
What should I avoid while using Vitamin A & D, (vitamin A, D, and E (topical))?
Avoid applying other creams, lotions, ointments, or other medicated skin products to the same areas you treat with vitamin A, D, and E topical.
Avoid excessive wetness of the skin areas you are treating. Keep clothing and diapers as dry as possible.
Vitamin A & D, (vitamin A, D, and E (topical)) side effects
Stop using this medication and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Vitamin A & D, (vitamin A, D, and E (topical))?
There may be other drugs that can affect vitamin A, D, and E topical. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Where can I get more information?
Your pharmacist can provide more information about vitamin A, D, and E topical.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Patients with acute promyelocytic leukemia (APL) are at high risk in general and can have severe adverse reactions to tretinoin. tretinoin should therefore be administered only to patients with APL under the strict supervision of a physician who is experienced in the management of patients with acute leukemia and ni a facility with laboratory and supportive services sufficient to monitor drug tolerance and protect and maintain a patient compromised by drug toxicity, including respiratory compromise. Use of tretinoin requires that the physician concludes that the possible benefit to the patient outweighs the following known adverse effects of the therapy.
Retinoic Acid-APL Syndrome
About 25% of patients with APL treated with tretinoin have experienced a syndrome called the retinoic acid-APL (RA-APL) syndrome characterized by fever, dyspnea, acute respiratory distress, weight gain, radiographic pulmonary infiltrates, pleural and pericardial effusions, edema, and hepatic, renal and multi-organ failure. This syndrome has occasionally been accompanied by impaired myocardial contractility and episodic hypotension. It has been observed with or without concomitant leukocytosis. Endotracheal intubation and mechanical ventilation have been required in some cases due to progressive hypoxemia, and several patients have expired with multi-organ failure. The syndrome generally occurs during the first month of treatment, with some cases reported following the first dose of tretinoin.
The management of the syndrome has not been defined rigorously, but high-dose steroids given at the first suspicion of the RA-APL syndrome appear to reduce morbidity and mortality. At the first signs suggestive of the syndrome (unexplained fever, dyspnea and/or weight gain, abnormal chest auscultatory findings or radiographic abnormalities), high-dose steroids (dexamethasone 10 mg intravenously administered every 12 hours for 3 days or until the resolution of symptoms) should be immediately initiated, irrespective of the leukocyte count. The majority of patients do not require termination of tretinoin therapy during treatment of the RA-APL syndrome. However, in cases of moderate and severe RA-APL syndrome, temporary interruption of tretinoin therapy should be considered.
Leukocytosis at Presentation and Rapidly Evolving Leukocytosis During Tretinoin Treatment
During tretinoin treatment about 40% of patients will develop rapidly evolving leukocytosis. Patients who present with high WBC at diagnosis (greater than 5×10(9)/L) have an increased risk of a further rapid increase in WBC counts. Rapidly evolving leukocytosis is associated with a higher risk of life-threatening complications.
If signs and symptoms of the RA-APL syndrome are present together with leukocytosis, treatment with high-dose steroids should be initiated immediately. Some investigators routinely add chemotherapy to tretinoin treatment in the case of patients presenting with a WBC count of greater than 5×10(9)/L or in the case of a rapid increase in WBC count for patients leukopenic at start of treatment, and have reported a lower incidence of the RA-APL syndrome. Consideration could be given to adding full-dose chemotherapy (including an anthracycline if not contraindicated) to the tretinoin therapy on day 1 or 2 for patients presenting with a WBC count of greater than 5×10(9)/L, or immediately, for patients presenting with a WBC count of less than 5×10(9)/L, if the WBC count reaches greater than or equal to 6×10(9)/L by day 5, or greater than or equal to 10×10(9)/L by day 10, or greater than or equal to 15×10(9)/L by day 28.
Teratogenic Effects. Pregnancy Category D
There is a high risk that a severely deformed infant will result if tretinoin is administered during pregnancy. If, nonetheless, it is determined that tretinoin represents the best available treatment for a pregnant woman or a woman of childbearing potential, it must be assured that the patient has received full information and warnings of the risk to the fetus if she were to be pregnant and of the risk of possible contraception failure and has been instructed in the need to use two reliable forms of contraception simultaneously during therapy and for 1 month following discontinuation of therapy, and has acknowledged her understanding of the need for using dual contraception, unless abstinence in the chosen method.
Within 1 week prior to the institution of tretinoin therapy, the patient should have blood or urine collected for a serum or urine pregnancy test with a sensitivity of at least 50 mIU/mL. When possible, tretinoin therapy should be delayed until a negative result from this test is obtained. When a delay is not possible, the patient should be placed on two reliable forms of contraception. Pregnancy testing and contraception counseling should be repeated monthly throughout the period of tretinoin treatment.
Patients with acute promyelocytic leukemia (APL) can have severe adverse reactions to tretinoin including retinoic acid-APL (RA-APL) syndrome characterized by fever, dyspnea, acute respiratory distress, weight gain, radiographic pulmonary infiltrates, pleural and pericardial effusions, edema, and hepatic, renal and multi-organ failure. High-dose steroids given at the first suspicion of the RA-APL syndrome appear to reduce morbidity and mortality. Patients can also develop rapidly evolving leukocytosis during therapy which can lead to an increased risk of life-threatening complications. There is a high risk that a severely deformed infant will result if tretinoin is administered during pregnancy. Pregnancy testing is necessary prior to initiation of treatment in women of childbearing potential and the patient must be instructed in the need to use two reliable forms of contraception simultaneously during therapy and for 1 month following discontinuation of therapy. Pregnancy testing and contraception counseling should be repeated monthly throughout the period of tretinoin treatment .
Commonly used brand name(s):
In the U.S.
Atralin
Avita
Refissa
Renova
Retin-A
Retin-A Micro
Tretin-X
In Canada
Rejuva-A
Stieva-A Cream
Stieva-A Cream Forte
Stieva-A Gel
Stieva-A Solution
Vitamin A Acid
Available Dosage Forms:
Gel/Jelly
Solution
Liquid
Cream
Therapeutic Class: Dermatological Agent
Chemical Class: Retinoid
Uses For Vitamin A Acid
Tretinoin is used to treat acne. It works partly by keeping skin pores clear.
One of the tretinoin creams is used to treat fine wrinkles, dark spots, or rough skin on the face caused by damaging rays of the sun. It works by lightening the skin, replacing older skin with newer skin, and by slowing down the way the body removes skin cells that may have been harmed by the sun. Tretinoin works best when used within a skin care program that includes protecting the treated skin from the sun. However, it does not completely or permanently erase these skin problems or greatly improve more obvious changes in the skin, such as deep wrinkles caused by sun or the natural aging process.
Tretinoin may also be used to treat other skin diseases as determined by your doctor.
Tretinoin is available only with your doctor’s prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, tretinoin is used in certain patients with the following medical conditions:
Keratosis follicularis (skin disorder of small, red bumps)
Verruca plana (flat warts)
Before Using Vitamin A Acid
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of this medicine in children with use in other age groups. Children are unlikely to have skin problems due to the sun. In older children treated for acne, tretinoin is not expected to cause different side effects or problems than it does in other age groups.
Geriatric
Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of tretinoin in patients 50 years of age and older with use in other age groups.
Pregnancy
Pregnancy Category
Explanation
All Trimesters
D
Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.
Breast Feeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Aminocaproic Acid
Aprotinin
Tetracycline
Tranexamic Acid
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Fluconazole
Ketoconazole
Voriconazole
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
Dermatitis, seborrheic or
Eczema or
Sunburn—Use of this medicine may cause or increase the irritation associated with these problems
Proper Use of tretinoin
This section provides information on the proper use of a number of products that contain tretinoin. It may not be specific to Vitamin A Acid. Please read with care.
It is very important that you use this medicine only as directed. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause irritation of the skin.
Do not apply this medicine to windburned or sunburned skin or on open wounds.
Do not use this medicine in or around the eyes or lips, or inside of the nose. Spread the medicine away from these areas when applying. If the medicine accidentally gets on these areas, wash with water at once.
This medicine usually comes with patient directions. Read them carefully before using the medicine.
Before applying tretinoin, wash the skin with a mild soap or cleanser and warm water by using the tips of your fingers. Then gently pat dry. Do not scrub your face with a sponge or washcloth. Wait 20 to 30 minutes before applying this medicine to make sure the skin is completely dry. Applying tretinoin to wet skin can irritate the skin.
To use the cream or gel form of this medicine:
Apply just enough medicine to very lightly cover the affected areas, and rub in gently but well. A pea-sized amount is enough to cover the whole face.
To use the solution form of this medicine:
Using your fingertips, a gauze pad, or a cotton swab, apply enough tretinoin solution to cover the affected areas. If you use a gauze pad or a cotton swab for applying the medicine, avoid getting it too wet. This will help prevent the medicine from running into areas not intended for treatment.
After applying the medicine, wash your hands to remove any medicine that might remain on them.
Dosing
The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For topical dosage forms (cream, gel, or solution):
For acne:
Adults and teenagers—Apply to the affected area(s) of the skin once a day, at bedtime.
For cream dosage form (brand name Renova only):
For fine wrinkles, dark spots, or rough skin caused by the sun:
Adults up to 50 years of age—Apply to the affected area(s) of the skin once a day, at bedtime.
Adults 50 years of age and older—Use and dose must be determined by your doctor.
Missed Dose
If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
The gel product is flammable and should be kept away from fire or excessive heat.
Precautions While Using Vitamin A Acid
During the first 3 weeks you are using tretinoin, your skin may become irritated. Also, your acne may seem to get worse before it gets better. It may take longer than 12 weeks before you notice full improvement of your acne, even if you use the medicine every day. Check with your health care professional at any time skin irritation becomes severe or if your acne does not improve within 8 to 12 weeks.
You should avoid washing the skin treated with tretinoin for at least 1 hour after applying it.
Avoid using any topical medicine on the same area within 1 hour before or after using tretinoin. Otherwise, tretinoin may not work properly or skin irritation might occur.
Unless your doctor tells you otherwise, it is especially important to avoid using the following skin products on the same area as tretinoin:
Any other topical acne product or skin product containing a peeling agent (such as benzoyl peroxide, resorcinol, salicylic acid, or sulfur)
Hair products that are irritating, such as permanents or hair removal products
Skin products that cause sensitivity to the sun, such as those containing spices or limes
Skin products containing a large amount of alcohol, such as astringents, shaving creams, or after-shave lotions
Skin products that are too drying or abrasive, such as some cosmetics, soaps, or skin cleansers
Using these products along with tretinoin may cause mild to severe irritation of the skin. Although skin irritation can occur, some doctors sometimes allow benzoyl peroxide to be used with tretinoin to treat acne. Usually tretinoin is applied at night so that it does not cause a problem with any other topical products that you might use during the day. Check with your doctor before using topical medicines with tretinoin.
During the first 6 months of use, avoid overexposing the treated areas to sunlight, wind, or cold weather. The skin will be more prone to sunburn, dryness, or irritation, especially during the first 2 or 3 weeks. However, you should not stop using this medicine unless the skin irritation becomes too severe. Do not use a sunlamp .
To help tretinoin work properly, regularly use sunscreen or sunblocking lotions with a sun protection factor (SPF) of at least 15. Also, wear protective clothing and hats, and apply creams, lotions, or moisturizers often.
Check with your doctor at any time your skin becomes too dry and irritated. Your health care professional can help you choose the right skin products for you to reduce skin dryness and irritation and may include the following:
For patients using tretinoin for the treatment of acne:
Regular use of water-based creams or lotions helps to reduce skin irritation or dryness that may be caused by the use of tretinoin.
For patients using tretinoin for the treatment of fine wrinkling, dark spots, and rough skin caused by the sun:
This medicine should be used as part of an ongoing program to avoid further damage to your skin from the sun. This program includes staying out of the sun when possible or wearing proper clothing or hats to protect your skin from sunlight.
Regular use of oil-based creams or lotions helps to reduce skin irritation or dryness caused by the use of tretinoin.
Vitamin A Acid Side Effects
In some animal studies, tretinoin has been shown to cause skin tumors to develop faster when the treated area is exposed to ultraviolet light (sunlight or artificial sunlight from a sunlamp). Other studies have not shown the same result and more studies need to be done. It is not known if tretinoin causes skin tumors to develop faster in humans.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
More common
Burning feeling or stinging skin (severe)
lightening of skin of treated area, unexpected
peeling of skin (severe)
redness of skin (severe)
unusual dryness of skin (severe)
Rare
Darkening of treated skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Burning feeling, stinging, or tingling of skin (mild)—lasting for a short time after first applying the medicine
chapping or slight peeling of skin (mild)
redness of skin (mild)
unusual dryness of skin (mild)
unusually warm skin (mild)
The side effects will go away after you stop using tretinoin. On the rare chance that your skin color changes, this effect may last for several months before your skin color returns to normal.
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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