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Xyzal Solution

30/06/10

Generic Name: Levocetirizine (LEE-voe-se-TIR-i-zeen)
Brand Name: Xyzal

Xyzal Solution is used for:

Treating allergy symptoms and chronic hives. It may also be used for other conditions as determined by your doctor.

Xyzal Solution is an antihistamine. It works by blocking a substance in the body called histamine. This helps to decrease allergy symptoms and hives.

Do NOT use Xyzal Solution if:

you are allergic to any ingredient in Xyzal Solution or to cetirizine
you have severe kidney problems or you are receiving dialysis
the patient is a child 6 months to 11 years old who has kidney problems

Contact your doctor or health care provider right away if any of these apply to you.

Before using Xyzal Solution:

Some medical conditions may interact with Xyzal Solution. Tell your doctor or pharmacist if you have any medical conditions, especially any of the following:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have kidney or liver problems

Some MEDICINES MAY INTERACT with Xyzal Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Ritonavir or theophylline because they may increase the risk of Xyzal Solution’s side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Xyzal Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Xyzal Solution:

Use Xyzal Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Xyzal Solution by mouth with or without food. Take it in the evening unless your doctor tells you otherwise.
Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
If you miss a dose of Xyzal Solution, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Xyzal Solution.

Important safety information:

Xyzal Solution may cause drowsiness. This effect may be worse if you take it with alcohol or certain medicines. Use Xyzal Solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Xyzal Solution; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
The risk of drowsiness may be greater if you take Xyzal Solution in high doses. Do NOT take more than the recommended dose without checking with your doctor.
Use Xyzal Solution with caution in the ELDERLY; they may be more sensitive to its effects.
Xyzal Solution should be used with extreme caution in CHILDREN younger than 6 months old; safety and effectiveness in these children have not been confirmed.
PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Xyzal Solution while you are pregnant. Xyzal Solution is found in breast milk. Do not breast-feed while taking Xyzal Solution.

Possible side effects of Xyzal Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; drowsiness; dry mouth; sore throat; tiredness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); dark urine; fainting; fever; irregular heartbeat; mental or mood changes (eg, aggression, agitation); seizure; severe or persistent dizziness; shortness of breath; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include agitation; irritability; restlessness; severe drowsiness.

Proper storage of Xyzal Solution:

Store Xyzal Solution between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Xyzal Solution out of the reach of children and away from pets.

General information:

If you have any questions about Xyzal Solution, please talk with your doctor, pharmacist, or other health care provider.
Xyzal Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Xyzal Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: May 5, 2010

Database Edition 10.2.1.002

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Xyzal

30/06/10

Generic Name: meclizine, buclizine, and cyclizine (Oral route, Parenteral route)

Commonly used brand name(s):

In the U.S.

Antivert
Antivert/25
Antivert/50
Atarax
Compazine
Permitil
Prolixin
Torecan
Trilafon
Vistaril
Xyzal
Zyrtec

In Canada

Moditen Hydrochloride
Pms-Hydroxyzine
Pms-Perphenazine
Stemetil
Trilafon Concentrate

Available Dosage Forms:

Tablet
Capsule
Liquid
Solution
Elixir
Tablet, Chewable
Capsule, Liquid Filled
Syrup
Capsule, Extended Release
Suspension

Uses For Xyzal

Buclizine, cyclizine, and meclizine are used to prevent and treat nausea, vomiting, and dizziness associated with motion sickness, and vertigo (dizziness caused by other medical problems).

Some of these preparations are available only with your doctor’s prescription. Others are available without a prescription; however, your doctor may have special instructions on the proper dose of the medicine for your medical condition.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, some of these medicines are used in certain patients to prevent the following medical conditions:

Nausea and vomiting following surgery
Nausea and vomiting following cancer radiation treatment

Before Using Xyzal

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

There is no specific information comparing use of buclizine, cyclizine, and meclizine in children with use in other age groups. However, children may be especially sensitive to the anticholinergic effects (e.g., dryness of mouth, nose, and throat) of these medicines.

Geriatric

There is no specific information comparing use of buclizine, cyclizine, and meclizine in the elderly with use in other age groups. Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. However, older people may be especially sensitive to the anticholinergic effects (e.g., constipation; difficult urination; dryness of mouth, nose, and throat) of these medicines.

Pregnancy

These medicines have not been shown to cause birth defects or other problems in humans. However, studies in animals have shown that buclizine, cyclizine, and meclizine given in doses many times the usual human dose cause birth defects, such as cleft palate.

Breast Feeding

Although these medicines may pass into breast milk, they have not been reported to cause problems in nursing babies. However, since these medicines tend to decrease the secretions of the body, it is possible that the flow of breast milk may be reduced in some patients.

Interactions with Medicines

Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

Arsenic Trioxide
Bepridil
Cisapride
Dofetilide
Droperidol
Grepafloxacin
Levomethadyl
Mesoridazine
Metoclopramide
Pimozide
Sparfloxacin
Terfenadine
Thioridazine
Venlafaxine
Ziprasidone

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acecainide
Ajmaline
Amiodarone
Amisulpride
Amitriptyline
Amoxapine
Aprindine
Arsenic Trioxide
Astemizole
Azimilide
Bretylium
Chloral Hydrate
Chloroquine
Chlorpromazine
Clarithromycin
Desipramine
Dibenzepin
Disopyramide
Dofetilide
Dolasetron
Doxepin
Droperidol
Encainide
Enflurane
Erythromycin
Fentanyl
Flecainide
Fluconazole
Fluoxetine
Foscarnet
Gatifloxacin
Gemifloxacin
Halofantrine
Haloperidol
Halothane
Hydromorphone
Hydroquinidine
Ibutilide
Imipramine
Isoflurane
Isradipine
Levofloxacin
Levomethadyl
Levorphanol
Lidoflazine
Lithium
Lorcainide
Mefloquine
Methadone
Metrizamide
Morphine
Morphine Sulfate Liposome
Moxifloxacin
Nortriptyline
Octreotide
Oxycodone
Paliperidone
Pentamidine
Pimozide
Pirmenol
Prajmaline
Probucol
Procainamide
Procarbazine
Prochlorperazine
Propafenone
Quetiapine
Quinidine
Risperidone
Sematilide
Sertindole
Sotalol
Spiramycin
Sulfamethoxazole
Sultopride
Tapentadol
Tedisamil
Telithromycin
Tramadol
Trifluoperazine
Trimethoprim
Trimipramine
Vasopressin
Ziprasidone
Zolmitriptan
Zolpidem
Zotepine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Proper Use of meclizine, buclizine, and cyclizine

This section provides information on the proper use of a number of products that contain meclizine, buclizine, and cyclizine. It may not be specific to Xyzal. Please read with care.

This medicine is used to relieve or prevent the symptoms of motion sickness or vertigo (dizziness caused by other medical problems). Take it only as directed. Do not take more of it or take it more often than stated on the label or ordered by your doctor. To do so may increase the chance of side effects.

Dosing

The dose medicines in this class will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For buclizine
For oral dosage form (chewable tablets):
- To prevent motion sickness:
  - Adults and teenagers—The usual dose is 50 milligrams (mg) thirty minutes before travel. The dose may be repeated every four to six hours if needed. Not more than 150 mg should be taken in one day.
  - Children—Dose must be determined by your doctor.

For cyclizine
For oral dosage form (tablets):
- To prevent and treat motion sickness:
  - Adults and teenagers—The usual dose is 50 milligrams (mg) thirty minutes before travel. The dose may be repeated every four to six hours if needed. Not more than 200 mg should be taken in one day.
  - Children 6 to 12 years of age—The usual dose is 25 mg thirty minutes before travel. The dose may be repeated every six to eight hours if needed. Not more than 75 mg should be taken in one day.
  - Children up to 6 years of age—Use and dose must be determined by your doctor.
For injection dosage form:
- To prevent and treat motion sickness:
  - Adults and teenagers—The usual dose is 50 mg injected into a muscle every four to six hours as needed.
  - Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 1 mg per kilogram (0.45 mg per pound) of body weight injected into a muscle three times a day as needed.

For meclizine
For oral dosage forms (tablets and chewable tablets):
- To prevent and treat motion sickness:
  - Adults and children 12 years of age or older—The usual dose is 25 to 50 milligrams (mg) one hour before travel. The dose may be repeated every twenty-four hours as needed.
  - Children up to 12 years of age—Use and dose must be determined by your doctor.
- To prevent and treat vertigo (dizziness):
  - Adults and children 12 years of age or older—The usual dose is 25 to 100 mg a day as needed, divided into smaller doses.
  - Children up to 12 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Xyzal

Tell the doctor in charge that you are taking this medicine before you have any skin tests for allergies. The results of the test may be affected by this medicine.

Buclizine, cyclizine, or meclizine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.

This medicine may cause some people to become drowsy or less alert than they are normally Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert.

Buclizine, cyclizine, and meclizine may cause dryness of the mouth. For temporary relief use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

Xyzal Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Drowsiness

Less common or rare

Blurred or double vision
constipation
diarrhea
difficult or painful urination
dizziness
dryness of mouth, nose, and throat
fast heartbeat
headache
loss of appetite
nervousness, restlessness, or trouble in sleeping
skin rash
upset stomach

Not all of the side effects listed above have been reported for each of these medicines, but they have been reported for at least one of them. Buclizine, cyclizine, and meclizine are similar, so any of the above side effects may occur with any of these medicines.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided “AS IS” and “as available” for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

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Xyralid RC Cream

30/06/10

Generic Name: Lidocaine/Hydrocortisone (LYE-doe-kane/HYE-droe-KOR-ti-sone/SIL-ee-um)
Brand Name: Xyralid RC

Xyralid RC Cream is used for:

Treating pain, itching, soreness, and discomfort caused by hemorrhoids or other anal conditions. It also helps to relieve constipation.

Xyralid RC Cream is a kit that contains an anesthetic and corticosteroid cream and a bulk-forming laxative. The anesthetic works by helping to decrease soreness and discomfort. The corticosteroid works by reducing swelling, redness, and itching. The bulk-forming laxative works by absorbing water in the intestines. This helps to soften and stool so it can be more easily passed.

Do NOT use Xyralid RC Cream if:

you are allergic to any ingredient in Xyralid RC Cream or to similar medications (eg, dibucaine)
you have a tuberculous or fungal skin infection, a herpes simplex skin infection, chickenpox, shingles, or a skin infection following smallpox vaccination

Contact your doctor or health care provider right away if any of these apply to you.

Before using Xyralid RC Cream:

Some medical conditions may interact with Xyralid RC Cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to any anesthetic medicine
if you have a history of thinning skin, skin infection, or other skin disorders
if you have recently received a vaccination or if you have ever had a positive tuberculin (TB) skin test
if you have stomach pain, nausea, vomiting, rectal bleeding, or trouble swallowing
if you have liver problems, diabetes, high blood sugar levels, very poor health, stomach or bowel pain, nausea, or vomiting; or if you have had a sudden change in bowel habits persisting for more than 2 weeks

Some MEDICINES MAY INTERACT with Xyralid RC Cream. Tell your health care provider if you are taking any other medicines, especially any of the following:

Class IA antiarrhythmics (eg, disopyramide) because the risk of their side effects may be increased by Xyralid RC Cream

This may not be a complete list of all interactions that may occur. Ask your health care provider if Xyralid RC Cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Xyralid RC Cream:

Use Xyralid RC Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

To use the rectal cream: Clean the affected area with the cleansing wipe as directed before you apply the cream. Attach the applicator to the tube of rectal cream and squeeze gently until a small amount of cream shows. Lubricate the tip of the applicator with the cream and apply as directed by your doctor.
To use the bulk-forming laxative: Mix the contents of the packet with fluid in the shaker cup provided. Take the laxative with plenty of fluid according to the directions provided or as directed by your doctor.
If you miss a dose of Xyralid RC Cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Xyralid RC Cream.

Important safety information:

Do not get Xyralid RC Cream in your eyes, ears, nose, or mouth. If you get it in any of these areas, rinse at once with cool tap water.
If your symptoms do not get better within 7 days or if they get worse, check with your doctor.
Do NOT use more than the recommended dose, use more often, or use for longer than prescribed without checking with your doctor.
If you use topical products too often, your condition may become worse.
Xyralid RC Cream may cause a numbing effect at the application site. Do not scratch, rub, or expose the area to extreme hot or cold temperature until the numbness is gone.
Xyralid RC Cream has a corticosteroid in it. Before you start any new medicine, check the label to see if it has a corticosteroid in it too. If it does or if you are not sure, check with your doctor or pharmacist.
Do not take additional laxatives or stool softeners with Xyralid RC Cream unless directed by your doctor.
Tell your doctor if you fail to have a bowel movement even after using Xyralid RC Cream.
Taking the bulk-forming laxative without enough liquid may cause it to swell and block your throat or esophagus and may cause choking. If you experience chest pain, vomiting, or difficulty swallowing or breathing after taking the laxative, seek immediate medical attention.
Tell your doctor or dentist that you take Xyralid RC Cream before you receive any medical or dental care, emergency care, or surgery.
Use Xyralid RC Cream with caution in the ELDERLY; they may be more sensitive to its effects.
Xyralid RC Cream should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
PREGNANCY and BREAST-FEEDING: It is not known if Xyralid RC Cream can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Xyralid RC Cream while you are pregnant. It is not known if Xyralid RC Cream is found in breast milk after topical use. If you are or will be breast-feeding while you use Xyralid RC Cream, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Xyralid RC Cream:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abdominal fullness; mild stinging, burning, redness, or discoloration at the application site; minor bloating.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; difficulty swallowing; excessive irritation; rectal bleeding; skin infection (eg, redness, swelling, pus discharge); vomiting.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Xyralid RC Cream may be harmful if swallowed.

Proper storage of Xyralid RC Cream:

Store Xyralid RC Cream at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat and light. Do not store in the bathroom. Protect from freezing. Keep Xyralid RC Cream out of the reach of children and away from pets.

General information:

If you have any questions about Xyralid RC Cream, please talk with your doctor, pharmacist, or other health care provider.
Xyralid RC Cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Xyralid RC Cream. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: May 5, 2010

Database Edition 10.2.1.002

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Xyrem

30/06/10

Generic Name: sodium oxybate (Oral route)

SOE-dee-um OX-i-bate

Oral routeSolution

Central nervous system (CNS) depressant with abuse potential. Should not be used with alcohol or other CNS depressants.

Sodium oxybate is GHB, a known drug of abuse. Abuse has been associated with some important CNS adverse events (including death). Even at recommended doses, use has been associated with confusion, depression and other neuropsychiatric events. Reports of respiratory depression occurred in clinical trials. Almost all of the patients who received sodium oxybate during clinical trials were receiving CNS stimulants; whether this affected respiration during the night is unknown.

Important CNS adverse events associated with abuse GHB include seizure, respiratory depression and profound decreases in level of consciousness, with instances of coma and death. For events that occurred outside of clinical trials, in people taking GHB for recreational purposes, the circumstances surrounding the events are often unclear (eg, dose of GHB taken, the nature and amount of alcohol or any concomitant drugs).

Sodium oxybate is available through the Xyrem Success Program, using a centralized pharmacy 1-866-XYREM88 (1-866-997-3688). The Success Program provides educational materials to the prescriber and the patient explaining the risks and proper use of sodium oxybate, and the required prescription form. Once it is documented that the patient has read and/or understood the materials, the drug will be shipped to the patient. The Xyrem Success Program also recommends patient follow-up every 3 months. Physicians are expected to report all serious events to the manufacturer .

Sodium oxybate is GHB (gamma hydroxybutyrate), a known drug of abuse. Do not use with alcohol or other CNS depressants. Use at recommended doses has been associated with confusion, depression, and other neuropsychiatric events. Reports of respiratory depression occurred in clinical trials. Profound decreases in level of consciousness, with instances of coma and death; respiratory depression; and seizures have been associated with abuse of GHB. Available only through the Xyrem Success Program, call 1-866-XYREM88 .

Commonly used brand name(s):

In the U.S.

Xyrem

Available Dosage Forms:

Solution

Therapeutic Class: Central Nervous System Agent

Uses For Xyrem

Sodium oxybate is used to treat excessive daytime sleepiness and to reduce the number of cataplexy (weak or paralyzed muscles) attacks in people with narcolepsy. This medicine is a narcotic agent that is used for sedation.

This medicine is available only with your doctor’s prescription, and you can only get it from one central pharmacy. Before you use sodium oxybate your doctor should teach you about the safe and effective use of this medicine. You cannot get the medicine until you have read the information the pharmacy will send you about sodium oxybate.

Note: Sodium oxybate is a Schedule III, federally controlled substance. This means that if you sell, distribute, or give your medicine to anyone else, or if you use your sodium oxybate for purposes other than what it was prescribed for, you may be punished under federal and state law by jail and fines. Your sodium oxybate should be used only by you, as prescribed by your doctor.

Before Using Xyrem

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of sodium oxybate in children below 16 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies on the relationship of age to the effects of sodium oxybate have not been performed in the geriatric population. However, elderly patients are more likely to have unwanted effects (e.g., clumsiness or memory loss) or age-related liver disease, which may require caution in patients receiving sodium oxybate.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Adinazolam
Alfentanil
Alprazolam
Amobarbital
Anileridine
Aprobarbital
Bromazepam
Brotizolam
Butabarbital
Butalbital
Carisoprodol
Chlordiazepoxide
Chlorzoxazone
Clobazam
Clonazepam
Clorazepate
Codeine
Dantrolene
Diazepam
Estazolam
Fentanyl
Flunitrazepam
Flurazepam
Halazepam
Hydrocodone
Hydromorphone
Ketazolam
Levorphanol
Lorazepam
Lormetazepam
Medazepam
Meperidine
Mephenesin
Mephobarbital
Meprobamate
Metaxalone
Methocarbamol
Methohexital
Midazolam
Morphine
Morphine Sulfate Liposome
Nitrazepam
Nordazepam
Oxazepam
Oxycodone
Oxymorphone
Pentobarbital
Phenobarbital
Prazepam
Primidone
Propoxyphene
Quazepam
Remifentanil
Secobarbital
Sufentanil
Temazepam
Thiopental
Triazolam

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of Xyrem

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

This medicine will come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

Food will decrease the amount of sodium oxybate that is absorbed by your body. It is best to take this medicine at least 2 hours after a meal.

To take sodium oxybate, you must first mix it with 2 ounces (60 mL) of water. Prepare both doses before bedtime. Place the caps provided on the dosing cups and turn each cap so it locks in its child resistant position. Use the oral solution within 24 hours after mixing.

Sodium oxybate causes sleep very quickly. Take it only at bedtime and while in bed. Drink all of the first dose while sitting in bed, recap the cup, and then lie down right away. Right before going to sleep place your second dose in a secure place near your bed. You might need to set an alarm to wake up to take the second dose. When you wake up to take the second dose, remove the cap from the second dosing cup. While sitting in bed, drink all of the second dose right before lying down to continue sleeping. Recap the second cup.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

For oral dosage form (oral solution):
- For treatment of excessive daytime sleepiness and cataplexy:
  - Adults—2.25 grams (g) given at bedtime and repeated one time during the night. The first dose should be taken at bedtime and the second dose taken 2.5 to 4 hours later. The dose may be increased as needed by your doctor up to a maximum of 9 grams.
  - Children—Use and dose must be determined by your doctor.

Missed Dose

Never take two doses of sodium oxybate at the same time. If you have any questions about this, ask your doctor.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Do not throw any unused medicine in the trash. Flush it down the toilet or take it to a community take-back program when available.

Precautions While Using Xyrem

It is very important that your doctor check your progress at regular visits to make sure the medicine is working properly and to check for any unwanted effects. This is especially important for elderly patients who may be more sensitive to the effects of this medicine.

Do not take other medicines unless they have been discussed with your doctor. This medicine will add to the effects of CNS depressants (medicines that make you drowsy or less alert). Check with your doctor or dentist before taking any of the above medicines while you are taking sodium oxybate.

While you are taking sodium oxybate, you should not drink alcohol. The effects of alcohol can increase the chance of dangerous side effects of sodium oxybate.

Other people living in your house should monitor you for the possibility of urinary or fecal incontinence (loss of bladder or bowel control), or sleepwalking. Tell your doctor if these symptoms occur.

Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert. Do not drive a car, operate heavy machinery, or perform any activity that is dangerous or requires mental alertness for at least 6 hours after taking sodium oxybate. When you first start taking sodium oxybate, until you know whether it makes you sleepy the next day, use extreme care while driving a car or doing anything else that could be dangerous or needs you to be fully mentally alert.

Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely.

Xyrem Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Blurred vision
burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feeling
change in vision
confusion
discouragement
dizziness
feeling sad or empty
headache
impaired vision
irritability
lack of appetite
lack or loss of strength
loss of bladder control
loss of interest or pleasure
loss of memory
loss of strength or energy
muscle pain or weakness
nervousness
pounding in the ears
problems with memory
sleepwalking
slow or fast heartbeat
tiredness
trouble concentrating
trouble sleeping

Symptoms of Overdose

Get emergency help immediately if any of the following symptoms of overdose occur:

Alternating periods of shallow and deep breathing
bluish lips or skin, not breathing
chest pain or discomfort
clumsiness
coma
confusional, agitated combative state
consciousness, depressed
convulsions
drowsiness
generalized slowing of mental and physical activity
inability to hold bowel movement or urine
increased sweating
lightheadedness, dizziness, or fainting
low body temperature
muscle aches or weakness
shakiness and unsteady walk
shivering
shortness of breath
sleepiness
slow or irregular heartbeat
trembling or other problems with muscle control or coordination
unusual tiredness
unusual weak feeling
vomiting
weak or feeble pulse

More Common

Abdominal or stomach pain
abnormal thinking
acid or sour stomach
back pain
belching
body aches or pain
chills
congestion
colds
cough or hoarseness
cramps
diarrhea
dreams, abnormal
dryness or soreness of the throat
fear
fever
flu-like symptoms
general feeling of discomfort or illness
heartburn
heavy bleeding
hoarseness
indigestion
joint pain
lower back or side pain
nausea
pain
pain or tenderness around the eyes and cheekbones
painful or difficult urination
runny nose
shivering
sleep disorder
sleepiness or unusual drowsiness
sneezing
sore throat
stomach discomfort, upset, or pain
stuffy nose
sweating
tender, swollen glands in the neck
tightness of the chest or wheezing
trouble with breathing
trouble with swallowing
unusual tiredness or weakness
voice changes
vomiting

Less common

Sleeplessness
unable to sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Xyralid

30/06/10

Generic Name: hydrocortisone and lidocaine topical (HYE droe KOR ti sone and LYE doe kane TOP ik al)
Brand Names: Xyralid

What is Xyralid (hydrocortisone and lidocaine topical)?

Hydrocortisone is a topical (for the skin) steroid. It reduces the actions of chemicals in the body that cause inflammation, redness, and swelling.

Lidocaine is a local anesthetic (numbing medication). It works by blocking nerve signals in your body.

Hydrocortisone and lidocaine topical is used to treat itching and inflammation of the skin caused by a number of conditions such as allergic reactions, eczema, psoriasis, minor burns, or insect bites.

Hydrocortisone and lidocaine topical may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Xyralid (hydrocortisone and lidocaine topical)?

Do not cover treated skin areas with a bandage or other covering unless your doctor has told you to. Covering the skin that is treated with hydrocortisone and lidocaine topical can increase the amount of the drug your skin absorbs, which may lead to unwanted side effects. Follow your doctor’s instructions.

Your body may absorb more of this medication if you use too much, if you apply it over large skin areas, or if you apply heat, bandages, or plastic wrap to treated skin areas. Skin that is cut or irritated may also absorb more topical medication than healthy skin.

Avoid using this medication on body areas where you have skin folds or thin skin, unless your doctor has told you to.

Do not use this medication on a child without a doctor’s advice. Children are more sensitive to the effects of hydrocortisone and lidocaine topical.

Hydrocortisone and lidocaine topical will not treat a bacterial, fungal, or viral skin infection.

Contact your doctor if your condition does not improve or if it gets worse after using this medication for several days.

What should I discuss with my healthcare provider before using Xyralid (hydrocortisone and lidocaine topical)?

You should not use this medication if you are allergic to hydrocortisone or lidocaine, or if you have:

herpes simplex;
smallpox or chickenpox; or
tuberculosis.

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before using hydrocortisone and lidocaine topical, tell your doctor if you have liver disease or a heart rhythm problem.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether hydrocortisone and lidocaine topical passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not use this medication on a child without a doctor’s advice. Children are more sensitive to the effects of hydrocortisone and lidocaine topical.

How should I use Xyralid (hydrocortisone and lidocaine topical)?

Use this medication exactly as directed on the label, or as it has been prescribed by your doctor. Do not use the medication in larger or smaller amounts, or use it for longer than recommended.

Hydrocortisone and lidocaine topical will not treat a bacterial, fungal, or viral skin infection.

Wash your hands before and after each application, unless you are using hydrocortisone and lidocaine topical to treat a hand condition.

The hydrocortisone and lidocaine topical kit comes with a soap-free cleanser. Use this cleanser daily as directed to add to the anti-itch effects of hydrocortisone and lidocaine topical.

Use only a small amount of hydrocortisone and lidocaine topical on the affected area and rub it gently into the skin.

Avoid using this medication on body areas where you have skin folds or thin skin unless your doctor has told you to.

Contact your doctor if your condition does not improve or if it gets worse after using this medication for several days. It is important to use hydrocortisone and lidocaine topical regularly to get the most benefit.

Hydrocortisone and lidocaine topical will not treat a bacterial, fungal, or viral skin infection.

Store hydrocortisone and lidocaine topical at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

An overdose of hydrocortisone topical applied to the skin is not expected to produce life-threatening symptoms. However, long-term use of high steroid doses can lead to symptoms such as thinning skin, easy bruising, changes in the shape or location of body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.

Lidocaine topical applied to the skin is not likely to cause an overdose unless you apply more than the recommended dose. Lidocaine overdose symptoms may include drowsiness, confusion, nervousness, ringing in your ears, blurred vision, feeling hot or cold, numbness, muscle twitches, uneven heartbeats, seizure (convulsions), slowed breathing, or respiratory failure (breathing stops).

What should I avoid while using Xyralid (hydrocortisone and lidocaine topical)?

Do not apply this medication to swollen skin areas or deep puncture wounds. Avoid using the medicine on skin that is raw or blistered, such as a severe burn or abrasion. Avoid getting hydrocortisone and lidocaine topical in your eyes, mouth, and nose, or on your lips. If it does get into any of these areas, wash with water.

Avoid using other topical medications on the affected area unless your doctor has told you to.

Xyralid (hydrocortisone and lidocaine topical) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have severe irritation or swelling of any treated skin, or if you show signs of absorbing hydrocortisone topical through your skin, such as:

blurred vision, or seeing halos around lights;
mood changes;
sleep problems (insomnia);
weight gain, puffiness in your face; or
muscle weakness, feeling tired.

Less serious side effects may include:

mild irritation, redness, or swelling where the medication is applied;
thinning of your skin;
numbness in places where the medicine is accidentally applied.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Xyralid (hydrocortisone and lidocaine topical)?

Tell your doctor about all other medications you use, especially a heart rhythm medication such as:

quinidine (Quinaglute, Quinidex, Quin-Release);
procainamide (Procan, Procanbid, Pronestyl);
disopyramide (Norpace);
flecaininde (Tambocor);
mexiletine (Mexitil);
morizicine (Ethmozine); or
propafenone, (Rythmol).

This list is not complete and there may be other drugs that can interact with hydrocortisone and lidocaine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about hydrocortisone and lidocaine topical.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Xyralid RC

30/06/10

Generic Name: hydrocortisone and lidocaine topical with psyllium (HYE droe KORT i sone, LYE doe kane TOP ik al, SIL ee um)
Brand Names: Xyralid RC

What is Xyralid RC (hydrocortisone and lidocaine topical with psyllium)?

Hydrocortisone is a steroid. It reduces the actions of chemicals in the body that cause inflammation, redness, and itching.

Lidocaine is a local anesthetic (numbing medication). It works by blocking nerve signals in your body.

Psyllium is a type of soluble fiber used as a bulk-forming stool softener. Psyllium is not a laxative.

The combination of hydrocortisone and lidocaine topical (for the skin) is used to relieve itching, pain or other discomforts caused by conditions such as hemorrhoids or anal fissures (tiny tears in the tissues surrounding the anus). Psyllium is provided as a medication you take by mouth to help soften your stools, making them easier and less painful to pass while your rectal condition is being treated.

Hydrocortisone and lidocaine topical may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Xyralid RC (hydrocortisone and lidocaine topical with psyllium)?

You should not use this medication if you are allergic to hydrocortisone, lidocaine (or any other type of numbing medicine), or psyllium, or if you have severe liver disease, a fungal infection, smallpox, chickenpox, herpes, or tuberculosis.

Before using hydrocortisone and lidocaine topical with psyllium, tell your doctor if you have liver or kidney disease, a heart rhythm problem, congestive heart failure, stomach or intestinal conditions, diabetes, or any type of infection.

Do not take hydrocortisone rectal by mouth. It is for use only in your rectum. Do not cover the treated rectal areas with a bandage, plastic pants or other covering unless your doctor has told you to. Covering the skin that is treated with hydrocortisone and lidocaine topical can increase the amount of the drug your skin absorbs, which may lead to unwanted side effects. Your body may also absorb more of this medication if you use too much. Contact your doctor if your condition does not improve or if it gets worse after using this medication. Do not use this medication in a child without a doctor’s advice. Children are more sensitive to the effects of hydrocortisone and lidocaine topical.

What should I discuss with my healthcare provider before using Xyralid RC (hydrocortisone and lidocaine topical with psyllium)?

You should not use this medication if you are allergic to hydrocortisone, lidocaine, or psyllium, or if you have:

severe liver disease;
a fungal infection;
herpes;
smallpox or chickenpox; or
tuberculosis.

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before using hydrocortisone and lidocaine topical with psyllium, tell your doctor if you have liver disease or a heart rhythm problem.

liver disease;
kidney disease;
a heart rhythm problem;
congestive heart failure;
a stomach or intestinal disorder; or
any type of infection.

Also tell your doctor if you have diabetes. Steroid medicines may increase the glucose (sugar) levels in your blood or urine. You may also need to adjust the dose of your diabetes medications.

FDA pregnancy category C. It is not known whether hydrocortisone and lidocaine topical with psyllium is harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether hydrocortisone and lidocaine topical with psyllium passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not use this medication in a child without a doctor’s advice. Children are more sensitive to the effects of hydrocortisone and lidocaine topical.

How should I use Xyralid RC (hydrocortisone and lidocaine topical with psyllium)?

Use this medication exactly as directed on the label, or as it has been prescribed by your doctor. Do not use the medication in larger or smaller amounts, or use it for longer than recommended.

Do not take hydrocortisone rectal by mouth. It is for use only in your rectum.

Hydrocortisone and lidocaine topical rectal cream is supplied in 14 medicine tubes with 14 disposable applicators. Each tube and applicator one is for a single use only. This medication is usually applied 2 times daily.

Peel off the seal under the tube cap and screw the applicator tip firmly onto the tube. Squeeze the tube to push the medication into the applicator. With the tube still attached to the applicator, insert only the tip of the applicator into the rectum. Continue squeezing the tube to apply the medicine. Also apply to the outer areas of the anus.

Do not insert the applicator deep into the rectum. Use only applicators that come with this medication, and throw each one away after one use.

Wash your hands before and after using the hydrocortisone and lidocaine rectal cream. Follow the application instructions provided with the medication.

Use the moist towelettes supplied with the medication to gently clean the rectal area before each time you apply the rectal cream. Each towelette is for one use only.

The hydrocortisone and lidocaine topical kit comes with 7 packets of psyllium labeled as Konsyl. A reusable shaker cup is also provided. Empty the contents of a psyllium packet into the shaker cup and fill the cup about half way with fruit juice or other desired liquid.

Place the cap tightly onto the shaker cup and shake vigorously for 3 to 5 seconds or until the psyllium granules are mixed well with the liquid. Drink all of this mixture right away. To make sure you get the entire dose, add a little more liquid to the shaker cup, swirl gently and drink right away.

Wash the shaker cup with soap and water between uses.

Do not cover the treated rectal areas with a bandage, plastic pants or other covering unless your doctor has told you to. Covering the skin that is treated with hydrocortisone and lidocaine topical can increase the amount of the drug your skin absorbs, which may lead to unwanted side effects. Your body may also absorb more of this medication if you use too much.

Your body may also absorb more of this medication if you use too much.

Contact your doctor if your condition does not improve or if it gets worse after using this medication.

Hydrocortisone and lidocaine topical will not treat a bacterial, fungal, or viral infection.

Store the rectal cream and psyllium packets at room temperature away from moisture and heat.

What happens if I miss a dose?

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

What should I avoid while using Xyralid RC (hydrocortisone and lidocaine topical with psyllium)?

Avoid getting the rectal cream in your eyes, ears, mouth, and nose, or on your lips. If it does get into any of these areas, rinse well with water or saline solution.

Avoid using other topical medications on the affected area unless your doctor has told you to.

Xyralid RC (hydrocortisone and lidocaine topical with psyllium) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have severe irritation or burning of the treated area, or if you show signs of absorbing hydrocortisone topical through your skin, such as:

blurred vision, or seeing halos around lights;
mood changes;
sleep problems (insomnia);
weight gain, puffiness in your face; or
muscle weakness, feeling tired.

Less serious side effects may include:

mild stinging, burning, or redness where the medication is applied;
thinning of your skin;
numbness in places where the medicine is accidentally applied.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Xyralid RC (hydrocortisone and lidocaine topical with psyllium)?

Tell your doctor about all other medications you use, especially a heart rhythm medication such as:

quinidine (Quinaglute, Quinidex, Quin-Release);
procainamide (Procan, Procanbid, Pronestyl);
disopyramide (Norpace);
flecaininde (Tambocor);
mexiletine (Mexitil);
morizicine (Ethmozine); or
propafenone, (Rythmol).

This list is not complete and there may be other drugs that can interact with hydrocortisone and lidocaine topical with psyllium. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about hydrocortisone and lidocaine topical with psyllium.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Concise,X

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xylometazoline nasal

30/06/10

Generic Name: xylometazoline nasal (zye loe me TAH zoe leen)
Brand names: Otrivin, Triaminic Decongestant

What is xylometazoline nasal?

Xylometazoline nasal is a decongestant. It works by constricting (shrinking) blood vessels (veins and arteries) in the body. The nasal formulation acts directly on the blood vessels in the nasal tissues. Constriction of the blood vessels in the nose and sinuses leads to a decrease in congestion.

Xylometazoline nasal is used to treat congestion associated with allergies, hay fever, sinus irritation, and the common cold.

Xylometazoline nasal may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about xylometazoline nasal?

Do not use xylometazoline nasal for longer than 3 to 5 days. Longer use could cause damage to the nasal tissue and lead to chronic congestion. If your symptoms do not improve, see your doctor.

Do not use this medication in larger doses or more often than is recommended. Too much xylometazoline nasal could be harmful. Xylometazoline nasal should not be used more often than two to three times a day (every 8 to 10 hours).

What should I discuss with my healthcare provider before using xylometazoline nasal?

Do not use xylometazoline nasal if you have taken a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. This could cause a dangerous drug interaction with serious side effects.

Before using this medication, tell your doctor if you have

high blood pressure;
heart disease, hardening of the arteries, or irregular heart beats;
thyroid problems;
diabetes;
glaucoma or increased pressure in the eye;
an enlarged prostate or difficulty urinating;
liver disease; or
kidney disease.

You may not be able to use xylometazoline nasal, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

It is not known whether xylometazoline nasal will be harmful to an unborn baby. Do not use xylometazoline nasal without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether xylometazoline nasal could be harmful to a nursing baby. Do not use this medication without first talking to your doctor if you are breast-feeding a baby.

How should I use xylometazoline nasal?

Use xylometazoline nasal exactly as directed by your doctor, or follow the instructions that accompany the package. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

To apply the nasal spray, keep your head upright, then spray and inhale sharply through the nose simultaneously.

To apply the nasal drops, lie on a bed on your back with your head hanging over the edge. Insert the drops and remain in this position for several minutes. Gently turn your head from side to side.

Do not allow the tip of the container to touch the inside of the nose, or any other surface.

To prevent the spread of infection, do not share this medication with others.

Discard this medication bottle after use. Do not save it for reuse.

Do not use xylometazoline nasal for longer than 3 to 5 days. Longer use could cause damage to the nasal tissue and lead to chronic congestion. If your symptoms do not improve, see your doctor.

Store xylometazoline nasal at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and use the next one as directed. Do not use a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a xylometazoline nasal overdose include extreme tiredness, sweating, dizziness, a slow heartbeat, and coma.

What should I avoid while taking xylometazoline nasal?

Xylometazoline nasal side effects

If you experience any of the following serious side effects from this medication, stop using xylometazoline nasal and seek emergency medical attention or contact your doctor immediately:

an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
seizures;
unusual behavior or hallucinations; or
an irregular or fast heartbeat.

More commonly, you may experience some sneezing or nasal burning, stinging, dryness, or irritation. These side effects are usually mild and temporary.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Xylometazoline nasal Dosing Information

Usual Pediatric Dose for Nasal Congestion:

Xylometazoline nasal 0.05% spray:
2 to 12 years: 1 to 2 sprays in each nostril every 8 to 10 hours not to exceed 3 doses daily. Do not use for more than 3 days.

What other drugs will affect xylometazoline nasal?

Do not use xylometazoline nasal if you have taken a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days.

Although drug interactions between topical nasal decongestants and other medications taken by mouth are not expected, they can occur. Rarely, xylometazoline nasal may interact with the following medicines:

furazolidone (Furoxone);
guanethidine (Ismelin);
indomethacin (Indocin);
methyldopa (Aldomet);
bromocriptine (Parlodel);
caffeine in cola, tea, coffee, chocolate, and other products;
theophylline (Theo-Dur, Theochron, Theolair, others);
tricyclic antidepressants such as amitriptyline (Elavil, Endep), doxepin (Sinequan), clomipramine (Anafranil), and nortriptyline (Pamelor), and others; and
phenothiazines such as chlorpromazine (Thorazine), thioridazine (Mellaril), and prochlorperazine (Compazine), and others.

You may not be able to use xylometazoline nasal, or you may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with xylometazoline nasal. Talk to your doctor and pharmacist before taking any prescription or over the counter medicines, including herbal products.

Where can I get more information?

Your pharmacist has additional information about xylometazoline nasal written for health professionals that you may read.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Xyntha

30/06/10

Generic Name: antihemophilic factor (Intravenous route, Injection route)

an-tee-hee-moe-FIL-ik FAK-tor

Commonly used brand name(s):

In the U.S.

Advate
Helixate FS
Hemofil-M
Hyate:C
Koate DVI
Kogenate FS
Kogenate FS w/BIO-SET
Monarc-M
Monoclate-P
Recombinate
Refacto
Xyntha

Available Dosage Forms:

Powder for Solution

Therapeutic Class: Antihemophilic Agent

Uses For Xyntha

Antihemophilic factor (AHF) is a protein produced naturally in the body. It helps the blood form clots to stop bleeding.

Hemophilia A, also called classical hemophilia, is a condition in which the body does not make enough AHF. If you do not have enough AHF and you become injured, your blood will not form clots as it should, and you may bleed into and damage your muscles and joints. One type of AHF is used to treat another condition called von Willebrand disease, in which there is a risk of bleeding. AHF also may be used for other conditions as determined by your doctor.

The AHF that your doctor will give you is obtained naturally from human or pig blood or artificially by a man-made process.

AHF obtained from human blood has been treated. It is not likely to contain harmful viruses such as hepatitis B virus; hepatitis C virus (non-A, non-B hepatitis); or human immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS). The man-made and pork AHF products do not contain these viruses.

AHF is available only with your doctor’s prescription.

Before Using Xyntha

Allergies

Pediatric

This medicine has been tested in children and, in effective doses, has not been shown to cause different side effects or problems than it does in adults.

Geriatric

This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of antihemophilic factor

This section provides information on the proper use of a number of products that contain antihemophilic factor. It may not be specific to Xyntha. Please read with care.

Some medicines given by injection may sometimes be given at home to patients who do not need to be in the hospital. If you are using this medicine at home, your health care professional will teach you how to prepare and inject the medicine. You will have a chance to practice preparing and injecting it. Be certain that you understand exactly how the medicine is to be prepared and injected.

To prepare this medicine:

Take the dry medicine and the liquid (diluent) out of the refrigerator or freezer and bring them to room temperature, as directed by your doctor.
Wipe rubber surface of bottles with alcohol swab and allow to dry.
When injecting the liquid (diluent) into the dry medicine, aim the stream of liquid (diluent) against the wall of the container of dry medicine to prevent foaming.
Swirl the container gently to dissolve the medicine. Do not shake the container.
Check the solution to make sure it is clear. Do not use medicine if you can see anything solid in the solution or if the solution is cloudy

Use this medicine right away. It should not be kept longer than 3 hours after it has been prepared, as directed on the package or by your doctor.

A plastic disposable syringe and filter needle must be used with this medicine. The medicine may stick to the inside of a glass syringe, and you may not receive a full dose.

Do not reuse syringes and needles. Put used syringes and needles in a puncture-resistant disposable container, or dispose of them as directed by your health care professional.

Dosing

Your body weight.
The amount of AHF your body is able to make.
How much, how often, and where in your body you are bleeding.
Whether or not your body has built up a defense (antibody) against this medicine.

Missed Dose

Call your doctor or pharmacist for instructions.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Some AHF products must be stored in the refrigerator and some in the freezer. However, some of them may be kept at room temperature for short periods of time. Store this medicine as directed by your doctor or by the manufacturer.

Precautions While Using Xyntha

If you were recently diagnosed with hemophilia A, you should receive hepatitis A and hepatitis B vaccines to reduce even further your risk of getting hepatitis A or B from antihemophilic factor.

It is recommended that you carry identification stating that you have hemophilia A, and what medicine you are using. If you have any questions about what kind of identification to carry, check with your health care professional.

After a while, your body may build up a defense (antibody) against this medicine. Tell your doctor if this medicine seems to be less effective than usual.

Xyntha Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Some side effects will have signs or symptoms that you can see or feel. Your doctor may watch for others by doing certain tests.

Check with your doctor immediately if any of the following side effects occur:

Less common or rare

Changes in facial skin color
fast or irregular breathing
puffiness or swelling of the eyelids or around the eyes
shortness of breath, troubled breathing, tightness in chest, and/or wheezing
skin rash, hives, and/or itching

Check with your doctor as soon as possible if any of the following side effects occur:

Less common or rare

Chills
fever
nausea
tenderness, pain, swelling, warmth, skin discoloration, and noticeable veins over affected area
sensation of burning, warmth, heat, numbness, tightness, or tingling
unusual bleeding or bruising
unusual tiredness or weakness

Less common

Burning, stinging, or swelling at place of injection
dizziness or lightheadedness
dry mouth or bad taste in mouth
headache
nosebleed
redness of face
vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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xylometazoline (Nasal route)

30/06/10

zye-loe-me-TAZ-oh-leen

Commonly used brand name(s):

In the U.S.

Otrivin
Otrivin Pediatric

Available Dosage Forms:

Spray
Solution

Therapeutic Class: Decongestant

Chemical Class: Imidazoline

Uses For xylometazoline

Xylometazoline is used for the temporary relief of congestion or stuffiness in the nose caused by hay fever or other allergies, colds, or sinus trouble.

xylometazoline may also be used for other conditions as determined by your doctor.

xylometazoline is available without a prescription.

Before Using xylometazoline

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For xylometazoline, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to xylometazoline or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Children may be especially sensitive to the effects of xylometazoline. This may increase the chance of side effects during treatment, especially sedation.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of xylometazoline in the elderly with use in other age groups.

Breast Feeding

Interactions with Medicines

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of xylometazoline

To use the nose drops:

Blow your nose gently. Tilt the head back while standing or sitting up. Place the drops into each nostril and immediately bend head forward toward the knees for a few seconds to allow the medicine to spread throughout the nose.
Rinse the dropper with hot water and dry with a clean tissue. Replace the cap right after use.

To use the nose spray:

Blow your nose gently. With the head upright, spray the medicine into each nostril. Sniff briskly while squeezing the bottle quickly and firmly. For best results, spray once into each nostril, wait 3 to 5 minutes to allow the medicine to work, then blow your nose gently and thoroughly. Repeat until the complete dose is used.
Rinse the tip of the spray bottle with hot water taking care not to suck water into the bottle, and dry with a clean tissue. Replace the cap right after use.

To avoid spreading the infection, do not use the container for more than one person.

Use xylometazoline only as directed. Do not use more of it, do not use it more often, and do not use it for longer than 3 days, unless otherwise directed by your doctor. To do so may make your runny or stuffy nose worse and may also increase the chance of side effects.

Dosing

The dose of xylometazoline will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of xylometazoline. If your dose is different, do not change it unless your doctor tells you to do so.

For stuffy nose:
- For nasal solution (nose drops or nose spray) dosage forms:
  - Adults and children 12 years of age and older—Use one to three drops or sprays of a 0.1% solution in each nostril every eight to ten hours as needed.
  - Children 2 to 12 years of age—Use two or three drops or sprays of a 0.05% solution in each nostril every eight to ten hours as needed.
  - Children up to 2 years of age—Use and dose must be determined by your doctor.
  - The following dosage guidelines are used in Canada for children up to 12 years of age:
    - Children 6 to 12 years of age—Use two or three drops or sprays of a 0.05% solution in each nostril every eight to ten hours as needed.
    - Children up to 6 years of age—Use one drop or spray of a 0.05% solution in each nostril every eight to ten hours as needed.

Missed Dose

If you miss a dose of xylometazoline, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

xylometazoline Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Symptoms of too much medicine being absorbed into the body

Blurred vision
dizziness
headache or light-headedness
hives
nausea
nervousness
pounding, irregular, or fast heartbeat
rash
shortness of breath
swelling of eyelids, face, or lips
troubled breathing
trouble in sleeping
wheezing

Increase in runny or stuffy nose

Burning, dryness, or stinging of inside of nose
discharge of fluid from the nose
sneezing

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Xylometazoline Spray

30/06/10

Generic Name: Xylometazoline (ZYE-loe-me-TAZ-oh-leen)
Brand Name: 4-Way Moisturizing Relief

Xylometazoline Spray is used for:

Relieving nasal congestion due to the common cold, hay fever, other upper respiratory tract allergies, or sinus infection. It also soothes nasal discomfort caused by dryness. It may also be used to treat other conditions as determined by your doctor.

Xylometazoline Spray is a decongestant. It works by shrinking swollen and congested nasal tissues (mucous membranes) by constricting blood vessels. This results in relief of congestion (stuffy feeling), improved drainage of mucus, and improved breathing through the nose. Local application (eg, nose drops and sprays) causes more intense and rapid vasoconstriction than oral medicines (eg, tablets, syrups).

Do NOT use Xylometazoline Spray if:

you are allergic to any ingredient in Xylometazoline Spray

Contact your doctor or health care provider right away if any of these apply to you.

Before using Xylometazoline Spray:

Some medical conditions may interact with Xylometazoline Spray. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have a history of high blood pressure, enlarged prostate or trouble urinating, diabetes, overactive thyroid, or heart disease

Some MEDICINES MAY INTERACT with Xylometazoline Spray. However, no specific interactions with Xylometazoline Spray are known at this time.

Ask your health care provider if Xylometazoline Spray may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Xylometazoline Spray:

Use Xylometazoline Spray as directed by your doctor. Check the label on the medicine for exact dosing instructions.

To use a nose spray, gently blow your nose. Sit down and tilt your head back slightly. Place the tip of the spray container into the nose. Using a finger from your other hand, press against the opposite nostril to close it off. Breathe gently through the open nostril and squeeze the spray container. If you are using more than 1 spray, wait for 1 to 2 minutes between sprays. After using the medicine, rinse the tip of the spray unit in hot water and dry with a clean tissue to prevent contamination.
If you miss a dose of Xylometazoline Spray and are using it regularly, use it as soon as possible. If it is much more than 1 hour since your missed dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Xylometazoline Spray.

Important safety information:

Do not use Xylometazoline Spray for more than 3 days unless advised to do so by your health care provider. Frequent or long-term use of Xylometazoline Spray may cause nasal congestion to recur or worsen.
Diabetes patients – Xylometazoline Spray may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
Xylometazoline Spray should not be used in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.
PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Xylometazoline Spray while you are pregnant. It is not known if Xylometazoline Spray is found in breast milk. If you are or will be breast-feeding while you use Xylometazoline Spray, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Xylometazoline Spray:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Increase in nasal discharge; temporary burning, stinging or sneezing.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fast or irregular heartbeat; nervousness; severe or persistent headache; tremor.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Xylometazoline Spray:

Store Xylometazoline Spray at room temperature, between 59 and 86 degrees F (15 and 30 degrees C) in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Xylometazoline Spray out of the reach of children and away from pets.

General information:

If you have any questions about Xylometazoline Spray, please talk with your doctor, pharmacist, or other health care provider.
Xylometazoline Spray is to be used only by the patient for whom it is prescribed. Do not share it with other due to increased risk of spreading infection.
If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Xylometazoline Spray. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: May 5, 2010

Database Edition 10.2.1.002

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30/06/10

Xyzal Solution is used for:

Do NOT use Xyzal Solution if:

Before using Xyzal Solution:

How to use Xyzal Solution:

Important safety information:

Possible side effects of Xyzal Solution:

If OVERDOSE is suspected:

General information:

30/06/10

Uses For Xyzal

Before Using Xyzal

Allergies

Pediatric

Geriatric

Pregnancy

Breast Feeding

Interactions with Medicines

Interactions with Food/Tobacco/Alcohol

Other Medical Problems

Proper Use of meclizine, buclizine, and cyclizine

Dosing

Missed Dose

Storage

Precautions While Using Xyzal

Xyzal Side Effects

30/06/10

Xyralid RC Cream is used for:

Do NOT use Xyralid RC Cream if:

Before using Xyralid RC Cream:

How to use Xyralid RC Cream:

Important safety information:

Possible side effects of Xyralid RC Cream:

If OVERDOSE is suspected:

General information:

30/06/10

Uses For Xyrem

Before Using Xyrem

Allergies

Pediatric

Geriatric

Pregnancy

Breast Feeding

Interactions with Medicines

Interactions with Food/Tobacco/Alcohol

Other Medical Problems

Proper Use of Xyrem

Dosing

Missed Dose

Storage

Precautions While Using Xyrem

Xyrem Side Effects

30/06/10

What is Xyralid (hydrocortisone and lidocaine topical)?

What is the most important information I should know about Xyralid (hydrocortisone and lidocaine topical)?

What should I discuss with my healthcare provider before using Xyralid (hydrocortisone and lidocaine topical)?

How should I use Xyralid (hydrocortisone and lidocaine topical)?

What happens if I miss a dose?

What happens if I overdose?

What should I avoid while using Xyralid (hydrocortisone and lidocaine topical)?

Xyralid (hydrocortisone and lidocaine topical) side effects

What other drugs will affect Xyralid (hydrocortisone and lidocaine topical)?

Where can I get more information?

30/06/10

What is Xyralid RC (hydrocortisone and lidocaine topical with psyllium)?

What is the most important information I should know about Xyralid RC (hydrocortisone and lidocaine topical with psyllium)?

What should I discuss with my healthcare provider before using Xyralid RC (hydrocortisone and lidocaine topical with psyllium)?

How should I use Xyralid RC (hydrocortisone and lidocaine topical with psyllium)?

What happens if I miss a dose?

What happens if I overdose?

What should I avoid while using Xyralid RC (hydrocortisone and lidocaine topical with psyllium)?

Xyralid RC (hydrocortisone and lidocaine topical with psyllium) side effects

What other drugs will affect Xyralid RC (hydrocortisone and lidocaine topical with psyllium)?

Where can I get more information?

30/06/10

What is xylometazoline nasal?

What is the most important information I should know about xylometazoline nasal?